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GENE - TERM ANNOTATION REPORT

RGD ID: 619908
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Braf
Name: B-Raf proto-oncogene, serine/threonine kinase
Acc ID: DOID:6420
Term: pulmonary valve stenosis
Definition: The pathologic narrowing of the orifice of the PULMONARY VALVE. This lesion restricts blood outflow from the RIGHT VENTRICLE to the PULMONARY ARTERY. When the trileaflet valve is fused into an imperforate membrane, the blockage is complete.
Definition Source(s): MESH:D011666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Braf ISOBRAF (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Pulmonic stenosisPMID:16439621 PMID:16474404 PMID:17366577 PMID:17483702 PMID:17704260 PMID:18413255 PMID:19206169 PMID:20186801 PMID:24033266 PMID:25463315 PMID:25741868 PMID:28492532
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