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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1increases activityISORaf1 (Mus musculus)6480464CTDHydrogen Peroxide results in increased activity of RAF1 proteinPMID:14623285
Raf1multiple interactionsISORaf1 (Mus musculus)6480464CTD[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased activity of RAF1 protein; cypermethrin promotes the reaction [[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased activity of RAF1 protein]; dephostatin promotes the reaction [[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased activity of RAF1 protein]; Okadaic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased activity of RAF1 protein]; RAF1 protein affects the susceptibility to [Hydrogen Peroxide results in increased activity of MAPK1 protein]; RAF1 protein affects the susceptibility to [Hydrogen Peroxide results in increased activity of MAPK3 protein]; tautomycin inhibits the reaction [[Hydrogen Peroxide co-treated with Tetradecanoylphorbol Acetate] results in increased activity of RAF1 protein]PMID:14623285 PMID:14975446
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