Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Hras (HRas proto-oncogene, GTPase) Rattus norvegicus
Analyze
Symbol: Hras
Name: HRas proto-oncogene, GTPase
Description: Predicted to have GTPase activity; protein C-terminus binding activity; and purine ribonucleoside binding activity. Involved in several processes, including cellular senescence; positive regulation of intracellular signal transduction; and protein heterooligomerization. Localizes to the intracellular membrane-bounded organelle and plasma membrane. Used to study diabetic retinopathy. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and obsessive-compulsive disorder. Orthologous to human HRAS (HRas proto-oncogene, GTPase); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (S)-nicotine; 1,2-dichlorobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-H-ras; GTPase HRas; H-Ras-1; Harvey ras1 protein; Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog; Harvey rat sarcoma virus oncogene; HRAS1; p21ras; transforming protein p21
Orthologs:
Homo sapiens (human) : HRAS (HRas proto-oncogene, GTPase)  HGNC  Alliance
Mus musculus (house mouse) : Hras (Harvey rat sarcoma virus oncogene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hras (HRas proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : HRAS (HRas proto-oncogene, GTPase)
Canis lupus familiaris (dog) : HRAS (HRas proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hras (HRas proto-oncogene, GTPase)
Sus scrofa (pig) : HRAS (HRas proto-oncogene, GTPase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01214,178,404 - 214,181,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01221,095,943 - 221,099,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,385,705 - 201,388,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,540,000 - 201,542,640 (-)NCBI
Celera1193,930,281 - 193,933,583 (-)NCBICelera
Cytogenetic Map1q41NCBI
RH 3.4 Map11437.21RGD
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Hras
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2827
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.