HRAS (HRas proto-oncogene, GTPase)

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Gene: HRAS (HRas proto-oncogene, GTPase) Homo sapiens

Analyze

Symbol:

HRAS

Name:

HRas proto-oncogene, GTPase

RGD ID:

730881

HGNC Page

HGNC:5173

Description:

Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in several processes, including positive regulation of MAPK cascade; regulation of GTPase activity; and regulation of protein localization to membrane. Located in several cellular components, including GTPase complex; Golgi apparatus; and nucleoplasm. Is active in glutamatergic synapse. Implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Biomarker of Alzheimer's disease; endometrial carcinoma; glioblastoma; liver disease (multiple); and urinary bladder cancer.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

C-BAS/HAS; C-H-RAS; C-HA-RAS1; c-has/bas p21 protein; c-K-ras; c-Ki-ras; c-ras-Ki-2 activated oncogene; CTLO; GTP- and GDP-binding peptide B; GTPase HRas; GTPase KRas; H-Ras-1; H-RASIDX; ha-Ras; Ha-Ras1 proto-oncoprotein; HAMSV; Harvey rat sarcoma viral oncogene homolog; Harvey rat sarcoma viral oncoprotein; HRAS1; K-RAS; K-Ras 2; Ki-Ras; KRAS; KRAS2; N-RAS; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; RASH1; RASK2; transformation gene: oncogene HAMSV; transforming protein p21; v-Ha-ras Harvey rat sarcoma viral oncogene homolog

RGD Orthologs

Mouse

Rat

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Allele / Splice:

See ClinVar data

Is Marker For:

Strains: SD-Tg(CAG-HRAS*G12V)250Htsu

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	532,242 - 535,576 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	11	532,242 - 537,321 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	532,242 - 535,576 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	522,242 - 525,550 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	522,242 - 525,550	NCBI
Celera	11	594,708 - 598,010 (-)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	346,981 - 349,115 (-)	NCBI		HuRef
CHM1_1	11	529,852 - 534,465 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	579,238 - 582,554 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

Manual Human Phenotype Annotations - RGD

Imported Human Phenotype Annotations - HPO

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