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Gene: Raf1 (Raf-1 proto-oncogene, serine/threonine kinase) Rattus norvegicus
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Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Description: Exhibits several functions, including ATP binding activity; adenylate cyclase activator activity; and enzyme binding activity. Involved in MAPK cascade; heart development; and response to hypoxia. Localizes to cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in LEOPARD syndrome 2; Noonan syndrome (multiple); adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase); PARTICIPATES IN the extracellular signal-regulated Raf/Mek/Erk signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: C-RAF; cRaf; Murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV); proto-oncogene c-RAF; RAF proto-oncogene serine/threonine-protein kinase; raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-leukemia viral oncogene 1
Orthologs:
Homo sapiens (human) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)  HGNC  Alliance
Mus musculus (house mouse) : Raf1 (v-raf-leukemia viral oncogene 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Canis lupus familiaris (dog) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
Sus scrofa (pig) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Chlorocebus sabaeus (African green monkey) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Heterocephalus glaber (naked mole-rat) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04147,532,040 - 147,592,769 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,532,042 - 147,592,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,819,148 - 210,878,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,752,583 - 151,775,609 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14151,997,425 - 152,020,450 (-)NCBI
Celera4137,570,499 - 137,631,125 (-)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Raf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3531
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.