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Gene: Gfpt1 (glutamine fructose-6-phosphate transaminase 1) Rattus norvegicus

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Symbol:

Gfpt1

Name:

glutamine fructose-6-phosphate transaminase 1

RGD ID:

1549703

Description:

Enables several functions, including amino acid binding activity; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; and identical protein binding activity. Involved in several processes, including cellular response to insulin stimulus; glucosamine biosynthetic process; and negative regulation of glycogen biosynthetic process. Biomarker of familial hyperlipidemia and hyperinsulinism. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12 and obesity. Orthologous to human GFPT1 (glutamine--fructose-6-phosphate transaminase 1); PARTICIPATES IN hexosamine biosynthetic pathway; 2-hydroxyglutaric aciduria pathway; amino sugar metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

D-fructose-6-phosphate amidotransferase 1; GFA; GFAT; GFAT 1; GFAT1; GFAT1m; Gfpt; glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine:fructose 6 phosphate amidotransferase 1; glutamine:fructose-6-phosphate amidotransferase 1; hexosephosphate aminotransferase 1; MGC95214

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Gfpt1 (glutamine fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	GFPT2 (glutamine-fructose-6-phosphate transaminase 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gfpt1 (glutamine fructose-6-phosphate transaminase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GFA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gfat1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gfat1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gfat2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gfat-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gfat-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YMR085W	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	YMR084W	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	gfpt1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	baalc	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	121,054,023 - 121,103,799 (+)	NCBI		GRCr8
mRatBN7.2	4	119,496,691 - 119,546,472 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	119,496,714 - 119,546,471 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	124,970,101 - 125,015,978 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	120,744,840 - 120,790,719 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	119,369,093 - 119,414,969 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	118,852,046 - 118,901,583 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	118,852,062 - 118,901,591 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	121,204,274 - 121,250,160 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	108,466,461 - 108,512,263 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	Diabetic Nephropathies		ISO	RGD:1353383	2313353		RGD
Gfpt1	Rat	Experimental Diabetes Mellitus		IEP		2313355	protein:decreased expression:epididymal fat pad, liver, skeletal muscle	RGD
Gfpt1	Rat	familial hyperlipidemia		IEP		1624365	mRNA:increased expression:gastrocnemius	RGD
Gfpt1	Rat	hyperinsulinism		IEP		1624365	mRNA:increased expression:gastrocnemius	RGD
Gfpt1	Rat	Hypertriglyceridemia		ISO	RGD:1353383	1625423		RGD
Gfpt1	Rat	Insulin Resistance		ISO	RGD:1353383	1625423		RGD
Gfpt1	Rat	obesity		ISO	RGD:1353383	1625423		RGD
Gfpt1	Rat	type 2 diabetes mellitus		ISO	RGD:1353383	2313352		RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	congenital myasthenic syndrome		ISO	RGD:1353383	8554872	ClinVar Annotator: match by term: Congenital Myasthenic Syndrome, Recessive \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:21310273\|PMID:23488891\|PMID:23569079\|PMID:23794683\|PMID:24033266\|PMID:25741868\|PMID:25765662\|PMID:28492532\|PMID:28712002\|PMID:29054425\|PMID:32403337\|PMID:33756069\|PMID:34978387\|PMID:36188410\|PMID:37366078\|PMID:8664562
Gfpt1	Rat	congenital myasthenic syndrome 12		ISO	RGD:1353383	8554872	ClinVar Annotator: match by term: Congenital myasthenic syndrome 12 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:12467753\|PMID:16199547\|PMID:17576681\|PMID:18414213\|PMID:21310273\|PMID:21975507\|PMID:23488891\|PMID:23569079\|PMID:23794683\|PMID:24033266\|PMID:25635128\|PMID:25741868\|PMID:25765662\|PMID:26467025\|PMID:27159402\|PMID:28464723\|PMID:28492532\|PMID:28712002\|PMID:29054425\|PMID:30124556\|PMID:30635494\|PMID:30653653\|PMID:32140910\|PMID:32403337\|PMID:32528171\|PMID:32754643\|PMID:33756069\|PMID:34978387\|PMID:36188410\|PMID:37366078\|PMID:37721175\|PMID:8664562\|PMID:9536098
Gfpt1	Rat	congenital myasthenic syndrome 4C		ISO	RGD:1353383	8554872	ClinVar Annotator: match by term: Congenital myasthenic syndrome 4C \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:23794683\|PMID:25741868\|PMID:28464723\|PMID:28492532\|PMID:29054425\|PMID:32403337\|PMID:32528171
Gfpt1	Rat	genetic disease		ISO	RGD:1353383	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	congenital myasthenic syndrome		ISO	RGD:1353383	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29905857
Gfpt1	Rat	congenital myasthenic syndrome 4C		ISO	RGD:1353383	11554173	CTD Direct Evidence: marker/mechanism	CTD
Gfpt1	Rat	muscular disease		ISO	RGD:1353383	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29905857
Gfpt1	Rat	obesity		ISO	RGD:1353383	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:20882379

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	congenital myasthenic syndrome 12		ISS	RGD:1557517	13592920	OMIM:610542	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	congenital myasthenic syndrome 12		ISO	RGD:1353383	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1557517	6480464	1,2-Dimethylhydrazine results in decreased expression of GFPT1 mRNA	CTD	PMID:22206623
Gfpt1	Rat	1,2-dimethylhydrazine	multiple interactions	ISO	RGD:1557517	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GFPT1 mRNA	CTD	PMID:22206623
Gfpt1	Rat	17alpha-ethynylestradiol	increases expression	EXP		6480464	Ethinyl Estradiol results in increased expression of GFPT1 mRNA	CTD	PMID:29097150
Gfpt1	Rat	17beta-estradiol	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in increased expression of GFPT1 mRNA	CTD	PMID:26496021
Gfpt1	Rat	17beta-estradiol	increases expression	ISO	RGD:1557517	6480464	Estradiol results in increased expression of GFPT1 mRNA	CTD	PMID:39298647
Gfpt1	Rat	17beta-hydroxy-5alpha-androstan-3-one	increases expression	ISO	RGD:1353383	6480464	Dihydrotestosterone results in increased expression of GFPT1 mRNA	CTD	PMID:29581250
Gfpt1	Rat	2,2',4,4'-Tetrabromodiphenyl ether	increases expression	ISO	RGD:1353383	6480464	2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of GFPT1 mRNA	CTD	PMID:19095052
Gfpt1	Rat	2,2',4,4'-Tetrabromodiphenyl ether	decreases expression	ISO	RGD:1353383	6480464	2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GFPT1 protein	CTD	PMID:31675489
Gfpt1	Rat	2,2',4,4'-Tetrabromodiphenyl ether	affects expression	ISO	RGD:1557517	6480464	2,2',4,4'-tetrabromodiphenyl ether affects the expression of GFPT1 mRNA	CTD	PMID:30294300
Gfpt1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1557517	6480464	Tetrachlorodibenzodioxin affects the expression of GFPT1 mRNA	CTD	PMID:21570461
Gfpt1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of GFPT1 mRNA	CTD	PMID:34747641
Gfpt1	Rat	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1557517	6480464	Tetrachlorodibenzodioxin results in increased expression of GFPT1 mRNA	CTD	PMID:19770486\|PMID:27562557
Gfpt1	Rat	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	ISO	RGD:1557517	6480464	[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression more ...	CTD	PMID:25975270
Gfpt1	Rat	2,6-dimethoxyphenol	multiple interactions	ISO	RGD:1353383	6480464	[Sodium Chloride co-treated with pyrogallol 1,3-dimethyl ether] results in decreased expression of and affects the more ...	CTD	PMID:38598786
Gfpt1	Rat	2,6-dinitrotoluene	affects expression	EXP		6480464	2,6-dinitrotoluene affects the expression of GFPT1 mRNA	CTD	PMID:21346803
Gfpt1	Rat	2-amino-2-deoxy-D-glucopyranose	multiple interactions	EXP		6480464	[Glucosamine co-treated with INS1 protein] affects the localization of GFPT1 protein	CTD	PMID:9453242
Gfpt1	Rat	2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one	decreases expression	ISO	RGD:1557517	6480464	Itraconazole results in decreased expression of GFPT1 mRNA	CTD	PMID:31099283
Gfpt1	Rat	3,4-methylenedioxymethamphetamine	increases expression	EXP		6480464	N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GFPT1 mRNA	CTD	PMID:28087314
Gfpt1	Rat	3,4-methylenedioxymethamphetamine	decreases expression	ISO	RGD:1557517	6480464	N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GFPT1 mRNA	CTD	PMID:26251327
Gfpt1	Rat	3-chloropropane-1,2-diol	increases expression	EXP		6480464	alpha-Chlorohydrin results in increased expression of GFPT1 protein	CTD	PMID:34915118
Gfpt1	Rat	4,4'-sulfonyldiphenol	increases expression	ISO	RGD:1353383	6480464	bisphenol S results in increased expression of GFPT1 protein	CTD	PMID:31945527\|PMID:34186270
Gfpt1	Rat	actinomycin D	multiple interactions	ISO	RGD:1353383	6480464	[Dactinomycin co-treated with nutlin 3] results in increased secretion of GFPT1 protein	CTD	PMID:38460933
Gfpt1	Rat	aflatoxin B1	decreases expression	ISO	RGD:1557517	6480464	Aflatoxin B1 results in decreased expression of GFPT1 mRNA	CTD	PMID:19770486
Gfpt1	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1353383	6480464	Aflatoxin B1 results in decreased methylation of GFPT1 gene	CTD	PMID:27153756
Gfpt1	Rat	aldehydo-D-glucosamine	multiple interactions	EXP		6480464	[Glucosamine co-treated with INS1 protein] affects the localization of GFPT1 protein	CTD	PMID:9453242
Gfpt1	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1353383	6480464	Tretinoin results in decreased expression of GFPT1 mRNA	CTD	PMID:15498508
Gfpt1	Rat	antirheumatic drug	increases expression	ISO	RGD:1353383	6480464	Antirheumatic Agents results in increased expression of GFPT1 mRNA	CTD	PMID:24449571
Gfpt1	Rat	aristolochic acid A	decreases expression	ISO	RGD:1353383	6480464	aristolochic acid I results in decreased expression of GFPT1 mRNA	CTD	PMID:33212167
Gfpt1	Rat	arsenite(3-)	multiple interactions	ISO	RGD:1353383	6480464	arsenite inhibits the reaction [G3BP1 protein binds to GFPT1 mRNA]	CTD	PMID:32406909
Gfpt1	Rat	Azoxymethane	multiple interactions	ISO	RGD:1557517	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GFPT1 more ...	CTD	PMID:29950665
Gfpt1	Rat	benzatropine	decreases expression	ISO	RGD:1353383	6480464	Benztropine results in decreased expression of GFPT1 protein	CTD	PMID:34122009
Gfpt1	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1557517	6480464	Benzo(a)pyrene results in decreased expression of GFPT1 mRNA	CTD	PMID:21715664
Gfpt1	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1353383	6480464	Benzo(a)pyrene results in decreased expression of GFPT1 mRNA	CTD	PMID:20064835\|PMID:26238291
Gfpt1	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1353383	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GFPT1 mRNA	CTD	PMID:19150397\|PMID:20018196
Gfpt1	Rat	beta-D-glucosamine	multiple interactions	EXP		6480464	[Glucosamine co-treated with INS1 protein] affects the localization of GFPT1 protein	CTD	PMID:9453242
Gfpt1	Rat	bisphenol A	multiple interactions	EXP		6480464	[bisphenol A co-treated with Estradiol] results in increased expression of GFPT1 mRNA	CTD	PMID:26496021
Gfpt1	Rat	bisphenol A	decreases expression	ISO	RGD:1353383	6480464	bisphenol A results in decreased expression of GFPT1 protein	CTD	PMID:31675489\|PMID:34186270\|PMID:37567409
Gfpt1	Rat	bisphenol A	increases expression	EXP		6480464	bisphenol A results in increased expression of GFPT1 mRNA	CTD	PMID:32145629
Gfpt1	Rat	bisphenol A	affects expression	ISO	RGD:1353383	6480464	bisphenol A affects the expression of GFPT1 mRNA	CTD	PMID:30903817
Gfpt1	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of GFPT1 gene	CTD	PMID:28505145
Gfpt1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of GFPT1 mRNA	CTD	PMID:25181051\|PMID:34947998
Gfpt1	Rat	bisphenol AF	increases expression	ISO	RGD:1353383	6480464	bisphenol AF results in increased expression of GFPT1 protein	CTD	PMID:34186270
Gfpt1	Rat	Bisphenol B	increases expression	ISO	RGD:1353383	6480464	bisphenol B results in increased expression of GFPT1 protein	CTD	PMID:34186270
Gfpt1	Rat	bisphenol F	increases expression	ISO	RGD:1557517	6480464	bisphenol F results in increased expression of GFPT1 mRNA	CTD	PMID:38685157
Gfpt1	Rat	bisphenol F	increases expression	ISO	RGD:1353383	6480464	bisphenol F results in increased expression of GFPT1 protein	CTD	PMID:34186270
Gfpt1	Rat	cadmium atom	multiple interactions	ISO	RGD:1353383	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GFPT1 more ...	CTD	PMID:35301059
Gfpt1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1353383	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of GFPT1 more ...	CTD	PMID:35301059
Gfpt1	Rat	carbon nanotube	increases expression	ISO	RGD:1557517	6480464	Nanotubes, Carbon analog results in increased expression of GFPT1 mRNA; Nanotubes, Carbon results in increased more ...	CTD	PMID:25620056
Gfpt1	Rat	CGP 52608	multiple interactions	ISO	RGD:1353383	6480464	CGP 52608 promotes the reaction [RORA protein binds to GFPT1 gene]	CTD	PMID:28238834
Gfpt1	Rat	chlorpyrifos	decreases expression	ISO	RGD:1557517	6480464	Chlorpyrifos results in decreased expression of GFPT1 mRNA	CTD	PMID:37019170
Gfpt1	Rat	chromium(6+)	affects expression	ISO	RGD:1557517	6480464	chromium hexavalent ion affects the expression of GFPT1 mRNA	CTD	PMID:28472532
Gfpt1	Rat	cisplatin	increases expression	ISO	RGD:1353383	6480464	Cisplatin results in increased expression of GFPT1 mRNA	CTD	PMID:19561079
Gfpt1	Rat	copper atom	multiple interactions	ISO	RGD:1353383	6480464	[NSC 689534 binds to Copper] which results in increased expression of GFPT1 mRNA	CTD	PMID:20971185
Gfpt1	Rat	copper(0)	multiple interactions	ISO	RGD:1353383	6480464	[NSC 689534 binds to Copper] which results in increased expression of GFPT1 mRNA	CTD	PMID:20971185
Gfpt1	Rat	copper(II) chloride	increases expression	ISO	RGD:1353383	6480464	cupric chloride results in increased expression of GFPT1 mRNA	CTD	PMID:38568856
Gfpt1	Rat	cyclosporin A	increases expression	ISO	RGD:1557517	6480464	Cyclosporine results in increased expression of GFPT1 mRNA	CTD	PMID:19770486
Gfpt1	Rat	cyclosporin A	increases expression	ISO	RGD:1353383	6480464	Cyclosporine results in increased expression of GFPT1 mRNA	CTD	PMID:20106945\|PMID:21632981\|PMID:25562108\|PMID:27989131
Gfpt1	Rat	DDE	decreases expression	ISO	RGD:1353383	6480464	Dichlorodiphenyl Dichloroethylene results in decreased expression of GFPT1 mRNA	CTD	PMID:38568856
Gfpt1	Rat	dextran sulfate	multiple interactions	ISO	RGD:1557517	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GFPT1 more ...	CTD	PMID:29950665
Gfpt1	Rat	dibutyl phthalate	decreases expression	EXP		6480464	Dibutyl Phthalate results in decreased expression of GFPT1 mRNA	CTD	PMID:21266533
Gfpt1	Rat	diclofenac	increases expression	ISO	RGD:1557517	6480464	Diclofenac results in increased expression of GFPT1 mRNA	CTD	PMID:26934552
Gfpt1	Rat	dorsomorphin	multiple interactions	ISO	RGD:1353383	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Gfpt1	Rat	endosulfan	affects expression	EXP		6480464	Endosulfan affects the expression of GFPT1 mRNA	CTD	PMID:29391264
Gfpt1	Rat	enzyme inhibitor	multiple interactions	ISO	RGD:1353383	6480464	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation more ...	CTD	PMID:23301498
Gfpt1	Rat	fipronil	increases expression	EXP		6480464	fipronil results in increased expression of GFPT1 mRNA	CTD	PMID:31881178
Gfpt1	Rat	folic acid	multiple interactions	ISO	RGD:1557517	6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GFPT1 mRNA	CTD	PMID:22206623
Gfpt1	Rat	formaldehyde	increases expression	ISO	RGD:1353383	6480464	Formaldehyde results in increased expression of GFPT1 mRNA	CTD	PMID:27664576
Gfpt1	Rat	FR900359	increases phosphorylation	ISO	RGD:1353383	6480464	FR900359 results in increased phosphorylation of GFPT1 protein	CTD	PMID:37730182
Gfpt1	Rat	furfural	multiple interactions	ISO	RGD:1353383	6480464	[Sodium Chloride co-treated with Furaldehyde] results in decreased expression of GFPT1 protein; [Sodium Chloride co-treated more ...	CTD	PMID:38598786
Gfpt1	Rat	graphite	affects expression	EXP		6480464	Graphite affects the expression of GFPT1 mRNA	CTD	PMID:29933104
Gfpt1	Rat	hydroquinone	increases expression	ISO	RGD:1353383	6480464	hydroquinone results in increased expression of GFPT1 mRNA	CTD	PMID:31256213
Gfpt1	Rat	itraconazole	decreases expression	ISO	RGD:1557517	6480464	Itraconazole results in decreased expression of GFPT1 mRNA	CTD	PMID:31099283
Gfpt1	Rat	ivermectin	decreases expression	ISO	RGD:1353383	6480464	Ivermectin results in decreased expression of GFPT1 protein	CTD	PMID:32959892
Gfpt1	Rat	lead(0)	affects expression	ISO	RGD:1353383	6480464	Lead affects the expression of GFPT1 mRNA	CTD	PMID:28903495
Gfpt1	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1353383	6480464	Methyl Methanesulfonate results in increased expression of GFPT1 mRNA	CTD	PMID:23649840
Gfpt1	Rat	methylmercury chloride	increases expression	ISO	RGD:1353383	6480464	methylmercuric chloride results in increased expression of GFPT1 mRNA	CTD	PMID:28001369
Gfpt1	Rat	nickel atom	increases expression	ISO	RGD:1353383	6480464	Nickel results in increased expression of GFPT1 mRNA	CTD	PMID:24768652\|PMID:25583101
Gfpt1	Rat	Nutlin-3	multiple interactions	ISO	RGD:1353383	6480464	[Dactinomycin co-treated with nutlin 3] results in increased secretion of GFPT1 protein	CTD	PMID:38460933
Gfpt1	Rat	paclitaxel	decreases response to substance	ISO	RGD:1353383	6480464	GFPT1 protein results in decreased susceptibility to Paclitaxel	CTD	PMID:16734730
Gfpt1	Rat	paracetamol	affects expression	ISO	RGD:1557517	6480464	Acetaminophen affects the expression of GFPT1 mRNA	CTD	PMID:17562736
Gfpt1	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of GFPT1 mRNA	CTD	PMID:33387578
Gfpt1	Rat	paracetamol	increases expression	ISO	RGD:1353383	6480464	Acetaminophen results in increased expression of GFPT1 mRNA	CTD	PMID:29067470
Gfpt1	Rat	perfluorooctanoic acid	increases expression	ISO	RGD:1353383	6480464	perfluorooctanoic acid results in increased expression of GFPT1 mRNA; perfluorooctanoic acid results in increased expression more ...	CTD	PMID:23978341\|PMID:26879310\|PMID:36326898
Gfpt1	Rat	phenylmercury acetate	increases expression	ISO	RGD:1353383	6480464	Phenylmercuric Acetate results in increased expression of GFPT1 mRNA	CTD	PMID:26272509
Gfpt1	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1353383	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Gfpt1	Rat	pirinixic acid	multiple interactions	ISO	RGD:1557517	6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ...	CTD	PMID:19710929
Gfpt1	Rat	propiconazole	increases expression	ISO	RGD:1557517	6480464	propiconazole results in increased expression of GFPT1 mRNA	CTD	PMID:21278054
Gfpt1	Rat	quercetin	increases phosphorylation	ISO	RGD:1353383	6480464	Quercetin results in increased phosphorylation of GFPT1 protein	CTD	PMID:35688186
Gfpt1	Rat	SB 431542	multiple interactions	ISO	RGD:1353383	6480464	[LDN 193189 co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with FGF2 protein] results in decreased expression of GFPT1 more ...	CTD	PMID:27188386\|PMID:37664457
Gfpt1	Rat	silicon dioxide	increases expression	ISO	RGD:1557517	6480464	Silicon Dioxide results in increased expression of GFPT1 mRNA	CTD	PMID:23221170
Gfpt1	Rat	sodium arsenite	decreases expression	ISO	RGD:1353383	6480464	sodium arsenite results in decreased expression of GFPT1 mRNA	CTD	PMID:28595984\|PMID:34032870
Gfpt1	Rat	sodium arsenite	increases expression	ISO	RGD:1353383	6480464	sodium arsenite results in increased expression of GFPT1 mRNA	CTD	PMID:38568856
Gfpt1	Rat	sodium chloride	multiple interactions	ISO	RGD:1353383	6480464	[Sodium Chloride co-treated with Furaldehyde] results in decreased expression of GFPT1 protein; [Sodium Chloride co-treated more ...	CTD	PMID:38598786
Gfpt1	Rat	sunitinib	increases expression	ISO	RGD:1353383	6480464	Sunitinib results in increased expression of GFPT1 mRNA	CTD	PMID:31533062
Gfpt1	Rat	swainsonine	decreases expression	EXP		6480464	Swainsonine results in decreased expression of GFAT1 protein	CTD	PMID:37442287
Gfpt1	Rat	T-2 toxin	decreases expression	ISO	RGD:1353383	6480464	T-2 Toxin results in decreased expression of GFPT1 mRNA	CTD	PMID:31863870
Gfpt1	Rat	tamibarotene	affects expression	ISO	RGD:1353383	6480464	tamibarotene affects the expression of GFPT1 mRNA	CTD	PMID:15498508
Gfpt1	Rat	tamoxifen	increases expression	ISO	RGD:1353383	6480464	Tamoxifen results in increased expression of GFPT1 mRNA	CTD	PMID:15604281
Gfpt1	Rat	testosterone	decreases expression	ISO	RGD:1353383	6480464	Testosterone results in decreased expression of GFPT1 mRNA	CTD	PMID:33359661
Gfpt1	Rat	tetrachloromethane	increases expression	ISO	RGD:1557517	6480464	Carbon Tetrachloride results in increased expression of GFPT1 mRNA	CTD	PMID:27339419\|PMID:31919559
Gfpt1	Rat	tetrachloromethane	increases expression	EXP		6480464	Carbon Tetrachloride results in increased expression of GFPT1 mRNA	CTD	PMID:31150632
Gfpt1	Rat	thapsigargin	increases expression	ISO	RGD:1353383	6480464	Thapsigargin results in increased expression of GFPT1 mRNA	CTD	PMID:22378314\|PMID:29453283
Gfpt1	Rat	thapsigargin	increases expression	EXP		6480464	Thapsigargin results in increased expression of GFPT1 protein	CTD	PMID:35544339
Gfpt1	Rat	theophylline	increases expression	ISO	RGD:1353383	6480464	Theophylline results in increased expression of GFPT1 mRNA	CTD	PMID:16083514
Gfpt1	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of GFPT1 mRNA	CTD	PMID:34492290
Gfpt1	Rat	thiram	increases expression	ISO	RGD:1353383	6480464	Thiram results in increased expression of GFPT1 mRNA	CTD	PMID:38568856
Gfpt1	Rat	titanium dioxide	multiple interactions	ISO	RGD:1557517	6480464	[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of GFPT1 more ...	CTD	PMID:29950665
Gfpt1	Rat	titanium dioxide	decreases methylation	ISO	RGD:1557517	6480464	titanium dioxide results in decreased methylation of GFPT1 promoter	CTD	PMID:35295148
Gfpt1	Rat	Tributyltin oxide	increases phosphorylation	ISO	RGD:1557517	6480464	bis(tri-n-butyltin)oxide results in increased phosphorylation of GFPT1 protein	CTD	PMID:22174045
Gfpt1	Rat	trimellitic anhydride	increases expression	ISO	RGD:1557517	6480464	trimellitic anhydride results in increased expression of GFPT1 mRNA	CTD	PMID:19042947
Gfpt1	Rat	triphenyl phosphate	affects expression	ISO	RGD:1353383	6480464	triphenyl phosphate affects the expression of GFPT1 mRNA	CTD	PMID:37042841
Gfpt1	Rat	tunicamycin	increases expression	ISO	RGD:1353383	6480464	Tunicamycin results in increased expression of GFPT1 mRNA	CTD	PMID:22378314\|PMID:29453283
Gfpt1	Rat	valproic acid	decreases expression	ISO	RGD:1353383	6480464	Valproic Acid results in decreased expression of GFPT1 mRNA	CTD	PMID:23179753
Gfpt1	Rat	valproic acid	increases expression	ISO	RGD:1353383	6480464	Valproic Acid results in increased expression of GFPT1 mRNA	CTD	PMID:23179753\|PMID:29154799
Gfpt1	Rat	vinclozolin	decreases expression	EXP		6480464	vinclozolin results in decreased expression of GFPT1 mRNA	CTD	PMID:23034163
Gfpt1	Rat	zinc atom	multiple interactions	ISO	RGD:1353383	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of GFPT1 mRNA	CTD	PMID:18593933
Gfpt1	Rat	zinc(0)	multiple interactions	ISO	RGD:1353383	6480464	[PCI 5002 co-treated with Zinc] results in increased expression of GFPT1 mRNA	CTD	PMID:18593933

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	carbohydrate derivative biosynthetic process	involved_in	IEA	InterPro:IPR005855	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gfpt1	Rat	carbohydrate derivative metabolic process	involved_in	IEA	InterPro:IPR001347\|InterPro:IPR046348	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gfpt1	Rat	cellular response to insulin stimulus		IEP		1625427		RGD
Gfpt1	Rat	circadian regulation of gene expression	involved_in	ISS	UniProtKB:P47856	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Gfpt1	Rat	circadian regulation of gene expression	involved_in	ISO	RGD:1557517	1624291	PMID:23395176	RGD	PMID:23395176
Gfpt1	Rat	fructose 6-phosphate metabolic process		IDA		1625426		RGD
Gfpt1	Rat	fructose 6-phosphate metabolic process	involved_in	IBA	PANTHER:PTN000101302\|RGD:1549703\|UniProtKB:O94808\|UniProtKB:Q06210	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gfpt1	Rat	fructose 6-phosphate metabolic process	involved_in	ISO	RGD:1353383	1624291	PMID:35229715	RGD	PMID:35229715
Gfpt1	Rat	glucosamine biosynthetic process		IDA		1625426		RGD
Gfpt1	Rat	negative regulation of glycogen biosynthetic process		IMP		1625425		RGD
Gfpt1	Rat	protein N-linked glycosylation	involved_in	IBA	CGD:CAL0000176261\|PANTHER:PTN000101302\|TAIR:locus:2076146	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gfpt1	Rat	response to insulin		IEP		2313355		RGD
Gfpt1	Rat	response to sucrose		IEP		1624365		RGD
Gfpt1	Rat	rhythmic process	involved_in	IEA	UniProtKB-KW:KW-0090	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Gfpt1	Rat	UDP-N-acetylglucosamine biosynthetic process	involved_in	ISO	RGD:1353383	1624291	PMID:26887390, PMID:35229715	RGD	PMID:26887390\|PMID:35229715
Gfpt1	Rat	UDP-N-acetylglucosamine biosynthetic process	involved_in	ISS	UniProtKB:Q06210	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Gfpt1	Rat	UDP-N-acetylglucosamine biosynthetic process	involved_in	IEA	UniPathway:UPA00113	1600115	GO_REF:0000041	UniProt	GO_REF:0000041
Gfpt1	Rat	UDP-N-acetylglucosamine metabolic process		IMP		1625426		RGD
Gfpt1	Rat	UDP-N-acetylglucosamine metabolic process	involved_in	IBA	FB:FBgn0039580\|FB:FBgn0287209\|PANTHER:PTN000101302\|RGD:1549703\|TAIR:locus:2076146\|UniProtKB:O94808\|UniProtKB:P17169\|UniProtKB:Q06210	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	amino acid binding		IDA		1625426	glutamine, fructose 6-phosphate	RGD
Gfpt1	Rat	carbohydrate binding		IDA		1625426	glutamine, fructose 6-phosphate	RGD
Gfpt1	Rat	carbohydrate derivative binding	enables	IEA	InterPro:IPR001347\|InterPro:IPR046348	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gfpt1	Rat	glutamine-fructose-6-phosphate transaminase (isomerizing) activity		IDA		1625426		RGD
Gfpt1	Rat	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	enables	IBA	CGD:CAL0000176261\|FB:FBgn0039580\|FB:FBgn0287209\|PANTHER:PTN000101302\|RGD:1549703\|SGD:S000001587\|TAIR:locus:2076146\|UniProtKB:O94808\|UniProtKB:P17169\|UniProtKB:Q06210	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Gfpt1	Rat	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	enables	IEA	RHEA:13237	1600115	GO_REF:0000116	RHEA	GO_REF:0000116
Gfpt1	Rat	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	enables	IEA	InterPro:IPR005855	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Gfpt1	Rat	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	enables	ISO	RGD:1353383	1624291	PMID:35229715	RGD	PMID:35229715
Gfpt1	Rat	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	enables	IEA	EC:2.6.1.16	1600115	GO_REF:0000003	UniProt	GO_REF:0000003
Gfpt1	Rat	identical protein binding		IPI	RGD:1549703	1625426	homotetramerization	RGD
Gfpt1	Rat	protein binding	enables	ISO	RGD:1353383	1624291	UniProtKB:O94808 PMID:33961781	RGD	PMID:33961781
Gfpt1	Rat	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	hexosamine biosynthetic pathway		IMP		1625426		RGD
Gfpt1	Rat	hexosamine biosynthetic pathway		ISO	RGD:1353383	1625539		RGD

Imported Annotations - SMPDB

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	2-hydroxyglutaric aciduria pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00136
Gfpt1	Rat	amino sugar metabolic pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00045
Gfpt1	Rat	french type sialuria pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00217
Gfpt1	Rat	french type sialuria pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00216
Gfpt1	Rat	glutamic acid/glutamate metabolic pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00072
Gfpt1	Rat	homocarnosinosis pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00385
Gfpt1	Rat	sialic acid storage disease pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00240
Gfpt1	Rat	succinic semialdehyde dehydrogenase deficiency pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00243
Gfpt1	Rat	succinic semialdehyde dehydrogenase deficiency pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00567
Gfpt1	Rat	Tay-Sachs disease pathway		ISO	RGD:1353383	10402751		SMPDB	SMP:00390

Imported Annotations - KEGG (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Gfpt1	Rat	alanine, aspartate and glutamate metabolic pathway		IEA		6907045		KEGG	rno:00250
Gfpt1	Rat	amino sugar metabolic pathway		IEA		6907045		KEGG	rno:00520
Gfpt1	Rat	nucleotide sugar metabolic pathway		IEA		6907045		KEGG	rno:00520

Disease Annotations Click to see Annotation Detail View

congenital myasthenic syndrome (ISO)

congenital myasthenic syndrome 12 (ISO,ISS)

congenital myasthenic syndrome 4C (ISO)

Diabetic Nephropathies (ISO)

Experimental Diabetes Mellitus (IEP)

familial hyperlipidemia (IEP)

genetic disease (ISO)

hyperinsulinism (IEP)

Hypertriglyceridemia (ISO)

Insulin Resistance (ISO)

muscular disease (ISO)

obesity (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (EXP)

2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one (ISO)

3,4-methylenedioxymethamphetamine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

Azoxymethane (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-D-glucosamine (EXP)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

cyclosporin A (ISO)

DDE (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

furfural (ISO)

graphite (EXP)

hydroquinone (ISO)

itraconazole (ISO)

ivermectin (ISO)

lead(0) (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

Nutlin-3 (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

sunitinib (ISO)

swainsonine (EXP)

T-2 toxin (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP,ISO)

theophylline (ISO)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (ISO)

Tributyltin oxide (ISO)

trimellitic anhydride (ISO)

triphenyl phosphate (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carbohydrate derivative biosynthetic process (IEA)

carbohydrate derivative metabolic process (IEA)

cellular response to insulin stimulus (IEP)

circadian regulation of gene expression (ISO,ISS)

fructose 6-phosphate metabolic process (IBA,IDA,ISO)

glucosamine biosynthetic process (IDA)

negative regulation of glycogen biosynthetic process (IMP)

protein N-linked glycosylation (IBA)

response to insulin (IEP)

response to sucrose (IEP)

rhythmic process (IEA)

UDP-N-acetylglucosamine biosynthetic process (IEA,ISO,ISS)

UDP-N-acetylglucosamine metabolic process (IBA,IMP)

Molecular Function

amino acid binding (IDA)

carbohydrate binding (IDA)

carbohydrate derivative binding (IEA)

glutamine-fructose-6-phosphate transaminase (isomerizing) activity (IBA,IDA,IEA,ISO)

identical protein binding (IPI)

protein binding (ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

2-hydroxyglutaric aciduria pathway (ISO)

alanine, aspartate and glutamate metabolic pathway (IEA)

amino sugar metabolic pathway (IEA,ISO)

french type sialuria pathway (ISO)

glutamic acid/glutamate metabolic pathway (ISO)

hexosamine biosynthetic pathway (IMP,ISO)

homocarnosinosis pathway (ISO)

nucleotide sugar metabolic pathway (IEA)

sialic acid storage disease pathway (ISO)

succinic semialdehyde dehydrogenase deficiency pathway (ISO)

Tay-Sachs disease pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The cellular fate of glucose and its relevance in type 2 diabetes.	Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
2.	Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts.	Crook ED, etal., Diabetes. 1993 Sep;42(9):1289-96.
3.	Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats.	Ferrer-Martinez A, etal., Lipids. 2006 Jan;41(1):55-62.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia.	Heptulla RA, etal., J Clin Endocrinol Metab. 2009 May;94(5):1608-11. Epub 2009 Feb 3.
6.	Purification and characterization of glutamine:fructose 6-phosphate amidotransferase from rat liver.	Huynh QK, etal., Arch Biochem Biophys. 2000 Jul 15;379(2):307-13.
7.	Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes.	Nerlich AG, etal., Diabetes. 1998 Feb;47(2):170-8.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver.	Robinson KA, etal., Diabetes. 1995 Dec;44(12):1438-46.
16.	Insulin stimulation of glutamine: fructose-6-phosphate amidotransferase occurs via an insulin-like growth factor-1 pathway in rat fibroblasts.	Simmons ST, etal., Res Commun Mol Pathol Pharmacol. 1999;104(1):63-72.
17.	Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: inter-relationships with hyperglycaemia and oxidative stress.	Srinivasan V, etal., Clin Biochem. 2007 Sep;40(13-14):952-7. Epub 2007 May 24.
18.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19.	Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.	Veerababu G, etal., Diabetes. 2000 Dec;49(12):2070-8.

Additional References at PubMed

PMID:15489334	PMID:20458337	PMID:20506529	PMID:23395176	PMID:24625528	PMID:25002582	PMID:31505169	PMID:34735873

Genomics

Comparative Map Data

Gfpt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	121,054,023 - 121,103,799 (+)	NCBI		GRCr8
mRatBN7.2	4	119,496,691 - 119,546,472 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	119,496,714 - 119,546,471 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	124,970,101 - 125,015,978 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	120,744,840 - 120,790,719 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	119,369,093 - 119,414,969 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	118,852,046 - 118,901,583 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	118,852,062 - 118,901,591 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	121,204,274 - 121,250,160 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	108,466,461 - 108,512,263 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

GFPT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	69,319,780 - 69,387,227 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	69,319,780 - 69,387,250 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	69,546,912 - 69,614,359 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	69,405,911 - 69,467,829 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	69,464,057 - 69,525,976	NCBI
Celera	2	69,396,783 - 69,495,538 (-)	NCBI		Celera
Cytogenetic Map	2	p13.3	NCBI
HuRef	2	69,283,030 - 69,350,894 (-)	NCBI		HuRef
CHM1_1	2	69,476,230 - 69,543,772 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	69,332,145 - 69,399,585 (-)	NCBI		T2T-CHM13v2.0

Gfpt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	87,019,828 - 87,069,189 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	87,019,828 - 87,069,179 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	87,042,846 - 87,092,207 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	87,042,846 - 87,092,197 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	86,992,840 - 87,042,201 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	87,008,484 - 87,054,005 (+)	NCBI		MGSCv36	mm8
Celera	6	88,982,225 - 89,031,325 (+)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	37.81	NCBI

Gfpt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	15,692,088 - 15,739,894 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	15,692,088 - 15,739,894 (+)	NCBI	ChiLan1.0	ChiLan1.0

GFPT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	57,024,296 - 57,094,979 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	57,028,236 - 57,098,926 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	69,363,229 - 69,430,182 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	70,483,499 - 70,551,141 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	70,488,763 - 70,551,141 (-)	Ensembl	panpan1.1		panPan2

GFPT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	68,067,817 - 68,125,001 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	68,073,062 - 68,125,007 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	67,960,535 - 68,017,522 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	69,091,496 - 69,148,774 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	69,089,869 - 69,148,726 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	68,772,533 - 68,829,292 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	69,073,628 - 69,129,790 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	69,369,742 - 69,426,801 (-)	NCBI		UU_Cfam_GSD_1.0

Gfpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	14,905,980 - 14,973,708 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	13,603,256 - 13,665,275 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936491	13,603,256 - 13,665,298 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GFPT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	73,028,804 - 73,085,319 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	73,028,750 - 73,086,191 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	76,459,764 - 76,509,989 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	3	q21-q27	NCBI

GFPT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	37,740,332 - 37,803,389 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	37,740,358 - 37,802,143 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	74,190,985 - 74,253,974 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gfpt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	3,942,972 - 4,010,498 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624762	3,943,074 - 4,016,090 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gfpt1
227 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	12
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000025070
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	85253748	148090731	Rat
631689	Scl4	Serum cholesterol level QTL 4	1.9	0.008	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	95174120	140174120	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	90850165	135850165	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	116179486	151161268	Rat
10755501	Bp390	Blood pressure QTL 390	2.5		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	4	26775591	168368347	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	70362013	132642728	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	106649412	151649412	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	109866907	167139601	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	109827074	154827074	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82798864	152731274	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	86730991	131730991	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	81192555	126192555	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
1578670	Bss14	Bone structure and strength QTL 14	16.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	4	87327165	132327165	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	110275411	168266883	Rat
724535	Cm18	Cardiac mass QTL 18	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	4	118856416	163856416	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
1578662	Bss15	Bone structure and strength QTL 15	19.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	4	87327165	132327165	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	105789505	150789505	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	119428175	157578333	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
738015	Pia9	Pristane induced arthritis QTL 9	4.5	0.048	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	80694870	125694870	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	109827074	154827074	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	93308457	167139447	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	73169846	132642728	Rat
634334	Xhs3	X-ray hypersensitivity QTL 3	10		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	84728680	129854654	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	106805662	151805662	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	83428419	177635233	Rat
631662	Hcar2	Hepatocarcinoma resistance QTL 2	3.1	0.0003	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	78878504	123878504	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	62277855	128289560	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	85379421	167139601	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
2306899	Bp338	Blood pressure QTL 338		0.071	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	81006124	120102625	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	114627026	159627026	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	85253748	150276390	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	103194656	148194656	Rat
12798527	Anxrr58	Anxiety related response QTL 58	4.11	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	119463257	147278687	Rat

Markers in Region

RH143774

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	119,533,771 - 119,533,942 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	118,888,707 - 118,888,877	NCBI	Rnor6.0
Rnor_5.0	4	183,457,991 - 183,458,161	UniSTS	Rnor5.0
RGSC_v3.4	4	121,241,285 - 121,241,455	UniSTS	RGSC3.4
Celera	4	108,503,388 - 108,503,558	UniSTS
RH 3.4 Map	4	701.1	UniSTS
Cytogenetic Map	4	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000004	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000025070 ⟹ ENSRNOP00000025070

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	119,499,652 - 119,546,471 (+)	Ensembl
Rnor_6.0 Ensembl	4	118,852,119 - 118,897,757 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000090827 ⟹ ENSRNOP00000075660

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	119,496,714 - 119,546,471 (+)	Ensembl
Rnor_6.0 Ensembl	4	118,852,062 - 118,901,591 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000100079 ⟹ ENSRNOP00000096242

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	119,499,652 - 119,546,471 (+)	Ensembl

RefSeq Acc Id:

NM_001005879 ⟹ NP_001005879

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	121,054,089 - 121,099,975 (+)	NCBI
mRatBN7.2	4	119,496,757 - 119,542,647 (+)	NCBI
Rnor_6.0	4	118,852,119 - 118,897,758 (+)	NCBI
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI
RGSC_v3.4	4	121,204,274 - 121,250,160 (+)	RGD
Celera	4	108,466,461 - 108,512,263 (+)	RGD

Sequence:

show sequence

CCCGGAGTCCATCTCATTGCCGCCACCCGGCCCGAGCTCATCCTCGCTTCCGAAGCTCTCGCGC
GCCCGACAGCTCGTCCCTCGCCAGTGACCAACATCATGTGTGGTATATTTGCTTATTTAAATTA
CCATGTTCCTCGAACAAGACGAGAAATCTTGGAGACATTAATCAAAGGCCTTCAGAGATTGGAG
TACAGAGGATATGATTCTGCTGGTGTGGGACTTGACGGAGGCAATGACAAAGACTGGGAAGCCA
ACGCCTGCAAAATCCAGCTCATCAAGAAGAAAGGAAAAGTTAAGGCTCTGGATGAAGAAGTTCA
CAAACAACAAGATATGGACTTGGATATAGAATTTGATGTGCATCTTGGAATAGCTCATACCCGT
TGGGCGACACATGGAGAACCTAGCCCTGTCAATAGTCACCCCCAGCGCTCTGATAAAAATAACG
AATTCATCGTTATTCATAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTTTCTGGAAAG
CAAAGGCTATGACTTTGAATCTGAAACAGACACAGAGACCATCGCTAAGCTAGTCAAGTACATG
TATGACAACTGGGAAAGCCAGGACGTCAGTTTTACTACCTTGGTGGAGAGAGTTATCCAGCAAT
TGGAAGGCGCCTTTGCTCTTGTGTTTAAAAGTGTCCATTTTCCGGGGCAAGCAGTTGGCACAAG
GCGAGGTAGCCCTCTCTTGATTGGTGTGCGGAGCGAACATAAGCTTTCTACAGATCACATTCCG
ATTCTGTACAGAACAGGCAAAGACAAGAAAGGAAGCTGTGGTCTTTCCCGAGTGGACAGCACGA
CATGCCTTTTCCCTGTTGAGGAAAAGGCGGTTGAATATTACTTTGCTTCTGATGCAAGTGCCGT
GATAGAGCACACCAATCGTGTCATCTTTCTGGAGGATGATGATGTTGCAGCCGTGGTGGACGGC
CGTCTCTCGATCCACCGAATTAAACGGACTGCAAGGGACCACCCTGGCCGAGCAGTGCAAACCC
TCCAGATGGAACTCCAGCAGATCATGAAGGGCAACTTTAGTTCATTTATGCAGAAGGAAATTTT
TGAGCAGCCAGAATCTGTTGTGAACACAATGAGAGGAAGAGTCAATTTTGATGACTACACTGTG
AACTTGGGAGGTCTGAAAGACCACATTAAGGAGATCCAGCGGTGTCGGCGGTTGATTCTGATTG
CTTGTGGCACAAGTTACCACGCTGGTATGGCAACCCGTCAGGTCCTAGAGGAGCTGACAGAGTT
ACCAGTGATGGTGGAGCTTGCCAGCGACTTCTTGGATAGAAACACTCCAGTCTTCCGAGATGAT
GTTTGCTTTTTCATCAGTCAATCAGGCGAGACAGCTGACACCCTGATGGGTCTTCGCTACTGTA
AGGAGAGAGGAGCCTTAACTGTGGGGATTACAAATACTGTCGGCAGTTCGATATCACGGGAGAC
AGATTGTGGGGTTCATATCAATGCTGGTCCTGAGATCGGCGTGGCCAGTACAAAGGCTTACACC
AGCCAGTTCGTGTCCCTTGTGATGTTTGCCCTCATGATGTGTGATGACAGAATCTCCATGCAAG
AAAGACGCAAAGAGATCATGCTGGGACTGAAGCGACTGCCGGACTTGATTAAGGAAGTGTTGAG
CATGGATGATGAAATTCAGAAGCTGGCGACAGAGCTTTACCACCAGAAGTCGGTCCTGATAATG
GGCCGAGGCTATCATTATGCTACATGTCTTGAAGGAGCCCTGAAAATCAAGGAGATTACATATA
TGCATTCTGAAGGCATCCTTGCTGGTGAGCTAAAACACGGCCCTCTGGCCTTGGTGGACAAGTT
GATGCCTGTCATCATGATCATCATGCGAGACCACACTTACGCCAAGTGCCAGAATGCTCTTCAG
CAAGTCGTTGCACGGCAGGGGCGTCCAGTCGTGATCTGTGATAAGGAGGATACTGAGACCATTA
AGAATACAAAAAGGACAATCAAGGTGCCCCACTCAGTGGACTGCTTGCAGGGCATTCTCAGCGT
GATCCCCTTACAGCTGCTGGCCTTCCATCTGGCTGTGCTGAGAGGCTACGATGTCGATTTCCCA
CGGAATCTTGCCAAATCTGTAACCGTAGAGTAAAAGACACCTGAAACTTAAGACAGCTAAGCAA
CACAAGATACCTTTTGTATTTAAATTTTTGATTTAAAATATTGCCTCCTGAAAGCCTTTTTTAG
TAAATCTTATTTATATATCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236823 ⟹ XP_006236885

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	4	121,054,023 - 121,103,799 (+)	NCBI
mRatBN7.2	4	119,496,691 - 119,546,472 (+)	NCBI
Rnor_6.0	4	118,852,046 - 118,901,583 (+)	NCBI
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI

Sequence:

show sequence

GCGTGGCCGGGGGGGCGGGGCGGCAGTTGAGAGAGGAGCAGCGAGTCCGGCAGTCTAGTCTGAG
CTGTCGCATCCCGGAGTCCATCTCATTGCCGCCACCCGGCCCGAGCTCATCCTCGCTTCCGAAG
CTCTCGCGCGCCCGACAGCTCGTCCCTCGCCAGTGACCAACATCATGTGTGGTATATTTGCTTA
TTTAAATTACCATGTTCCTCGAACAAGACGAGAAATCTTGGAGACATTAATCAAAGGCCTTCAG
AGATTGGAGTACAGAGGATATGATTCTGCTGGTGTGGGACTTGACGGAGGCAATGACAAAGACT
GGGAAGCCAACGCCTGCAAAATCCAGCTCATCAAGAAGAAAGGAAAAGTTAAGGCTCTGGATGA
AGAAGTTCACAAACAACAAGATATGGACTTGGATATAGAATTTGATGTGCATCTTGGAATAGCT
CATACCCGTTGGGCGACACATGGAGAACCTAGCCCTGTCAATAGTCACCCCCAGCGCTCTGATA
AAAATAACGAATTCATCGTTATTCATAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTT
TCTGGAAAGCAAAGGCTATGACTTTGAATCTGAAACAGACACAGAGACCATCGCTAAGCTAGTC
AAGTACATGTATGACAACTGGGAAAGCCAGGACGTCAGTTTTACTACCTTGGTGGAGAGAGTTA
TCCAGCAATTGGAAGGCGCCTTTGCTCTTGTGTTTAAAAGTGTCCATTTTCCGGGGCAAGCAGT
TGGCACAAGGCGAGGTAGCCCTCTCTTGATTGGTGTGCGGAGCGAACATAAGCTTTCTACAGAT
CACATTCCGATTCTGTACAGAACAGCTAGGACTCAGATTGGATCAAAGTTCACATGGTGGGGAT
CACAGGCAGAACGAGGCAAAGACAAGAAAGGAAGCTGTGGTCTTTCCCGAGTGGACAGCACGAC
ATGCCTTTTCCCTGTTGAGGAAAAGGCGGTTGAATATTACTTTGCTTCTGATGCAAGTGCCGTG
ATAGAGCACACCAATCGTGTCATCTTTCTGGAGGATGATGATGTTGCAGCCGTGGTGGACGGCC
GTCTCTCGATCCACCGAATTAAACGGACTGCAAGGGACCACCCTGGCCGAGCAGTGCAAACCCT
CCAGATGGAACTCCAGCAGATCATGAAGGGCAACTTTAGTTCATTTATGCAGAAGGAAATTTTT
GAGCAGCCAGAATCTGTTGTGAACACAATGAGAGGAAGAGTCAATTTTGATGACTACACTGTGA
ACTTGGGAGGTCTGAAAGACCACATTAAGGAGATCCAGCGGTGTCGGCGGTTGATTCTGATTGC
TTGTGGCACAAGTTACCACGCTGGTATGGCAACCCGTCAGGTCCTAGAGGAGCTGACAGAGTTA
CCAGTGATGGTGGAGCTTGCCAGCGACTTCTTGGATAGAAACACTCCAGTCTTCCGAGATGATG
TTTGCTTTTTCATCAGTCAATCAGGCGAGACAGCTGACACCCTGATGGGTCTTCGCTACTGTAA
GGAGAGAGGAGCCTTAACTGTGGGGATTACAAATACTGTCGGCAGTTCGATATCACGGGAGACA
GATTGTGGGGTTCATATCAATGCTGGTCCTGAGATCGGCGTGGCCAGTACAAAGGCTTACACCA
GCCAGTTCGTGTCCCTTGTGATGTTTGCCCTCATGATGTGTGATGACAGAATCTCCATGCAAGA
AAGACGCAAAGAGATCATGCTGGGACTGAAGCGACTGCCGGACTTGATTAAGGAAGTGTTGAGC
ATGGATGATGAAATTCAGAAGCTGGCGACAGAGCTTTACCACCAGAAGTCGGTCCTGATAATGG
GCCGAGGCTATCATTATGCTACATGTCTTGAAGGAGCCCTGAAAATCAAGGAGATTACATATAT
GCATTCTGAAGGCATCCTTGCTGGTGAGCTAAAACACGGCCCTCTGGCCTTGGTGGACAAGTTG
ATGCCTGTCATCATGATCATCATGCGAGACCACACTTACGCCAAGTGCCAGAATGCTCTTCAGC
AAGTCGTTGCACGGCAGGGGCGTCCAGTCGTGATCTGTGATAAGGAGGATACTGAGACCATTAA
GAATACAAAAAGGACAATCAAGGTGCCCCACTCAGTGGACTGCTTGCAGGGCATTCTCAGCGTG
ATCCCCTTACAGCTGCTGGCCTTCCATCTGGCTGTGCTGAGAGGCTACGATGTCGATTTCCCAC
GGAATCTTGCCAAATCTGTAACCGTAGAGTAAAAGACACCTGAAACTTAAGACAGCTAAGCAAC
ACAAGATACCTTTTGTATTTAAATTTTTGATTTAAAATATTGCCTCCTGAAAGCCTTTTTTAGT
AAATCTTATTTATATATCAGTTATAATGTTCCCACTCAACTAATGATTTTTGTGCAATTGCCTC
ATTTTCATTAATACATGGGGAGCTTGATTTATAGACTTTAAATCTAAGCCTAAAATCAGAGAGC
TGTAGTTTGTTTTAAAAACTGGATAATGGATTGATTTCTGGGTCCTCCACTTCGATCAAGGAGG
CTCGTCGAGTGTTTGAGGTGCTTGGTGTTTGCTTTAGCATAACTTGACTCAGTCAGACTGAGGA
AGACCAGTGCATAGCATACAGTTGGAATACTCCCAAGTCCATGCGTGCCAGTGCTGGACAGCCA
CCGAAGGCTTTGCTGCACTGTCTATAAATAGAAGATGGCTGTAGGTTATTTTGAAGCTTGTTTC
TGTTTTATTTTTAAATCAAACTGTACACCAAAAAAACCTTGATGAGATTTATGTCTAAGTGTAG
TTAAATTAGGTTTAGACACATCTGCCATCTCTGTAGGTAGTGCATTTGGGTCCTCCACAGCTGT
ATAGAAGACCTTTGGAGTTGGGCAAATTTGTACCGTCAGACACTGACGTCTGGCTGGACATGTG
GAGAGAGGACACGGAGATCCTTCTCTGTACTCCTTCCTCGCCTAATCGTAGTTCGCATTTTCTT
GCAGCTGTAGCGCTTAACTGAAAAACAAATACTGTTGAGCGACAGACGTCGTAATTGCCTTTGT
GATCATAGCCCAGAGTCGCTGTCAAGTGGATGACATGCCGATGTTATCGGGCATGCTCAGCTCT
TTCTTCAGCTTTGCAAGAAGAGTTTCCTGCAGTTGTTTCCAACTCCCTTCCCTGCCTTGTTGCA
GAGAGCGTCCCTTGGTGCCAGTCTGGAGTTCTTTCAGTTGCCCGGGAGATCAGCACACTTTGCT
GCTCATGTGACCCTAAGTGTATGATAGGCTAGGCACAGACTTGGCACTGCGGGAGGCTGTCAGT
TTCAGGGTTGCTTTCTTGATGTTTTCCTTTGACTGTCTTGACTCCTGTTCTGGAACGAGTGCCG
TATACAGAGTGATTCTGTCATGCCTTCAGCTGATAGTGTCAGAAATGCAAGTCAGCCATTCGGA
TAAGATATGTAGAAAGGACATATGTGCAGAGTAGTTTCTTCGCGGAGCTCCTTGGGCCGGATTG
TGTGGGCAGTGGGAAGGGATGTTATGTTGGGTTAGGTCCAGTGTTTCAAAGCCTGTACCCTGAG
AGTGCAGTGGTGAGTGGAGCTGGAAGCTCACGCGTTGCGTTTGGACTTGATGGTGGGCAGTGTG
GTAACGCTTGTGAAGGCGGTTGAAGGAAGAGTTGATGTCATTTTAGGTATTTTGGAAGGCTTCA
GTCGCCCTGATGGACAAGGCCGCAGGTGATACTCCACACCGCTGCTTTGGATATGTTTCTCAGT
TGTGTTTATCTCTGGGACCTCACGTTAGCGTGGCAAGGGCGTAAAGTCTGGTGTCTGGTGTCTG
GTGTCTGGTGGAGTAGCACAACTGCTCATGTTTGGGCGTGGCTTTTGTTTGGTTTGGTTTCTGG
CGTTGCCTGTGTGGCTCTGGAGCACAGGGGGTGATGTTGGTAAGCTGAGACACTGAAATTGGGA
GACCGTCCGCTCAGCTAATTACCCAGAGTCCTGTTGGAGCTGTTTTGAATTACACAGTTCAGTC
TTGCTAACCCCCTCTGTGTAGCAGAGCATCACAACTTTTCTTTTAATCCACTCACCAGTTTCCC
TTCCATTCACACTCCCAAGCTAGAATACATGCTAAACCAGTCAGAAGCCCAAATGAAGACCAGA
GCAGTGTTGTCTAAACAAATATTATTCTTTTCCATATCCCTTGTTGCTTTCTACCTAAATTCTT
TTCTTAATTCTTACACCTAGATATTTTAGTGAGCCAAGACACTAGGTGAGTAGGGCCCACTACT
TTGGTATAATACAGGACATAGAAATCTAATTTTTCAAAACAAAAATACCCCGTAAAAGGGTGGC
TTTCTATTAAAATTCTTCCCCACCTCCCAGCCCCCTTTATTTTTTTTTCAAGACAGGGTTTCTC
TGTGCAGTCCTGGGTGTTCTGGAACTTACTCTGTGTATTAGGTTGGCCTCACAGAGATCTGCCT
ACCTCTGCCTCCATAGTGCTGGCTGGCATCAAAGGCATATACATCTGCCTGGCTAAAATTCTTT
TCATTCTTTCTTTTTAAAAAGTAACTATTTTATTTATTTACATTTCAAATGCCCCCCTTCCTGG
TCTCCCCTCCATGAATGTTCCTCCCTATCCCCCTCCCCTTGACCTCTAAGGAGGGCACTCCCCC
ACTTCCCCTCCCCCTTCTCAGGGGTGTCAAGCCTCCACAGGACCAAGCACATCTAATGGTGTGT
TTAAAGTGTAAGTTCCCACATTCCTCCTTACCTGGAGTAGCTGCTAGGCAGGGAGGATGGTGAG
GCACCTGACACATGGCCTGGTTGATGGTTATTACTTGGAAATCAGCTTTAAAAAAGAAGACCAG
CCCATGCCCTAAGAGTAAGACAGTTAAAAAGGGAACTGCTCACTCTTAGCCTGTGACTGGCTCA
GGGCTGGGTATGAGCGGGCCGCTGGGCAGGGCAACAGAGTTCCAACTTCAGAGCAGGTCTGACT
GCCCCTGCGGGGCCTTGTGAGGCCCAGGTGGAGCTGGGATGGGGTACTAAATGCTGTGGATGTG
TTTGTGTACCATGTTCATAAACTTTCCCTAGCCTGTCCATGAAACATGGATCTACGGTACCGTA
AAGAACAGTTAATAATAGGACAAGCAGTTGTGTGTCCCTGTTCCCCAGAGGGATGTCGAAGAGT
ACTGTGCAGAAGGCTCTTAGTTCAGAACACTGACATTGGCTTTTCTCTAGCGGGTTGTTTCTGA
GGTGACAGGGTCATATTCCTTCAGTCCAGGCCTCTTGCCTCAGTGGTTCTGAAGATGGGAGGAA
AGGTGCCTACATTTGGTCCCTAGAAGAGGGAAACTAATATACTTTCACAACACACCTCTGTCTT
TGGGGTTACTCTTACCTTTTTTTATAATTAGGATATTCTAGAGCAATAAAAGAGACTAAGGTTA
CCAGTTTATTATATACTTTAACTTTTTTCTAAAAAAATAATAAAGCACAATGTCATTGGAAAAT
GTTTGTTAAAAAAAGAATTCATAATTCACAATTTGGAAAGGCCAAAGACATGGAGGGGAAAAAG
ACATTTTGGTTTATGACATCCACACGTTTAGTGAGGTGTGTGTACAGTAATACTAGGCAGGGTT
TTAAGCTTGGAAACAGATTTCAGATGGCTTTTATTTAGTTTCACATTCAAAAGTTTTAACATAA
GTTGGTCTTTCTCACTATATTTAAAGATTGTTAATTAGTATTTCAGTATCTTTATAGCTTGAAT
TTAAATATATCCTCAGTCTGGGATGGTGACAGATAACAAAACTGTCAGTATTGGCTTTGAATAG
TTAAGTCCATAGTTATGAGCAAGACGGCTAAGTTTTGTTGTGTTAACTGTCAGTCTGTACTCGC
TTGGTAGTGATGCTGTAAGAGCTGATGGGGACATCTTAGGAAATGCTCACCTTATTTTGTCTGT
ACTGGTTTCCAGAGGGTGTGGAAATGGTCTTGCTAACTTTTGAATGTTCTCTGGTGAATGTGTT
TTCCATTAATAAAGTTTTGATATTTGTTTAAATTATACTTCTGTGGGACTGGGGATTAGAATAT
CATTGCTCTGTTTTGATTTTGTATTCTTTTAAATGAATGTTTAGTTTTCTGAGCCAGATGGTTA
TTTCATCCTTGTGTCCTGTTCAATCCAGTGACTACACCGGAACTGTGAATAAATTACCCAAAAC
CTTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001005879	(Get FASTA)	NCBI Sequence Viewer
	XP_006236885	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83889	(Get FASTA)	NCBI Sequence Viewer
	EDL91267	(Get FASTA)	NCBI Sequence Viewer
	EDL91268	(Get FASTA)	NCBI Sequence Viewer
	EDL91269	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000075660
GenBank Protein	P82808	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001005879 ⟸ NM_001005879

- UniProtKB:

Q5XI08 (UniProtKB/Swiss-Prot), P82808 (UniProtKB/Swiss-Prot), A6IB01 (UniProtKB/TrEMBL), A0A8L2QET6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKG
KVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITN
YKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSV
HFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCGLSRVDSTTCLFPVEEKAVE
YYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTARDHPGRAVQTLQMELQQIMKGN
FSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGMAT
RQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITN
TVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKR
LPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELK
HGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHS
VDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

hide sequence

RefSeq Acc Id:	XP_006236885 ⟸ XM_006236823
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KB56 (UniProtKB/TrEMBL), A6IB00 (UniProtKB/TrEMBL), A0A8I6AP47 (UniProtKB/TrEMBL)
- Sequence:	show sequence MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKG KVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITN YKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSV HFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTWWGSQAERGKDKKGSCGL SRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTARDHP GRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRC RRLILIACGTSYHAGMATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTL MGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCD DRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALK IKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDK EDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE hide sequence

Ensembl Acc Id:

ENSRNOP00000075660 ⟸ ENSRNOT00000090827

Ensembl Acc Id:

ENSRNOP00000025070 ⟸ ENSRNOT00000025070

Ensembl Acc Id:

ENSRNOP00000096242 ⟸ ENSRNOT00000100079

Protein Domains

Glutamine amidotransferase type-2 SIS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P82808-F1-model_v2	AlphaFold	P82808	1-681	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693228

Promoter ID:

EPDNEW_R3742

Type:

initiation region

Name:

Gfpt1_1

Description:

glutamine fructose-6-phosphate transaminase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	118,852,102 - 118,852,162	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549703	AgrOrtholog
BioCyc Gene	G2FUF-43875	BioCyc
Ensembl Genes	ENSRNOG00000018507	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000090827	ENTREZGENE
Gene3D-CATH	3.60.20.10	UniProtKB/Swiss-Prot
	Glucose-6-phosphate isomerase like protein, domain 1	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7132442	IMAGE-MGC_LOAD
InterPro	GATase_2_dom	UniProtKB/Swiss-Prot
	GFAT_N	UniProtKB/Swiss-Prot
	GlmS/AgaS_SIS	UniProtKB/Swiss-Prot
	GlmS/FrlB_SIS	UniProtKB/Swiss-Prot
	GlmS_trans	UniProtKB/Swiss-Prot
	Ntn_hydrolases_N	UniProtKB/Swiss-Prot
	SIS	UniProtKB/Swiss-Prot
	SIS_dom_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:297417	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95214	IMAGE-MGC_LOAD
NCBI Gene	297417	ENTREZGENE
PANTHER	GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING	UniProtKB/Swiss-Prot
	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 1	UniProtKB/Swiss-Prot
Pfam	GATase_6	UniProtKB/Swiss-Prot
	SIS	UniProtKB/Swiss-Prot
PhenoGen	Gfpt1	PhenoGen
PROSITE	GATASE_TYPE_2	UniProtKB/Swiss-Prot
	SIS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000018507	RatGTEx
Superfamily-SCOP	SSF53697	UniProtKB/Swiss-Prot
	SSF56235	UniProtKB/Swiss-Prot
UniProt	A0A0G2KB56	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AP47	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QET6	ENTREZGENE, UniProtKB/TrEMBL
	A6IB00	ENTREZGENE, UniProtKB/TrEMBL
	A6IB01	ENTREZGENE, UniProtKB/TrEMBL
	GFPT1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5XI08	ENTREZGENE
UniProt Secondary	Q5XI08	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Gfpt1	glutamine fructose-6-phosphate transaminase 1			Symbol and Name status set to approved	1299863	APPROVED
2005-09-15	Gfpt1	glutamine fructose-6-phosphate transaminase 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)