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GENE - TERM ANNOTATION REPORT

RGD ID: 3531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Raf1
Name: Raf-1 proto-oncogene, serine/threonine kinase
Acc ID: GO:0008625
Term: extrinsic apoptotic signaling pathway via death domain receptors
Definition: The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered.
Definition Source(s): GOC:mah, GOC:mtg_apoptosis
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Raf1acts_upstream_ofISORaf1 (Mus musculus)1624291RGDMGI:2388026 MGI:95484 MGI:99255 PMID:16365167

PMID:16365167
Raf1involved_inIEAUniProtKB:Q99N57 or ensembl:ENSMUSP000000004511600115EnsemblGO_REF:0000107

GO_REF:0000107
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