BRAF (B-Raf proto-oncogene, serine/threonine kinase) - Rat Genome Database

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Gene: BRAF (B-Raf proto-oncogene, serine/threonine kinase) Pan paniscus
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Symbol: BRAF
Name: B-Raf proto-oncogene, serine/threonine kinase
RGD ID: 11781420
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); identical protein binding (ortholog); MAP kinase kinase kinase activity (ortholog); INVOLVED IN activation of MAPKK activity (ortholog); alpha-beta T cell differentiation (ortholog); CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (ortholog); PARTICIPATES IN adenosine signaling pathway; altered extracellular signal-regulated Raf/Mek/Erk signaling pathway; colorectal cancer pathway; ASSOCIATED WITH adrenal carcinoma (ortholog); adrenocortical carcinoma (ortholog); ameloblastoma (ortholog); FOUND IN cell body (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serine/threonine-protein kinase B-raf; v-raf murine sarcoma viral oncogene homolog B1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17145,124,291 - 145,327,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenal carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
ameloblastoma  (ISO)
Aortic Aneurysm, Giant Congenital  (ISO)
arteriovenous malformations of the brain  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bile duct adenoma  (ISO)
bladder urothelial carcinoma  (ISO)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
cancer  (ISO)
Carcinogenesis  (ISO)
cardiofaciocutaneous syndrome  (ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic myeloid leukemia  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniopharyngioma  (ISO)
Cutaneous Malignant Melanoma, Susceptibility To, 1  (ISO)
cutaneous T cell lymphoma  (ISO)
Dandy Walker Cyst  (ISO)
Dandy-Walker syndrome  (ISO)
Developmental Disabilities  (ISO)
disease of cellular proliferation  (ISO)
dysembryoplastic neuroepithelial tumor  (ISO)
endometrial carcinoma  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Follicular Thyroid Cancer  (ISO)
ganglioglioma  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
germinoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Kidney Neoplasms  (ISO)
Liver Metastasis  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mandibular Neoplasms  (ISO)
melanoma  (ISO)
Microsatellite Instability  (ISO)
multiple myeloma  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
Nevus  (ISO)
non-Hodgkin lymphoma  (ISO)
Nonseminomatous Germ Cell Tumor  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO)
Noonan syndrome 7  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 3  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic acinar cell adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
PHACE Association  (ISO)
plasma cell neoplasm  (ISO)
plasmacytoma  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Premature Birth  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
thyroid gland papillary carcinoma  (ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
uterine cancer  (ISO)
ventricular septal defect  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (ISO)
alpha-beta T cell differentiation  (ISO)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (ISO)
CD4-positive, alpha-beta T cell differentiation  (ISO)
cell differentiation  (ISO)
cellular response to calcium ion  (ISO)
cellular response to drug  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
establishment of protein localization to membrane  (ISO)
face development  (ISO)
head morphogenesis  (ISO)
long-term synaptic potentiation  (ISO)
MAPK cascade  (ISO)
myeloid progenitor cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of synaptic vesicle exocytosis  (ISO)
positive regulation of axon regeneration  (ISO)
positive regulation of axonogenesis  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of substrate adhesion-dependent cell spreading  (ISO)
positive T cell selection  (ISO)
protein phosphorylation  (ISO)
regulation of axon regeneration  (ISO)
regulation of cell population proliferation  (ISO)
regulation of T cell differentiation  (ISO)
response to cAMP  (ISO)
response to peptide hormone  (ISO)
somatic stem cell population maintenance  (ISO)
T cell receptor signaling pathway  (ISO)
thymus development  (ISO)
thyroid gland development  (ISO)
trehalose metabolism in response to stress  (ISO)
visual learning  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
BRAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17145,124,291 - 145,327,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0panPan3
BRAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7140,719,327 - 140,924,928 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl7140,719,327 - 140,924,929 (-)EnsemblGRCh38hg38GRCh38
GRCh387140,713,328 - 140,924,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377140,413,128 - 140,624,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367140,080,751 - 140,271,033 (-)NCBINCBI36hg18NCBI36
Build 347139,887,462 - 140,077,748NCBI
Celera7135,155,867 - 135,346,614 (-)NCBI
Cytogenetic Map7q34NCBI
HuRef7134,729,459 - 134,920,529 (-)NCBIHuRef
CHM1_17140,368,045 - 140,559,148 (-)NCBICHM1_1
CRA_TCAGchr7v27139,771,989 - 139,962,886 (-)NCBI
Braf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39639,580,171 - 39,702,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl639,580,171 - 39,702,397 (-)Ensembl
GRCm38639,603,231 - 39,725,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv37639,553,236 - 39,675,462 (-)NCBIGRCm37mm9NCBIm37
MGSCv36639,557,807 - 39,675,462 (-)NCBImm8
Celera639,588,093 - 39,710,723 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.43NCBI
Braf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2468,375,484 - 68,510,652 (-)NCBI
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Celera463,383,337 - 63,515,499 (-)NCBICelera
Cytogenetic Map4q22NCBI
Braf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBIChiLan1.0ChiLan1.0
BRAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1168,222,909 - 8,318,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl168,222,907 - 8,317,906 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,989,501 - 9,160,850 (+)NCBI
ROS_Cfam_1.0168,065,738 - 8,237,942 (+)NCBI
UMICH_Zoey_3.1168,017,140 - 8,188,930 (+)NCBI
UNSW_CanFamBas_1.0167,861,588 - 8,033,660 (+)NCBI
UU_Cfam_GSD_1.0167,929,505 - 8,101,841 (+)NCBI
Braf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511814,385,958 - 14,495,443 (+)NCBI
SpeTri2.0NW_0049365924,728,371 - 4,833,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,957,959 - 9,132,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,957,963 - 9,132,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,522,257 - 9,636,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRAF
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121109,495,525 - 109,690,261 (-)NCBI
Braf
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476520,766,368 - 20,951,560 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048582   ⟹   ENSPPAP00000025752
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7145,138,510 - 145,327,054 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048585   ⟹   ENSPPAP00000025755
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7145,138,510 - 145,256,303 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048586   ⟹   ENSPPAP00000025756
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl7145,139,101 - 145,327,115 (-)Ensembl
RefSeq Acc Id: XM_008965952   ⟹   XP_008964200
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.17145,124,291 - 145,327,115 (-)NCBI
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034965106   ⟹   XP_034820997
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBI
RefSeq Acc Id: XM_034965107   ⟹   XP_034820998
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v07132,655,496 - 132,855,420 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008964200 (Get FASTA)   NCBI Sequence Viewer  
  XP_034820997 (Get FASTA)   NCBI Sequence Viewer  
  XP_034820998 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008964200   ⟸   XM_008965952
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034820997   ⟸   XM_034965106
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034820998   ⟸   XM_034965107
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000025752   ⟸   ENSPPAT00000048582
RefSeq Acc Id: ENSPPAP00000025755   ⟸   ENSPPAT00000048585
RefSeq Acc Id: ENSPPAP00000025756   ⟸   ENSPPAT00000048586
Protein Domains
Phorbol-ester/DAG-type   Protein kinase   RBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036004 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000025752 UniProtKB/TrEMBL
  ENSPPAP00000025755 UniProtKB/TrEMBL
  ENSPPAP00000025756 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048582 UniProtKB/TrEMBL
  ENSPPAT00000048585 UniProtKB/TrEMBL
  ENSPPAT00000048586 UniProtKB/TrEMBL
InterPro DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  RBD_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
KEGG Report pps:100971666 UniProtKB/TrEMBL
NCBI Gene BRAF ENTREZGENE
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RBD UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART RBD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SM00109 UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9B9I1_PANPA UniProtKB/TrEMBL
  A0A2R9BBV0_PANPA UniProtKB/TrEMBL
  A0A2R9BFH5_PANPA UniProtKB/TrEMBL