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Gene: Hras (Harvey rat sarcoma virus oncogene) Mus musculus
Symbol: Hras
Name: Harvey rat sarcoma virus oncogene
Description: Exhibits GTP binding activity. Involved in several processes, including T cell receptor signaling pathway; defense response to protozoan; and intracellular signal transduction. Predicted to localize to several cellular components, including Golgi apparatus; glutamatergic synapse; and nucleoplasm. Is expressed in several structures, including central nervous system; early embryo; metanephros; sensory organ; and tooth. Used to study Costello syndrome; astrocytoma; and malignant glioma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; autoimmune hepatitis; carcinoma (multiple); and epidermal nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH (+)-epicatechin-3-O-gallate; (-)-epigallocatechin 3-gallate; (S)-nicotine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: c-H-ras; c-Ha-ras; c-Ha-ras p21 protein; c-Ha-ras transgene; c-rasHa; GTPase HRas; H-ras; H-ras 1 protein; H-Ras-1; Ha-ras; Harvey rat sarcoma virus oncogene 1; Harvey-ras; Hras-1; Hras1; Kras2; p21ras; ras; transforming protein P21
Homo sapiens (human) : HRAS (HRas proto-oncogene, GTPase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hras (HRas proto-oncogene, GTPase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hras (HRas proto-oncogene, GTPase)
Pan paniscus (bonobo/pygmy chimpanzee) : HRAS (HRas proto-oncogene, GTPase)
Canis lupus familiaris (dog) : HRAS (HRas proto-oncogene, GTPase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hras (HRas proto-oncogene, GTPase)
Sus scrofa (pig) : HRAS (HRas proto-oncogene, GTPase)
Chlorocebus sabaeus (African green monkey) : HRAS (HRas proto-oncogene, GTPase)
Heterocephalus glaber (naked mole-rat) : Hras (HRas proto-oncogene, GTPase)
more info ...
Related Pseudogenes: Hras1-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl7141,189,105 - 141,194,005 (-)EnsemblGRCm38mm10GRCm38
GRCm387141,189,934 - 141,194,019 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv377148,375,833 - 148,379,903 (-)NCBIGRCm37mm9NCBIm37
MGSCv367141,042,668 - 141,044,260 (-)NCBImm8
Celera7140,983,643 - 140,987,701 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Hras
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10730
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.