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Gene: Raf1 (v-raf-leukemia viral oncogene 1) Mus musculus
Symbol: Raf1
Name: v-raf-leukemia viral oncogene 1
Description: Exhibits Ras GTPase binding activity. Involved in several processes, including cell surface receptor signaling pathway; gland development; and positive regulation of nitrogen compound metabolic process. Localizes to pseudopodium. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and immune system. Used to study Noonan syndrome 5. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase); PARTICIPATES IN altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; ceramide signaling pathway; endothelin signaling pathway; INTERACTS WITH (S)-(-)-perillyl alcohol; (S)-nicotine; 15-deoxy-Delta(12,14)-prostaglandin J2.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6430402F14Rik; AA990557; BB129353; c-Raf; cRaf; Craf1; Craf1 transforming; D830050J10Rik; MGC102375; murine sarcoma 3611 oncogene 1; proto-oncogene c-RAF; RAF proto-oncogene serine/threonine-protein kinase; Raf-1; sarcoma 3611 oncogene; v-Raf; v-raf-1 leukemia viral oncogene 1
Homo sapiens (human) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Canis lupus familiaris (dog) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
Sus scrofa (pig) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Chlorocebus sabaeus (African green monkey) : RAF1 (Raf-1 proto-oncogene, serine/threonine kinase)
Heterocephalus glaber (naked mole-rat) : Raf1 (Raf-1 proto-oncogene, serine/threonine kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl6115,618,067 - 115,676,635 (-)EnsemblGRCm38mm10GRCm38
GRCm386115,618,569 - 115,676,635 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376115,568,591 - 115,626,653 (-)NCBIGRCm37mm9NCBIm37
MGSCv366115,584,216 - 115,642,122 (-)NCBImm8
Celera6117,458,696 - 117,516,733 (-)NCBICelera
Cytogenetic Map6E3NCBI
cM Map653.62NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Raf1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11215
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.