RGD Reference Report - Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis. - Rat Genome Database

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Difference of interleukin-23 receptor gene haplotype variants in ulcerative colitis compared to Crohn's disease and psoriasis.

Authors: Safrany, E  Szabo, M  Szell, M  Kemeny, L  Sumegi, K  Melegh, BI  Magyari, L  Matyas, P  Figler, M  Weber, A  Tulassay, Z  Melegh, B 
Citation: Safrany E, etal., Inflamm Res. 2013 Feb;62(2):195-200. doi: 10.1007/s00011-012-0566-z. Epub 2012 Oct 25.
RGD ID: 8549574
Pubmed: PMID:23093364   (View Abstract at PubMed)
DOI: DOI:10.1007/s00011-012-0566-z   (Journal Full-text)

OBJECTIVE: Polymorphisms of the interleukin-23 receptor (IL23R) gene have been found to play a role in the development of several autoimmune diseases. Our aim was to examine the possible effect of not only simple individual variants, but of haplotypes composed of them. SUBJECTS: We analysed 263 patients with psoriasis, 199 patients with Crohn's disease (CD), 282 patients with ulcerative colitis (UC), and 253 controls for rs1884444, rs11805303, rs7517847, rs2201841, rs10889677 and rs11209032 variants. METHODS: The genotypes were determined by using PCR/RFLP assay. Logistic regression analysis was used to compare the genotype distribution of the polymorphisms and haplotypes between the examined autoimmune diseases and healthy controls. RESULTS: Rs1884444 was found to confer risk for UC and psoriasis, rs10889677 for CD and psoriasis, while rs2201841 and rs7517847 had effect only in CD. Using these SNPs we could study the susceptibility haplotype profiles in these diseases with special attention to UC. Eight different haplotypes could be differentiated. We found that the SNPs exert their susceptibility character in specific haplotype blocks, and the frequency of one haplotype differed significantly in UC compared with both other diseases and also with healthy controls. This haplotype conferred risk for UC, even while it had a somewhat lower frequency in the other diseases than in controls. CONCLUSIONS: The data presented here serve as evidence for the need of haplotype analysis instead of just single standing SNP analysis when susceptibility is interpreted.




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
IL23RHumanpsoriasis  IAGP DNA:SNPs: :rs1884444 and rs10889677(human)RGD 
Il23rRatpsoriasis  ISOIL23R (Homo sapiens)DNA:SNPs: :rs1884444 and rs10889677(human)RGD 
Il23rMousepsoriasis  ISOIL23R (Homo sapiens)DNA:SNPs: :rs1884444 and rs10889677(human)RGD 
IL23RHumanulcerative colitis  IAGP DNA:SNP and Haplotype: :rs1884444(human)RGD 
Il23rRatulcerative colitis  ISOIL23R (Homo sapiens)DNA:SNP and Haplotype: :rs1884444(human)RGD 
Il23rMouseulcerative colitis  ISOIL23R (Homo sapiens)DNA:SNP and Haplotype: :rs1884444(human)RGD 


Genes (Rattus norvegicus)
Il23r  (interleukin 23 receptor)

Genes (Mus musculus)
Il23r  (interleukin 23 receptor)

Genes (Homo sapiens)
IL23R  (interleukin 23 receptor)