RGD Reference Report - ras gene mutations in human endometrial carcinoma. - Rat Genome Database

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ras gene mutations in human endometrial carcinoma.

Authors: Varras, M N  Koffa, M  Koumantakis, E  Ergazaki, M  Protopapa, E  Michalas, S  Spandidos, D A 
Citation: Varras MN, etal., Oncology. 1996 Nov-Dec;53(6):505-10. doi: 10.1159/000227627.
RGD ID: 13781876
Pubmed: PMID:8960147   (View Abstract at PubMed)
DOI: DOI:10.1159/000227627   (Journal Full-text)

The purpose of this study was to assess the extent of involvement of the ras oncogene activation by point mutations in endometrial carcinoma in the Greek population. The PCR technique was employed, followed by RFLP analysis to identify the point mutations in codon 12 of the K-ras, H-ras and N-ras genes. K-ras gene point mutations were detected in 8 of the 55 cases (15%) of primary endometrial carcinoma, H-ras in 4 (7.3%), while no mutations were found for the N-ras gene. No correlation was found between the presence of ras gene mutations and the clinicopathological parameters, or patient survival. The only association found was between H-ras mutations and the FIGO stage of the tumor (Fisher's exact test, p = 0.011). These results indicate a possible role of ras gene activation in a small subset of endometrial carcinomas.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
endometrial carcinoma disease_progressionIAGP 13781876DNA:snps:cds: (human)RGD 
endometrial carcinoma disease_progressionISOHRAS (Homo sapiens)13781876; 13781876DNA:snps:cds: (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Hras  (HRas proto-oncogene, GTPase)

Genes (Mus musculus)
Hras  (Harvey rat sarcoma virus oncogene)

Genes (Homo sapiens)
HRAS  (HRas proto-oncogene, GTPase)


Additional Information