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Gene: Mthfd2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase) Rattus norvegicus
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Symbol: Mthfd2
Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Description: Predicted to have several functions, including magnesium ion binding activity; methenyltetrahydrofolate cyclohydrolase activity; and oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor. Predicted to be involved in tetrahydrofolate interconversion. Biomarker of hepatocellular carcinoma. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase); PARTICIPATES IN folate cycle metabolic pathway; folate mediated one-carbon metabolic pathway; folate metabolic pathway; INTERACTS WITH 17beta-estradiol; acrylamide; aflatoxin B1.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial; LOC312483; LOC680308; methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; methylenetetrahydrofolate dehydrogenase 2; similar to Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04115,004,433 - 115,015,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04179,592,799 - 179,604,331 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44117,517,611 - 117,529,128 (-)NCBIRGSC3.4rn4RGSC3.4
Celera4104,805,220 - 104,816,732 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Mthfd2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1311313
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.