Tpk1 (thiamin pyrophosphokinase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tpk1 (thiamin pyrophosphokinase 1) Rattus norvegicus
Analyze
Symbol: Tpk1
Name: thiamin pyrophosphokinase 1
RGD ID: 1589408
Description: Predicted to enable identical protein binding activity and thiamine diphosphokinase activity. Predicted to be involved in thiamine diphosphate biosynthetic process. Predicted to act upstream of or within thiamine metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1); PARTICIPATES IN thiamine metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; thioacetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC680668; MGC188595; similar to Thiamin pyrophosphokinase 1 (Thiamine pyrophosphokinase 1) (mTPK1); thiamine pyrophosphokinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8473,170,125 - 73,557,683 (-)NCBIGRCr8
mRatBN7.2472,170,134 - 72,557,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl472,170,134 - 72,557,694 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx477,158,223 - 77,536,500 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0473,071,450 - 73,449,736 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0471,460,747 - 71,842,026 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0472,792,252 - 73,174,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,792,252 - 73,174,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04137,495,338 - 137,661,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04137,705,456 - 137,869,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4471,113,965 - 71,521,331 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera467,116,073 - 67,485,255 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10567383   PMID:12477932   PMID:15632090   PMID:25502805   PMID:29892012   PMID:31515488  


Genomics

Comparative Map Data
Tpk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8473,170,125 - 73,557,683 (-)NCBIGRCr8
mRatBN7.2472,170,134 - 72,557,707 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl472,170,134 - 72,557,694 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx477,158,223 - 77,536,500 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0473,071,450 - 73,449,736 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0471,460,747 - 71,842,026 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0472,792,252 - 73,174,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl472,792,252 - 73,174,179 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04137,495,338 - 137,661,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04137,705,456 - 137,869,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4471,113,965 - 71,521,331 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera467,116,073 - 67,485,255 (-)NCBICelera
Cytogenetic Map4q24NCBI
TPK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387144,451,941 - 144,836,437 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7144,451,941 - 144,836,395 (-)EnsemblGRCh38hg38GRCh38
GRCh377144,149,034 - 144,533,146 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367143,779,967 - 144,164,079 (-)NCBINCBI36Build 36hg18NCBI36
Build 347143,586,690 - 143,970,781NCBI
Celera7138,823,074 - 139,207,017 (-)NCBICelera
Cytogenetic Map7q35NCBI
HuRef7138,228,218 - 138,611,054 (-)NCBIHuRef
CHM1_17144,157,512 - 144,541,732 (-)NCBICHM1_1
T2T-CHM13v2.07145,632,112 - 146,017,232 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27143,487,292 - 143,871,298 (-)NCBI
Tpk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39643,316,510 - 43,644,726 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl643,321,935 - 43,643,212 (-)EnsemblGRCm39 Ensembl
GRCm38643,339,576 - 43,667,792 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl643,345,001 - 43,666,278 (-)EnsemblGRCm38mm10GRCm38
MGSCv37643,295,006 - 43,616,174 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36643,274,614 - 43,595,782 (-)NCBIMGSCv36mm8
Celera643,288,958 - 43,609,819 (-)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map621.19NCBI
Tpk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955491623,530 - 968,253 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955491621,941 - 968,570 (-)NCBIChiLan1.0ChiLan1.0
TPK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26181,024,614 - 181,404,296 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1733,034,876 - 33,414,560 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07136,165,941 - 136,549,606 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17148,653,898 - 149,036,602 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7148,654,445 - 149,036,342 (-)Ensemblpanpan1.1panPan2
TPK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1165,257,749 - 5,588,179 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl165,257,205 - 5,636,153 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha166,370,726 - 6,696,344 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0165,117,780 - 5,448,228 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl165,117,828 - 5,448,212 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1165,053,899 - 5,379,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0164,910,996 - 5,236,586 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0164,981,542 - 5,307,335 (+)NCBIUU_Cfam_GSD_1.0
Tpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511811,116,997 - 11,488,862 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365271,450,430 - 1,786,521 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365271,450,918 - 1,786,431 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9112,931,795 - 113,305,175 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19112,931,370 - 113,305,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29124,255,226 - 124,629,455 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Tpk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480010,382,717 - 10,792,605 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480010,382,409 - 10,792,459 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpk1
2323 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:303
Count of miRNA genes:198
Interacting mature miRNAs:241
Transcripts:ENSRNOT00000048203
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)45664777678882945Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)45664777678882945Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)45664777678882945Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)45664777678882945Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45711443281266970Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711470578881294Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45863587778886137Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)46293350882490359Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in mean arterial blood pressure (CMO:0002035)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)percent change in systolic blood pressure (CMO:0000747)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in pulse pressure (CMO:0001882)462933508114921294Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)46699318572752834Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)46699318572752834Rat
2317577Eae24Experimental allergic encephalomyelitis QTL 24nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)46699318572752834Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)470808386115808386Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat

Markers in Region
D4Rat27  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2472,500,510 - 72,500,627 (+)MAPPERmRatBN7.2
Rnor_6.0473,197,805 - 73,197,921NCBIRnor6.0
Rnor_6.0473,113,618 - 73,113,734NCBIRnor6.0
Rnor_5.04137,814,925 - 137,815,041UniSTSRnor5.0
Rnor_5.04137,893,587 - 137,893,703UniSTSRnor5.0
RGSC_v3.4471,439,886 - 71,440,163RGDRGSC3.4
RGSC_v3.4471,440,003 - 71,440,119UniSTSRGSC3.4
RGSC_v3.1471,716,133 - 71,716,249RGD
Celera467,434,468 - 67,434,584UniSTS
RH 3.4 Map4436.8RGD
RH 3.4 Map4436.8UniSTS
RH 2.0 Map4465.9RGD
SHRSP x BN Map435.13RGD
Cytogenetic Map4q23UniSTS
AU047001  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2472,175,393 - 72,175,535 (+)MAPPERmRatBN7.2
Rnor_6.0472,797,512 - 72,797,653NCBIRnor6.0
Rnor_5.04137,500,598 - 137,500,739UniSTSRnor5.0
RGSC_v3.4471,119,225 - 71,119,366UniSTSRGSC3.4
Celera467,121,333 - 67,121,474UniSTS
Cytogenetic Map4q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 5 5 5 27 9
Low 1 43 52 36 19 36 8 11 74 8 32 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000048203   ⟹   ENSRNOP00000044768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl472,170,134 - 72,557,694 (-)Ensembl
Rnor_6.0 Ensembl472,792,252 - 73,174,179 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102331   ⟹   ENSRNOP00000086227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl472,170,134 - 72,557,694 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107440   ⟹   ENSRNOP00000081223
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl472,170,134 - 72,557,694 (-)Ensembl
RefSeq Acc Id: NM_001134994   ⟹   NP_001128466
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8473,170,125 - 73,557,672 (-)NCBI
mRatBN7.2472,170,134 - 72,557,694 (-)NCBI
Rnor_6.0472,792,252 - 73,174,179 (-)NCBI
Rnor_5.04137,495,338 - 137,661,388 (-)NCBI
Rnor_5.04137,705,456 - 137,869,961 (-)NCBI
RGSC_v3.4471,113,965 - 71,521,331 (-)RGD
Celera467,116,073 - 67,485,255 (-)RGD
Sequence:
RefSeq Acc Id: XM_039108343   ⟹   XP_038964271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8473,170,908 - 73,557,682 (-)NCBI
mRatBN7.2472,170,917 - 72,557,707 (-)NCBI
RefSeq Acc Id: XM_039108344   ⟹   XP_038964272
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8473,174,262 - 73,557,682 (-)NCBI
mRatBN7.2472,210,483 - 72,557,707 (-)NCBI
RefSeq Acc Id: XM_063286677   ⟹   XP_063142747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8473,170,908 - 73,557,683 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001128466   ⟸   NM_001134994
- UniProtKB: B5DEJ6 (UniProtKB/TrEMBL),   F1LQE3 (UniProtKB/TrEMBL),   A0A9K3Y7A3 (UniProtKB/TrEMBL),   A0A8I6A5F8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044768   ⟸   ENSRNOT00000048203
RefSeq Acc Id: XP_038964271   ⟸   XM_039108343
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5F8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964272   ⟸   XM_039108344
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000086227   ⟸   ENSRNOT00000102331
RefSeq Acc Id: ENSRNOP00000081223   ⟸   ENSRNOT00000107440
RefSeq Acc Id: XP_063142747   ⟸   XM_063286677
- Peptide Label: isoform X3
Protein Domains
Thiamin pyrophosphokinase thiamin-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEJ6-F1-model_v2 AlphaFold B5DEJ6 1-243 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693015
Promoter ID:EPDNEW_R3540
Type:initiation region
Name:Tpk1_1
Description:thiamin pyrophosphokinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0473,174,082 - 73,174,142EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589408 AgrOrtholog
BioCyc Gene G2FUF-45038 BioCyc
Ensembl Genes ENSRNOG00000029922 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048203 ENTREZGENE
  ENSRNOT00000048203.5 UniProtKB/TrEMBL
  ENSRNOT00000102331.1 UniProtKB/TrEMBL
  ENSRNOT00000107440.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10240 UniProtKB/TrEMBL
  Thiamin pyrophosphokinase, thiamin-binding domain UniProtKB/TrEMBL
InterPro Thi_PPkinase UniProtKB/TrEMBL
  Thiamin_pyrophosphokinase_euk UniProtKB/TrEMBL
  Thiamin_PyroPKinase_vitB1-bd UniProtKB/TrEMBL
  TPK_B1-bd_sf UniProtKB/TrEMBL
  TPK_catalytic UniProtKB/TrEMBL
  TPK_catalytic_sf UniProtKB/TrEMBL
KEGG Report rno:680668 UniProtKB/TrEMBL
NCBI Gene 680668 ENTREZGENE
PANTHER THIAMIN PYROPHOSPHOKINASE UniProtKB/TrEMBL
  THIAMIN PYROPHOSPHOKINASE 1 UniProtKB/TrEMBL
Pfam TPK_B1_binding UniProtKB/TrEMBL
  TPK_catalytic UniProtKB/TrEMBL
PhenoGen Tpk1 PhenoGen
PIRSF Thiamin_pyrophosphokinase UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029922 RatGTEx
SMART TPK_B1_binding UniProtKB/TrEMBL
Superfamily-SCOP TPK_B1_bd UniProtKB/TrEMBL
  TPK_catalytic UniProtKB/TrEMBL
UniProt A0A8I5ZSI7_RAT UniProtKB/TrEMBL
  A0A8I6A5F8 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y7A3 ENTREZGENE, UniProtKB/TrEMBL
  B5DEJ6 ENTREZGENE, UniProtKB/TrEMBL
  F1LQE3 ENTREZGENE
UniProt Secondary F1LQE3 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-11 Tpk1  thiamin pyrophosphokinase 1  Tpk1  thiamine pyrophosphokinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Tpk1  thiamine pyrophosphokinase  LOC680668  similar to Thiamin pyrophosphokinase 1 (Thiamine pyrophosphokinase 1) (mTPK1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC680668  similar to Thiamin pyrophosphokinase 1 (Thiamine pyrophosphokinase 1) (mTPK1)  LOC686257  similar to Thiamin pyrophosphokinase 1 (Thiamine pyrophosphokinase 1) (mTPK1)  Data merged from RGD:1584307 1643240 APPROVED
2006-11-19 LOC680668  similar to Thiamin pyrophosphokinase 1 (Thiamine pyrophosphokinase 1) (mTPK1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC686257  similar to Thiamin pyrophosphokinase 1 (Thiamine pyrophosphokinase 1) (mTPK1)      Symbol and Name status set to provisional 70820 PROVISIONAL