Braf (B-Raf proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: Braf (B-Raf proto-oncogene, serine/threonine kinase) Chinchilla lanigera
Analyze
Symbol: Braf
Name: B-Raf proto-oncogene, serine/threonine kinase
RGD ID: 8800749
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); MAP kinase kinase kinase activity (ortholog); INVOLVED IN activation of MAPKK activity (ortholog); alpha-beta T cell differentiation (ortholog); CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (ortholog); PARTICIPATES IN adenosine signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; colorectal cancer pathway; ASSOCIATED WITH adrenal carcinoma (ortholog); adrenocortical carcinoma (ortholog); ameloblastoma (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenal carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
ameloblastoma  (ISO)
Aortic Aneurysm, Giant Congenital  (ISO)
arteriovenous malformations of the brain  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bile duct adenoma  (ISO)
bladder urothelial carcinoma  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
cancer  (ISO)
Carcinogenesis  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniopharyngioma  (ISO)
Cutaneous Malignant Melanoma, Susceptibility To, 1  (ISO)
cutaneous T cell lymphoma  (ISO)
Dandy Walker Cyst  (ISO)
Dandy-Walker syndrome  (ISO)
Developmental Disabilities  (ISO)
disease of cellular proliferation  (ISO)
dysembryoplastic neuroepithelial tumor  (ISO)
endometrial carcinoma  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Follicular Thyroid Cancer  (ISO)
ganglioglioma  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
germinoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Kidney Neoplasms  (ISO)
Liver Metastasis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mandibular Neoplasms  (ISO)
melanoma  (ISO)
Microsatellite Instability  (ISO)
multiple myeloma  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
Nevus  (ISO)
non-Hodgkin lymphoma  (ISO)
Nonseminomatous Germ Cell Tumor  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 7  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 3  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic acinar cell adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
PHACE Association  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Premature Birth  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
thyroid gland papillary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
uterine cancer  (ISO)
ventricular septal defect  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (ISO)
alpha-beta T cell differentiation  (ISO)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (ISO)
CD4-positive, alpha-beta T cell differentiation  (ISO)
cell differentiation  (ISO)
cellular response to calcium ion  (ISO)
cellular response to drug  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
establishment of protein localization to membrane  (ISO)
face development  (ISO)
head morphogenesis  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of synaptic vesicle exocytosis  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive T cell selection  (ISO)
protein phosphorylation  (ISO)
regulation of axon regeneration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of T cell differentiation  (ISO)
response to cAMP  (ISO)
response to peptide hormone  (ISO)
somatic stem cell population maintenance  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trehalose metabolism in response to stress  (ISO)
visual learning  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Braf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBIChiLan1.0ChiLan1.0
BRAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7140,719,327 - 140,924,928 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl7140,719,327 - 140,924,929 (-)EnsemblGRCh38hg38GRCh38
GRCh387140,713,328 - 140,924,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377140,413,128 - 140,624,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367140,080,751 - 140,271,033 (-)NCBINCBI36hg18NCBI36
Build 347139,887,462 - 140,077,748NCBI
Celera7135,155,867 - 135,346,614 (-)NCBI
Cytogenetic Map7q34NCBI
HuRef7134,729,459 - 134,920,529 (-)NCBIHuRef
CHM1_17140,368,045 - 140,559,148 (-)NCBICHM1_1
CRA_TCAGchr7v27139,771,989 - 139,962,886 (-)NCBI
Braf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39639,580,171 - 39,702,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl639,580,171 - 39,702,397 (-)Ensembl
GRCm38639,603,231 - 39,725,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv37639,553,236 - 39,675,462 (-)NCBIGRCm37mm9NCBIm37
MGSCv36639,557,807 - 39,675,462 (-)NCBImm8
Celera639,588,093 - 39,710,723 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.43NCBI
Braf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2468,375,484 - 68,510,652 (-)NCBI
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Celera463,383,337 - 63,515,499 (-)NCBICelera
Cytogenetic Map4q22NCBI
BRAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17145,124,291 - 145,327,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0panPan3
BRAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1168,222,909 - 8,318,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl168,222,907 - 8,317,906 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,989,501 - 9,160,850 (+)NCBI
ROS_Cfam_1.0168,065,738 - 8,237,942 (+)NCBI
UMICH_Zoey_3.1168,017,140 - 8,188,930 (+)NCBI
UNSW_CanFamBas_1.0167,861,588 - 8,033,660 (+)NCBI
UU_Cfam_GSD_1.0167,929,505 - 8,101,841 (+)NCBI
Braf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511814,385,958 - 14,495,443 (+)NCBI
SpeTri2.0NW_0049365924,728,371 - 4,833,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,957,959 - 9,132,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,957,963 - 9,132,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,522,257 - 9,636,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRAF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121109,495,525 - 109,690,261 (-)NCBI
Braf
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476520,766,368 - 20,951,560 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005405413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005405415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005405418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005405419 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013504993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013504994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013504995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013504996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_013504997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001231320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001231321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01061441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01061442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01061443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01061444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01061445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01061446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01061447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01061448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBDF01011297 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBDF01011303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005405413   ⟹   XP_005405470
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,711,454 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005405415   ⟹   XP_005405472
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,703,492 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005405418   ⟹   XP_005405475
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,698,832 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005405419   ⟹   XP_005405476
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,698,815 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504993   ⟹   XP_013360447
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504994   ⟹   XP_013360448
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504995   ⟹   XP_013360449
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504996   ⟹   XP_013360450
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,711,118 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013504997   ⟹   XP_013360451
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,692,429 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001231320
RefSeq Status:
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,711,469 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001231321
RefSeq Status:
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554942,567,238 - 2,711,469 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005405470   ⟸   XM_005405413
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_005405472   ⟸   XM_005405415
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_005405475   ⟸   XM_005405418
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_005405476   ⟸   XM_005405419
- Peptide Label: isoform X9
- Sequence:
RefSeq Acc Id: XP_013360447   ⟸   XM_013504993
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013360449   ⟸   XM_013504995
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013360448   ⟸   XM_013504994
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013360450   ⟸   XM_013504996
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013360451   ⟸   XM_013504997
- Peptide Label: isoform X7
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001297 ENTREZGENE
Ensembl Protein ENSCLAP00000001737 ENTREZGENE
Ensembl Transcript ENSCLAT00000001780 ENTREZGENE
NCBI Gene Braf ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Braf  B-Raf proto-oncogene, serine/threonine kinase    v-raf murine sarcoma viral oncogene homolog B  Symbol and/or name change 5135510 APPROVED