Gfpt1 (glutamine fructose-6-phosphate transaminase 1)

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Gene: Gfpt1 (glutamine fructose-6-phosphate transaminase 1) Rattus norvegicus

Analyze

Symbol:

Gfpt1

Name:

glutamine fructose-6-phosphate transaminase 1

RGD ID:

1549703

Description:

Enables several functions, including amino acid binding activity; glutamine-fructose-6-phosphate transaminase (isomerizing) activity; and identical protein binding activity. Involved in several processes, including fructose 6-phosphate metabolic process; glucosamine biosynthetic process; and negative regulation of glycogen biosynthetic process. Biomarker of familial hyperlipidemia and hyperinsulinism. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12 and obesity. Orthologous to human GFPT1 (glutamine--fructose-6-phosphate transaminase 1); PARTICIPATES IN hexosamine biosynthetic pathway; 2-hydroxyglutaric aciduria pathway; amino sugar metabolic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

D-fructose-6-phosphate amidotransferase 1; GFA; GFAT; GFAT 1; GFAT1; GFAT1m; Gfpt; glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; glutamine:fructose 6 phosphate amidotransferase 1; glutamine:fructose-6-phosphate amidotransferase 1; hexosephosphate aminotransferase 1; MGC95214

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Gfpt1 (glutamine fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GFPT1 (glutamine--fructose-6-phosphate transaminase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gfpt1 (glutamine fructose-6-phosphate transaminase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gfpt1 (glutamine--fructose-6-phosphate transaminase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	GFA1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gfat1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Gfat2	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gfat-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gfat-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YMR085W	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):	YMR084W	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	119,496,691 - 119,546,472 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	119,496,714 - 119,546,471 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	124,970,101 - 125,015,978 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	120,744,840 - 120,790,719 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	119,369,093 - 119,414,969 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	118,852,046 - 118,901,583 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	118,852,062 - 118,901,591 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	121,204,274 - 121,250,160 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	108,466,461 - 108,512,263 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital myasthenic syndrome (ISO)

congenital myasthenic syndrome 12 (ISO)

congenital myasthenic syndrome 4C (ISO)

Diabetic Nephropathies (ISO)

Experimental Diabetes Mellitus (IEP)

familial hyperlipidemia (IEP)

genetic disease (ISO)

hyperinsulinism (IEP)

Hypertriglyceridemia (ISO)

Insulin Resistance (ISO)

muscular disease (ISO)

obesity (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-amino-2-deoxy-D-glucopyranose (EXP)

3,4-methylenedioxymethamphetamine (EXP,ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzatropine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-D-glucosamine (EXP)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chromium(6+) (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

dibutyl phthalate (EXP)

diclofenac (ISO)

dorsomorphin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

fipronil (EXP)

folic acid (ISO)

formaldehyde (ISO)

graphite (EXP)

hydroquinone (ISO)

ivermectin (ISO)

lead(0) (ISO)

lead(2+) (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

perfluorooctanoic acid (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

quercetin (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

T-2 toxin (ISO)

tamibarotene (ISO)

tamoxifen (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (EXP,ISO)

theophylline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

Tributyltin oxide (ISO)

trimellitic anhydride (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to insulin stimulus (IEP)

circadian regulation of gene expression (IEA,ISO,ISS)

fructose 6-phosphate metabolic process (IBA,IDA)

glucosamine biosynthetic process (IDA)

glutamine metabolic process (IEA)

negative regulation of glycogen biosynthetic process (IMP)

protein N-linked glycosylation (IBA)

response to insulin (IEP)

response to sucrose (IEP)

UDP-N-acetylglucosamine biosynthetic process (IEA,ISO,ISS)

UDP-N-acetylglucosamine metabolic process (IBA,IMP)

Molecular Function

amino acid binding (IDA)

carbohydrate binding (IDA)

carbohydrate derivative binding (IEA)

glutamine-fructose-6-phosphate transaminase (isomerizing) activity (IBA,IDA,IEA)

identical protein binding (IPI)

Molecular Pathway Annotations Click to see Annotation Detail View

2-hydroxyglutaric aciduria pathway (ISO)

alanine, aspartate and glutamate metabolic pathway (IEA)

amino sugar metabolic pathway (IEA,ISO)

french type sialuria pathway (ISO)

glutamic acid/glutamate metabolic pathway (ISO)

hexosamine biosynthetic pathway (IMP,ISO)

homocarnosinosis pathway (ISO)

nucleotide sugar metabolic pathway (IEA)

sialic acid storage disease pathway (ISO)

succinic semialdehyde dehydrogenase deficiency pathway (ISO)

Tay-Sachs disease pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	The cellular fate of glucose and its relevance in type 2 diabetes.	Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
2.	Regulation of insulin-stimulated glycogen synthase activity by overexpression of glutamine: fructose-6-phosphate amidotransferase in rat-1 fibroblasts.	Crook ED, etal., Diabetes. 1993 Sep;42(9):1289-96.
3.	Effect of sucrose and saturated-fat diets on mRNA levels of genes limiting muscle fatty acid and glucose supply in rats.	Ferrer-Martinez A, etal., Lipids. 2006 Jan;41(1):55-62.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Twenty-four-hour simultaneous subcutaneous Basal-bolus administration of insulin and amylin in adolescents with type 1 diabetes decreases postprandial hyperglycemia.	Heptulla RA, etal., J Clin Endocrinol Metab. 2009 May;94(5):1608-11. Epub 2009 Feb 3.
6.	Purification and characterization of glutamine:fructose 6-phosphate amidotransferase from rat liver.	Huynh QK, etal., Arch Biochem Biophys. 2000 Jul 15;379(2):307-13.
7.	Expression of glutamine:fructose-6-phosphate amidotransferase in human tissues: evidence for high variability and distinct regulation in diabetes.	Nerlich AG, etal., Diabetes. 1998 Feb;47(2):170-8.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
11.	GOA pipeline	RGD automated data pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Comprehensive gene review and curation	RGD comprehensive gene curation
15.	Effects of diabetes and hyperglycemia on the hexosamine synthesis pathway in rat muscle and liver.	Robinson KA, etal., Diabetes. 1995 Dec;44(12):1438-46.
16.	Insulin stimulation of glutamine: fructose-6-phosphate amidotransferase occurs via an insulin-like growth factor-1 pathway in rat fibroblasts.	Simmons ST, etal., Res Commun Mol Pathol Pharmacol. 1999;104(1):63-72.
17.	Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes: inter-relationships with hyperglycaemia and oxidative stress.	Srinivasan V, etal., Clin Biochem. 2007 Sep;40(13-14):952-7. Epub 2007 May 24.
18.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19.	Overexpression of glutamine: fructose-6-phosphate amidotransferase in the liver of transgenic mice results in enhanced glycogen storage, hyperlipidemia, obesity, and impaired glucose tolerance.	Veerababu G, etal., Diabetes. 2000 Dec;49(12):2070-8.

Additional References at PubMed

PMID:15489334	PMID:20458337	PMID:20506529	PMID:23395176	PMID:24625528	PMID:25002582	PMID:31505169	PMID:34735873

Genomics

Comparative Map Data

Gfpt1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	4	119,496,691 - 119,546,472 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	119,496,714 - 119,546,471 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	124,970,101 - 125,015,978 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	4	120,744,840 - 120,790,719 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	4	119,369,093 - 119,414,969 (+)	NCBI	Rnor_WKY
Rnor_6.0	4	118,852,046 - 118,901,583 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	118,852,062 - 118,901,591 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	121,204,274 - 121,250,160 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	4	108,466,461 - 108,512,263 (+)	NCBI		Celera
Cytogenetic Map	4	q34	NCBI

GFPT1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	69,319,780 - 69,387,227 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	2	69,319,780 - 69,387,250 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	69,546,912 - 69,614,359 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	69,405,911 - 69,467,829 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	69,464,057 - 69,525,976	NCBI
Celera	2	69,396,783 - 69,495,538 (-)	NCBI		Celera
Cytogenetic Map	2	p13.3	NCBI
HuRef	2	69,283,030 - 69,350,894 (-)	NCBI		HuRef
CHM1_1	2	69,476,230 - 69,543,772 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	69,332,145 - 69,399,585 (-)	NCBI		T2T-CHM13v2.0

Gfpt1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	87,019,828 - 87,069,189 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	87,019,828 - 87,069,179 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	87,042,846 - 87,092,207 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	87,042,846 - 87,092,197 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	86,992,840 - 87,042,201 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	87,008,484 - 87,054,005 (+)	NCBI		MGSCv36	mm8
Celera	6	88,982,225 - 89,031,325 (+)	NCBI		Celera
Cytogenetic Map	6	D1	NCBI
cM Map	6	37.81	NCBI

Gfpt1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955424	15,692,088 - 15,739,894 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955424	15,692,088 - 15,739,894 (+)	NCBI	ChiLan1.0	ChiLan1.0

GFPT1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2A	70,483,499 - 70,551,141 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	70,488,763 - 70,551,141 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2A	69,363,229 - 69,430,182 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

GFPT1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	68,067,817 - 68,125,001 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	68,073,062 - 68,125,007 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	67,960,535 - 68,017,522 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	69,091,496 - 69,148,774 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	69,089,869 - 69,148,726 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	68,772,533 - 68,829,292 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	69,073,628 - 69,129,790 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	69,369,742 - 69,426,801 (-)	NCBI		UU_Cfam_GSD_1.0

Gfpt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	14,905,980 - 14,973,708 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936491	13,603,256 - 13,665,275 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936491	13,603,256 - 13,665,298 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GFPT1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	73,028,804 - 73,085,319 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	73,028,750 - 73,086,191 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	76,459,764 - 76,509,989 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	3	q21-q27	NCBI

GFPT1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	37,740,332 - 37,803,389 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	37,740,358 - 37,802,143 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	74,190,985 - 74,253,974 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gfpt1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624762	3,942,972 - 4,010,498 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624762	3,943,074 - 4,016,090 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gfpt1
218 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	18
Count of miRNA genes:	12
Interacting mature miRNAs:	17
Transcripts:	ENSRNOT00000025070
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2303168	Bp330	Blood pressure QTL 330	4.25	0.017	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	4	5214602	146446691	Rat
2316958	Gluco58	Glucose level QTL 58	10		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	11320076	180699135	Rat
1358352	Srcrt3	Stress Responsive Cort QTL 3	2.29		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	38465774	146803430	Rat
1576305	Emca6	Estrogen-induced mammary cancer QTL 6	5.8		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	4	44463720	155883716	Rat
1354612	Foco1	Food consumption QTL 1	8.87		eating behavior trait (VT:0001431)	food intake rate (CMO:0000427)	4	44463908	148090542	Rat
1354660	Salc1	Saline consumption QTL 1	11.26		drinking behavior trait (VT:0001422)	saline drink intake rate (CMO:0001627)	4	44463908	148090542	Rat
2312567	Glom19	Glomerulus QTL 19	1.9	0.006	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	4	45456990	146803430	Rat
1298082	Stresp4	Stress response QTL 4			blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	4	50119848	146803430	Rat
70200	Alc18	Alcohol consumption QTL 18	9.2		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	4	56647873	149491524	Rat
1641833	Alc21	Alcohol consumption QTL 21	8.6	0.0001	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	56698790	126192555	Rat
738009	Sach4	Saccharine consumption QTL 4	4.9	0.000016	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	4	59948935	154902892	Rat
738016	Alc16	Alcohol consumption QTL 16	3.6	0.00015	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
738031	Alc14	Alcohol consumption QTL 14	7.6	0.00003	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	4	59948935	154902892	Rat
61418	Pia5	Pristane induced arthritis QTL 5	4.5		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	62277855	128289560	Rat
631674	Iddm14	Insulin dependent diabetes mellitus QTL 14			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	4	64528739	157573521	Rat
61330	Eau1	Experimental allergic uveoretinitis QTL 1		0.0003	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	4	70362013	132642728	Rat
631646	Stl4	Serum triglyceride level QTL 4	6.5	0.0001	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	4	73169846	132642728	Rat
631662	Hcar2	Hepatocarcinoma resistance QTL 2	3.1	0.0003	liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	78878504	123878504	Rat
738015	Pia9	Pristane induced arthritis QTL 9	4.5	0.048	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	80694870	125694870	Rat
2306899	Bp338	Blood pressure QTL 338		0.071	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	4	81006124	120102625	Rat
1641919	Alc22	Alcohol consumption QTL 22		0.0005	drinking behavior trait (VT:0001422)	ethanol drink intake rate (CMO:0001407)	4	81192555	126192555	Rat
70177	Xhs1	X-ray hypersensitivity QTL 1	25.1		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	82798864	152731274	Rat
1576316	Ept5	Estrogen-induced pituitary tumorigenesis QTL 5	3.8		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	4	83428419	177635233	Rat
634334	Xhs3	X-ray hypersensitivity QTL 3	10		intestine integrity trait (VT:0010554)	post-insult time to onset of moribundity (CMO:0001896)	4	84728680	129854654	Rat
1582232	Gluco25	Glucose level QTL 25	3.6	0.0023	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	4	85253748	148090731	Rat
12798523	Anxrr56	Anxiety related response QTL 56	2.83	0.05	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	85253748	150276390	Rat
1358202	Gluco11	Glucose level QTL 11	2.4	0.02	adipocyte glucose uptake trait (VT:0004185)	absolute change in adipocyte glucose uptake (CMO:0000873)	4	85379421	167139601	Rat
61476	Aia3	Adjuvant induced arthritis QTL 3	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	86730991	131730991	Rat
1578662	Bss15	Bone structure and strength QTL 15	19.6		femur width (VT:1000666)	femoral neck width (CMO:0001695)	4	87327165	132327165	Rat
1578670	Bss14	Bone structure and strength QTL 14	16.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	4	87327165	132327165	Rat
1578655	Bmd11	Bone mineral density QTL 11	11		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	4	90850165	135850165	Rat
634335	Anxrr16	Anxiety related response QTL 16	7.22		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	4	93308457	167139447	Rat
631689	Scl4	Serum cholesterol level QTL 4	1.9	0.008	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	4	95174120	140174120	Rat
61434	Cia3	Collagen induced arthritis QTL 3	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	4	103194656	148194656	Rat
2302049	Pia32	Pristane induced arthritis QTL 32	5.1	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)	4	105789505	150789505	Rat
731165	Uae21	Urinary albumin excretion QTL 21	2.4	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	4	106649412	151649412	Rat
61406	Scwia1	Streptococcal cell wall induced arthritis QTL 1	2.3		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	4	106805662	151805662	Rat
7207480	Bss105	Bone structure and strength QTL 105	8.1		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	4	109827074	154827074	Rat
1549832	Bss3	Bone structure and strength QTL 3	11		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	4	109827074	154827074	Rat
737821	Hcar9	Hepatocarcinoma resistance QTL 9	3.7		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	4	109866907	167139601	Rat
1331759	Hrtrt13	Heart rate QTL 13	3.54628		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	110275411	168266883	Rat
6478760	Anxrr45	Anxiety related response QTL 45		0.06717	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
6478763	Anxrr46	Anxiety related response QTL 46		0.07428	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	4	110870972	155870972	Rat
12798519	Anxrr54	Anxiety related response QTL 54	2.54	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	114627026	159627026	Rat
1300116	Hrtrt5	Heart rate QTL 5	3.76		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	4	116179486	151161268	Rat
724535	Cm18	Cardiac mass QTL 18	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	4	118856416	163856416	Rat
1331802	Srn5	Serum renin concentration QTL 5	3.045		renin activity (VT:0005581)	plasma renin activity level (CMO:0000116)	4	119428175	157578333	Rat
12798527	Anxrr58	Anxiety related response QTL 58	4.11	0.05	locomotor behavior trait (VT:0001392)	distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)	4	119463257	147278687	Rat

Markers in Region

RH143774

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	119,533,771 - 119,533,942 (+)	MAPPER	mRatBN7.2
Rnor_6.0	4	118,888,707 - 118,888,877	NCBI	Rnor6.0
Rnor_5.0	4	183,457,991 - 183,458,161	UniSTS	Rnor5.0
RGSC_v3.4	4	121,241,285 - 121,241,455	UniSTS	RGSC3.4
Celera	4	108,503,388 - 108,503,558	UniSTS
RH 3.4 Map	4	701.1	UniSTS
Cytogenetic Map	4	q34	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	33	57	41	19	41	8	11	74	35	41	11	8
Low		10
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006236823	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC083889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000148	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025070 ⟹ ENSRNOP00000025070

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	119,499,652 - 119,546,471 (+)	Ensembl
Rnor_6.0 Ensembl	4	118,852,119 - 118,897,757 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000090827 ⟹ ENSRNOP00000075660

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	119,496,714 - 119,546,471 (+)	Ensembl
Rnor_6.0 Ensembl	4	118,852,062 - 118,901,591 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100079 ⟹ ENSRNOP00000096242

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	4	119,499,652 - 119,546,471 (+)	Ensembl

RefSeq Acc Id:

NM_001005879 ⟹ NP_001005879

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	119,496,757 - 119,542,647 (+)	NCBI
Rnor_6.0	4	118,852,119 - 118,897,758 (+)	NCBI
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI
RGSC_v3.4	4	121,204,274 - 121,250,160 (+)	RGD
Celera	4	108,466,461 - 108,512,263 (+)	RGD

Sequence:

show sequence

CCCGGAGTCCATCTCATTGCCGCCACCCGGCCCGAGCTCATCCTCGCTTCCGAAGCTCTCGCGC
GCCCGACAGCTCGTCCCTCGCCAGTGACCAACATCATGTGTGGTATATTTGCTTATTTAAATTA
CCATGTTCCTCGAACAAGACGAGAAATCTTGGAGACATTAATCAAAGGCCTTCAGAGATTGGAG
TACAGAGGATATGATTCTGCTGGTGTGGGACTTGACGGAGGCAATGACAAAGACTGGGAAGCCA
ACGCCTGCAAAATCCAGCTCATCAAGAAGAAAGGAAAAGTTAAGGCTCTGGATGAAGAAGTTCA
CAAACAACAAGATATGGACTTGGATATAGAATTTGATGTGCATCTTGGAATAGCTCATACCCGT
TGGGCGACACATGGAGAACCTAGCCCTGTCAATAGTCACCCCCAGCGCTCTGATAAAAATAACG
AATTCATCGTTATTCATAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTTTCTGGAAAG
CAAAGGCTATGACTTTGAATCTGAAACAGACACAGAGACCATCGCTAAGCTAGTCAAGTACATG
TATGACAACTGGGAAAGCCAGGACGTCAGTTTTACTACCTTGGTGGAGAGAGTTATCCAGCAAT
TGGAAGGCGCCTTTGCTCTTGTGTTTAAAAGTGTCCATTTTCCGGGGCAAGCAGTTGGCACAAG
GCGAGGTAGCCCTCTCTTGATTGGTGTGCGGAGCGAACATAAGCTTTCTACAGATCACATTCCG
ATTCTGTACAGAACAGGCAAAGACAAGAAAGGAAGCTGTGGTCTTTCCCGAGTGGACAGCACGA
CATGCCTTTTCCCTGTTGAGGAAAAGGCGGTTGAATATTACTTTGCTTCTGATGCAAGTGCCGT
GATAGAGCACACCAATCGTGTCATCTTTCTGGAGGATGATGATGTTGCAGCCGTGGTGGACGGC
CGTCTCTCGATCCACCGAATTAAACGGACTGCAAGGGACCACCCTGGCCGAGCAGTGCAAACCC
TCCAGATGGAACTCCAGCAGATCATGAAGGGCAACTTTAGTTCATTTATGCAGAAGGAAATTTT
TGAGCAGCCAGAATCTGTTGTGAACACAATGAGAGGAAGAGTCAATTTTGATGACTACACTGTG
AACTTGGGAGGTCTGAAAGACCACATTAAGGAGATCCAGCGGTGTCGGCGGTTGATTCTGATTG
CTTGTGGCACAAGTTACCACGCTGGTATGGCAACCCGTCAGGTCCTAGAGGAGCTGACAGAGTT
ACCAGTGATGGTGGAGCTTGCCAGCGACTTCTTGGATAGAAACACTCCAGTCTTCCGAGATGAT
GTTTGCTTTTTCATCAGTCAATCAGGCGAGACAGCTGACACCCTGATGGGTCTTCGCTACTGTA
AGGAGAGAGGAGCCTTAACTGTGGGGATTACAAATACTGTCGGCAGTTCGATATCACGGGAGAC
AGATTGTGGGGTTCATATCAATGCTGGTCCTGAGATCGGCGTGGCCAGTACAAAGGCTTACACC
AGCCAGTTCGTGTCCCTTGTGATGTTTGCCCTCATGATGTGTGATGACAGAATCTCCATGCAAG
AAAGACGCAAAGAGATCATGCTGGGACTGAAGCGACTGCCGGACTTGATTAAGGAAGTGTTGAG
CATGGATGATGAAATTCAGAAGCTGGCGACAGAGCTTTACCACCAGAAGTCGGTCCTGATAATG
GGCCGAGGCTATCATTATGCTACATGTCTTGAAGGAGCCCTGAAAATCAAGGAGATTACATATA
TGCATTCTGAAGGCATCCTTGCTGGTGAGCTAAAACACGGCCCTCTGGCCTTGGTGGACAAGTT
GATGCCTGTCATCATGATCATCATGCGAGACCACACTTACGCCAAGTGCCAGAATGCTCTTCAG
CAAGTCGTTGCACGGCAGGGGCGTCCAGTCGTGATCTGTGATAAGGAGGATACTGAGACCATTA
AGAATACAAAAAGGACAATCAAGGTGCCCCACTCAGTGGACTGCTTGCAGGGCATTCTCAGCGT
GATCCCCTTACAGCTGCTGGCCTTCCATCTGGCTGTGCTGAGAGGCTACGATGTCGATTTCCCA
CGGAATCTTGCCAAATCTGTAACCGTAGAGTAAAAGACACCTGAAACTTAAGACAGCTAAGCAA
CACAAGATACCTTTTGTATTTAAATTTTTGATTTAAAATATTGCCTCCTGAAAGCCTTTTTTAG
TAAATCTTATTTATATATCAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006236823 ⟹ XP_006236885

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	4	119,496,691 - 119,546,472 (+)	NCBI
Rnor_6.0	4	118,852,046 - 118,901,583 (+)	NCBI
Rnor_5.0	4	183,421,338 - 183,470,867 (+)	NCBI

Sequence:

show sequence

GCGTGGCCGGGGGGGCGGGGCGGCAGTTGAGAGAGGAGCAGCGAGTCCGGCAGTCTAGTCTGAG
CTGTCGCATCCCGGAGTCCATCTCATTGCCGCCACCCGGCCCGAGCTCATCCTCGCTTCCGAAG
CTCTCGCGCGCCCGACAGCTCGTCCCTCGCCAGTGACCAACATCATGTGTGGTATATTTGCTTA
TTTAAATTACCATGTTCCTCGAACAAGACGAGAAATCTTGGAGACATTAATCAAAGGCCTTCAG
AGATTGGAGTACAGAGGATATGATTCTGCTGGTGTGGGACTTGACGGAGGCAATGACAAAGACT
GGGAAGCCAACGCCTGCAAAATCCAGCTCATCAAGAAGAAAGGAAAAGTTAAGGCTCTGGATGA
AGAAGTTCACAAACAACAAGATATGGACTTGGATATAGAATTTGATGTGCATCTTGGAATAGCT
CATACCCGTTGGGCGACACATGGAGAACCTAGCCCTGTCAATAGTCACCCCCAGCGCTCTGATA
AAAATAACGAATTCATCGTTATTCATAATGGAATCATCACCAACTACAAAGACTTGAAAAAGTT
TCTGGAAAGCAAAGGCTATGACTTTGAATCTGAAACAGACACAGAGACCATCGCTAAGCTAGTC
AAGTACATGTATGACAACTGGGAAAGCCAGGACGTCAGTTTTACTACCTTGGTGGAGAGAGTTA
TCCAGCAATTGGAAGGCGCCTTTGCTCTTGTGTTTAAAAGTGTCCATTTTCCGGGGCAAGCAGT
TGGCACAAGGCGAGGTAGCCCTCTCTTGATTGGTGTGCGGAGCGAACATAAGCTTTCTACAGAT
CACATTCCGATTCTGTACAGAACAGCTAGGACTCAGATTGGATCAAAGTTCACATGGTGGGGAT
CACAGGCAGAACGAGGCAAAGACAAGAAAGGAAGCTGTGGTCTTTCCCGAGTGGACAGCACGAC
ATGCCTTTTCCCTGTTGAGGAAAAGGCGGTTGAATATTACTTTGCTTCTGATGCAAGTGCCGTG
ATAGAGCACACCAATCGTGTCATCTTTCTGGAGGATGATGATGTTGCAGCCGTGGTGGACGGCC
GTCTCTCGATCCACCGAATTAAACGGACTGCAAGGGACCACCCTGGCCGAGCAGTGCAAACCCT
CCAGATGGAACTCCAGCAGATCATGAAGGGCAACTTTAGTTCATTTATGCAGAAGGAAATTTTT
GAGCAGCCAGAATCTGTTGTGAACACAATGAGAGGAAGAGTCAATTTTGATGACTACACTGTGA
ACTTGGGAGGTCTGAAAGACCACATTAAGGAGATCCAGCGGTGTCGGCGGTTGATTCTGATTGC
TTGTGGCACAAGTTACCACGCTGGTATGGCAACCCGTCAGGTCCTAGAGGAGCTGACAGAGTTA
CCAGTGATGGTGGAGCTTGCCAGCGACTTCTTGGATAGAAACACTCCAGTCTTCCGAGATGATG
TTTGCTTTTTCATCAGTCAATCAGGCGAGACAGCTGACACCCTGATGGGTCTTCGCTACTGTAA
GGAGAGAGGAGCCTTAACTGTGGGGATTACAAATACTGTCGGCAGTTCGATATCACGGGAGACA
GATTGTGGGGTTCATATCAATGCTGGTCCTGAGATCGGCGTGGCCAGTACAAAGGCTTACACCA
GCCAGTTCGTGTCCCTTGTGATGTTTGCCCTCATGATGTGTGATGACAGAATCTCCATGCAAGA
AAGACGCAAAGAGATCATGCTGGGACTGAAGCGACTGCCGGACTTGATTAAGGAAGTGTTGAGC
ATGGATGATGAAATTCAGAAGCTGGCGACAGAGCTTTACCACCAGAAGTCGGTCCTGATAATGG
GCCGAGGCTATCATTATGCTACATGTCTTGAAGGAGCCCTGAAAATCAAGGAGATTACATATAT
GCATTCTGAAGGCATCCTTGCTGGTGAGCTAAAACACGGCCCTCTGGCCTTGGTGGACAAGTTG
ATGCCTGTCATCATGATCATCATGCGAGACCACACTTACGCCAAGTGCCAGAATGCTCTTCAGC
AAGTCGTTGCACGGCAGGGGCGTCCAGTCGTGATCTGTGATAAGGAGGATACTGAGACCATTAA
GAATACAAAAAGGACAATCAAGGTGCCCCACTCAGTGGACTGCTTGCAGGGCATTCTCAGCGTG
ATCCCCTTACAGCTGCTGGCCTTCCATCTGGCTGTGCTGAGAGGCTACGATGTCGATTTCCCAC
GGAATCTTGCCAAATCTGTAACCGTAGAGTAAAAGACACCTGAAACTTAAGACAGCTAAGCAAC
ACAAGATACCTTTTGTATTTAAATTTTTGATTTAAAATATTGCCTCCTGAAAGCCTTTTTTAGT
AAATCTTATTTATATATCAGTTATAATGTTCCCACTCAACTAATGATTTTTGTGCAATTGCCTC
ATTTTCATTAATACATGGGGAGCTTGATTTATAGACTTTAAATCTAAGCCTAAAATCAGAGAGC
TGTAGTTTGTTTTAAAAACTGGATAATGGATTGATTTCTGGGTCCTCCACTTCGATCAAGGAGG
CTCGTCGAGTGTTTGAGGTGCTTGGTGTTTGCTTTAGCATAACTTGACTCAGTCAGACTGAGGA
AGACCAGTGCATAGCATACAGTTGGAATACTCCCAAGTCCATGCGTGCCAGTGCTGGACAGCCA
CCGAAGGCTTTGCTGCACTGTCTATAAATAGAAGATGGCTGTAGGTTATTTTGAAGCTTGTTTC
TGTTTTATTTTTAAATCAAACTGTACACCAAAAAAACCTTGATGAGATTTATGTCTAAGTGTAG
TTAAATTAGGTTTAGACACATCTGCCATCTCTGTAGGTAGTGCATTTGGGTCCTCCACAGCTGT
ATAGAAGACCTTTGGAGTTGGGCAAATTTGTACCGTCAGACACTGACGTCTGGCTGGACATGTG
GAGAGAGGACACGGAGATCCTTCTCTGTACTCCTTCCTCGCCTAATCGTAGTTCGCATTTTCTT
GCAGCTGTAGCGCTTAACTGAAAAACAAATACTGTTGAGCGACAGACGTCGTAATTGCCTTTGT
GATCATAGCCCAGAGTCGCTGTCAAGTGGATGACATGCCGATGTTATCGGGCATGCTCAGCTCT
TTCTTCAGCTTTGCAAGAAGAGTTTCCTGCAGTTGTTTCCAACTCCCTTCCCTGCCTTGTTGCA
GAGAGCGTCCCTTGGTGCCAGTCTGGAGTTCTTTCAGTTGCCCGGGAGATCAGCACACTTTGCT
GCTCATGTGACCCTAAGTGTATGATAGGCTAGGCACAGACTTGGCACTGCGGGAGGCTGTCAGT
TTCAGGGTTGCTTTCTTGATGTTTTCCTTTGACTGTCTTGACTCCTGTTCTGGAACGAGTGCCG
TATACAGAGTGATTCTGTCATGCCTTCAGCTGATAGTGTCAGAAATGCAAGTCAGCCATTCGGA
TAAGATATGTAGAAAGGACATATGTGCAGAGTAGTTTCTTCGCGGAGCTCCTTGGGCCGGATTG
TGTGGGCAGTGGGAAGGGATGTTATGTTGGGTTAGGTCCAGTGTTTCAAAGCCTGTACCCTGAG
AGTGCAGTGGTGAGTGGAGCTGGAAGCTCACGCGTTGCGTTTGGACTTGATGGTGGGCAGTGTG
GTAACGCTTGTGAAGGCGGTTGAAGGAAGAGTTGATGTCATTTTAGGTATTTTGGAAGGCTTCA
GTCGCCCTGATGGACAAGGCCGCAGGTGATACTCCACACCGCTGCTTTGGATATGTTTCTCAGT
TGTGTTTATCTCTGGGACCTCACGTTAGCGTGGCAAGGGCGTAAAGTCTGGTGTCTGGTGTCTG
GTGTCTGGTGGAGTAGCACAACTGCTCATGTTTGGGCGTGGCTTTTGTTTGGTTTGGTTTCTGG
CGTTGCCTGTGTGGCTCTGGAGCACAGGGGGTGATGTTGGTAAGCTGAGACACTGAAATTGGGA
GACCGTCCGCTCAGCTAATTACCCAGAGTCCTGTTGGAGCTGTTTTGAATTACACAGTTCAGTC
TTGCTAACCCCCTCTGTGTAGCAGAGCATCACAACTTTTCTTTTAATCCACTCACCAGTTTCCC
TTCCATTCACACTCCCAAGCTAGAATACATGCTAAACCAGTCAGAAGCCCAAATGAAGACCAGA
GCAGTGTTGTCTAAACAAATATTATTCTTTTCCATATCCCTTGTTGCTTTCTACCTAAATTCTT
TTCTTAATTCTTACACCTAGATATTTTAGTGAGCCAAGACACTAGGTGAGTAGGGCCCACTACT
TTGGTATAATACAGGACATAGAAATCTAATTTTTCAAAACAAAAATACCCCGTAAAAGGGTGGC
TTTCTATTAAAATTCTTCCCCACCTCCCAGCCCCCTTTATTTTTTTTTCAAGACAGGGTTTCTC
TGTGCAGTCCTGGGTGTTCTGGAACTTACTCTGTGTATTAGGTTGGCCTCACAGAGATCTGCCT
ACCTCTGCCTCCATAGTGCTGGCTGGCATCAAAGGCATATACATCTGCCTGGCTAAAATTCTTT
TCATTCTTTCTTTTTAAAAAGTAACTATTTTATTTATTTACATTTCAAATGCCCCCCTTCCTGG
TCTCCCCTCCATGAATGTTCCTCCCTATCCCCCTCCCCTTGACCTCTAAGGAGGGCACTCCCCC
ACTTCCCCTCCCCCTTCTCAGGGGTGTCAAGCCTCCACAGGACCAAGCACATCTAATGGTGTGT
TTAAAGTGTAAGTTCCCACATTCCTCCTTACCTGGAGTAGCTGCTAGGCAGGGAGGATGGTGAG
GCACCTGACACATGGCCTGGTTGATGGTTATTACTTGGAAATCAGCTTTAAAAAAGAAGACCAG
CCCATGCCCTAAGAGTAAGACAGTTAAAAAGGGAACTGCTCACTCTTAGCCTGTGACTGGCTCA
GGGCTGGGTATGAGCGGGCCGCTGGGCAGGGCAACAGAGTTCCAACTTCAGAGCAGGTCTGACT
GCCCCTGCGGGGCCTTGTGAGGCCCAGGTGGAGCTGGGATGGGGTACTAAATGCTGTGGATGTG
TTTGTGTACCATGTTCATAAACTTTCCCTAGCCTGTCCATGAAACATGGATCTACGGTACCGTA
AAGAACAGTTAATAATAGGACAAGCAGTTGTGTGTCCCTGTTCCCCAGAGGGATGTCGAAGAGT
ACTGTGCAGAAGGCTCTTAGTTCAGAACACTGACATTGGCTTTTCTCTAGCGGGTTGTTTCTGA
GGTGACAGGGTCATATTCCTTCAGTCCAGGCCTCTTGCCTCAGTGGTTCTGAAGATGGGAGGAA
AGGTGCCTACATTTGGTCCCTAGAAGAGGGAAACTAATATACTTTCACAACACACCTCTGTCTT
TGGGGTTACTCTTACCTTTTTTTATAATTAGGATATTCTAGAGCAATAAAAGAGACTAAGGTTA
CCAGTTTATTATATACTTTAACTTTTTTCTAAAAAAATAATAAAGCACAATGTCATTGGAAAAT
GTTTGTTAAAAAAAGAATTCATAATTCACAATTTGGAAAGGCCAAAGACATGGAGGGGAAAAAG
ACATTTTGGTTTATGACATCCACACGTTTAGTGAGGTGTGTGTACAGTAATACTAGGCAGGGTT
TTAAGCTTGGAAACAGATTTCAGATGGCTTTTATTTAGTTTCACATTCAAAAGTTTTAACATAA
GTTGGTCTTTCTCACTATATTTAAAGATTGTTAATTAGTATTTCAGTATCTTTATAGCTTGAAT
TTAAATATATCCTCAGTCTGGGATGGTGACAGATAACAAAACTGTCAGTATTGGCTTTGAATAG
TTAAGTCCATAGTTATGAGCAAGACGGCTAAGTTTTGTTGTGTTAACTGTCAGTCTGTACTCGC
TTGGTAGTGATGCTGTAAGAGCTGATGGGGACATCTTAGGAAATGCTCACCTTATTTTGTCTGT
ACTGGTTTCCAGAGGGTGTGGAAATGGTCTTGCTAACTTTTGAATGTTCTCTGGTGAATGTGTT
TTCCATTAATAAAGTTTTGATATTTGTTTAAATTATACTTCTGTGGGACTGGGGATTAGAATAT
CATTGCTCTGTTTTGATTTTGTATTCTTTTAAATGAATGTTTAGTTTTCTGAGCCAGATGGTTA
TTTCATCCTTGTGTCCTGTTCAATCCAGTGACTACACCGGAACTGTGAATAAATTACCCAAAAC
CTTG

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Protein Sequences


Protein RefSeqs	NP_001005879	(Get FASTA)	NCBI Sequence Viewer
	XP_006236885	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH83889	(Get FASTA)	NCBI Sequence Viewer
	EDL91267	(Get FASTA)	NCBI Sequence Viewer
	EDL91268	(Get FASTA)	NCBI Sequence Viewer
	EDL91269	(Get FASTA)	NCBI Sequence Viewer
	P82808	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001005879 ⟸ NM_001005879

- UniProtKB:

Q5XI08 (UniProtKB/Swiss-Prot), P82808 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKG
KVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITN
YKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSV
HFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCGLSRVDSTTCLFPVEEKAVE
YYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTARDHPGRAVQTLQMELQQIMKGN
FSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGMAT
RQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITN
TVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKR
LPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELK
HGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHS
VDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE

hide sequence

RefSeq Acc Id:	XP_006236885 ⟸ XM_006236823
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2KB56 (UniProtKB/TrEMBL)
- Sequence:	show sequence MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKG KVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITN YKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSV HFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTARTQIGSKFTWWGSQAERGKDKKGSCGL SRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTARDHP GRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRC RRLILIACGTSYHAGMATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTL MGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCD DRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALK IKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDK EDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE hide sequence

RefSeq Acc Id:

ENSRNOP00000075660 ⟸ ENSRNOT00000090827

RefSeq Acc Id:

ENSRNOP00000025070 ⟸ ENSRNOT00000025070

RefSeq Acc Id:

ENSRNOP00000096242 ⟸ ENSRNOT00000100079

Protein Domains

Glutamine amidotransferase type-2 SIS

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P82808-F1-model_v2	AlphaFold	P82808	1-681	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13693228

Promoter ID:

EPDNEW_R3742

Type:

initiation region

Name:

Gfpt1_1

Description:

glutamine fructose-6-phosphate transaminase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	4	118,852,102 - 118,852,162	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1549703	AgrOrtholog
BioCyc Gene	G2FUF-43875	BioCyc
Ensembl Genes	ENSRNOG00000018507	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000025070.6	UniProtKB/TrEMBL
	ENSRNOP00000075660	ENTREZGENE
	ENSRNOP00000075660.1	UniProtKB/TrEMBL
	ENSRNOP00000096242.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025070.6	UniProtKB/TrEMBL
	ENSRNOT00000090827	ENTREZGENE
	ENSRNOT00000090827.2	UniProtKB/TrEMBL
	ENSRNOT00000100079.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.20.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7132442	IMAGE-MGC_LOAD
InterPro	GATase_2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GlmS/AgaS_SIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GlmS/FrlB_SIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GlmS_trans	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ntn_hydrolases_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIS_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:297417	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:95214	IMAGE-MGC_LOAD
NCBI Gene	297417	ENTREZGENE
PANTHER	GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GLUTAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE [ISOMERIZING] 1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	GATase_6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gfpt1	PhenoGen
PROSITE	GATASE_TYPE_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SIS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF53697	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56235	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	glmS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2KB56	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AP47_RAT	UniProtKB/TrEMBL
	A0A8L2QET6_RAT	UniProtKB/TrEMBL
	GFPT1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q5XI08	ENTREZGENE
UniProt Secondary	Q5XI08	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Gfpt1	glutamine fructose-6-phosphate transaminase 1			Symbol and Name status set to approved	1299863	APPROVED
2005-09-15	Gfpt1	glutamine fructose-6-phosphate transaminase 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)