Gene: Sec61a1 (Sec61 translocon alpha 1 subunit) Rattus norvegicus
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Symbol: Sec61a1
Name: Sec61 translocon alpha 1 subunit
Description: ENCODES a protein that exhibits calcium channel activity (ortholog); ribosome binding (ortholog); transmembrane transporter activity (ortholog); INVOLVED IN response to interferon-gamma; cotranslational protein targeting to membrane (ortholog); endoplasmic reticulum organization (ortholog); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; phagocytosis pathway; ASSOCIATED WITH agammaglobulinemia (ortholog); Craniofacial Abnormalities (ortholog); Familial Juvenile Hyperuricemic Nephropathy 4 (ortholog); FOUND IN rough endoplasmic reticulum; endoplasmic reticulum membrane (ortholog); integral component of endoplasmic reticulum membrane (ortholog); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A
AGR Description: Predicted to have ribosome binding activity, signal sequence binding activity, and transmembrane transporter activity; involved in response to interferon-gamma; localizes to the rough endoplasmic reticulum; orthologous to human SEC61A1 (Sec61 translocon alpha 1 subunit).
Merged Description: Predicted to have ribosome binding activity, signal sequence binding activity, and transmembrane transporter activity; involved in response to interferon-gamma; localizes to the rough endoplasmic reticulum; orthologous to human SEC61A1 (Sec61 translocon alpha 1 subunit); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; phagocytosis pathway; INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: protein transport protein Sec61 subunit alpha; protein transport protein Sec61 subunit alpha isoform 1; Sec61 alpha 1 subunit; Sec61 alpha 1 subunit (S. cerevisiae); Sec61 alpha subunit homolog; sec61 alpha-1; SEC61, alpha subunit; SEC61, alpha subunit (S. cerevisiae); Sec61a
Orthologs:
Homo sapiens (human) : SEC61A1 (Sec61 translocon alpha 1 subunit)  HGNC  Alliance
Mus musculus (house mouse) : Sec61a1 (Sec61 alpha 1 subunit (S. cerevisiae))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sec61a1 (Sec61 translocon alpha 1 subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : SEC61A1 (Sec61 translocon alpha 1 subunit)
Canis lupus familiaris (dog) : SEC61A1 (Sec61 translocon alpha 1 subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sec61a1 (Sec61 translocon alpha 1 subunit)
Sus scrofa (pig) : SEC61A1 (Sec61 translocon alpha 1 subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04120,453,577 - 120,467,932 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04185,693,504 - 185,707,859 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44122,597,889 - 122,612,245 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14122,842,369 - 122,856,726 (-)NCBI
Celera4109,929,352 - 109,943,708 (-)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Sec61a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68321
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.