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Gene: Braf (B-Raf proto-oncogene, serine/threonine kinase) Rattus norvegicus
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Symbol: Braf
Name: B-Raf proto-oncogene, serine/threonine kinase
Description: Exhibits MAP kinase kinase kinase activity; Ras GTPase binding activity; and mitogen-activated protein kinase kinase binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; positive regulation of ERK1 and ERK2 cascade; and response to cAMP. Localizes to neuron projection; nucleus; and plasma membrane. Used to study bile duct adenoma; cholangiocarcinoma; intrahepatic cholangiocarcinoma; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; Noonan syndrome with multiple lentigines 3; astrocytoma (multiple); carcinoma (multiple); and cardiofaciocutaneous syndrome (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; adenosine signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: MODEL
Also known as: B-Raf; serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B; v-raf murine sarcoma viral oncogene homolog B1
Orthologs:
Homo sapiens (human) : BRAF (B-Raf proto-oncogene, serine/threonine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Braf (Braf transforming gene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Braf (B-Raf proto-oncogene, serine/threonine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : BRAF (B-Raf proto-oncogene, serine/threonine kinase)
Canis lupus familiaris (dog) : BRAF (B-Raf proto-oncogene, serine/threonine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Braf (B-Raf proto-oncogene, serine/threonine kinase)
Sus scrofa (pig) : BRAF (B-Raf proto-oncogene, serine/threonine kinase)
Chlorocebus sabaeus (African green monkey) : BRAF (B-Raf proto-oncogene, serine/threonine kinase)
Heterocephalus glaber (naked mole-rat) : Braf (B-Raf proto-oncogene, serine/threonine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Celera463,383,337 - 63,515,499 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Braf
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619908
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.