Kcnd3 (potassium voltage-gated channel subfamily D member 3) - Rat Genome Database

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Gene: Kcnd3 (potassium voltage-gated channel subfamily D member 3) Rattus norvegicus
Analyze
Symbol: Kcnd3
Name: potassium voltage-gated channel subfamily D member 3
RGD ID: 68394
Description: Enables A-type (transient outward) potassium channel activity. Involved in cellular response to BMP stimulus; potassium ion export across plasma membrane; and potassium ion import across plasma membrane. Located in several cellular components, including caveola; neuronal cell body; and perinuclear endoplasmic reticulum. Part of voltage-gated potassium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-type voltage-gated potassium channel KCND3; Kv4.3; LOC684161; potassium channel, voltage-gated Shal-related subfamily D, member 3; potassium voltage gated channel, Shal-related family, member 3; potassium voltage-gated channel, Shal-related subfamily, member 3; similar to Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3); voltage-gated potassium channel subunit Kv4.3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,626,316 - 195,843,690 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2195,626,316 - 195,843,690 (+)EnsemblGRCr8
mRatBN7.22192,937,950 - 193,155,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,937,950 - 193,155,345 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2200,532,308 - 200,749,767 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,418,563 - 198,635,769 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,235,506 - 193,452,721 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,923,775 - 208,140,727 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,923,775 - 208,140,727 (+)Ensemblrn6Rnor6.0
Rnor_5.02227,345,052 - 227,561,680 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42200,709,778 - 200,924,575 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2185,602,165 - 185,617,489 (+)NCBICelera
RGSC_v3.13128,828,320 - 128,840,436 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4-aminopyridine  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chelerythrine  (ISO)
clothianidin  (ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
decabromodiphenyl ether  (EXP)
diallyl trisulfide  (ISO)
dimethylarsinic acid  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenvalerate  (EXP)
ferrostatin-1  (ISO)
fluoxetine  (ISO)
fulvestrant  (EXP)
genistein  (ISO)
glufosinate  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
phenylephrine  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
progesterone  (ISO)
raloxifene  (EXP,ISO)
reserpine  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sarin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP)
testosterone  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
verapamil  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
excitatory synaptic transmission pathway  (TAS)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
long term potentiation  (TAS)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. alpha1-adrenoceptors regulate only the caveolae-located subpopulation of cardiac K(V)4 channels. Alday A, etal., Channels (Austin). 2010 May-Jun;4(3):168-78.
2. Complex expression and localization of inactivating Kv channels in cultured hippocampal astrocytes. Bekar LK, etal., J Neurophysiol. 2005 Mar;93(3):1699-709.
3. Expression and high glucose-mediated regulation of K+ channel interacting protein 3 (KChIP3) and KV4 channels in retinal Muller glial cells. Chavira-Suarez E, etal., Biochem Biophys Res Commun. 2011 Jan 14;404(2):678-83. doi: 10.1016/j.bbrc.2010.12.041. Epub 2010 Dec 11.
4. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala. Dabrowska J and Rainnie DG, Neuroscience. 2010 Dec 15;171(3):721-33. doi: 10.1016/j.neuroscience.2010.09.011. Epub 2010 Sep 16.
5. Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. Deschenes I, etal., J Mol Cell Cardiol. 2008 Sep;45(3):336-46. Epub 2008 May 12.
6. Role of the Kv4.3 K+ channel in ventricular muscle. A molecular correlate for the transient outward current. Dixon JE, etal., Circ Res 1996 Oct;79(4):659-68.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones. Kim J, etal., J Physiol. 2005 Nov 15;569(Pt 1):41-57. Epub 2005 Sep 1.
9. Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes. Kobayashi T, etal., J Mol Cell Cardiol. 2003 Sep;35(9):1073-82.
10. KChAP as a chaperone for specific K(+) channels. Kuryshev YA, etal., Am J Physiol Cell Physiol. 2000 May;278(5):C931-41.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Molecular cloning and tissue distribution of an alternatively spliced variant of an A-type K+ channel alpha-subunit, Kv4.3 in the rat. Ohya S, etal., FEBS Lett 1997 Dec 22;420(1):47-53.
14. Regional expression of the splice variants of Kv4.3 in rat brain and effects of C-terminus deletion on expressed K+ currents. Ohya S, etal., Life Sci 2001 Mar 2;68(15):1703-16.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. Pioletti M, etal., Nat Struct Mol Biol. 2006 Nov;13(11):987-95. Epub 2006 Oct 22.
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. Scannevin RH, etal., Neuron. 2004 Feb 19;41(4):587-98. doi: 10.1016/s0896-6273(04)00049-2.
22. Cloning of a novel component of A-type K+ channels operating at subthreshold potentials with unique expression in heart and brain. Serodio P, etal., J Neurophysiol 1996 May;75(5):2174-9.
23. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity. Shiina Y, etal., Sci Rep. 2016 May 20;6:26290. doi: 10.1038/srep26290.
24. Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones. Song M, etal., J Biol Chem 2001 Aug 24;276(34):31883-90.
25. Bone morphogenetic protein-4 contributes to the down-regulation of Kv4.3 K+ channels in pathological cardiac hypertrophy. Sun B, etal., Biochem Biophys Res Commun. 2013 Jul 12;436(4):591-4. doi: 10.1016/j.bbrc.2013.05.113. Epub 2013 Jun 6.
26. Decreased expression of Kv4.2 and novel Kv4.3 K+ channel subunit mRNAs in ventricles of renovascular hypertensive rats. Takimoto K, etal., Circ Res 1997 Oct;81(4):533-9.
27. Cloning, expression and CNS distribution of Kv4.3, an A-type K+ channel alpha subunit. Tsaur ML, etal., FEBS Lett. 1997 Jan 3;400(2):215-20. doi: 10.1016/s0014-5793(96)01388-9.
28. Molecular structure of cardiac Ito channels: Kv4.2, Kv4.3, and other possibilities? Tseng GN Cardiovasc Res 1999 Jan;41(1):16-8.
29. Kinetic properties of Kv4.3 and their modulation by KChIP2b. Wang S, etal., Biochem Biophys Res Commun. 2002 Jul 12;295(2):223-9.
30. Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. Wickenden AD, etal., Am J Physiol 1999 May;276(5 Pt 2):H1599-607.
31. Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function. You T, etal., Int J Mol Med. 2015 Jul;36(1):309-15. doi: 10.3892/ijmm.2015.2223. Epub 2015 May 26.
Additional References at PubMed
PMID:10479680   PMID:10676964   PMID:11805342   PMID:12006572   PMID:12911756   PMID:12928444   PMID:15342638   PMID:15356203   PMID:16176357   PMID:16271805   PMID:16553778   PMID:16648177  
PMID:17122053   PMID:17314290   PMID:17855600   PMID:18270591   PMID:18495361   PMID:18515646   PMID:18603586   PMID:18789946   PMID:19171649   PMID:19213956   PMID:19912787   PMID:20044444  
PMID:20861393   PMID:21349352   PMID:21451062   PMID:21493962   PMID:22245500   PMID:22266351   PMID:22700470   PMID:24037673   PMID:24845726   PMID:25917026   PMID:26721612   PMID:28566490  
PMID:29313436   PMID:30462989   PMID:31935048   PMID:33254430   PMID:33472822  


Genomics

Comparative Map Data
Kcnd3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82195,626,316 - 195,843,690 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2195,626,316 - 195,843,690 (+)EnsemblGRCr8
mRatBN7.22192,937,950 - 193,155,345 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2192,937,950 - 193,155,345 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2200,532,308 - 200,749,767 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,418,563 - 198,635,769 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,235,506 - 193,452,721 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02207,923,775 - 208,140,727 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2207,923,775 - 208,140,727 (+)Ensemblrn6Rnor6.0
Rnor_5.02227,345,052 - 227,561,680 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42200,709,778 - 200,924,575 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2185,602,165 - 185,617,489 (+)NCBICelera
RGSC_v3.13128,828,320 - 128,840,436 (+)NCBI
Cytogenetic Map2q34NCBI
KCND3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,770,662 - 111,989,668 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,770,662 - 111,989,668 (-)Ensemblhg38GRCh38
GRCh371112,313,284 - 112,532,290 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361112,119,977 - 112,333,300 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341112,030,495 - 112,243,819NCBI
Celera1110,565,074 - 110,778,378 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1110,189,856 - 110,403,378 (-)NCBIHuRef
CHM1_11112,433,439 - 112,646,758 (-)NCBICHM1_1
T2T-CHM13v2.01111,785,561 - 112,004,582 (-)NCBIT2T-CHM13v2.0
Kcnd3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,359,206 - 105,581,318 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,359,646 - 105,581,318 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383105,451,890 - 105,674,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,452,330 - 105,674,002 (+)Ensemblmm10GRCm38
MGSCv373105,255,248 - 105,476,920 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363105,580,386 - 105,802,058 (+)NCBIMGSCv36mm8
Celera3107,640,899 - 107,862,899 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.32NCBI
Kcnd3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543515,227,615 - 15,431,190 (-)Ensembl
ChiLan1.0NW_00495543515,227,386 - 15,431,136 (-)NCBIChiLan1.0ChiLan1.0
KCND3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,037,963 - 115,255,901 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,185,438 - 114,404,074 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,433,203 - 114,651,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11125,702,654 - 125,910,075 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1125,696,907 - 125,909,814 (+)EnsemblpanPan2panpan1.1
KCND3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11763,470,829 - 63,668,354 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1763,470,415 - 63,668,035 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1762,986,103 - 63,182,211 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01764,647,680 - 64,841,597 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1764,637,936 - 64,841,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11763,378,372 - 63,574,346 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01763,437,366 - 63,633,850 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01764,235,078 - 64,431,380 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnd3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505816,850,374 - 17,059,824 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936690422,883 - 621,308 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936690417,907 - 627,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCND3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,246,237 - 108,621,510 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14108,394,687 - 108,621,514 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24118,542,614 - 118,763,673 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCND3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12021,618,365 - 21,833,443 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2021,625,147 - 21,833,186 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603836,641,070 - 36,861,725 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnd3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,484,632 - 7,693,329 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247727,482,462 - 7,694,316 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnd3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1352,458,161 - 52,673,860 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnd3
1062 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:293
Count of miRNA genes:139
Interacting mature miRNAs:153
Transcripts:ENSRNOT00000019997, ENSRNOT00000047827, ENSRNOT00000051835
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2163997722225110681Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2169358774214358774Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2149957381221199885Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2138595962205135428Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2124537199209621565Rat
1581578Cm49Cardiac mass QTL 494.90.01heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2145807215220931416Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2122597372215234002Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2154723085199723085Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2154723085199723085Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2154723085199723085Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2159440891205135267Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2154723085199723085Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170652929215652929Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2159440891220931218Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2171994826205135428Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2154723085199723085Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2144882354205135428Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2191709311217961898Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1357991Ael2Aortic elastin QTL 24.20.000071aorta elastin amount (VT:0003905)aortic elastin2169227906214227906Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2192287802221089121Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
1578671Bmd10Bone mineral density QTL 105.4femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)2175931416220931416Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2143746578205135428Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2114384617215381366Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2145306936212705578Rat
7488929Bp366Blood pressure QTL 3660.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2187663373195783351Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2113746222205135428Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2114384617215381366Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660223841096Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2117415288205135428Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2175008837220008837Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2165453811210453811Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2163253030208253030Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat

Markers in Region
D2Rat52  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82195,783,205 - 195,783,351 (+)Marker Load Pipeline
mRatBN7.22193,094,852 - 193,094,998 (+)MAPPERmRatBN7.2
Rnor_6.02208,081,050 - 208,081,195NCBIRnor6.0
Rnor_5.02227,502,003 - 227,502,148UniSTSRnor5.0
RGSC_v3.42200,866,668 - 200,866,813UniSTSRGSC3.4
RGSC_v3.42200,866,667 - 200,866,813RGDRGSC3.4
Celera2185,557,445 - 185,557,622UniSTS
RGSC_v3.12200,829,422 - 200,829,567RGD
RH 3.4 Map21366.3RGD
RH 3.4 Map21366.3UniSTS
RH 2.0 Map21028.7RGD
SHRSP x BN Map273.4398RGD
Cytogenetic Map2q34UniSTS
D2Got136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,054,714 - 193,054,910 (+)MAPPERmRatBN7.2
Rnor_6.02208,040,915 - 208,041,110NCBIRnor6.0
Rnor_5.02227,461,868 - 227,462,063UniSTSRnor5.0
RGSC_v3.42200,826,441 - 200,826,748RGDRGSC3.4
RGSC_v3.42200,826,530 - 200,826,725UniSTSRGSC3.4
Celera2185,517,570 - 185,517,765UniSTS
RGSC_v3.12200,789,284 - 200,789,479RGD
RH 3.4 Map21358.4RGD
RH 3.4 Map21358.4UniSTS
Cytogenetic Map2q34UniSTS
D2Cebr1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82195,759,422 - 195,759,644 (+)Marker Load Pipeline
mRatBN7.22193,071,067 - 193,071,289 (+)MAPPERmRatBN7.2
Rnor_6.02208,057,268 - 208,057,488NCBIRnor6.0
Rnor_5.02227,478,221 - 227,478,441UniSTSRnor5.0
RGSC_v3.42200,842,883 - 200,843,104UniSTSRGSC3.4
Celera2185,533,858 - 185,534,077UniSTS
Cytogenetic Map2q34UniSTS
RH140120  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,153,088 - 193,153,303 (+)MAPPERmRatBN7.2
Rnor_6.02208,138,471 - 208,138,685NCBIRnor6.0
Rnor_5.02227,559,424 - 227,559,638UniSTSRnor5.0
RGSC_v3.42200,924,314 - 200,924,528UniSTSRGSC3.4
Celera2185,615,233 - 185,615,447UniSTS
RH 3.4 Map21366.3UniSTS
Cytogenetic Map2q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
14 12 79 169 91 90 59 70 59 6 357 182 11 156 94 120 31 26 26

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB003587 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB008806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF334791 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB581807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK475885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK477645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L48619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M74898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U75448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U92897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000019997   ⟹   ENSRNOP00000019997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2195,626,316 - 195,843,690 (+)Ensembl
mRatBN7.2 Ensembl2192,937,950 - 193,155,345 (+)Ensembl
Rnor_6.0 Ensembl2207,923,775 - 208,140,727 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000047827   ⟹   ENSRNOP00000041746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2207,930,796 - 208,136,385 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000051835   ⟹   ENSRNOP00000049111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2195,626,316 - 195,843,690 (+)Ensembl
mRatBN7.2 Ensembl2192,937,950 - 193,155,345 (+)Ensembl
Rnor_6.0 Ensembl2207,923,775 - 208,140,727 (+)Ensembl
RefSeq Acc Id: NM_001270962   ⟹   NP_001257891
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82195,626,316 - 195,843,690 (+)NCBI
mRatBN7.22192,937,950 - 193,155,345 (+)NCBI
Rnor_6.02207,923,775 - 208,140,727 (+)NCBI
Rnor_5.02227,345,052 - 227,561,680 (+)NCBI
Celera2185,602,165 - 185,617,489 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270963   ⟹   NP_001257892
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82195,626,316 - 195,843,690 (+)NCBI
mRatBN7.22192,937,950 - 193,155,345 (+)NCBI
Rnor_6.02207,923,775 - 208,140,727 (+)NCBI
Rnor_5.02227,345,052 - 227,561,680 (+)NCBI
Celera2185,602,165 - 185,617,489 (+)NCBI
Sequence:
RefSeq Acc Id: NM_031739   ⟹   NP_113927
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82195,626,316 - 195,843,690 (+)NCBI
mRatBN7.22192,937,950 - 193,155,345 (+)NCBI
Rnor_6.02207,923,775 - 208,140,727 (+)NCBI
Rnor_5.02227,345,052 - 227,561,680 (+)NCBI
RGSC_v3.42200,709,778 - 200,924,575 (+)RGD
Celera2185,602,165 - 185,617,489 (+)NCBI
Sequence:
RefSeq Acc Id: NP_113927   ⟸   NM_031739
- Peptide Label: isoform 3
- UniProtKB: Q99P42 (UniProtKB/Swiss-Prot),   Q63286 (UniProtKB/Swiss-Prot),   P70622 (UniProtKB/Swiss-Prot),   O08723 (UniProtKB/Swiss-Prot),   Q62897 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001257891   ⟸   NM_001270962
- Peptide Label: isoform 1
- UniProtKB: Q99P42 (UniProtKB/Swiss-Prot),   Q63286 (UniProtKB/Swiss-Prot),   P70622 (UniProtKB/Swiss-Prot),   O08723 (UniProtKB/Swiss-Prot),   Q62897 (UniProtKB/Swiss-Prot),   A0A0G2JSN5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257892   ⟸   NM_001270963
- Peptide Label: isoform 2
- UniProtKB: Q99P42 (UniProtKB/Swiss-Prot),   Q63286 (UniProtKB/Swiss-Prot),   P70622 (UniProtKB/Swiss-Prot),   O08723 (UniProtKB/Swiss-Prot),   Q62897 (UniProtKB/Swiss-Prot),   A0A0G2JSW5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000041746   ⟸   ENSRNOT00000047827
Ensembl Acc Id: ENSRNOP00000049111   ⟸   ENSRNOT00000051835
Ensembl Acc Id: ENSRNOP00000019997   ⟸   ENSRNOT00000019997
Protein Domains
BTB   Potassium channel voltage dependent Kv4 C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62897-F1-model_v2 AlphaFold Q62897 1-655 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691642
Promoter ID:EPDNEW_R2167
Type:single initiation site
Name:Kcnd3_1
Description:potassium voltage-gated channel subfamily D member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02207,923,696 - 207,923,756EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68394 AgrOrtholog
BioCyc Gene G2FUF-51729 BioCyc
Ensembl Genes ENSRNOG00000014686 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019997 ENTREZGENE
  ENSRNOT00000051835 ENTREZGENE
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  1.20.120.350 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BTB/POZ_dom UniProtKB/Swiss-Prot
  Ion_trans_dom UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv4 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv4.3 UniProtKB/Swiss-Prot
  K_chnl_volt-dep_Kv4_C UniProtKB/Swiss-Prot
  Shal-type_N UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
  T1-type_BTB UniProtKB/Swiss-Prot
  VG_K_chnl UniProtKB/Swiss-Prot
  Volt_channel_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:65195 UniProtKB/Swiss-Prot
NCBI Gene 65195 ENTREZGENE
PANTHER POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY D MEMBER 3 UniProtKB/Swiss-Prot
  PTHR11537 UniProtKB/Swiss-Prot
Pfam BTB_2 UniProtKB/Swiss-Prot
  DUF3399 UniProtKB/Swiss-Prot
  Ion_trans UniProtKB/Swiss-Prot
  Shal-type UniProtKB/Swiss-Prot
PharmGKB KCND3 RGD
PhenoGen Kcnd3 PhenoGen
PRINTS KCHANNEL UniProtKB/Swiss-Prot
  KV43CHANNEL UniProtKB/Swiss-Prot
  KVCHANNEL UniProtKB/Swiss-Prot
  SHALCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014686 RatGTEx
SMART BTB UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54695 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
UniProt A0A0G2JSN5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JSW5 ENTREZGENE, UniProtKB/TrEMBL
  A6K3Q9_RAT UniProtKB/TrEMBL
  A6K3R0_RAT UniProtKB/TrEMBL
  A6K3R1_RAT UniProtKB/TrEMBL
  KCND3_RAT UniProtKB/Swiss-Prot
  O08723 ENTREZGENE
  P70622 ENTREZGENE
  Q62897 ENTREZGENE
  Q63286 ENTREZGENE
  Q99P42 ENTREZGENE
UniProt Secondary O08723 UniProtKB/Swiss-Prot
  P70622 UniProtKB/Swiss-Prot
  Q63286 UniProtKB/Swiss-Prot
  Q99P42 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Kcnd3  potassium voltage-gated channel subfamily D member 3  Kcnd3  potassium channel, voltage-gated Shal-related subfamily D, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-26 Kcnd3  potassium channel, voltage-gated Shal-related subfamily D, member 3  Kcnd3  potassium voltage-gated channel, Shal-related subfamily, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-04-17 Kcnd3  potassium voltage-gated channel, Shal-related subfamily, member 3  LOC684161  similar to Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)  Data merged from RGD:1593894 737654 PROVISIONAL
2010-04-20 Kcnd3  potassium voltage-gated channel, Shal-related subfamily, member 3  Kcnd3  potassium voltage gated channel, Shal-related family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC684161  similar to Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Kcnd3  potassium voltage gated channel, Shal-related family, member 3      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pyramidal cell layers of the hippocampus and the granule cell layer of the cerebellum 633155
gene_expression mRNA expressed in the rat cardiac myocytes 628469
gene_expression mRNA expressed in the rat cardiac myocytes 628470
gene_function forms voltage-gated outward current during repolarization in cardiac myocytes 628469
gene_function forms voltage-gated outward current during repolarization in cardiac myocytes 628470
gene_physical_interaction forms heteromultimer channels with Kcnd2 which helps in increasing the rate of recovery from inactivation 628469
gene_physical_interaction forms heteromultimer channels with Kcnd2 which helps in increasing the rate of recovery from inactivation 628470
gene_process in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction 628469
gene_process in the left ventricle the mRNA level displays transmural gradient of the voltage-gated transient outward current density which impacts on cardiac functions such as contractility and impulse conduction 628470
gene_process contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle 628469
gene_process contributes to the calcium independent voltage-gated transient outward current density in the right wall and septum of the ventricle 628470