Mir96 (microRNA 96) - Rat Genome Database

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Gene: Mir96 (microRNA 96) Rattus norvegicus
Analyze
Symbol: Mir96
Name: microRNA 96
RGD ID: 2325582
Description: Predicted to enable mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in positive regulation of neuron apoptotic process. Located in neuronal cell body. Biomarker of hepatocellular carcinoma and sciatic neuropathy. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder and autosomal dominant nonsyndromic deafness 50. Orthologous to human MIR96 (microRNA 96); INTERACTS WITH 2-acetamidofluorene; atrazine; benzophenone.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-96; rno-mir-96
RGD Orthologs
Human
Mouse
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2458,788,411 - 58,788,516 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,788,411 - 58,788,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx463,765,533 - 63,765,638 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,681,700 - 59,681,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,083,605 - 58,083,710 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0457,463,366 - 57,463,471 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,463,366 - 57,463,471 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0457,225,167 - 57,225,272 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera453,887,982 - 53,888,087 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation. Aldrich BT, etal., Neuroscience. 2009 Dec 1;164(2):711-23. doi: 10.1016/j.neuroscience.2009.08.033. Epub 2009 Aug 20.
2. Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury. Chen HP, etal., Neurochem Res. 2014 Jan;39(1):76-83.
3. Wnt/β-Catenin activates MiR-183/96/182 expression in hepatocellular carcinoma that promotes cell invasion. Leung WK, etal., Cancer Lett. 2015 Jun 28;362(1):97-105. doi: 10.1016/j.canlet.2015.03.023. Epub 2015 Mar 23.
4. miR-96 targets SOX6 and promotes proliferation, migration, and invasion of hepatocellular carcinoma. Li Z and Wang Y, Biochem Cell Biol. 2018 Jun;96(3):365-371. doi: 10.1139/bcb-2017-0183. Epub 2017 Sep 11.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Evaluation of single nucleotide polymorphisms in the miR-183-96-182 cluster in adulthood attention-deficit and hyperactivity disorder (ADHD) and substance use disorders (SUDs). Sanchez-Mora C, etal., Eur Neuropsychopharmacol. 2013 Nov;23(11):1463-73. doi: 10.1016/j.euroneuro.2013.07.002. Epub 2013 Jul 29.
9. Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Ubhi K, etal., Eur J Neurosci. 2014 Mar;39(6):1026-41. doi: 10.1111/ejn.12444. Epub 2013 Dec 5.
10. MicroRNA-96 regulates RGC-5 cell growth through caspase-dependent apoptosis. Wang S and Li K, Int J Clin Exp Med. 2014 Oct 15;7(10):3694-702. eCollection 2014.
11. miR-96 and miR-330 overexpressed and targeted AQP5 in lipopolysaccharide-induced rat lung damage of disseminated intravascular coagulation. Zhang Y, etal., Blood Coagul Fibrinolysis. 2014 Oct;25(7):731-7. doi: 10.1097/MBC.0000000000000133.
Additional References at PubMed
PMID:16381832   PMID:16766679   PMID:17604727   PMID:19363478   PMID:20403161   PMID:20439489   PMID:23097335   PMID:23341629   PMID:23646144   PMID:23946534   PMID:26782545   PMID:26823769  
PMID:27208084   PMID:28819115   PMID:28860495   PMID:29236317   PMID:30134226   PMID:36789690   PMID:37099528   PMID:37248076  


Genomics

Comparative Map Data
Mir96
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2458,788,411 - 58,788,516 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl458,788,411 - 58,788,516 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx463,765,533 - 63,765,638 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0459,681,700 - 59,681,805 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0458,083,605 - 58,083,710 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0457,463,366 - 57,463,471 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl457,463,366 - 57,463,471 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0457,225,167 - 57,225,272 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera453,887,982 - 53,888,087 (-)NCBICelera
Cytogenetic Map4q22NCBI
MIR96
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387129,774,692 - 129,774,769 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7129,774,692 - 129,774,769 (-)EnsemblGRCh38hg38GRCh38
GRCh377129,414,532 - 129,414,609 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367129,201,767 - 129,201,844 (-)NCBINCBI36Build 36hg18NCBI36
Celera7124,210,277 - 124,210,354 (-)NCBICelera
Cytogenetic Map7q32.2NCBI
HuRef7123,775,817 - 123,775,894 (-)NCBIHuRef
CHM1_17129,347,923 - 129,348,000 (-)NCBICHM1_1
T2T-CHM13v2.07131,087,826 - 131,087,903 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27128,798,808 - 128,798,885 (-)NCBI
Mir96
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39630,169,445 - 30,169,550 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl630,169,445 - 30,169,550 (-)EnsemblGRCm39 Ensembl
GRCm38630,169,446 - 30,169,551 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl630,169,446 - 30,169,551 (-)EnsemblGRCm38mm10GRCm38
MGSCv37630,119,446 - 30,119,551 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera630,176,274 - 30,176,379 (-)NCBICelera
Cytogenetic Map6A3.3NCBI
cM Map612.52NCBI
MIR96
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1147,068,754 - 7,068,842 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl147,068,754 - 7,068,842 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha146,754,051 - 6,754,139 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0146,831,753 - 6,831,841 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl146,831,753 - 6,831,841 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1147,037,336 - 7,037,424 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0146,779,495 - 6,779,583 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0146,923,777 - 6,923,865 (+)NCBIUU_Cfam_GSD_1.0
MIR96
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1818,982,506 - 18,982,590 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11818,982,506 - 18,982,590 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21820,030,888 - 20,030,972 (+)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mitfrno-miR-96-5pMirtarbaseexternal_infoWestern blotFunctional MTI19167416

Predicted Targets
Summary Value
Count of predictions:7577
Count of gene targets:5072
Count of transcripts:5411
Interacting mature miRNAs:rno-miR-96-3p, rno-miR-96-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

respiratory system
High
Medium
Low 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_031854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACYVU010000141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000053747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl458,788,411 - 58,788,516 (-)Ensembl
Rnor_6.0 Ensembl457,463,366 - 57,463,471 (-)Ensembl
RefSeq Acc Id: NR_031854
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2458,788,411 - 58,788,516 (-)NCBI
Rnor_6.0457,463,366 - 57,463,471 (-)NCBI
Rnor_5.0457,225,167 - 57,225,272 (-)NCBI
Celera453,887,982 - 53,888,087 (-)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325582 AgrOrtholog
BioCyc Gene G2FUF-45366 BioCyc
Ensembl Genes ENSRNOG00000035624 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000053747 ENTREZGENE
miRBase MI0000881 ENTREZGENE
NCBI Gene 100314017 ENTREZGENE
PhenoGen Mir96 PhenoGen
RatGTEx ENSRNOG00000035624 RatGTEx
RNAcentral URS000016FF9C RNACentral
  URS000075DD95 RNACentral
  URS000075EC9A RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir96  microRNA 96  Mir96  microRNA mir-96  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir96  microRNA mir-96      Symbol and Name status set to provisional 70820 PROVISIONAL