RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) Homo sapiens
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Symbol: RAF1
Name: Raf-1 proto-oncogene, serine/threonine kinase
RGD ID: 737596
HGNC Page HGNC:9829
Description: Enables enzyme binding activity; identical protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including activation of adenylate cyclase activity; positive regulation of MAPK cascade; and positive regulation of peptidyl-serine phosphorylation. Located in Golgi apparatus; cytosol; and plasma membrane. Implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Biomarker of colorectal adenocarcinoma; colorectal adenoma; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c-Raf; C-Raf proto-oncogene, serine/threonine kinase; CMD1NN; CRAF; murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-msv); NS5; Oncogene RAF1; proto-oncogene c-RAF; raf proto-oncogene serine/threonine protein kinase; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; v-raf-1 murine leukemia viral oncogene homolog 1; v-raf-1 murine leukemia viral oncogene-like protein 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: RAF1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38312,583,601 - 12,664,117 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl312,582,101 - 12,664,201 (-)EnsemblGRCh38hg38GRCh38
GRCh37312,625,100 - 12,705,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,600,108 - 12,680,678 (-)NCBINCBI36Build 36hg18NCBI36
Build 34312,600,107 - 12,680,678NCBI
Celera312,563,426 - 12,643,994 (-)NCBICelera
Cytogenetic Map3p25.2NCBI
HuRef312,559,317 - 12,640,382 (-)NCBIHuRef
CHM1_1312,575,179 - 12,655,743 (-)NCBICHM1_1
T2T-CHM13v2.0312,582,405 - 12,665,632 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(20R)-protopanaxadiol  (EXP)
(S)-(-)-perillyl alcohol  (ISO)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acetylsalicylic acid  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (EXP)
AICA ribonucleotide  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (EXP,ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[e]pyrene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisdemethoxycurcumin  (EXP)
bisphenol A  (ISO)
bortezomib  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
calciol  (EXP)
cannabidiol  (EXP)
carbon nanotube  (ISO)
chaetoglobosin A  (ISO)
choline  (ISO)
ciglitazone  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cocaine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (EXP)
crocidolite asbestos  (EXP)
Cruentaren A  (EXP)
curcumin  (ISO)
cypermethrin  (ISO)
D-glucose  (EXP)
dabrafenib  (EXP)
decabromodiphenyl ether  (EXP)
demethoxycurcumin  (EXP)
deoxycholic acid  (EXP)
Dephostatin  (ISO)
diarsenic trioxide  (EXP,ISO)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dibutylstannane  (EXP)
Dictamnine  (EXP)
dieldrin  (EXP)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioxygen  (EXP)
doxorubicin  (EXP)
eckol  (EXP)
emodin  (EXP,ISO)
endosulfan  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ferrostatin-1  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
FR900359  (EXP)
gamma-hexachlorocyclohexane  (EXP)
geldanamycin  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (ISO)
glucose  (EXP)
Goe 6976  (ISO)
GW 1929  (ISO)
heptachlor  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (EXP)
hydroxyflutamide  (EXP)
indole-3-methanol  (ISO)
lapatinib  (EXP)
lead diacetate  (EXP)
letrozole  (ISO)
lipopolysaccharide  (ISO)
lipoteichoic acid  (ISO)
lovastatin  (EXP)
LY294002  (EXP)
maneb  (ISO)
mangiferin  (ISO)
manumycin A  (ISO)
melatonin  (ISO)
metformin  (EXP)
Methanandamide  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methylarsonic acid  (EXP)
methylmercury chloride  (ISO)
morphine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
naphthalene  (EXP)
naringin  (EXP,ISO)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nimodipine  (ISO)
nitric oxide  (ISO)
okadaic acid  (ISO)
ouabain  (EXP)
oxaliplatin  (ISO)
ozone  (EXP)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
Parthenin  (EXP)
PD173074  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perillyl alcohol  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pifithrin-?  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP)
propofol  (ISO)
prostaglandin F2alpha  (ISO)
pyrogallol  (ISO)
quercetin  (EXP,ISO)
quinomethionate  (EXP)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
romidepsin  (EXP)
rottlerin  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
Salvianolic acid A  (EXP)
semilicoisoflavone B  (EXP)
sevoflurane  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sorafenib  (EXP)
SR 144528  (EXP)
streptozocin  (ISO)
styrene  (EXP)
SU6656  (EXP)
tanespimycin  (EXP)
Tautomycin  (ISO)
testosterone  (EXP,ISO)
tetrahydropalmatine  (EXP)
thapsigargin  (EXP,ISO)
tipifarnib  (ISO)
titanium dioxide  (ISO)
trans-caffeic acid  (EXP,ISO)
tributylstannane  (EXP)
trichostatin A  (EXP)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
troglitazone  (ISO)
tunicamycin  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (EXP)
vemurafenib  (EXP)
vitamin E  (ISO)
vorinostat  (EXP)
wortmannin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of adenylate cyclase activity  (IDA)
apoptotic process  (TAS)
cell differentiation  (IEA,ISO)
chromatin remodeling  (IEA)
death-inducing signaling complex assembly  (IEA,ISO)
ERBB2-ERBB3 signaling pathway  (IEA)
extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
face development  (IEA,ISO)
heart development  (ISO)
insulin receptor signaling pathway  (IEA)
insulin secretion involved in cellular response to glucose stimulus  (IEA,ISO)
insulin-like growth factor receptor signaling pathway  (IEA)
intermediate filament cytoskeleton organization  (IEA,ISO)
intracellular glucose homeostasis  (IEA,ISO)
MAPK cascade  (IBA,IEA,ISO)
myelination  (IEA)
negative regulation of apoptotic process  (IDA,IEA)
negative regulation of cell population proliferation  (IDA)
negative regulation of cysteine-type endopeptidase activity  (TAS)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of protein-containing complex assembly  (IDA)
neurotrophin TRK receptor signaling pathway  (IEA,ISO)
positive regulation of macromolecule metabolic process  (IEA)
positive regulation of MAPK cascade  (IDA)
positive regulation of peptidyl-serine phosphorylation  (IDA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
protein modification process  (IEA)
protein phosphorylation  (ISO,TAS)
regulation of apoptotic process  (TAS)
regulation of cell differentiation  (TAS)
regulation of cell motility  (TAS)
regulation of Rho protein signal transduction  (TAS)
response to hypoxia  (ISO)
response to muscle stretch  (IEA,ISO)
Schwann cell development  (IEA)
signal transduction  (IEA,TAS)
somatic stem cell population maintenance  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
type B pancreatic cell proliferation  (IEA,ISO)
type II interferon-mediated signaling pathway  (TAS)
wound healing  (TAS)

Cellular Component
cytoplasm  (IDA,IEA,ISS)
cytosol  (IBA,IDA,TAS)
Golgi apparatus  (IPI)
membrane  (IEA)
mitochondrial outer membrane  (TAS)
mitochondrion  (IBA,IEA)
nucleus  (IEA)
plasma membrane  (IDA,IEA,TAS)
pseudopodium  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
acute myeloid leukemia pathway  (IEA)
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  (TAS)
B cell receptor signaling pathway  (IEA)
ceramide signaling pathway  (EXP,IEA)
chronic myeloid leukemia pathway   (IEA)
colorectal cancer pathway   (IEA)
endometrial cancer pathway  (IEA)
endothelin signaling pathway   (EXP)
epidermal growth factor/neuregulin signaling pathway  (IEA)
Fc epsilon receptor mediated signaling pathway  (EXP)
glioma pathway  (IEA)
gonadotropin-releasing hormone signaling pathway  (IEA)
granulocyte-macrophage colony-stimulating factor signaling pathway  (EXP)
hepatitis C pathway   (IEA)
insulin signaling pathway  (EXP,IEA)
insulin-like growth factor signaling pathway  (EXP)
interleukin-2 signaling pathway  (EXP)
long term depression  (IEA)
long term potentiation  (IEA)
melanoma pathway   (IEA)
mitogen activated protein kinase signaling pathway   (IEA)
mTOR signaling pathway  (EXP)
neurotrophic factor signaling pathway   (IEA)
non-small cell lung carcinoma pathway   (IEA)
pancreatic cancer pathway   (IEA)
phosphatidylinositol 3-kinase-Akt signaling pathway  (EXP)
platelet-derived growth factor signaling pathway   (EXP)
prostate cancer pathway   (IEA)
renal cell carcinoma pathway  (IEA)
T cell receptor signaling pathway   (IEA)
the extracellular signal-regulated Raf/Mek/Erk signaling pathway  (ISO,TAS)
tuberculosis pathway  (IEA)
urinary bladder cancer pathway   (IEA)
vascular endothelial growth factor signaling pathway  (EXP,IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal bleeding  (IAGP)
Abnormal cardiovascular system morphology  (IAGP)
Abnormal dermatoglyphics  (IAGP)
Abnormal EKG  (IAGP)
Abnormal endocardium morphology  (IAGP)
Abnormal facial shape  (IAGP)
Abnormal hair quantity  (IAGP)
Abnormal localization of kidney  (IAGP)
Abnormal mitral valve morphology  (IAGP)
Abnormal platelet function  (IAGP)
Abnormal pulmonary valve morphology  (IAGP)
Abnormal speech pattern  (IAGP)
Abnormal ST segment  (IAGP)
Abnormal sternum morphology  (IAGP)
Abnormality of coagulation  (IAGP)
Abnormality of skin pigmentation  (IAGP)
Abnormality of the face  (IAGP)
Abnormality of the genital system  (IAGP)
Abnormality of the lymphatic system  (IAGP)
Abnormality of the pulmonary artery  (IAGP)
Abnormality of the spleen  (IAGP)
Abnormality of the voice  (IAGP)
Anhidrosis  (IAGP)
Aplasia of the semicircular canal  (IAGP)
Aplasia/Hypoplasia of the abdominal wall musculature  (IAGP)
Arrhythmia  (IAGP)
Atrial septal defect  (IAGP)
Atrioventricular canal defect  (IAGP)
Atypical behavior  (IAGP)
Autosomal dominant inheritance  (IAGP)
Blue irides  (IAGP)
Brachycephaly  (IAGP)
Brachydactyly  (IAGP)
Bruising susceptibility  (IAGP)
Bundle branch block  (IAGP)
Cafe-au-lait spot  (IAGP)
Childhood onset  (IAGP)
Clinodactyly of the 5th finger  (IAGP)
Coarctation of aorta  (IAGP)
Coarse hair  (IAGP)
Congenital giant melanocytic nevus  (IAGP)
Congestive heart failure  (IAGP)
Cryptorchidism  (IAGP)
Cubitus valgus  (IAGP)
Curly hair  (IAGP)
Cutaneous melanoma  (IAGP)
Cystic hygroma  (IAGP)
Decreased fertility  (IAGP)
Delayed menarche  (IAGP)
Delayed skeletal maturation  (IAGP)
Depressed nasal bridge  (IAGP)
Dilatation of the renal pelvis  (IAGP)
Dilated cardiomyopathy  (IAGP)
Dolichocephaly  (IAGP)
Downslanted palpebral fissures  (IAGP)
Dry skin  (IAGP)
Dysarthria  (IAGP)
Edema  (IAGP)
EMG abnormality  (IAGP)
Enlarged thorax  (IAGP)
Epicanthus  (IAGP)
Excessive wrinkled skin  (IAGP)
Exertional dyspnea  (IAGP)
Fatigue  (IAGP)
Feeding difficulties in infancy  (IAGP)
Fine hair  (IAGP)
Freckling  (IAGP)
Gastric adenocarcinoma  (IAGP)
Glioma  (IAGP)
Global developmental delay  (IAGP)
Growth delay  (IAGP)
Headache  (IAGP)
Hepatomegaly  (IAGP)
High forehead  (IAGP)
High palate  (IAGP)
Hydrocephalus  (IAGP)
Hyperextensible skin  (IAGP)
Hypertelorism  (IAGP)
Hypertrichosis  (IAGP)
Hypertrophic cardiomyopathy  (IAGP)
Hypogonadotropic hypogonadism  (IAGP)
Hypophosphatemic rickets  (IAGP)
Hypopigmented skin patches  (IAGP)
Hypospadias  (IAGP)
Hypotonia  (IAGP)
Increased intracranial pressure  (IAGP)
Increased left ventricular end-diastolic volume  (IAGP)
Intellectual disability  (IAGP)
Intellectual disability, mild  (IAGP)
Intrauterine growth retardation  (IAGP)
Joint hypermobility  (IAGP)
Juvenile myelomonocytic leukemia  (IAGP)
Juvenile onset  (IAGP)
Keratosis pilaris  (IAGP)
Large for gestational age  (IAGP)
Laryngomalacia  (IAGP)
Left ventricular noncompaction cardiomyopathy  (IAGP)
Left ventricular systolic dysfunction  (IAGP)
Lipoatrophy  (IAGP)
Low posterior hairline  (IAGP)
Low-set ears  (IAGP)
Lung adenocarcinoma  (IAGP)
Lymphedema  (IAGP)
Macrocephaly  (IAGP)
Mandibular prognathia  (IAGP)
Melanocytic nevus  (IAGP)
Melanoma  (IAGP)
Micrognathia  (IAGP)
Middle age onset  (IAGP)
Midface retrusion  (IAGP)
Mitral regurgitation  (IAGP)
Mitral valve prolapse  (IAGP)
Multiple lentigines  (IAGP)
Muscle weakness  (IAGP)
Myelodysplasia  (IAGP)
Myocardial infarction  (IAGP)
Myopathy  (IAGP)
Neoplasm of the large intestine  (IAGP)
Neuroblastoma  (IAGP)
Neurodevelopmental delay  (IAGP)
Nevus  (IAGP)
Nystagmus  (IAGP)
Orthopnea  (IAGP)
Osteopenia  (IAGP)
Patent ductus arteriosus  (IAGP)
Pectus carinatum  (IAGP)
Pectus excavatum  (IAGP)
Polyhydramnios  (IAGP)
Poor wound healing  (IAGP)
Posteriorly rotated ears  (IAGP)
Postnatal growth retardation  (IAGP)
Premature thelarche  (IAGP)
Prominent forehead  (IAGP)
Proptosis  (IAGP)
Pruritus  (IAGP)
Ptosis  (IAGP)
Pulmonary artery stenosis  (IAGP)
Pulmonic stenosis  (IAGP)
Radioulnar synostosis  (IAGP)
Reduced left ventricular ejection fraction  (IAGP)
Scapular winging  (IAGP)
Scoliosis  (IAGP)
Seizure  (IAGP)
Sensorineural hearing impairment  (IAGP)
Severe sensorineural hearing impairment  (IAGP)
Short neck  (IAGP)
Short stature  (IAGP)
Small nail  (IAGP)
Sparse eyebrow  (IAGP)
Specific learning disability  (IAGP)
Spina bifida occulta  (IAGP)
Spinal cord compression  (IAGP)
Sprengel anomaly  (IAGP)
Strabismus  (IAGP)
Subcutaneous nodule  (IAGP)
Thick lower lip vermilion  (IAGP)
Thick vermilion border  (IAGP)
Thickened helices  (IAGP)
Thickened nuchal skin fold  (IAGP)
Thromboembolic stroke  (IAGP)
Triangular face  (IAGP)
Vascular dilatation  (IAGP)
Ventricular arrhythmia  (IAGP)
Ventricular tachycardia  (IAGP)
Webbed neck  (IAGP)
Wide intermamillary distance  (IAGP)
Wide mouth  (IAGP)
Wide nasal bridge  (IAGP)
Young adult onset  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Role of Raf in vascular protection from distinct apoptotic stimuli. Alavi A, etal., Science 2003 Jul 4;301(5629):94-6.
2. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Chang F, etal., Leukemia 2003 Jul;17(7):1263-93.
3. Endothelial ERK signaling controls lymphatic fate specification. Deng Y, etal., J Clin Invest. 2013 Mar;123(3):1202-15. doi: 10.1172/JCI63034. Epub 2013 Feb 8.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Molecular and clinical analysis of RAF1 in Noonan syndrome and related disorders: dephosphorylation of serine 259 as the essential mechanism for mutant activation. Kobayashi T, etal., Hum Mutat. 2010 Mar;31(3):284-94. doi: 10.1002/humu.21187.
6. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. McCubrey JA, etal., Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7.
7. Raf-1 expression may influence progression to androgen insensitive prostate cancer. Mukherjee R, etal., Prostate. 2005 Jun 15;64(1):101-7. doi: 10.1002/pros.20211.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Systemic delivery of RafsiRNA using cationic cardiolipin liposomes silences Raf-1 expression and inhibits tumor growth in xenograft model of human prostate cancer. Pal A, etal., Int J Oncol. 2005 Apr;26(4):1087-91.
10. Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. Pandit B, etal., Nat Genet. 2007 Aug;39(8):1007-12. Epub 2007 Jul 1.
11. Combination with liposome-entrapped, ends-modified raf antisense oligonucleotide (LErafAON) improves the anti-tumor efficacies of cisplatin, epirubicin, mitoxantrone, docetaxel and gemcitabine. Pei J, etal., Anticancer Drugs. 2004 Mar;15(3):243-53.
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. Germline gain-of-function mutations in RAF1 cause Noonan syndrome. Razzaque MA, etal., Nat Genet. 2007 Aug;39(8):1013-7. Epub 2007 Jul 1.
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
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21. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
22. Expression of c-myc, c-raf-1, and c-Ki-ras in azaserine-induced pancreatic carcinomas and growing pancreas in rats. Silverman JA, etal., Mol Carcinog. 1990;3(6):379-86.
23. Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation. Trakul N, etal., J Biol Chem. 2005 Jul 1;280(26):24931-40. Epub 2005 May 10.
24. [Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma]. Wu WX, etal., Zhonghua Zhong Liu Za Zhi. 2010 Sep;32(9):671-5.
25. MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation. Wu X, etal., J Clin Invest. 2011 Mar;121(3):1009-25. doi: 10.1172/JCI44929. Epub 2011 Feb 21.
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27. Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning. Xuan YT, etal., Circulation. 2005 Sep 27;112(13):1971-8. Epub 2005 Sep 19.
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