Hras (HRas proto-oncogene, GTPase) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Hras (HRas proto-oncogene, GTPase) Ictidomys tridecemlineatus
Analyze
Symbol: Hras
Name: HRas proto-oncogene, GTPase
RGD ID: 12619795
Description: ENCODES a protein that exhibits protein-containing complex binding (ortholog); INVOLVED IN apoptotic process (ortholog); cellular senescence (ortholog); defense response to protozoan (ortholog); PARTICIPATES IN adenosine signaling pathway; endothelin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenoid cystic carcinoma (ortholog); Alzheimer's disease (ortholog); FOUND IN glutamatergic synapse (ortholog); Golgi apparatus (ortholog); GTPase complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GTPase HRas; HRas proto-oncogene, GTPase, transcript variant X1; HRas proto-oncogene, GTPase, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947375,371 - 378,065 (-)NCBI
SpeTri2.0NW_004936888375,372 - 378,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenoid cystic carcinoma  (ISO)
Alzheimer's disease  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
autistic disorder  (ISO)
autoimmune hepatitis  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cardiofaciocutaneous syndrome  (ISO)
chronic lymphocytic leukemia  (ISO)
Colorectal Neoplasms  (ISO)
complex cortical dysplasia with other brain malformations  (ISO)
Congenital Myopathy with Excess of Muscle Spindles  (ISO)
Costello syndrome  (ISO)
developmental and epileptic encephalopathy  (ISO)
diabetic retinopathy  (ISO)
disease of cellular proliferation  (ISO)
Disease Progression  (ISO)
early infantile epileptic encephalopathy  (ISO)
endometrial carcinoma  (ISO)
epidermal nevus  (ISO)
esophageal carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Neoplasms  (ISO)
Follicular Thyroid Cancer  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Hydrops Fetalis  (ISO)
Hypophosphatemic Rickets  (ISO)
immunodeficiency 39  (ISO)
intellectual disability  (ISO)
large congenital melanocytic nevus  (ISO)
linear nevus sebaceous syndrome  (ISO)
liver cancer  (ISO)
liver carcinoma  (ISO)
liver cirrhosis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (ISO)
Mouth Neoplasms  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
Nasopharyngeal Neoplasms  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplastic Cell Transformation  (ISO)
Neoplastic Processes  (ISO)
neuroblastoma  (ISO)
neuronal ceroid lipofuscinosis  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 3  (ISO)
obsessive-compulsive disorder  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
papillary renal cell carcinoma  (ISO)
papilloma  (ISO)
Paraproteinemias  (ISO)
parathyroid adenoma  (ISO)
Penile Neoplasms  (ISO)
phobic disorder  (ISO)
Pigmented Nevus  (ISO)
plasma cell neoplasm  (ISO)
pre-malignant neoplasm  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Recurrence  (ISO)
rhabdomyosarcoma  (ISO)
Salivary Gland Neoplasms  (ISO)
Sebaceous Nevus Syndrome and Hemimegalencephaly  (ISO)
seminoma  (ISO)
skin benign neoplasm  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
spermatocytoma  (ISO)
Splenic Neoplasms  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
T-Cell Lymphoma  (ISO)
thymoma  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
Trichilemmoma  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
uterine cancer  (ISO)
uterine carcinosarcoma  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IEA)
apoptotic process  (ISO)
cellular response to gamma radiation  (IEA)
cellular senescence  (IEA,ISO)
defense response to protozoan  (IEA,ISO)
endocytosis  (IEA,ISO)
fibroblast proliferation  (IEA,ISO)
intrinsic apoptotic signaling pathway  (IEA,ISO)
liver development  (ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of gene expression  (IEA)
negative regulation of GTPase activity  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
positive regulation of actin cytoskeleton reorganization  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of GTPase activity  (IEA)
positive regulation of interferon-gamma production  (IEA,ISO)
positive regulation of JNK cascade  (IEA)
positive regulation of MAP kinase activity  (IEA)
positive regulation of MAPK cascade  (IEA)
positive regulation of miRNA metabolic process  (IEA)
positive regulation of phospholipase C activity  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein targeting to membrane  (IEA)
positive regulation of Ras protein signal transduction  (ISO)
positive regulation of ruffle assembly  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of wound healing  (IEA)
Ras protein signal transduction  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell population proliferation  (IEA)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of MAP kinase activity  (IEA)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to isolation stress  (ISO)
signal transduction  (IEA)
small GTPase mediated signal transduction  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
T-helper 1 type immune response  (IEA,ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
Hras
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947375,371 - 378,065 (-)NCBI
SpeTri2.0NW_004936888375,372 - 378,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HRAS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811532,242 - 535,576 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11532,242 - 537,321 (-)EnsemblGRCh38hg38GRCh38
GRCh3711532,242 - 535,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611522,242 - 525,550 (-)NCBINCBI36hg18NCBI36
Build 3411522,242 - 525,550NCBI
Celera11594,708 - 598,010 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef11346,981 - 349,115 (-)NCBIHuRef
CHM1_111529,852 - 534,465 (-)NCBICHM1_1
Hras
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,769,847 - 140,773,938 (-)NCBIGRCm39mm39
GRCm39 Ensembl7140,769,018 - 140,773,918 (-)Ensembl
GRCm387141,189,934 - 141,194,019 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,189,105 - 141,194,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,375,833 - 148,379,903 (-)NCBIGRCm37mm9NCBIm37
MGSCv367141,042,668 - 141,044,260 (-)NCBImm8
Celera7140,983,643 - 140,987,701 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map786.48NCBI
Hras
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21196,290,127 - 196,299,823 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1196,296,263 - 196,300,615 (-)Ensembl
Rnor_6.01214,178,404 - 214,181,841 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,178,407 - 214,181,686 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,095,943 - 221,099,362 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,385,705 - 201,388,987 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,540,000 - 201,542,640 (-)NCBI
Celera1193,930,281 - 193,933,583 (-)NCBICelera
RH 3.4 Map11437.21RGD
Cytogenetic Map1q41NCBI
Hras
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,508,126 - 11,510,333 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,508,446 - 11,510,333 (+)NCBIChiLan1.0ChiLan1.0
HRAS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111568,305 - 571,078 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11568,305 - 571,078 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011537,488 - 540,810 (-)NCBIMhudiblu_PPA_v0panPan3
HRAS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,642,844 - 25,644,717 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,642,844 - 25,644,717 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,291,831 - 25,293,704 (-)NCBI
ROS_Cfam_1.01826,227,144 - 26,230,043 (-)NCBI
ROS_Cfam_1.0 Ensembl1826,220,886 - 26,230,059 (-)Ensembl
UMICH_Zoey_3.11825,736,932 - 25,738,805 (-)NCBI
UNSW_CanFamBas_1.01825,381,917 - 25,383,790 (-)NCBI
UU_Cfam_GSD_1.01825,994,065 - 25,995,938 (-)NCBI
HRAS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2299,660 - 302,501 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12299,662 - 302,539 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HRAS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11343,613 - 345,782 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1343,506 - 346,637 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603897,407,188 - 97,410,502 (-)NCBIVero_WHO_p1.0
Hras
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476621,907,423 - 21,913,414 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005341617   ⟹   XP_005341674
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947375,371 - 378,060 (-)NCBI
SpeTri2.0NW_004936888375,372 - 378,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013365835   ⟹   XP_013221289
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947375,371 - 378,065 (-)NCBI
SpeTri2.0NW_004936888375,372 - 378,125 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005341674 (Get FASTA)   NCBI Sequence Viewer  
  XP_013221289 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3284293 (Get FASTA)   NCBI Sequence Viewer  
  KAG3284294 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013221289   ⟸   XM_013365835
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005341674   ⟸   XM_005341617
- Peptide Label: isoform X2
- UniProtKB: A0A287D4T5 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021206 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000021762 ENTREZGENE, UniProtKB/TrEMBL
  ENSSTOP00000028539 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022153 UniProtKB/TrEMBL
  ENSSTOT00000032291 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/TrEMBL
NCBI Gene Hras ENTREZGENE
PANTHER PTHR24070 UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PROSITE RAS UniProtKB/TrEMBL
SMART RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/TrEMBL
UniProt A0A287D4T5 ENTREZGENE, UniProtKB/TrEMBL
  I3NBL5_ICTTR UniProtKB/TrEMBL