Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2827
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hras
Name: HRas proto-oncogene, GTPase
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hrasmultiple interactionsISOHras (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein]; [Tunicamycin co-treated with HRAS protein] results in decreased phosphorylation of MAPK1 protein; [Tunicamycin co-treated with HRAS protein] results in decreased phosphorylation of MAPK3 protein; [Tunicamycin co-treated with HRAS protein] results in increased expression of EIF2AK3 protein; [Tunicamycin co-treated with HRAS protein] results in increased expression of ERN1 protein; [Tunicamycin co-treated with HRAS protein] results in increased expression of HSPA5 protein; [Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein; [Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein; [Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein; HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of AKT1 protein]; HSPA5 protein affects the reaction [[Tunicamycin co-treated with HRAS protein] results in increased phosphorylation of RB1 protein]PMID:24898257
Go Back to source page   Continue to Ontology report