Kcnip1 (potassium voltage-gated channel interacting protein 1) - Rat Genome Database
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Gene: Kcnip1 (potassium voltage-gated channel interacting protein 1) Rattus norvegicus
Analyze
Symbol: Kcnip1
Name: potassium voltage-gated channel interacting protein 1
RGD ID: 70886
Description: Exhibits several functions, including ion channel binding activity; potassium channel regulator activity; and protein N-terminus binding activity. Involved in positive regulation of action potential. Localizes to several cellular components, including dendrite; neuronal cell body; and potassium channel complex. Orthologous to human KCNIP1 (potassium voltage-gated channel interacting protein 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A-type potassium channel modulatory protein 1; Kchip1; Kv channel-interacting protein 1; potassium channel interacting protein 1; potassium channel-interacting protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21018,219,519 - 18,588,833 (-)NCBI
Rnor_6.0 Ensembl1018,558,128 - 18,942,540 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01018,558,128 - 18,942,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01018,443,846 - 18,821,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,549,984 - 18,565,789 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1017,854,471 - 18,221,759 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:10676964   PMID:11423117   PMID:12138168   PMID:15356203   PMID:17187064   PMID:17725712   PMID:19261906   PMID:19713751   PMID:19896980   PMID:24037673   PMID:25917026  


Genomics

Comparative Map Data
Kcnip1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21018,219,519 - 18,588,833 (-)NCBI
Rnor_6.0 Ensembl1018,558,128 - 18,942,540 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01018,558,128 - 18,942,677 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01018,443,846 - 18,821,334 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41018,549,984 - 18,565,789 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1017,854,471 - 18,221,759 (-)NCBICelera
Cytogenetic Map10q12NCBI
KCNIP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5170,353,487 - 170,736,632 (+)EnsemblGRCh38hg38GRCh38
GRCh385170,353,055 - 170,736,632 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375169,780,491 - 170,163,636 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365169,713,459 - 170,096,214 (+)NCBINCBI36hg18NCBI36
Build 345169,863,625 - 170,096,212NCBI
Celera5165,812,814 - 166,196,213 (+)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5164,879,389 - 165,261,398 (+)NCBIHuRef
CHM1_15169,213,393 - 169,596,144 (+)NCBICHM1_1
Kcnip1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,579,339 - 33,943,854 (-)NCBIGRCm39mm39
GRCm39 Ensembl1133,579,339 - 33,943,152 (-)Ensembl
GRCm381133,629,339 - 33,993,348 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,629,339 - 33,993,152 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,529,780 - 33,743,527 (-)NCBIGRCm37mm9NCBIm37
MGSCv361133,529,780 - 33,743,527 (-)NCBImm8
Celera1136,039,564 - 36,254,398 (-)NCBICelera
Cytogenetic Map11A4NCBI
Kcnip1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540823,437,358 - 23,662,533 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540823,299,192 - 23,662,395 (+)NCBIChiLan1.0ChiLan1.0
KCNIP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15172,470,524 - 172,853,992 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5172,622,331 - 172,853,992 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05165,711,110 - 166,095,049 (+)NCBIMhudiblu_PPA_v0panPan3
KCNIP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl441,223,369 - 41,431,510 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1441,220,128 - 41,566,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Kcnip1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366094,168,487 - 4,481,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNIP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1653,267,523 - 53,650,721 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11653,272,652 - 53,694,974 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21657,545,284 - 57,558,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNIP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12372,555,329 - 72,934,425 (+)NCBI
ChlSab1.1 Ensembl2372,910,263 - 72,934,422 (+)Ensembl
Kcnip1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473319,255,938 - 19,625,087 (-)NCBI

Position Markers
AU046920  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01018,629,143 - 18,629,305NCBIRnor6.0
Rnor_5.01018,514,094 - 18,514,256UniSTSRnor5.0
RGSC_v3.41018,623,429 - 18,623,591UniSTSRGSC3.4
Celera1017,918,049 - 17,918,211UniSTS
Cytogenetic Map10q12UniSTS
RH142383  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01018,919,035 - 18,919,210NCBIRnor6.0
Rnor_5.01018,797,692 - 18,797,867UniSTSRnor5.0
RGSC_v3.41018,911,999 - 18,912,174UniSTSRGSC3.4
Celera1018,196,301 - 18,196,476UniSTS
Cytogenetic Map10q12UniSTS
BF405894  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01018,746,739 - 18,746,829NCBIRnor6.0
Rnor_5.01018,625,945 - 18,626,035UniSTSRnor5.0
RGSC_v3.41018,743,401 - 18,743,491UniSTSRGSC3.4
Celera1018,030,228 - 18,030,318UniSTS
Cytogenetic Map10q12UniSTS
AA849706  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01018,558,309 - 18,558,503NCBIRnor6.0
Rnor_5.01018,444,027 - 18,444,221UniSTSRnor5.0
RGSC_v3.41018,549,360 - 18,549,554UniSTSRGSC3.4
Celera1017,854,652 - 17,854,846UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101537547462469074Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101646873661468736Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11712154262121542Rat
737823Alc12Alcohol consumption QTL 124.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)101755538619743866Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101824639453637634Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:69
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000007187, ENSRNOT00000040737
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 60 4 15
Low 2 14 13 6 2 6 14 31 25 7
Below cutoff 9 21 12 11 12 8 10 1 4 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007187   ⟹   ENSRNOP00000007187
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,558,936 - 18,942,540 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000040737   ⟹   ENSRNOP00000046697
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,558,128 - 18,579,632 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079031   ⟹   ENSRNOP00000071584
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,558,128 - 18,574,710 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083090   ⟹   ENSRNOP00000074006
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1018,558,129 - 18,574,909 (-)Ensembl
RefSeq Acc Id: NM_001261387   ⟹   NP_001248316
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,219,519 - 18,588,833 (-)NCBI
Rnor_6.01018,558,128 - 18,942,677 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Celera1017,854,471 - 18,221,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001261388   ⟹   NP_001248317
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,219,519 - 18,588,833 (-)NCBI
Rnor_6.01018,558,128 - 18,942,677 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Celera1017,854,471 - 18,221,759 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001261389   ⟹   NP_001248318
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,219,519 - 18,436,095 (-)NCBI
Rnor_6.01018,558,128 - 18,784,083 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Celera1017,854,471 - 18,068,210 (-)NCBI
Sequence:
RefSeq Acc Id: NM_022929   ⟹   NP_075218
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,219,519 - 18,436,095 (-)NCBI
Rnor_6.01018,558,128 - 18,784,083 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
RGSC_v3.41018,549,984 - 18,565,789 (-)RGD
Celera1017,854,471 - 18,068,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006246105   ⟹   XP_006246167
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21018,219,519 - 18,272,740 (-)NCBI
Rnor_6.01018,558,132 - 18,616,322 (-)NCBI
Rnor_5.01018,443,846 - 18,821,334 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_075218   ⟸   NM_022929
- Peptide Label: isoform 4
- UniProtKB: Q8R426 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001248317   ⟸   NM_001261388
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_001248316   ⟸   NM_001261387
- Peptide Label: isoform 1
- UniProtKB: A0A0H2UHE0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001248318   ⟸   NM_001261389
- Peptide Label: isoform 3
- UniProtKB: Q8R426 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006246167   ⟸   XM_006246105
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000071584   ⟸   ENSRNOT00000079031
RefSeq Acc Id: ENSRNOP00000074006   ⟸   ENSRNOT00000083090
RefSeq Acc Id: ENSRNOP00000007187   ⟸   ENSRNOT00000007187
RefSeq Acc Id: ENSRNOP00000046697   ⟸   ENSRNOT00000040737
Protein Domains
EF-hand

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70886 AgrOrtholog
Ensembl Genes ENSRNOG00000005365 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000007187 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000046697 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000071584 UniProtKB/TrEMBL
  ENSRNOP00000074006 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007187 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000040737 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000079031 UniProtKB/TrEMBL
  ENSRNOT00000083090 ENTREZGENE, UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Recoverin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:65023 UniProtKB/Swiss-Prot
NCBI Gene 65023 ENTREZGENE
PANTHER PTHR23055 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Kcnip1 PhenoGen
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K0U3_RAT UniProtKB/TrEMBL
  A0A0G2K701_RAT UniProtKB/TrEMBL
  A0A0H2UHE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A0H2UHY1_RAT UniProtKB/TrEMBL
  KCIP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q793P9 UniProtKB/Swiss-Prot
  Q8CIR1 UniProtKB/Swiss-Prot
  Q8R425 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnip1  potassium voltage-gated channel interacting protein 1  Kcnip1  Kv channel-interacting protein 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Kcnip1  Kv channel-interacting protein 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process coexpression of the two splice variants with Kv4.2 channels in oocytes slows the K current decay and destabilizes the open-inactivated channel gating 724600
gene_product member of the rapidly inactivating K channels in brain and heart 724600