Il23r (interleukin 23 receptor) - Rat Genome Database

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Gene: Il23r (interleukin 23 receptor) Rattus norvegicus
Analyze
Symbol: Il23r
Name: interleukin 23 receptor
RGD ID: 1586368
Description: Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to contribute to interleukin-12 receptor binding activity; interleukin-23 binding activity; and interleukin-23 receptor activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to type II interferon. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bone disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor); PARTICIPATES IN interleukin-23 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH 2-amino-2-deoxy-D-glucopyranose; 3,7-dihydropurine-6-thione; aldehydo-D-glucosamine.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin 23 receptor-like; interleukin-23 receptor; interleukin-23 receptor-like; LOC103690079; LOC689932; similar to interleukin 23 receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,910,230 - 98,003,759 (-)NCBIGRCr8
mRatBN7.2496,580,568 - 96,672,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,580,714 - 96,674,021 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0498,203,788 - 98,306,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,203,958 - 98,305,173 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,989,461 - 163,092,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04163,191,096 - 163,200,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4497,087,580 - 97,768,978 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera491,260,435 - 91,346,771 (-)NCBICelera
Cytogenetic Map4q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis. Agarwal SK, etal., J Rheumatol. 2009 Dec;36(12):2715-23. Epub 2009 Nov 16.
2. Blocking of IL-6 suppresses experimental autoimmune myasthenia gravis. Aricha R, etal., J Autoimmun. 2011 Mar;36(2):135-41. Epub 2010 Dec 30.
3. Association studies of the IL-23R gene in autoimmune thyroid disease in the Japanese population. Ban Y, etal., Autoimmunity. 2009 Feb;42(2):126-30. doi: 10.1080/08916930802422265.
4. Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis. Capon F, etal., Hum Genet. 2007 Sep;122(2):201-6. Epub 2007 Jun 22.
5. Association of ERAP1, but not IL23R, with ankylosing spondylitis in a Han Chinese population. Davidson SI, etal., Arthritis Rheum. 2009 Nov;60(11):3263-8. doi: 10.1002/art.24933.
6. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Duerr RH, etal., Science. 2006 Dec 1;314(5804):1461-3. Epub 2006 Oct 26.
7. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. Einarsdottir E, etal., BMC Med Genet. 2009 Jan 28;10:8. doi: 10.1186/1471-2350-10-8.
8. Investigation of association of the IL12B and IL23R genes with psoriatic arthritis. Filer C, etal., Arthritis Rheum. 2008 Dec;58(12):3705-9. doi: 10.1002/art.24128.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Evidence for association of an interleukin 23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Hollis-Moffatt JE, etal., Ann Rheum Dis. 2009 Aug;68(8):1340-4. doi: 10.1136/ard.2008.090142. Epub 2008 Jul 22.
11. Association between polymorphisms of the IL-23R gene and allergic rhinitis in a Chinese Han population. Hu D, etal., PLoS One. 2013 May 16;8(5):e63858. doi: 10.1371/journal.pone.0063858. Print 2013.
12. Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity. Huber AK, etal., J Clin Endocrinol Metab. 2008 Mar;93(3):1077-81. Epub 2007 Dec 11.
13. IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population. Jiang Z, etal., Ann Rheum Dis. 2010 Jul;69(7):1325-8. doi: 10.1136/ard.2009.119420. Epub 2010 Apr 7.
14. Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population. Kim ES, etal., Life Sci. 2012 May 22;90(19-20):740-6. doi: 10.1016/j.lfs.2012.03.017. Epub 2012 Mar 27.
15. Association of interleukin 23 receptor gene with sarcoidosis. Kim HS, etal., Dis Markers. 2011;31(1):17-24. doi: 10.3233/DMA-2011-0796.
16. Association of IL-23 and its receptor gene single-nucleotide polymorphisms with multiple sclerosis in Chinese southern population. Liu M, etal., Int J Neurosci. 2014 Mar 19.
17. Expression of IL-17, IL-23 and their receptors in minor salivary glands of patients with primary Sjogren's syndrome. Mieliauskaite D, etal., Clin Dev Immunol. 2012;2012:187258. doi: 10.1155/2012/187258. Epub 2012 Jan 3.
18. IL23R: a susceptibility locus for celiac disease and multiple sclerosis? Nunez C, etal., Genes Immun. 2008 Jun;9(4):289-93. doi: 10.1038/gene.2008.16. Epub 2008 Mar 27.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Peng J, etal., Cell Res. 2010 Jan;20(1):62-71. Epub 2009 Nov 24.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
23. Increased interleukin-23 receptor(+) T cells in peripheral blood mononuclear cells of patients with systemic lupus erythematosus. Puwipirom H, etal., Arthritis Res Ther. 2010;12(6):R215. doi: 10.1186/ar3194. Epub 2010 Nov 29.
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype. Rueda B, etal., Ann Rheum Dis. 2009 Feb;68(2):253-6. doi: 10.1136/ard.2008.096719. Epub 2008 Aug 19.
28. Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis. Safrany E, etal., Inflamm Res. 2013 Feb;62(2):195-200. doi: 10.1007/s00011-012-0566-z. Epub 2012 Oct 25.
29. Polymorphisms of the IL23R gene are associated with psoriasis but not with immunoglobulin A nephropathy in a Hungarian population. Safrany E, etal., Inflammation. 2011 Dec;34(6):603-8. doi: 10.1007/s10753-010-9268-2.
30. Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples. Safrany E, etal., Scand J Immunol. 2009 Jul;70(1):68-74. doi: 10.1111/j.1365-3083.2009.02265.x.
31. Combination analysis of NOS3, ABCB1 and IL23R polymorphisms with alcohol-induced osteonecrosis of the femoral head risk in Chinese males. Wang Y, etal., Oncotarget. 2017 May 16;8(20):33770-33778. doi: 10.18632/oncotarget.16809.
32. Genetic profiling in Graves' disease: further evidence for lack of a distinct genetic contribution to Graves' ophthalmopathy. Yin X, etal., Thyroid. 2012 Jul;22(7):730-6. doi: 10.1089/thy.2012.0007. Epub 2012 Jun 4.
Additional References at PubMed
PMID:11114383   PMID:12023369   PMID:12421946   PMID:15114670   PMID:16751425   PMID:20027291   PMID:23382219   PMID:25600958   PMID:33843019  


Genomics

Comparative Map Data
Il23r
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8497,910,230 - 98,003,759 (-)NCBIGRCr8
mRatBN7.2496,580,568 - 96,672,540 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl496,580,714 - 96,674,021 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0498,203,788 - 98,306,729 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl498,203,958 - 98,305,173 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04162,989,461 - 163,092,313 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04163,191,096 - 163,200,531 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4497,087,580 - 97,768,978 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera491,260,435 - 91,346,771 (-)NCBICelera
Cytogenetic Map4q31NCBI
IL23R
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38167,138,637 - 67,265,903 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl167,138,907 - 67,259,979 (+)EnsemblGRCh38hg38GRCh38
GRCh37167,632,137 - 67,725,662 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36167,404,757 - 67,498,250 (+)NCBINCBI36Build 36hg18NCBI36
Build 34167,344,189 - 67,437,669NCBI
Celera165,922,104 - 66,015,428 (+)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef165,740,552 - 65,835,548 (+)NCBIHuRef
CHM1_1167,747,479 - 67,841,006 (+)NCBICHM1_1
T2T-CHM13v2.0167,016,149 - 67,143,448 (+)NCBIT2T-CHM13v2.0
Il23r
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39667,399,906 - 67,468,838 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl667,399,916 - 67,468,839 (-)EnsemblGRCm39 Ensembl
GRCm38667,422,932 - 67,491,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl667,422,932 - 67,491,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv37667,372,926 - 67,441,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36667,352,510 - 67,421,433 (-)NCBIMGSCv36mm8
Celera669,541,500 - 69,610,484 (-)NCBICelera
Cytogenetic Map6C1NCBI
cM Map630.85NCBI
Il23r
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542323,842,475 - 23,884,904 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542323,841,342 - 23,885,191 (-)NCBIChiLan1.0ChiLan1.0
IL23R
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21159,561,801 - 159,727,876 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11158,721,629 - 158,887,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0166,408,839 - 66,502,535 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1168,293,514 - 68,386,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl168,293,514 - 68,386,815 (+)Ensemblpanpan1.1panPan2
IL23R
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1543,307,422 - 43,369,806 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl543,308,982 - 43,368,474 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha543,492,672 - 43,558,098 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0543,489,715 - 43,555,184 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl543,494,316 - 43,555,221 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1543,455,682 - 43,521,106 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0543,402,563 - 43,468,018 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0543,641,801 - 43,707,245 (-)NCBIUU_Cfam_GSD_1.0
Il23r
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505880,065,633 - 80,123,951 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365914,365,762 - 4,425,005 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365914,365,598 - 4,425,053 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23R
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6145,335,741 - 145,401,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16145,337,765 - 145,401,909 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26134,219,683 - 134,283,706 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IL23R
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12065,853,379 - 65,946,000 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2065,854,349 - 65,938,024 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603351,655,750 - 51,751,460 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il23r
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474227,901,071 - 27,941,109 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474227,899,934 - 27,954,145 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il23r
705 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:44
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000010151
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
2317587Eae26Experimental allergic encephalomyelitis QTL 26nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)488656681103194984Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat

Markers in Region
BI301678  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04166,754,352 - 166,754,517NCBIRnor5.0
Rnor_5.04166,745,460 - 166,745,622NCBIRnor5.0
Rnor_5.01119,929,467 - 119,929,629NCBIRnor5.0
Rnor_5.04166,762,264 - 166,762,429NCBIRnor5.0
RGSC_v3.4497,544,598 - 97,544,761UniSTSRGSC3.4
RGSC_v3.4497,479,951 - 97,480,112UniSTSRGSC3.4
RH 3.4 Map4593.4UniSTS
Cytogenetic Map4q31UniSTS
AU048125  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.04166,498,717 - 166,498,876NCBIRnor5.0
Rnor_5.04166,239,430 - 166,239,589NCBIRnor5.0
Rnor_5.0X96,779,107 - 96,779,266NCBIRnor5.0
RGSC_v3.4497,251,868 - 97,252,026UniSTSRGSC3.4
Cytogenetic Map4q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 1
Low 2 7 17 6 1 15 6
Below cutoff 1 1 4 2 2 2 2 3 23 13 14 5 2

Sequence


Ensembl Acc Id: ENSRNOT00000010151   ⟹   ENSRNOP00000010151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl496,580,714 - 96,674,021 (-)Ensembl
Rnor_6.0 Ensembl498,203,958 - 98,305,173 (-)Ensembl
RefSeq Acc Id: XM_039108697   ⟹   XP_038964625
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,910,230 - 98,003,759 (-)NCBI
mRatBN7.2496,580,568 - 96,672,540 (-)NCBI
RefSeq Acc Id: XM_063286966   ⟹   XP_063143036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,912,299 - 98,003,759 (-)NCBI
RefSeq Acc Id: XR_010066178
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,910,899 - 98,003,759 (-)NCBI
RefSeq Acc Id: XR_010066179
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8497,912,561 - 98,003,759 (-)NCBI
Protein Sequences
Protein RefSeqs XP_038964625 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143036 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010151.6
Ensembl Acc Id: ENSRNOP00000010151   ⟸   ENSRNOT00000010151
RefSeq Acc Id: XP_038964625   ⟸   XM_039108697
- Peptide Label: isoform X1
- UniProtKB: F1LX96 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143036   ⟸   XM_063286966
- Peptide Label: isoform X2
Protein Domains
Fibronectin type-III

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LX96-F1-model_v2 AlphaFold F1LX96 1-624 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586368 AgrOrtholog
BioCyc Gene G2FUF-44559 BioCyc
Ensembl Genes ENSRNOG00000007544 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010151.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Fibronectin_type3 UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
NCBI Gene 689932 ENTREZGENE
PANTHER CYTOKINE RECEPTOR UniProtKB/TrEMBL
  INTERLEUKIN-23 RECEPTOR UniProtKB/TrEMBL
PhenoGen Il23r PhenoGen
PROSITE FN3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007544 RatGTEx
Superfamily-SCOP FN_III-like UniProtKB/TrEMBL
UniProt F1LX96 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Il23r  interleukin 23 receptor  LOC103690079  interleukin-23 receptor-like  Data merged from RGD:9432483 737654 PROVISIONAL
2014-08-25 LOC103690079  interleukin-23 receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-05-24 Il23r  interleukin 23 receptor  LOC100364993  interleukin 23 receptor-like  Data merged from RGD:2319973 1643240 APPROVED
2010-05-05 LOC100364993  interleukin 23 receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-06 Il23r  interleukin 23 receptor  LOC689932  similar to interleukin 23 receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689932  similar to interleukin 23 receptor  LOC683816  similar to interleukin 23 receptor  Data merged from RGD:1597863 1643240 APPROVED
2006-11-20 LOC683816  similar to interleukin 23 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC689932  similar to interleukin 23 receptor      Symbol and Name status set to provisional 70820 PROVISIONAL