RGD Reference Report - Expression of ras p21 in the stromal cells of human neoplastic endometrium. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

Expression of ras p21 in the stromal cells of human neoplastic endometrium.

Authors: Miturski, R  Semczuk, A  Jakowicki, J A 
Citation: Miturski R, etal., Eur J Gynaecol Oncol. 1998;19(3):308-11.
RGD ID: 13441555
Pubmed: PMID:9641239   (View Abstract at PubMed)

ras p21 proteins have been reported to take part in signal transduction through a cell membrane to the nucleus and they also play a crucial role in the process of carcinogenesis. Forty specimens of neoplastic endometrium, ten slides of normal endometrium and one case of uterine carcinosarcoma were investigated for ras p21 expression in the stromal cells by immunohistochemistry. Stromal cells expressed ras p21 protein in 13 out of 40 (33%) cases of neoplastic endometrium. These cells were randomly dispersed wound the glandular crypts of the endometrium and were also detected in the adjacent myometrium surrounding the cancer tissue. When cancers were grouped by surgical stage, ras p21 protein was detected in 11/22 (50%) of stage I, but only in 2/18 (11%) of stages II-IV according to FIGO. None of the stromal cells immunostained for p21 in normal endometrium or myometrium, however, a single case of carcinosarcoma expressed ras p21 within the stromal cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
HRASHumanendometrial carcinoma disease_progressionIEP protein:increased expression:endometrial stroma and cytoplasm (human)RGD 
HrasRatendometrial carcinoma disease_progressionISOHRAS (Homo sapiens)protein:increased expression:endometrial stroma and cytoplasm (human)RGD 
HrasMouseendometrial carcinoma disease_progressionISOHRAS (Homo sapiens)protein:increased expression:endometrial stroma and cytoplasm (human)RGD 
HRASHumanOvarian Neoplasms onsetIEP protein:increased expression:endometrial stroma (human)RGD 
HrasRatOvarian Neoplasms onsetISOHRAS (Homo sapiens)protein:increased expression:endometrial stroma (human)RGD 
HrasMouseOvarian Neoplasms onsetISOHRAS (Homo sapiens)protein:increased expression:endometrial stroma (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hras  (HRas proto-oncogene, GTPase)

Genes (Mus musculus)
Hras  (Harvey rat sarcoma virus oncogene)

Genes (Homo sapiens)
HRAS  (HRas proto-oncogene, GTPase)


Additional Information