Braf (Braf transforming gene) - Rat Genome Database

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Gene: Braf (Braf transforming gene) Mus musculus
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Symbol: Braf
Name: Braf transforming gene
RGD ID: 735646
MGI Page MGI
Description: Enables protein kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; negative regulation of apoptotic process; and positive regulation of cellular component organization. Located in several cellular components, including cell body; mitochondrion; and neuron projection. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Langerhans-cell histiocytosis; cardiofaciocutaneous syndrome; melanoma (multiple); prostate cancer; and thyroid gland papillary carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 7; carcinoma (multiple); cardiofaciocutaneous syndrome (multiple); central nervous system benign neoplasm (multiple); and melanoma (multiple). Orthologous to human BRAF (B-Raf proto-oncogene, serine/threonine kinase).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 9930012E13Rik; AA120551; AA387315; AA473386; B-raf; B-Raf proto-oncogene serine/threonine-protein kinase (p94); Bra; Braf-2; Braf2; C230098H17; C87398; D6Ertd631; D6Ertd631e; proto-oncogene B-Raf; serine/threonine-protein kinase B-raf
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18189  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39639,580,171 - 39,702,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl639,580,171 - 39,702,397 (-)Ensembl
GRCm38639,603,231 - 39,725,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv37639,553,236 - 39,675,462 (-)NCBIGRCm37mm9NCBIm37
MGSCv36639,557,807 - 39,675,462 (-)NCBImm8
Celera639,588,093 - 39,710,723 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenocortical carcinoma  (ISO)
ameloblastoma  (ISO)
Aortic Aneurysm, Giant Congenital  (ISO)
arteriovenous malformation  (ISO)
arteriovenous malformations of the brain  (ISO)
ataxia telangiectasia  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
bile duct adenoma  (IAGP)
Brain Neoplasms  (ISO)
Breast Neoplasms  (ISO)
cancer  (ISO)
Carcinogenesis  (ISO)
cardiofaciocutaneous syndrome  (IEA,IMP,ISO)
cardiofaciocutaneous syndrome 1  (ISO)
cardiomyopathy  (ISO)
cholangiocarcinoma  (IAGP)
chronic lymphocytic leukemia  (ISO)
chronic myelogenous leukemia, BCR-ABL1 positive  (ISO)
chronic myeloid leukemia  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
Costello syndrome  (ISO)
craniopharyngioma  (ISO)
Cutaneous Malignant Melanoma, Susceptibility To, 1  (ISO)
Dandy-Walker syndrome  (ISO)
Developmental Disabilities  (ISO)
disease of cellular proliferation  (ISO)
dysembryoplastic neuroepithelial tumor  (ISO)
endometrial carcinoma  (ISO)
Experimental Melanoma  (ISO)
Experimental Neoplasms  (ISO)
Follicular Thyroid Cancer  (ISO)
gallbladder cancer  (ISO)
ganglioglioma  (ISO)
gastric adenocarcinoma  (ISO)
gastrointestinal stromal tumor  (ISO)
genetic disease  (ISO)
germinoma  (ISO)
glioblastoma  (ISO)
head and neck squamous cell carcinoma  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic cardiomyopathy 4  (ISO)
intrahepatic cholangiocarcinoma  (IAGP)
Kidney Neoplasms  (ISO)
Langerhans-cell histiocytosis  (IEA)
Liver Metastasis  (IAGP)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
lung cancer  (ISO,ISS)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mandibular Neoplasms  (ISO)
melanoma  (IEA,ISO)
Microsatellite Instability  (ISO)
multiple myeloma  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
neuroendocrine tumor  (ISO)
Nevus  (ISO)
newborn respiratory distress syndrome  (ISO)
non-Hodgkin lymphoma  (ISO)
Nonseminomatous Germ Cell Tumor  (ISO)
Noonan syndrome  (ISO)
Noonan syndrome 1  (ISO,ISS)
Noonan syndrome 7  (ISO)
Noonan syndrome with multiple lentigines  (ISO)
Noonan syndrome with multiple lentigines 3  (ISO)
Ovarian Neoplasms  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic acinar cell adenocarcinoma  (ISO)
pancreatic cancer  (IMP,ISO)
papillary renal cell carcinoma  (ISO)
Paraproteinemias  (ISO)
PHACE Association  (ISO)
plasma cell neoplasm  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Premature Birth  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate adenocarcinoma  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary valve stenosis  (ISO)
RASopathy  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Sporadic Papillary Renal Cell Carcinoma  (ISO)
tethered spinal cord syndrome  (ISO)
thyroid gland papillary carcinoma  (IEA,ISO)
Thyroid Neoplasms  (ISO)
transitional cell carcinoma  (ISO)
type 2 diabetes mellitus  (ISO)
uterine cancer  (ISO)
ventricular septal defect  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,6-dinitrotoluene  (ISO)
3',5'-cyclic AMP  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-vinylcyclohexene dioxide  (EXP)
ABT-737  (ISO)
afimoxifene  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
benzo[a]pyrene  (ISO)
betulin  (ISO)
Biflorin  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP)
cisplatin  (EXP,ISO)
cobimetinib  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (EXP)
cyclosporin A  (ISO)
cypermethrin  (ISO)
dabrafenib  (ISO)
diarsenic trioxide  (EXP,ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
endosulfan  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
famotidine  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
gemcitabine  (ISO)
gentamycin  (ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (EXP)
icariside II  (ISO)
isotretinoin  (ISO)
ketamine  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (EXP)
lycopene  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (ISO)
methyl methanesulfonate  (ISO)
miconazole  (EXP)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
nicotine  (EXP)
Nor-9-carboxy-delta9-THC  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
Pentoxifylline  (ISO)
phenobarbital  (EXP,ISO)
Pirarubicin  (ISO)
pirinixic acid  (ISO)
ponatinib  (ISO)
potassium cyanide  (EXP)
propiconazole  (EXP)
quercetin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (EXP)
rutin  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (ISO)
sorafenib  (ISO)
succimer  (EXP)
tamoxifen  (EXP)
tanespimycin  (ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
trametinib  (ISO)
trichostatin A  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vemurafenib  (EXP,ISO)
vorinostat  (ISO)
zearalenone  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell differentiation  (IMP)
CD4-positive or CD8-positive, alpha-beta T cell lineage commitment  (IMP)
CD4-positive, alpha-beta T cell differentiation  (IMP)
cell differentiation  (IGI)
cellular response to calcium ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to xenobiotic stimulus  (IDA)
endothelial cell apoptotic process  (IMP)
epidermal growth factor receptor signaling pathway  (ISO)
ERK1 and ERK2 cascade  (IMP)
establishment of protein localization to membrane  (ISO)
face development  (IGI)
head morphogenesis  (IMP)
long-term synaptic potentiation  (IMP)
MAPK cascade  (IBA,ISO)
myeloid progenitor cell differentiation  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of endothelial cell apoptotic process  (IMP)
negative regulation of fibroblast migration  (IMP)
negative regulation of neuron apoptotic process  (IMP,ISO)
negative regulation of synaptic vesicle exocytosis  (IMP)
phosphorylation  (IEA)
positive regulation of axon regeneration  (IDA)
positive regulation of axonogenesis  (IGI,IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IMP,ISO)
positive regulation of gene expression  (IGI,ISO)
positive regulation of glucose transmembrane transport  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of stress fiber assembly  (IGI,IMP)
positive regulation of substrate adhesion-dependent cell spreading  (IMP)
positive T cell selection  (IMP)
protein phosphorylation  (IDA,ISO)
regulation of axon regeneration  (IGI)
regulation of cell population proliferation  (IGI)
regulation of T cell differentiation  (IMP)
response to cAMP  (ISO)
response to peptide hormone  (ISO)
signal transduction  (IEA)
somatic stem cell population maintenance  (IGI)
stress fiber assembly  (IMP)
substrate adhesion-dependent cell spreading  (IMP)
synaptic vesicle exocytosis  (IMP)
T cell differentiation in thymus  (IMP)
T cell receptor signaling pathway  (IDA)
thymus development  (IGI)
thyroid gland development  (IGI)
trehalose metabolism in response to stress  (ISO)
visual learning  (IMP)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adenohypophysis morphology  (IAGP)
abnormal aorta morphology  (IAGP)
abnormal apoptosis  (IAGP)
abnormal associative learning  (IAGP)
abnormal astrocyte morphology  (IAGP)
abnormal atrioventricular cushion morphology  (IAGP)
abnormal axon extension  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal blood vessel morphology  (IAGP)
abnormal body temperature homeostasis  (IAGP)
abnormal cardinal vein morphology  (IAGP)
abnormal cell morphology  (IAGP)
abnormal cell physiology  (IEA)
abnormal cerebellar molecular layer  (IAGP)
abnormal cerebellum morphology  (IAGP)
abnormal cerebellum vermis lobule I morphology  (IAGP)
abnormal cerebellum vermis lobule II morphology  (IAGP)
abnormal cerebellum vermis lobule III morphology  (IAGP)
abnormal cerebellum vermis lobule morphology  (IAGP)
abnormal cerebellum vermis lobule V morphology  (IAGP)
abnormal cerebellum vermis lobule VII morphology  (IAGP)
abnormal cerebellum vermis lobule X morphology  (IAGP)
abnormal cerebral cortex pyramidal cell morphology  (IAGP)
abnormal conotruncus morphology  (IAGP)
abnormal coronary artery morphology  (IAGP)
abnormal crypts of Lieberkuhn morphology  (IAGP)
abnormal dermal melanocyte morphology  (IAGP)
abnormal dorsal root ganglion morphology  (IAGP)
abnormal epicardium morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal frontal bone morphology  (IAGP)
abnormal growth hormone level  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal hippocampus granule cell layer  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal innervation  (IAGP)
abnormal intestinal epithelium morphology  (IAGP)
abnormal intestinal mucosa morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal large intestine crypts of Lieberkuhn morphology  (IAGP)
abnormal large intestine morphology  (IAGP)
abnormal liver morphology  (IAGP)
abnormal locomotor behavior  (IAGP)
abnormal long term object recognition memory  (IAGP)
abnormal lung morphology  (IAGP)
abnormal lymph organ development  (IAGP)
abnormal mating frequency  (IAGP)
abnormal melanocyte morphology  (IAGP)
abnormal myocardial fiber morphology  (IAGP)
abnormal myocardial trabeculae morphology  (IAGP)
abnormal myometrium morphology  (IAGP)
abnormal nervous system electrophysiology  (IAGP)
abnormal neurocranium morphology  (IAGP)
abnormal neuron morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal neuronal precursor proliferation  (IAGP)
abnormal pancreatic acinar cell morphology  (IAGP)
abnormal parietal bone morphology  (IAGP)
abnormal placenta labyrinth morphology  (IAGP)
abnormal placenta morphology  (IAGP)
abnormal placental labyrinth vasculature morphology  (IAGP)
abnormal pulmonary valve cusp morphology  (IAGP)
abnormal Purkinje cell dendrite morphology  (IAGP)
abnormal Purkinje cell morphology  (IAGP)
abnormal sensory neuron innervation pattern  (IAGP)
abnormal skin sebaceous gland morphology  (IAGP)
abnormal small intestinal villus morphology  (IAGP)
abnormal small intestine morphology  (IAGP)
abnormal somatosensory cortex morphology  (IAGP)
abnormal spatial learning  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal stratification in cerebral cortex  (IAGP)
abnormal telencephalon development  (IAGP)
abnormal thymus morphology  (IAGP)
abnormal thyroid follicle morphology  (IAGP)
abnormal thyroid gland morphology  (IAGP)
abnormal trophoblast layer morphology  (IAGP)
abnormal tumor pathology  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
abnormal visual cortex morphology  (IAGP)
abnormal vitelline vasculature morphology  (IAGP)
anemia  (IAGP)
atrial septal defect  (IAGP)
branched small intestinal villi  (IAGP)
cardiac hypertrophy  (IAGP)
cataract  (IAGP)
cerebellum hypoplasia  (IAGP)
convulsive seizures  (IAGP)
cyanosis  (IAGP)
cytokine storm  (IAGP)
decreased activity of thyroid gland  (IAGP)
decreased birth weight  (IAGP)
decreased body height  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased bone marrow cell number  (IAGP)
decreased brain weight  (IAGP)
decreased cell proliferation  (IAGP)
decreased circulating thyroxine level  (IAGP)
decreased cranium length  (IAGP)
decreased creatinine clearance  (IAGP)
decreased embryo size  (IAGP)
decreased embryo weight  (IAGP)
decreased erythrocyte cell number  (IAGP)
decreased food intake  (IAGP)
decreased heart rate  (IAGP)
decreased leukocyte cell number  (IAGP)
decreased liver weight  (IAGP)
decreased Purkinje cell number  (IAGP)
decreased spleen weight  (IAGP)
decreased thymocyte number  (IAGP)
decreased thymus weight  (IAGP)
decreased vertical activity  (IAGP)
decreased white adipose tissue amount  (IAGP)
double outlet right ventricle  (IAGP)
edema  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
enhanced behavioral response to xenobiotic  (IAGP)
enlarged heart  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged mitral valve  (IAGP)
enlarged myocardial fiber  (IAGP)
enlarged pulmonary valve  (IAGP)
enlarged spleen  (IAGP)
enlarged thyroid gland  (IAGP)
enlarged tricuspid valve  (IAGP)
excessive scratching  (IAGP)
extramedullary hematopoiesis  (IAGP)
female infertility  (IAGP)
granulomatous inflammation  (IAGP)
heart hyperplasia  (IAGP)
hematoma  (IAGP)
hemopericardium  (IAGP)
hemorrhage  (IAGP)
hepatic necrosis  (IAGP)
hepatosplenomegaly  (IAGP)
hyperactivity  (IAGP)
hyperpigmentation  (IAGP)
hypoglycemia  (IAGP)
impaired balance  (IAGP)
impaired contextual conditioning behavior  (IAGP)
impaired coordination  (IAGP)
impaired neuron differentiation  (IAGP)
increased aggression  (IAGP)
increased apoptosis  (IAGP)
increased carcinoma incidence  (IAGP)
increased cardiac muscle contractility  (IAGP)
increased cell proliferation  (IAGP)
increased circulating noradrenaline level  (IAGP)
increased circulating thyroid-stimulating hormone level  (IAGP)
increased circulating thyroxine level  (IAGP)
increased cutaneous melanoma incidence  (IAGP)
increased dendritic cell number  (IAGP)
increased fibroblast proliferation  (IAGP)
increased gastrointestinal tumor incidence  (IAGP)
increased gland tumor incidence  (IAGP)
increased heart weight  (IAGP)
increased incidence of tumors by chemical induction  (IAGP)
increased inflammatory response  (IAGP)
increased intestinal adenoma incidence  (IAGP)
increased large intestine length  (IAGP)
increased leukemia incidence  (IAGP)
increased locomotor activity  (IAGP)
increased lung adenocarcinoma incidence  (IAGP)
increased lung adenoma incidence  (IAGP)
increased lung non-small cell carcinoma incidence  (IAGP)
increased lung tumor incidence  (IAGP)
increased melanoma incidence  (IAGP)
increased metastatic potential  (IAGP)
increased neuron apoptosis  (IAGP)
increased neuronal precursor proliferation  (IAGP)
increased pheochromocytoma incidence  (IAGP)
increased prostate gland adenocarcinoma incidence  (IAGP)
increased prostate gland tumor incidence  (IAGP)
increased prostate intraepithelial neoplasia incidence  (IAGP)
increased skin papilloma incidence  (IAGP)
increased skin tumor incidence  (IAGP)
increased small intestine length  (IAGP)
increased spleen weight  (IAGP)
increased splenocyte apoptosis  (IAGP)
increased susceptibility to ischemic brain injury  (IAGP)
increased tail pigmentation  (IEA)
increased thymocyte apoptosis  (IAGP)
increased thyroid carcinoma incidence  (IAGP)
increased thyroid tumor incidence  (IAGP)
increased thyroid-stimulating hormone level  (IAGP)
increased tumor incidence  (IAGP)
increased vascular endothelial cell number  (IAGP)
intestine polyps  (IAGP)
intraventricular hemorrhage  (IAGP)
kyphosis  (IAGP)
lethality at weaning, complete penetrance  (IAGP)
lethality at weaning, incomplete penetrance  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
liver inflammation  (IAGP)
long incisors  (IAGP)
long nails  (IAGP)
lung epithelium hyperplasia  (IAGP)
lung inflammation  (IAGP)
lymphoid hyperplasia  (IAGP)
mandible hypoplasia  (IAGP)
nail dystrophy  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
oliguria  (IAGP)
ostium secundum atrial septal defect  (IAGP)
ovary cyst  (IAGP)
patent cardiac foramen ovale  (IAGP)
persistent truncus arteriosis  (IAGP)
polydactyly  (IAGP)
poor circulation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
premature death  (IAGP)
pulmonary alveolar hemorrhage  (IAGP)
pulmonary valve stenosis  (IAGP)
reduced long term potentiation  (IAGP)
respiratory failure  (IAGP)
round head  (IAGP)
ruffled hair  (IAGP)
short maxilla  (IAGP)
shortened head  (IAGP)
skin lesions  (IAGP)
slow postnatal weight gain  (IAGP)
small adenohypophysis  (IAGP)
small liver  (IAGP)
small placenta  (IAGP)
small thymus  (IAGP)
small thyroid gland  (IAGP)
sparse hair  (IAGP)
spontaneous skin ulceration  (IAGP)
tachypnea  (IAGP)
thick interventricular septum  (IAGP)
thick mitral valve cusps  (IAGP)
thick pulmonary valve  (IAGP)
thick pulmonary valve cusps  (IAGP)
thick tricuspid valve  (IAGP)
thick ventricular wall  (IAGP)
thin cerebral cortex  (IAGP)
thin myocardium compact layer  (IAGP)
thymus atrophy  (IAGP)
uterus prolapse  (IAGP)
ventricular septal defect  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Tumour mutation status and sites of metastasis in patients with cutaneous melanoma. Adler NR, etal., Br J Cancer. 2017 Sep 26;117(7):1026-1035. doi: 10.1038/bjc.2017.254. Epub 2017 Aug 8.
2. KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling. Appleman VA, etal., Mol Cancer Res. 2012 Sep;10(9):1228-39. doi: 10.1158/1541-7786.MCR-12-0340-T. Epub 2012 Aug 7.
3. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes. Chmielecki J, etal., Cancer Discov. 2014 Dec;4(12):1398-405. doi: 10.1158/2159-8290.CD-14-0617. Epub 2014 Sep 29.
4. A central role for RAF¿MEK¿ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Collisson EA, etal., Cancer Discov. 2012 Aug;2(8):685-93. doi: 10.1158/2159-8290.CD-11-0347. Epub 2012 May 24.
5. Clonal architectures and driver mutations in metastatic melanomas. Ding L, etal., PLoS One. 2014 Nov 13;9(11):e111153. doi: 10.1371/journal.pone.0111153. eCollection 2014.
6. Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy. Estep AL, etal., PLoS ONE. 2007 Dec 5;2(12):e1279.
7. BRAF mutation in endometrial carcinoma and hyperplasia: correlation with KRAS and p53 mutations and mismatch repair protein expression. Feng YZ, etal., Clin Cancer Res. 2005 Sep 1;11(17):6133-8.
8. Mutation location on the RAS oncogene affects pathologic features and survival after resection of colorectal liver metastases. Frankel TL, etal., Cancer. 2017 Feb 15;123(4):568-575. doi: 10.1002/cncr.30351. Epub 2016 Oct 13.
9. Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Hoeflich KP, etal., Cancer Res. 2006 Jan 15;66(2):999-1006.
10. Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. Honecker F, etal., J Clin Oncol. 2009 May 1;27(13):2129-36. Epub 2009 Mar 16.
11. New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Inoue S, etal., Hum Mol Genet. 2014 Dec 15;23(24):6553-66. doi: 10.1093/hmg/ddu376. Epub 2014 Jul 17.
12. CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity. James J, etal., Mol Cancer Ther. 2012 Apr;11(4):930-41. doi: 10.1158/1535-7163.MCT-11-0645. Epub 2012 Feb 7.
13. BRAF activation initiates but does not maintain invasive prostate adenocarcinoma. Jeong JH, etal., PLoS One. 2008;3(12):e3949. Epub 2008 Dec 16.
14. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
15. An Animal Model Further Uncovers the Role of Mutant BrafV600E during Papillary Thyroid Cancer Development. Koelsch B, etal., Am J Pathol. 2020 Mar;190(3):702-710. doi: 10.1016/j.ajpath.2019.11.006. Epub 2020 Jan 14.
16. BRAF V600E mutations are frequent in dysembryoplastic neuroepithelial tumors and subependymal giant cell astrocytomas. Lee D, etal., J Surg Oncol. 2015 Mar;111(3):359-64. doi: 10.1002/jso.23822. Epub 2014 Oct 24.
17. Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. McCubrey JA, etal., Biochim Biophys Acta. 2007 Aug;1773(8):1263-84. Epub 2006 Oct 7.
18. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. MGD IEA MGD IEA
21. Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. Niihori T, etal., Nat Genet. 2006 Mar;38(3):294-6. Epub 2006 Feb 12.
22. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Nucera C, etal., Oncologist. 2011;16(3):296-309. doi: 10.1634/theoncologist.2010-0317. Epub 2011 Feb 25.
23. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. The T1796A mutation of the BRAF gene is absent in Spitz nevi. Palmedo G, etal., J Cutan Pathol. 2004 Mar;31(3):266-70.
26. New driver mutations in non-small-cell lung cancer. Pao W and Girard N, Lancet Oncol. 2011 Feb;12(2):175-80.
27. Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis. Passiglia F, etal., Crit Rev Oncol Hematol. 2016 Mar;99:150-7. doi: 10.1016/j.critrevonc.2015.12.015. Epub 2016 Jan 2.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
31. Prognostic and predictive values of oncogenic BRAF, NRAS, c-KIT and MITF in cutaneous and mucous melanoma. Pracht M, etal., J Eur Acad Dermatol Venereol. 2015 Aug;29(8):1530-8. doi: 10.1111/jdv.12910. Epub 2015 Jan 26.
32. BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations. Preto A, et al., J Pathol. 2008 Feb;214(3):320-7.
33. BRAF V600E mutational status in bile duct adenomas and hamartomas. Pujals A, etal., Histopathology. 2015 Oct;67(4):562-7. doi: 10.1111/his.12674. Epub 2015 Mar 31.
34. Mouse MP Annotation Import Pipeline RGD automated import pipeline
35. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
36. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
37. The frequency of KRAS and BRAF mutations in intrahepatic cholangiocarcinomas and their correlation with clinical outcome. Robertson S, etal., Hum Pathol. 2013 Dec;44(12):2768-73. doi: 10.1016/j.humpath.2013.07.026. Epub 2013 Oct 15.
38. MEK1/2 dual-specificity protein kinases: Structure and regulation. Roskoski R Jr Biochem Biophys Res Commun. 2012 Jan 6;417(1):5-10. Epub 2011 Dec 8.
39. Regulation and role of Raf-1/B-Raf heterodimerization. Rushworth LK, etal., Mol Cell Biol. 2006 Mar;26(6):2262-72.
40. Mutational analysis and clinical correlation of metastatic colorectal cancer. Russo AL, etal., Cancer. 2014 May 15;120(10):1482-90. doi: 10.1002/cncr.28599. Epub 2014 Feb 5.
41. BRAF mutations are also associated with neurocutaneous melanocytosis and large/giant congenital melanocytic nevi. Salgado CM, etal., Pediatr Dev Pathol. 2015 Jan-Feb;18(1):1-9. doi: 10.2350/14-10-1566-OA.1. Epub 2014 Dec 9.
42. Somatic mutations of signaling genes in non-small-cell lung cancer. Sanders HR and Albitar M, Cancer Genet Cytogenet. 2010 Nov;203(1):7-15.
43. Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Santos SD, etal., Nat Cell Biol. 2007 Mar;9(3):324-30. Epub 2007 Feb 18.
44. B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis. Sobczak I, etal., Oncogene. 2008 Aug 14;27(35):4779-87. doi: 10.1038/onc.2008.128. Epub 2008 May 19.
45. Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Tannapfel A, etal., Gut. 2003 May;52(5):706-12.
46. BRAF mutation is a prognostic biomarker for colorectal liver metastasectomy. Teng HW, etal., J Surg Oncol. 2012 Aug 1;106(2):123-9. doi: 10.1002/jso.23063. Epub 2012 Feb 13.
47. In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval. Ulisse S, etal., Clin Endocrinol (Oxf). 2012 Nov;77(5):780-6. doi: 10.1111/j.1365-2265.2012.04465.x.
48. Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability. Umeda Y, etal., J Hepatobiliary Pancreat Sci. 2013 Feb;20(2):223-33. doi: 10.1007/s00534-012-0531-9.
49. Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Urosevic J, etal., Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5015-20. doi: 10.1073/pnas.1016933108. Epub 2011 Mar 7.
50. v-Raf murine sarcoma viral oncogene mutation status in serous borderline ovarian tumors and the effect on clinical behavior. Verbruggen MB, etal., Int J Gynecol Cancer. 2009 Dec;19(9):1560-3.
51. A dual-color FISH gene map of the proximal region of rat Chromosome 4 and comparative analysis in human and mouse. Walentinsson A, etal., Mamm Genome 2001 Dec;12(12):900-8.
52. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Yu J, etal., Neurology. 2009 Nov 10;73(19):1526-31. doi: 10.1212/WNL.0b013e3181c0664a. Epub 2009 Sep 30.
Additional References at PubMed
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Genomics

Comparative Map Data
Braf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39639,580,171 - 39,702,592 (-)NCBIGRCm39mm39
GRCm39 Ensembl639,580,171 - 39,702,397 (-)Ensembl
GRCm38639,603,231 - 39,725,658 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)EnsemblGRCm38mm10GRCm38
MGSCv37639,553,236 - 39,675,462 (-)NCBIGRCm37mm9NCBIm37
MGSCv36639,557,807 - 39,675,462 (-)NCBImm8
Celera639,588,093 - 39,710,723 (-)NCBICelera
Cytogenetic Map6B1NCBI
cM Map618.43NCBI
BRAF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387140,713,328 - 140,924,929 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl7140,719,327 - 140,924,929 (-)EnsemblGRCh38hg38GRCh38
GRCh377140,413,128 - 140,624,729 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367140,080,751 - 140,271,033 (-)NCBINCBI36hg18NCBI36
Build 347139,887,462 - 140,077,748NCBI
Celera7135,155,867 - 135,346,614 (-)NCBI
Cytogenetic Map7q34NCBI
HuRef7134,729,459 - 134,920,529 (-)NCBIHuRef
CHM1_17140,368,045 - 140,559,148 (-)NCBICHM1_1
T2T-CHM13v2.07142,027,505 - 142,239,131 (-)NCBI
CRA_TCAGchr7v27139,771,989 - 139,962,886 (-)NCBI
Braf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2468,375,484 - 68,510,652 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl468,384,649 - 68,510,463 (-)Ensembl
Rnor_6.0467,389,331 - 67,520,549 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl467,396,192 - 67,520,356 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0467,196,477 - 67,327,649 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4467,117,759 - 67,243,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1467,405,110 - 67,426,026 (-)NCBI
Celera463,383,337 - 63,515,499 (-)NCBICelera
Cytogenetic Map4q22NCBI
Braf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554942,567,238 - 2,712,708 (+)NCBIChiLan1.0ChiLan1.0
BRAF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17145,124,291 - 145,327,115 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7145,138,510 - 145,327,115 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07132,651,908 - 132,855,422 (-)NCBIMhudiblu_PPA_v0panPan3
BRAF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1168,222,909 - 8,318,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl168,222,907 - 8,317,906 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha168,989,501 - 9,160,850 (+)NCBI
ROS_Cfam_1.0168,065,738 - 8,237,942 (+)NCBI
ROS_Cfam_1.0 Ensembl168,065,737 - 8,239,141 (+)Ensembl
UMICH_Zoey_3.1168,017,140 - 8,188,930 (+)NCBI
UNSW_CanFamBas_1.0167,861,588 - 8,033,660 (+)NCBI
UU_Cfam_GSD_1.0167,929,505 - 8,101,841 (+)NCBI
Braf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511814,385,958 - 14,495,443 (+)NCBI
SpeTri2.0NW_0049365924,728,371 - 4,833,830 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BRAF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl188,957,991 - 9,132,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1188,957,963 - 9,132,558 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2189,522,257 - 9,636,501 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BRAF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121109,495,525 - 109,690,261 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660726,137,051 - 6,336,885 (-)NCBIVero_WHO_p1.0
Braf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476520,773,885 - 20,951,736 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462476520,766,368 - 20,951,560 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
C87398  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,642,239 - 39,642,322UniSTSGRCm38
MGSCv37639,592,238 - 39,592,321UniSTSGRCm37
Celera639,627,092 - 39,627,175UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
Whitehead/MRC_RH6358.03UniSTS
D6Mit153  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,637,674 - 39,637,807UniSTSGRCm38
MGSCv37639,587,673 - 39,587,806UniSTSGRCm37
Celera639,622,529 - 39,622,660UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.3UniSTS
Whitehead Genetic67.7UniSTS
Whitehead_YAC6 UniSTS
AI447469  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,603,704 - 39,603,802UniSTSGRCm38
MGSCv37639,553,703 - 39,553,801UniSTSGRCm37
Celera639,588,560 - 39,588,658UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
Whitehead/MRC_RH6358.03UniSTS
UniSTS:235419  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,609,834 - 39,610,109UniSTSGRCm38
MGSCv37639,559,833 - 39,560,108UniSTSGRCm37
Celera639,594,690 - 39,594,965UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
UniSTS:235420  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,611,905 - 39,612,106UniSTSGRCm38
MGSCv37639,561,904 - 39,562,105UniSTSGRCm37
Celera639,596,761 - 39,596,962UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
UniSTS:235421  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,609,046 - 39,609,352UniSTSGRCm38
MGSCv37639,559,045 - 39,559,351UniSTSGRCm37
Celera639,593,902 - 39,594,208UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
UniSTS:235425  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,611,054 - 39,611,339UniSTSGRCm38
MGSCv37639,561,053 - 39,561,338UniSTSGRCm37
Celera639,595,910 - 39,596,195UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
UniSTS:235427  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,643,423 - 39,643,625UniSTSGRCm38
MGSCv37639,593,422 - 39,593,624UniSTSGRCm37
Celera639,628,276 - 39,628,478UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
AU015031  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,602,766 - 39,602,968UniSTSGRCm38
MGSCv37639,552,765 - 39,552,967UniSTSGRCm37
Celera639,587,622 - 39,587,824UniSTS
Cytogenetic Map6B1UniSTS
cM Map621.0UniSTS
Whitehead/MRC_RH6317.15UniSTS
RH137260  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,603,412 - 39,603,594UniSTSGRCm38
MGSCv37639,553,411 - 39,553,593UniSTSGRCm37
Celera639,588,268 - 39,588,450UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
Braf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38639,614,104 - 39,614,254UniSTSGRCm38
MGSCv37639,564,103 - 39,564,253UniSTSGRCm37
Celera639,598,960 - 39,599,110UniSTS
Cytogenetic Map6B1UniSTS
cM Map615.5UniSTS
cM Map6 UniSTS
Braf  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6B1UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2932
Count of miRNA genes:900
Interacting mature miRNAs:1256
Transcripts:ENSMUST00000002487, ENSMUST00000101497, ENSMUST00000167073, ENSMUST00000167169, ENSMUST00000169647
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_139294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006505358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011241139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030255095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036165750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001785085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001785086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001785087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942908 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004942909 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC163109 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF454556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF454557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF454558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF454559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276308 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ276309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK046760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK049095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK051252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK082596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK088830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK135401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK140431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK164972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC038063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF466677 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK393545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ545840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S79859 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000002487   ⟹   ENSMUSP00000002487
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl639,580,171 - 39,702,397 (-)Ensembl
GRCm38.p6 Ensembl639,603,237 - 39,725,463 (-)Ensembl
RefSeq Acc Id: ENSMUST00000101497   ⟹   ENSMUSP00000099036
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl639,591,046 - 39,702,127 (-)Ensembl
GRCm38.p6 Ensembl639,614,112 - 39,725,193 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167073
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl639,616,226 - 39,621,720 (-)Ensembl
GRCm38.p6 Ensembl639,639,292 - 39,644,786 (-)Ensembl
RefSeq Acc Id: ENSMUST00000167169
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl639,617,241 - 39,620,188 (-)Ensembl
GRCm38.p6 Ensembl639,640,307 - 39,643,254 (-)Ensembl
RefSeq Acc Id: ENSMUST00000169647
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl639,628,513 - 39,642,013 (-)Ensembl
GRCm38.p6 Ensembl639,651,579 - 39,665,079 (-)Ensembl
RefSeq Acc Id: NM_139294   ⟹   NP_647455
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,171 - 39,702,397 (-)NCBI
GRCm38639,603,237 - 39,725,463 (-)NCBI
MGSCv37639,553,236 - 39,675,462 (-)RGD
Celera639,588,093 - 39,710,723 (-)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006505353   ⟹   XP_006505416
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
GRCm38639,603,231 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505355   ⟹   XP_006505418
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
GRCm38639,603,231 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006505358   ⟹   XP_006505421
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
GRCm38639,603,231 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241134   ⟹   XP_011239436
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
GRCm38639,603,231 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241135   ⟹   XP_011239437
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
GRCm38639,603,231 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241136   ⟹   XP_011239438
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,478 (-)NCBI
GRCm38639,603,231 - 39,725,535 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241137   ⟹   XP_011239439
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,480 (-)NCBI
GRCm38639,603,379 - 39,725,538 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241138   ⟹   XP_011239440
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
GRCm38639,603,231 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011241139   ⟹   XP_011239441
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
GRCm38639,603,231 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255094   ⟹   XP_030110954
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,474 (-)NCBI
GRCm38639,603,231 - 39,725,533 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030255095   ⟹   XP_030110955
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,425 (-)NCBI
GRCm38639,603,231 - 39,725,525 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165746   ⟹   XP_036021639
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165747   ⟹   XP_036021640
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165748   ⟹   XP_036021641
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,426 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165749   ⟹   XP_036021642
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,420 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036165750   ⟹   XP_036021643
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,580,313 - 39,702,592 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001785085
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,621,172 - 39,702,592 (-)NCBI
GRCm38639,644,238 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001785086
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,623,723 - 39,702,592 (-)NCBI
GRCm38639,646,798 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XR_001785087
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,625,384 - 39,702,592 (-)NCBI
GRCm38639,648,450 - 39,725,658 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942908
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,592,626 - 39,702,592 (-)NCBI
Sequence:
RefSeq Acc Id: XR_004942909
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39639,592,626 - 39,702,592 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_647455 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505416 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505418 (Get FASTA)   NCBI Sequence Viewer  
  XP_006505421 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239436 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239437 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239438 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239439 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239440 (Get FASTA)   NCBI Sequence Viewer  
  XP_011239441 (Get FASTA)   NCBI Sequence Viewer  
  XP_030110954 (Get FASTA)   NCBI Sequence Viewer  
  XP_030110955 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021639 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021640 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021641 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021642 (Get FASTA)   NCBI Sequence Viewer  
  XP_036021643 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB35395 (Get FASTA)   NCBI Sequence Viewer  
  AAQ04690 (Get FASTA)   NCBI Sequence Viewer  
  AAQ04691 (Get FASTA)   NCBI Sequence Viewer  
  AAQ04692 (Get FASTA)   NCBI Sequence Viewer  
  AAQ04693 (Get FASTA)   NCBI Sequence Viewer  
  BAE24384 (Get FASTA)   NCBI Sequence Viewer  
  CAB81555 (Get FASTA)   NCBI Sequence Viewer  
  CAB81556 (Get FASTA)   NCBI Sequence Viewer  
  CAB81557 (Get FASTA)   NCBI Sequence Viewer  
  P28028 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_647455   ⟸   NM_139294
- UniProtKB: P28028 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006505416   ⟸   XM_006505353
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006505418   ⟸   XM_006505355
- Peptide Label: isoform X5
- Sequence: