Rheb (Ras homolog, mTORC1 binding) - Rat Genome Database

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Gene: Rheb (Ras homolog, mTORC1 binding) Rattus norvegicus
Analyze
Symbol: Rheb
Name: Ras homolog, mTORC1 binding
RGD ID: 621840
Description: Enables GDP binding activity; GTP binding activity; and GTPase activity. Involved in regulation of postsynapse organization and small GTPase-mediated signal transduction. Located in dendrite and neuronal cell body. Is active in glutamatergic synapse. Orthologous to human RHEB (Ras homolog, mTORC1 binding); PARTICIPATES IN mTOR signaling pathway; insulin signaling pathway; Rheb mediated signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GTP-binding protein Rheb; Ras homolog enriched in brain
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,012,173 - 11,053,860 (+)NCBIGRCr8
mRatBN7.2410,278,970 - 10,320,160 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,278,765 - 15,319,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,093,025 - 11,133,503 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.049,445,606 - 9,486,084 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.046,827,429 - 6,873,384 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,827,429 - 6,873,383 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.046,843,897 - 6,889,004 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera43,156 - 43,581 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP)
Allylamine  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carnosic acid  (ISO)
chloropicrin  (ISO)
chloroquine  (EXP)
choline  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
lonafarnib  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
methapyrilene  (EXP,ISO)
methidathion  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nitroglycerin  (EXP)
Nonylphenol  (EXP)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
succimer  (ISO)
T-2 toxin  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thiram  (ISO)
tipifarnib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The Rheb family of GTP-binding proteins. Aspuria PJ and Tamanoi F, Cell Signal. 2004 Oct;16(10):1105-12.
2. Regulation of mTORC1 by PI3K signaling. Dibble CC and Cantley LC, Trends Cell Biol. 2015 Sep;25(9):545-55. doi: 10.1016/j.tcb.2015.06.002. Epub 2015 Jul 6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. Karbowniczek M, etal., J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.
6. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
7. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
8. Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway. Meng W, etal., Diabetes. 2017 May;66(5):1198-1213. doi: 10.2337/db16-0886. Epub 2017 Feb 27.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Brain-derived neurotrophic factor induces mammalian target of rapamycin-dependent local activation of translation machinery and protein synthesis in neuronal dendrites. Takei N, etal., J Neurosci. 2004 Nov 3;24(44):9760-9.
16. Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Tzatsos A and Kandror KV, Mol Cell Biol. 2006 Jan;26(1):63-76.
17. rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein. Yamagata K, etal., J Biol Chem 1994 Jun 10;269(23):16333-9.
18. Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex. Yasuda S, etal., Sci Rep. 2014 Jun 3;4:5155. doi: 10.1038/srep05155.
Additional References at PubMed
PMID:11555636   PMID:12477932   PMID:15489334   PMID:15728574   PMID:17074751   PMID:18722381   PMID:18842593   PMID:19056867   PMID:19258434   PMID:19636840   PMID:20381137   PMID:20458337  
PMID:21336308   PMID:22294621   PMID:23376485   PMID:25385233   PMID:25411504   PMID:25880340   PMID:26245968   PMID:27865617   PMID:27898073   PMID:28025572   PMID:29287199   PMID:30053369  
PMID:34673407  


Genomics

Comparative Map Data
Rheb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,012,173 - 11,053,860 (+)NCBIGRCr8
mRatBN7.2410,278,970 - 10,320,160 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,278,765 - 15,319,243 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,093,025 - 11,133,503 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.049,445,606 - 9,486,084 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.046,827,429 - 6,873,384 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl46,827,429 - 6,873,383 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.046,843,897 - 6,889,004 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera43,156 - 43,581 (-)NCBICelera
Cytogenetic Map4q11NCBI
RHEB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387151,466,012 - 151,519,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7151,466,012 - 151,520,120 (-)EnsemblGRCh38hg38GRCh38
GRCh377151,163,098 - 151,216,981 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,794,031 - 150,847,943 (-)NCBINCBI36Build 36hg18NCBI36
Build 347150,601,443 - 150,654,657NCBI
Celera7145,720,573 - 145,774,491 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,974,671 - 145,028,586 (-)NCBIHuRef
CHM1_17151,171,499 - 151,225,408 (-)NCBICHM1_1
T2T-CHM13v2.07152,638,843 - 152,692,729 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,492,679 - 150,546,598 (-)NCBI
Rheb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39525,007,821 - 25,047,359 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl525,007,821 - 25,047,622 (-)EnsemblGRCm39 Ensembl
GRCm38524,802,823 - 24,842,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,802,823 - 24,842,624 (-)EnsemblGRCm38mm10GRCm38
MGSCv37524,308,641 - 24,348,179 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36524,312,888 - 24,352,426 (-)NCBIMGSCv36mm8
Celera521,753,578 - 21,793,634 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.93NCBI
Rheb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,794,911 - 5,834,912 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,795,040 - 5,833,897 (-)NCBIChiLan1.0ChiLan1.0
RHEB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,889,998 - 187,943,262 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,900,264 - 39,953,504 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07143,054,747 - 143,108,011 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17155,203,244 - 155,235,404 (-)NCBIpanpan1.1PanPan1.1panPan2
RHEB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,439,910 - 15,483,489 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,434,111 - 15,483,419 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1616,047,342 - 16,090,853 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01617,162,021 - 17,205,547 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1617,156,207 - 17,205,573 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,534,296 - 15,577,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01616,115,524 - 16,159,011 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01616,166,245 - 16,209,781 (-)NCBIUU_Cfam_GSD_1.0
Rheb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,025,492 - 6,071,143 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,832,169 - 6,878,164 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,832,286 - 6,877,938 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHEB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl185,779,212 - 5,822,257 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1185,779,439 - 5,821,839 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,029,721 - 6,072,123 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHEB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,652,692 - 119,704,833 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,652,127 - 119,703,458 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,623,250 - 15,675,215 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rheb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,221,605 - 5,264,965 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,221,630 - 5,262,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rheb
109 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:278
Count of miRNA genes:207
Interacting mature miRNAs:222
Transcripts:ENSRNOT00000071737
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat

Markers in Region
RHEB  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,319,613 - 10,319,858 (+)MAPPERmRatBN7.2
Rnor_6.046,872,910 - 6,873,154NCBIRnor6.0
Rnor_5.046,888,530 - 6,888,774UniSTSRnor5.0
Celera43,386 - 3,630UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000071737   ⟹   ENSRNOP00000063915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)Ensembl
Rnor_6.0 Ensembl46,827,429 - 6,873,383 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108274   ⟹   ENSRNOP00000083387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,291,585 - 10,320,160 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113919   ⟹   ENSRNOP00000086692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,279,973 - 10,320,160 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114997   ⟹   ENSRNOP00000095272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,279,370 - 10,320,160 (+)Ensembl
RefSeq Acc Id: NM_013216   ⟹   NP_037348
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,013,383 - 11,053,860 (+)NCBI
mRatBN7.2410,279,606 - 10,320,088 (+)NCBI
Rnor_6.046,827,429 - 6,873,384 (+)NCBI
Rnor_5.046,843,897 - 6,889,004 (+)NCBI
Celera43,156 - 43,581 (-)RGD
Sequence:
RefSeq Acc Id: XM_063285650   ⟹   XP_063141720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,012,173 - 11,053,391 (+)NCBI
RefSeq Acc Id: NP_037348   ⟸   NM_013216
- UniProtKB: Q62639 (UniProtKB/Swiss-Prot),   A6KJH3 (UniProtKB/TrEMBL),   M0R3K1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063915   ⟸   ENSRNOT00000071737
Ensembl Acc Id: ENSRNOP00000095272   ⟸   ENSRNOT00000114997
Ensembl Acc Id: ENSRNOP00000086692   ⟸   ENSRNOT00000113919
Ensembl Acc Id: ENSRNOP00000083387   ⟸   ENSRNOT00000108274
RefSeq Acc Id: XP_063141720   ⟸   XM_063285650
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62639-F1-model_v2 AlphaFold Q62639 1-184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692784
Promoter ID:EPDNEW_R3307
Type:initiation region
Name:Rheb_1
Description:Ras homolog, mTORC1 binding
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.046,827,394 - 6,827,454EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621840 AgrOrtholog
BioCyc Gene G2FUF-46063 BioCyc
Ensembl Genes ENSRNOG00000050578 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055022385 UniProtKB/Swiss-Prot
  ENSRNOG00060023259 UniProtKB/Swiss-Prot
  ENSRNOG00065004059 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000071737 UniProtKB/TrEMBL
  ENSRNOT00000071737.3 UniProtKB/Swiss-Prot
  ENSRNOT00000108274.1 UniProtKB/TrEMBL
  ENSRNOT00000113919.1 UniProtKB/TrEMBL
  ENSRNOT00000114997.1 UniProtKB/TrEMBL
  ENSRNOT00055038470 UniProtKB/Swiss-Prot
  ENSRNOT00060040324 UniProtKB/Swiss-Prot
  ENSRNOT00065005931 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7307969 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Ras-type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105484 IMAGE-MGC_LOAD
NCBI Gene 26954 ENTREZGENE
PANTHER PTHR24070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24070:SF264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rheb PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
RatGTEx ENSRNOG00000050578 RatGTEx
  ENSRNOG00055022385 RatGTEx
  ENSRNOG00060023259 RatGTEx
  ENSRNOG00065004059 RatGTEx
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZVS8_RAT UniProtKB/TrEMBL
  A0A8I6A6R1_RAT UniProtKB/TrEMBL
  A0A8I6AN58_RAT UniProtKB/TrEMBL
  A6KJH2_RAT UniProtKB/TrEMBL
  A6KJH3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJH4_RAT UniProtKB/TrEMBL
  A6KJH5_RAT UniProtKB/TrEMBL
  M0R3K1 ENTREZGENE, UniProtKB/TrEMBL
  Q62639 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-22 Rheb  Ras homolog, mTORC1 binding  Rheb  Ras homolog enriched in brain  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rheb  Ras homolog enriched in brain      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Rheb  Ras homolog enriched in brain      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation mRNA expression increases in response to seizures and to NMDA-dependent synaptic activity 729721