Kcnd2 (potassium voltage-gated channel subfamily D member 2) - Rat Genome Database

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Gene: Kcnd2 (potassium voltage-gated channel subfamily D member 2) Heterocephalus glaber
Analyze
Symbol: Kcnd2
Name: potassium voltage-gated channel subfamily D member 2
RGD ID: 18920892
Description: ENCODES a protein that exhibits A-type (transient outward) potassium channel activity (ortholog); monoatomic ion channel activity (ortholog); potassium channel activity (ortholog); INVOLVED IN action potential (ortholog); cardiac muscle cell action potential (ortholog); cellular response to hypoxia (ortholog); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; ASSOCIATED WITH cholangiocarcinoma (ortholog); early myoclonic encephalopathy (ortholog); genetic disease (ortholog); FOUND IN caveola (ortholog); dendrite (ortholog); dendritic spine (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: potassium voltage-gated channel, Shal-related subfamily, member 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478315,351,870 - 15,891,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478315,349,416 - 15,892,011 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
alfentanil pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Kcnd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478315,351,870 - 15,891,057 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478315,349,416 - 15,892,011 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
KCND2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387120,272,908 - 120,750,337 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7120,273,175 - 120,750,337 (+)EnsemblGRCh38hg38GRCh38
GRCh377119,913,229 - 120,390,391 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367119,700,958 - 120,177,623 (+)NCBINCBI36Build 36hg18NCBI36
Build 347119,507,672 - 119,984,338NCBI
Celera7114,723,245 - 115,199,902 (+)NCBICelera
Cytogenetic Map7q31.31NCBI
HuRef7114,276,961 - 114,753,560 (+)NCBIHuRef
CHM1_17119,847,044 - 120,323,690 (+)NCBICHM1_1
T2T-CHM13v2.07121,573,495 - 122,065,688 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27119,308,832 - 119,785,474 (+)NCBI
Kcnd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39621,212,101 - 21,729,804 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl621,215,502 - 21,729,804 (+)EnsemblGRCm39 Ensembl
GRCm38621,215,346 - 21,729,805 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl621,215,503 - 21,729,805 (+)EnsemblGRCm38mm10GRCm38
MGSCv37621,166,109 - 21,679,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36621,166,110 - 21,679,806 (+)NCBIMGSCv36mm8
Celera621,270,473 - 21,783,671 (+)NCBICelera
Cytogenetic Map6A2- A3.1NCBI
cM Map68.49NCBI
Kcnd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8450,741,595 - 51,243,540 (+)NCBIGRCr8
mRatBN7.2449,775,812 - 50,277,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl449,776,246 - 50,277,728 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx454,749,390 - 55,256,964 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0450,670,509 - 51,178,050 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0449,094,034 - 49,606,328 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0448,309,283 - 48,816,804 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0448,099,455 - 48,609,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4447,541,787 - 48,047,924 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1447,772,679 - 48,277,046 (+)NCBI
Celera444,984,114 - 45,483,230 (+)NCBICelera
Cytogenetic Map4q22NCBI
Kcnd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554792,062,608 - 2,543,125 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554792,062,607 - 2,545,576 (+)NCBIChiLan1.0ChiLan1.0
KCND2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26157,137,701 - 157,618,726 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan179,147,110 - 9,628,983 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07112,277,018 - 112,751,896 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17124,965,851 - 125,439,913 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7124,966,816 - 125,437,430 (+)Ensemblpanpan1.1panPan2
KCND2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11458,441,274 - 58,915,512 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1457,856,409 - 58,331,857 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01458,473,978 - 58,950,142 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11458,569,218 - 59,043,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01458,192,134 - 58,667,882 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01458,569,685 - 59,045,993 (+)NCBIUU_Cfam_GSD_1.0
Kcnd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511847,376,410 - 47,833,708 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366054,372,671 - 4,825,423 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366054,370,222 - 4,828,972 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCND2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1826,139,457 - 26,623,233 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11826,139,457 - 26,624,210 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21827,744,043 - 27,759,304 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCND2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12189,091,939 - 89,575,464 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604214,004,421 - 14,488,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_004856458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AHKG01060306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060315 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AHKG01060331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GEBF01003024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSHGLT00000014916   ⟹   ENSHGLP00000014771
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478315,351,870 - 15,891,057 (-)Ensembl
RefSeq Acc Id: XM_004856458   ⟹   XP_004856515
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478315,349,416 - 15,892,011 (-)NCBI
Protein Sequences
Protein RefSeqs XP_004856515 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000014771
  ENSHGLP00100018839
GenBank Protein JAO00609 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004856515   ⟸   XM_004856458
- UniProtKB: A0A0P6JWD6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000014771   ⟸   ENSHGLT00000014916


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000010555 Ensembl, ENTREZGENE
  ENSHGLG00100013900 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000014916 ENTREZGENE
  ENSHGLT00100019036 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4.2 UniProtKB/TrEMBL
  K_chnl_volt-dep_Kv4_C UniProtKB/TrEMBL
  Shal-type_N UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
  VG_K_chnl UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
KEGG Report hgl:101712898 UniProtKB/TrEMBL
NCBI Gene Kcnd2 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 2 UniProtKB/TrEMBL
  PTHR11537 UniProtKB/TrEMBL
Pfam BTB_2 UniProtKB/TrEMBL
  DUF3399 UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  Shal-type UniProtKB/TrEMBL
PRINTS KCHANNEL UniProtKB/TrEMBL
  KV42CHANNEL UniProtKB/TrEMBL
  KVCHANNEL UniProtKB/TrEMBL
  SHALCHANNEL UniProtKB/TrEMBL
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A0P6JWD6 ENTREZGENE, UniProtKB/TrEMBL