RGD Reference Report - Somatic mutations of signaling genes in non-small-cell lung cancer. - Rat Genome Database

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Somatic mutations of signaling genes in non-small-cell lung cancer.

Authors: Sanders, HR  Albitar, M 
Citation: Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
RGD ID: 5133242
Pubmed: PMID:20951313   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cancergencyto.2010.07.134   (Journal Full-text)

Lung cancer is the leading cause of cancer-related deaths, with non-small-cell lung cancer (NSCLC) accounting for approximately 85% of cases. A significant proportion of NSCLC cases are not diagnosed until a late stage, when aggressive treatments are required but often prolong survival only modestly. Recent advances in molecular characterization of NSCLC have enabled identification of numerous cell growth and proliferation pathways that are disrupted in these tumors. This knowledge has provided insight into the mechanisms of tumor development in various histologic subtypes of NSCLC and has pointed the way toward targeted treatment strategies. In this review, we highlight literature findings of somatic mutations in genes involved in cell growth and proliferation that are commonly found in the various subtypes of NSCLC, and we discuss how these findings may relate to treatment strategies.


Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
altered epidermal growth factor/neuregulin signaling pathway  TAS 5133242 RGD 
altered epidermal growth factor/neuregulin signaling pathway  ISOEGFR (Homo sapiens)5133242; 5133242 RGD 
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  TAS 5133242; 5133242; 5133242 RGD 
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  ISOBRAF (Homo sapiens)5133242; 5133242 RGD 
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  ISOKRAS (Homo sapiens)5133242; 5133242 RGD 
altered extracellular signal-regulated Raf/Mek/Erk signaling pathway  ISOMAP2K1 (Homo sapiens)5133242; 5133242 RGD 
altered p53 signaling pathway   TAS 5133242 RGD 
altered p53 signaling pathway   ISOTP53 (Homo sapiens)5133242; 5133242 RGD 
altered phosphatidylinositol 3-kinase-Akt signaling pathway  TAS 5133242; 5133242 RGD 
altered phosphatidylinositol 3-kinase-Akt signaling pathway  ISOPIK3CA (Homo sapiens)5133242; 5133242 RGD 
altered phosphatidylinositol 3-kinase-Akt signaling pathway  ISOPTEN (Homo sapiens)5133242; 5133242 RGD 
altered scatter factor/hepatocyte growth factor signaling pathway  TAS 5133242 RGD 
altered scatter factor/hepatocyte growth factor signaling pathway  ISOMET (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   TAS 5133242; 5133242; 5133242; 5133242; 5133242; 5133242; 5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOBRAF (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOEGFR (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOKRAS (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOMAP2K1 (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOMET (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOPIK3CA (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOPTEN (Homo sapiens)5133242; 5133242 RGD 
non-small cell lung carcinoma pathway   ISOTP53 (Homo sapiens)5133242; 5133242 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Braf  (B-Raf proto-oncogene, serine/threonine kinase)
Egfr  (epidermal growth factor receptor)
Kras  (KRAS proto-oncogene, GTPase)
Map2k1  (mitogen activated protein kinase kinase 1)
Met  (MET proto-oncogene, receptor tyrosine kinase)
Pik3ca  (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha)
Pten  (phosphatase and tensin homolog)
Tp53  (tumor protein p53)

Genes (Mus musculus)
Braf  (Braf transforming gene)
Egfr  (epidermal growth factor receptor)
Kras  (Kirsten rat sarcoma viral oncogene homolog)
Map2k1  (mitogen-activated protein kinase kinase 1)
Met  (met proto-oncogene)
Pik3ca  (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
Pten  (phosphatase and tensin homolog)
Trp53  (transformation related protein 53)

Genes (Homo sapiens)
BRAF  (B-Raf proto-oncogene, serine/threonine kinase)
EGFR  (epidermal growth factor receptor)
KRAS  (KRAS proto-oncogene, GTPase)
MAP2K1  (mitogen-activated protein kinase kinase 1)
MET  (MET proto-oncogene, receptor tyrosine kinase)
PIK3CA  (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha)
PTEN  (phosphatase and tensin homolog)
TP53  (tumor protein p53)


Additional Information