RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) Canis lupus familiaris
Analyze
Symbol: RAF1
Name: Raf-1 proto-oncogene, serine/threonine kinase
RGD ID: 12290914
Description: ENCODES a protein that exhibits adenylate cyclase activator activity (ortholog); adenylate cyclase binding (ortholog); ATP binding (ortholog); INVOLVED IN cell differentiation (ortholog); cellular glucose homeostasis (ortholog); death-inducing signaling complex assembly (ortholog); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; endothelin signaling pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Cardiomegaly (ortholog); colorectal adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: RAF proto-oncogene serine/threonine-protein kinase; v-raf-1 murine leukemia viral oncogene homolog 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1205,892,839 - 5,972,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl205,892,834 - 5,972,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha205,929,501 - 6,009,310 (+)NCBI
ROS_Cfam_1.0205,921,808 - 6,000,868 (+)NCBI
UMICH_Zoey_3.1205,637,969 - 5,717,035 (+)NCBI
UNSW_CanFamBas_1.0205,991,105 - 6,070,948 (+)NCBI
UU_Cfam_GSD_1.0205,966,879 - 6,046,000 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
RAF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1205,892,839 - 5,972,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl205,892,834 - 5,972,090 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha205,929,501 - 6,009,310 (+)NCBI
ROS_Cfam_1.0205,921,808 - 6,000,868 (+)NCBI
UMICH_Zoey_3.1205,637,969 - 5,717,035 (+)NCBI
UNSW_CanFamBas_1.0205,991,105 - 6,070,948 (+)NCBI
UU_Cfam_GSD_1.0205,966,879 - 6,046,000 (+)NCBI
RAF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl312,583,601 - 12,664,125 (-)EnsemblGRCh38hg38GRCh38
GRCh38312,583,601 - 12,664,117 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37312,625,100 - 12,705,616 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36312,600,108 - 12,680,678 (-)NCBINCBI36hg18NCBI36
Build 34312,600,107 - 12,680,678NCBI
Celera312,563,426 - 12,643,994 (-)NCBI
Cytogenetic Map3p25.2NCBI
HuRef312,559,317 - 12,640,382 (-)NCBIHuRef
CHM1_1312,575,179 - 12,655,743 (-)NCBICHM1_1
Raf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396115,595,530 - 115,653,596 (-)NCBIGRCm39mm39
GRCm39 Ensembl6115,595,028 - 115,653,596 (-)Ensembl
GRCm386115,618,569 - 115,676,635 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6115,618,067 - 115,676,635 (-)EnsemblGRCm38mm10GRCm38
MGSCv376115,568,591 - 115,626,653 (-)NCBIGRCm37mm9NCBIm37
MGSCv366115,584,216 - 115,642,122 (-)NCBImm8
Celera6117,458,696 - 117,516,733 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.62NCBI
Raf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24148,679,534 - 148,740,265 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl4148,679,530 - 148,740,317 (-)Ensembl
Rnor_6.04147,532,040 - 147,592,769 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4147,532,042 - 147,592,699 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04210,819,148 - 210,878,226 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44151,752,583 - 151,775,609 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14151,997,425 - 152,020,450 (-)NCBI
Celera4137,570,499 - 137,631,125 (-)NCBICelera
Cytogenetic Map4q42NCBI
Raf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542918,025,932 - 18,049,723 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,980,956 - 18,049,723 (+)NCBIChiLan1.0ChiLan1.0
RAF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1312,853,415 - 12,932,871 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl312,853,415 - 12,932,871 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0312,510,084 - 12,590,598 (-)NCBIMhudiblu_PPA_v0panPan3
Raf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494217,795,336 - 17,819,736 (-)NCBI
SpeTri2.0NW_0049366021,089,979 - 1,114,376 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1368,580,812 - 68,657,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11368,581,128 - 68,657,911 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21375,848,344 - 75,927,158 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12248,560,270 - 48,643,537 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2248,561,161 - 48,618,020 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041117,857,289 - 117,941,171 (+)NCBIVero_WHO_p1.0
Raf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624872204,357 - 284,487 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005632141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038455983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502689 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502691 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038502692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038565610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629740 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038629743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_854141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000007966   ⟹   ENSCAFP00000007376
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl205,892,834 - 5,972,090 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000046046   ⟹   ENSCAFP00000040498
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl205,892,834 - 5,972,090 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092937   ⟹   ENSCAFP00000058931
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl205,892,834 - 5,971,794 (+)Ensembl
RefSeq Acc Id: XM_005632141   ⟹   XP_005632198
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1205,892,839 - 5,972,672 (+)NCBI
Dog10K_Boxer_Tasha205,929,501 - 6,009,310 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022406357   ⟹   XP_022262065
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1205,895,012 - 5,972,672 (+)NCBI
Dog10K_Boxer_Tasha205,931,674 - 6,009,310 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022406358   ⟹   XP_022262066
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1205,943,517 - 5,972,672 (+)NCBI
Dog10K_Boxer_Tasha205,980,163 - 6,009,310 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038426891   ⟹   XP_038282819
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0205,921,808 - 6,000,868 (+)NCBI
RefSeq Acc Id: XM_038426892   ⟹   XP_038282820
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0205,923,984 - 6,000,868 (+)NCBI
RefSeq Acc Id: XM_038426893   ⟹   XP_038282821
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0205,921,808 - 6,000,868 (+)NCBI
RefSeq Acc Id: XM_038426894   ⟹   XP_038282822
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0205,971,800 - 6,000,868 (+)NCBI
RefSeq Acc Id: XM_038426895   ⟹   XP_038282823
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0205,971,800 - 6,000,868 (+)NCBI
RefSeq Acc Id: XM_038455983   ⟹   XP_038311911
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha205,980,163 - 6,009,310 (+)NCBI
RefSeq Acc Id: XM_038502688   ⟹   XP_038358616
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1205,637,969 - 5,717,035 (+)NCBI
RefSeq Acc Id: XM_038502689   ⟹   XP_038358617
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1205,640,145 - 5,717,035 (+)NCBI
RefSeq Acc Id: XM_038502690   ⟹   XP_038358618
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1205,637,969 - 5,717,035 (+)NCBI
RefSeq Acc Id: XM_038502691   ⟹   XP_038358619
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1205,687,999 - 5,717,035 (+)NCBI
RefSeq Acc Id: XM_038502692   ⟹   XP_038358620
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1205,687,999 - 5,717,035 (+)NCBI
RefSeq Acc Id: XM_038565606   ⟹   XP_038421534
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0205,966,879 - 6,046,000 (+)NCBI
RefSeq Acc Id: XM_038565607   ⟹   XP_038421535
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0205,969,052 - 6,046,000 (+)NCBI
RefSeq Acc Id: XM_038565608   ⟹   XP_038421536
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0205,966,879 - 6,046,000 (+)NCBI
RefSeq Acc Id: XM_038565609   ⟹   XP_038421537
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0206,016,917 - 6,046,000 (+)NCBI
RefSeq Acc Id: XM_038565610   ⟹   XP_038421538
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0206,016,917 - 6,046,000 (+)NCBI
RefSeq Acc Id: XM_038629738   ⟹   XP_038485666
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0205,991,105 - 6,070,948 (+)NCBI
RefSeq Acc Id: XM_038629739   ⟹   XP_038485667
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0205,993,278 - 6,070,948 (+)NCBI
RefSeq Acc Id: XM_038629740   ⟹   XP_038485668
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0205,991,105 - 6,070,948 (+)NCBI
RefSeq Acc Id: XM_038629742   ⟹   XP_038485670
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0206,041,764 - 6,070,948 (+)NCBI
RefSeq Acc Id: XM_038629743   ⟹   XP_038485671
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0206,041,764 - 6,070,948 (+)NCBI
RefSeq Acc Id: XM_854141   ⟹   XP_859234
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1205,892,839 - 5,972,672 (+)NCBI
Dog10K_Boxer_Tasha205,929,501 - 6,009,310 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005632198   ⟸   XM_005632141
- Peptide Label: isoform X1
- UniProtKB: E2REI6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_859234   ⟸   XM_854141
- Peptide Label: isoform X2
- UniProtKB: J9P4L9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022262065   ⟸   XM_022406357
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_022262066   ⟸   XM_022406358
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSCAFP00000058931   ⟸   ENSCAFT00000092937
RefSeq Acc Id: ENSCAFP00000007376   ⟸   ENSCAFT00000007966
RefSeq Acc Id: ENSCAFP00000040498   ⟸   ENSCAFT00000046046
RefSeq Acc Id: XP_038358616   ⟸   XM_038502688
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038358618   ⟸   XM_038502690
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038358617   ⟸   XM_038502689
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038358619   ⟸   XM_038502691
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038358620   ⟸   XM_038502692
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038485666   ⟸   XM_038629738
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038485668   ⟸   XM_038629740
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038485667   ⟸   XM_038629739
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038485670   ⟸   XM_038629742
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038485671   ⟸   XM_038629743
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038282819   ⟸   XM_038426891
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282821   ⟸   XM_038426893
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038282820   ⟸   XM_038426892
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038282822   ⟸   XM_038426894
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038282823   ⟸   XM_038426895
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038311911   ⟸   XM_038455983
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038421534   ⟸   XM_038565606
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038421536   ⟸   XM_038565608
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038421535   ⟸   XM_038565607
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038421537   ⟸   XM_038565609
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038421538   ⟸   XM_038565610
- Peptide Label: isoform X4


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004951 Ensembl
NCBI Gene RAF1 ENTREZGENE
UniProt E2REI6 ENTREZGENE
  J9P4L9 ENTREZGENE
VGNC ID VGNC:45325 ENTREZGENE