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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2827
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hras
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrasincreases expressionEXP 6480464CTDDiethylnitrosamine results in increased expression of HRAS mRNAPMID:7910516
Hrasincreases expressionISOHras (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of HRAS mRNAPMID:26464624
Hrasincreases mutagenesisISOHras (Mus musculus)6480464CTDDiethylnitrosamine results in increased mutagenesis of HRAS genePMID:15592514 PMID:24535843 PMID:25319454 PMID:2675901
Hrasmultiple interactionsISOHras (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with HRAS protein] results in increased activity of GOT1 protein; [Diethylnitrosamine co-treated with HRAS protein] results in increased activity of MDH1 protein; [Fenofibrate co-treated with Diethylnitrosamine] results in increased expression of HRAS mRNAPMID:12499697 PMID:18978307
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