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Gene: Scn1b (sodium voltage-gated channel beta subunit 1) Rattus norvegicus
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Symbol: Scn1b
Name: sodium voltage-gated channel beta subunit 1
Description: Exhibits sodium channel regulator activity. Involved in regulation of voltage-gated sodium channel activity and response to pyrethroid. Localizes to the voltage-gated sodium channel complex. Colocalizes with the node of Ranvier. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Brugada syndrome 5; early infantile epileptic encephalopathy 52; familial atrial fibrillation; and generalized epilepsy with febrile seizures plus. Orthologous to human SCN1B (sodium voltage-gated channel beta subunit 1); PARTICIPATES IN alfentanil pharmacodynamics pathway; bupivacaine pharmacodynamics pathway; buprenorphine pharmacodynamics pathway; INTERACTS WITH (+)-trans-(S)-allethrin; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: sodium channel subunit beta-1; sodium channel voltage-gated type 1 beta polypeptide; sodium channel voltage-gated type I beta polypeptide; sodium channel, voltage-gated, type 1, beta polypeptide; sodium channel, voltage-gated, type I, beta; sodium channel, voltage-gated, type I, beta polypeptide; sodium channel, voltage-gated, type I, beta subunit
Orthologs:
Homo sapiens (human) : SCN1B (sodium voltage-gated channel beta subunit 1)  HGNC  Alliance
Mus musculus (house mouse) : Scn1b (sodium channel, voltage-gated, type I, beta)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn1b (sodium voltage-gated channel beta subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN1B (sodium voltage-gated channel beta subunit 1)
Canis lupus familiaris (dog) : SCN1B (sodium voltage-gated channel beta subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn1b (sodium voltage-gated channel beta subunit 1)
Sus scrofa (pig) : SCN1B (sodium voltage-gated channel beta subunit 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0189,550,738 - 89,560,469 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0190,705,285 - 90,715,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4186,162,254 - 86,172,128 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1186,240,364 - 86,250,239 (-)NCBI
Celera180,722,797 - 80,732,619 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Scn1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3631
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.