Mthfd2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase) - Rat Genome Database

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Gene: Mthfd2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase) Rattus norvegicus
Analyze
Symbol: Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
RGD ID: 1311313
Description: Predicted to enable several functions, including magnesium ion binding activity; methenyltetrahydrofolate cyclohydrolase activity; and methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Biomarker of hepatocellular carcinoma. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase); PARTICIPATES IN folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; folate metabolic pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; LOC312483; LOC680308; methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; methylenetetrahydrofolate dehydrogenase 2; similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,368,833 - 117,380,350 (-)NCBIGRCr8
mRatBN7.24115,811,135 - 115,822,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,811,139 - 115,822,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,288,124 - 121,299,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,063,296 - 117,074,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,677,666 - 115,689,194 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,004,433 - 115,015,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,004,448 - 115,015,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,592,799 - 179,604,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,517,611 - 117,529,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4104,805,220 - 104,816,732 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-D  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-methylcholanthrene  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amiodarone  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
azoxystrobin  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
etoposide  (ISO)
fenpyroximate  (ISO)
fluoranthene  (ISO)
folic acid  (ISO)
fructose  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP)
gentamycin  (EXP,ISO)
glucose  (ISO)
glycine betaine  (EXP)
indole-3-methanol  (EXP)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP)
leflunomide  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
mitoxantrone  (ISO)
N(4)-hydroxycytidine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pemetrexed  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phosgene  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
potassium bromate  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
pyrimidifen  (ISO)
quinoline  (ISO)
resveratrol  (ISO)
riddelliine  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sinapic acid  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP,ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zidovudine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Transpupillary thermotherapy-induced modification of angiogenesis- and coagulation-related gene expression in the rat posterior fundus. Ito YN, etal., Mol Vis. 2006 Jul 20;12:802-10.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Methenyltetrahydrofolate cyclohydrolase is rate limiting for the enzymatic conversion of 10-formyltetrahydrofolate to 5,10-methylenetetrahydrofolate in bifunctional dehydrogenase-cyclohydrolase enzymes. Pawelek PD and MacKenzie RE, Biochemistry 1998 Jan 27;37(4):1109-15.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. In vitro synthesis of the trifunctional protein, methylenetetrahydrofolate dehydrogenase--methenyltetrahydrofolate cyclohydrolase--formyltetrahydrofolate synthetase, in normal and transformed cells. Rozen R, etal., Can J Biochem Cell Biol. 1985 Nov;63(11):1189-93.
11. Compartmentalization of Mammalian folate-mediated one-carbon metabolism. Tibbetts AS and Appling DR, Annu Rev Nutr. 2010 Aug 21;30:57-81. doi: 10.1146/annurev.nutr.012809.104810.
12. Update and new concepts in vitamin responsive disorders of folate transport and metabolism. Watkins D and Rosenblatt DS, J Inherit Metab Dis. 2012 Jul;35(4):665-70. doi: 10.1007/s10545-011-9418-1. Epub 2011 Nov 23.
Additional References at PubMed
PMID:8218174   PMID:14651853   PMID:16100107   PMID:18614015   PMID:22664934  


Genomics

Comparative Map Data
Mthfd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,368,833 - 117,380,350 (-)NCBIGRCr8
mRatBN7.24115,811,135 - 115,822,663 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,811,139 - 115,822,608 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4121,288,124 - 121,299,748 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04117,063,296 - 117,074,920 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,677,666 - 115,689,194 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04115,004,433 - 115,015,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4115,004,448 - 115,015,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04179,592,799 - 179,604,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,517,611 - 117,529,128 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera4104,805,220 - 104,816,732 (-)NCBICelera
Cytogenetic Map4q34NCBI
MTHFD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,198,615 - 74,217,565 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,186,172 - 74,217,565 (+)EnsemblGRCh38hg38GRCh38
GRCh37274,425,742 - 74,444,692 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,279,198 - 74,295,933 (+)NCBINCBI36Build 36hg18NCBI36
Build 34274,337,366 - 74,354,067NCBI
Celera274,256,899 - 74,273,604 (+)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,161,958 - 74,178,696 (+)NCBIHuRef
CHM1_1274,355,004 - 74,371,783 (+)NCBICHM1_1
T2T-CHM13v2.0274,207,390 - 74,226,316 (+)NCBIT2T-CHM13v2.0
Mthfd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,282,686 - 83,302,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,282,673 - 83,302,890 (-)EnsemblGRCm39 Ensembl
GRCm38683,305,704 - 83,326,011 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,305,691 - 83,325,908 (-)EnsemblGRCm38mm10GRCm38
MGSCv37683,255,698 - 83,267,598 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36683,271,364 - 83,283,262 (-)NCBIMGSCv36mm8
Celera685,286,788 - 85,298,680 (-)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Mthfd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,539,399 - 11,550,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542411,538,344 - 11,550,119 (-)NCBIChiLan1.0ChiLan1.0
MTHFD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21252,172,141 - 52,189,641 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A52,174,894 - 52,192,394 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,270,161 - 74,285,790 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,777,023 - 75,792,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,777,028 - 75,792,699 (+)Ensemblpanpan1.1panPan2
MTHFD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,882,838 - 48,896,816 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,883,724 - 48,941,949 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1748,522,746 - 48,538,308 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01749,740,851 - 49,756,419 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,742,732 - 49,756,640 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,757,467 - 48,773,023 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,824,290 - 48,839,869 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,382,307 - 49,398,081 (-)NCBIUU_Cfam_GSD_1.0
Mthfd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,262,753 - 10,274,900 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556462,974 - 475,159 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936556462,998 - 475,092 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTHFD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,818,119 - 68,833,600 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1368,819,171 - 68,833,641 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2372,058,348 - 72,067,128 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTHFD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11433,063,485 - 33,080,703 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1433,064,542 - 33,080,366 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604579,087,248 - 79,105,477 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mthfd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474929,264,577 - 29,276,769 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mthfd2
98 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:333
Count of miRNA genes:209
Interacting mature miRNAs:243
Transcripts:ENSRNOT00000014603
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat

Markers in Region
RH129440  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,811,419 - 115,811,601 (+)MAPPERmRatBN7.2
Rnor_6.04115,004,727 - 115,004,908NCBIRnor6.0
Rnor_5.04179,593,093 - 179,593,274UniSTSRnor5.0
RGSC_v3.44117,517,890 - 117,518,071UniSTSRGSC3.4
Celera4104,805,499 - 104,805,680UniSTS
RH 3.4 Map5787.3UniSTS
Cytogenetic Map4q34UniSTS
RH143378  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24115,811,951 - 115,812,115 (+)MAPPERmRatBN7.2
Rnor_6.05120,870,150 - 120,870,313NCBIRnor6.0
Rnor_6.04115,005,259 - 115,005,422NCBIRnor6.0
Rnor_5.05124,739,260 - 124,739,423UniSTSRnor5.0
Rnor_5.04179,593,625 - 179,593,788UniSTSRnor5.0
RGSC_v3.44117,518,422 - 117,518,585UniSTSRGSC3.4
RGSC_v3.45122,695,402 - 122,695,565UniSTSRGSC3.4
Celera5115,158,092 - 115,158,255UniSTS
Celera4104,806,031 - 104,806,194UniSTS
Cytogenetic Map5q33UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000014603   ⟹   ENSRNOP00000014603
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,811,139 - 115,822,606 (-)Ensembl
Rnor_6.0 Ensembl4115,004,448 - 115,015,965 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103961   ⟹   ENSRNOP00000089768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4115,811,849 - 115,822,608 (-)Ensembl
RefSeq Acc Id: NM_001109398   ⟹   NP_001102868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,368,835 - 117,380,350 (-)NCBI
mRatBN7.24115,811,141 - 115,822,659 (-)NCBI
Rnor_6.04115,004,448 - 115,015,965 (-)NCBI
Rnor_5.04179,592,799 - 179,604,331 (-)NCBI
RGSC_v3.44117,517,611 - 117,529,128 (-)RGD
Celera4104,805,220 - 104,816,732 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108338   ⟹   XP_038964266
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,368,833 - 117,380,336 (-)NCBI
mRatBN7.24115,811,135 - 115,822,663 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102868 (Get FASTA)   NCBI Sequence Viewer  
  XP_038964266 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91136 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014603.6
  ENSRNOP00000089768.1
RefSeq Acc Id: NP_001102868   ⟸   NM_001109398
- UniProtKB: A6IAL8 (UniProtKB/TrEMBL),   D4A1Y5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014603   ⟸   ENSRNOT00000014603
RefSeq Acc Id: XP_038964266   ⟸   XM_039108338
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GID3 (UniProtKB/TrEMBL),   D4A1Y5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089768   ⟸   ENSRNOT00000103961
Protein Domains
Tetrahydrofolate dehydrogenase/cyclohydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A1Y5-F1-model_v2 AlphaFold D4A1Y5 1-349 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693176
Promoter ID:EPDNEW_R3701
Type:multiple initiation site
Name:Mthfd2_1
Description:methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2,methenyltetrahydrofolate cyclohydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04115,015,916 - 115,015,976EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311313 AgrOrtholog
BioCyc Gene G2FUF-44012 BioCyc
BioCyc Pathway 1CMET2-PWY [folate transformations III (E. coli)] BioCyc
  PWY-5030 [L-histidine degradation III] BioCyc
BioCyc Pathway Image 1CMET2-PWY BioCyc
  PWY-5030 BioCyc
Ensembl Genes ENSRNOG00000010833 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014603.6 UniProtKB/TrEMBL
  ENSRNOT00000103961.1 UniProtKB/TrEMBL
Gene3D-CATH Leucine Dehydrogenase, chain A, domain 1 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Aminiacid_DH-like_N_sf UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  THF_DH/CycHdrlase UniProtKB/TrEMBL
  THF_DH/CycHdrlase_cat_dom UniProtKB/TrEMBL
  THF_DH/CycHdrlase_CS UniProtKB/TrEMBL
  THF_DH/CycHdrlase_NAD-bd_dom UniProtKB/TrEMBL
KEGG Report rno:680308 UniProtKB/TrEMBL
NCBI Gene Mthfd2 ENTREZGENE
PANTHER BIFUNCTIONAL METHYLENETETRAHYDROFOLATE DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL UniProtKB/TrEMBL
  C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED UniProtKB/TrEMBL
Pfam THF_DHG_CYH UniProtKB/TrEMBL
  THF_DHG_CYH_C UniProtKB/TrEMBL
PharmGKB MTHFD2 RGD
PhenoGen Mthfd2 PhenoGen
PRINTS THFDHDRGNASE UniProtKB/TrEMBL
PROSITE THF_DHG_CYH_1 UniProtKB/TrEMBL
  THF_DHG_CYH_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010833 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF53223 UniProtKB/TrEMBL
UniProt A0A8I6GID3 ENTREZGENE, UniProtKB/TrEMBL
  A6IAL8 ENTREZGENE, UniProtKB/TrEMBL
  D4A1Y5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-12-10 Mthfd2  methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase   LOC680308  similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor  Data merged from RGD:1593019 737654 APPROVED
2008-12-10 Mthfd2  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase  Mthfd2  methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mthfd2  methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase   Mthfd2_predicted  methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC680308  similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor  LOC684490  similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor  Data merged from RGD:1590277 1643240 APPROVED
2006-11-20 LOC680308  similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC684490  similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Mthfd2_predicted  methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (predicted)      Symbol and Name status set to approved 70820 APPROVED