Slc6a6 (solute carrier family 6 member 6) - Rat Genome Database

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Gene: Slc6a6 (solute carrier family 6 member 6) Rattus norvegicus
Analyze
Symbol: Slc6a6
Name: solute carrier family 6 member 6
RGD ID: 61912
Description: Enables gamma-aminobutyric acid:sodium:chloride symporter activity; taurine binding activity; and taurine:sodium symporter activity. Involved in gamma-aminobutyric acid import; import across plasma membrane; and taurine transport. Located in dendrite; neuronal cell body; and plasma membrane. Part of plasma membrane protein complex. Orthologous to human SLC6A6 (solute carrier family 6 member 6); INTERACTS WITH 1-benzylpiperazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: sodium- and chloride-dependent taurine transporter; Solute carrier 6 ,member 6 (taurine transporter); Solute carrier 6 member 6 (taurine transporter); solute carrier family 6 (neurotransmitter transporter), member 6; solute carrier family 6 (neurotransmitter transporter, taurine), member 6; solute carrier family 6, member 6; taurine/beta-alanine transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24124,195,186 - 124,268,880 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4124,195,218 - 124,268,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,662,156 - 129,732,221 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04125,436,590 - 125,506,651 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04124,061,127 - 124,131,197 (+)NCBIRnor_WKY
Rnor_6.04123,638,619 - 123,713,469 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4123,642,210 - 123,713,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04188,172,660 - 188,246,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,875,817 - 125,945,795 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14126,120,297 - 126,190,631 (+)NCBI
Celera4113,114,633 - 113,184,598 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1-benzylpiperazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
azathioprine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroacetaldehyde  (ISO)
chloroprene  (EXP)
chlorpromazine  (EXP)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clomipramine  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethylstilbestrol  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (EXP)
fenthion  (ISO)
fulvestrant  (ISO)
genistein  (ISO)
gentamycin  (EXP)
imipramine  (EXP)
indole-3-methanol  (EXP)
ketoconazole  (EXP)
L-ethionine  (EXP)
lead diacetate  (EXP)
lead(II) chloride  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
metformin  (EXP)
methidathion  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel sulfate  (ISO)
O-methyleugenol  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
parathion  (ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
resveratrol  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
streptozocin  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
taurine  (ISO)
temozolomide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (EXP)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
valproic acid  (EXP,ISO)
venlafaxine hydrochloride  (EXP)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. Han X, etal., J Biol Chem 2002 Oct 18;277(42):39266-73.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. Expression of organic osmolyte transporters in cultured rat astrocytes and rat and human cerebral cortex. Oenarto J, etal., Arch Biochem Biophys. 2014 Oct 15;560:59-72. doi: 10.1016/j.abb.2014.06.024. Epub 2014 Jul 5.
7. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Cloning and expression of a high affinity taurine transporter from rat brain. Smith KE, etal., Mol Pharmacol 1992 Oct;42(4):563-9.
12. Assembly of Taurine Transporter (Slc6a6) with Na+-H+ Exchanger Regulatory Factor 1 (Slc9a3r1) Improves GABA Transport Activity by Increasing the Maximum Transport Velocity. Tachikawa M, etal., Biol Pharm Bull. 2018;41(3):338-341. doi: 10.1248/bpb.b17-00664.
13. Taurine transporter in primary cultured neonatal rat heart cells: a comparison between cardiac myocytes and nonmyocytes. Takahashi K, etal., Biochem Pharmacol 2003 Apr 1;65(7):1181-7.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15. Function of taurine transporter (Slc6a6/TauT) as a GABA transporting protein and its relevance to GABA transport in rat retinal capillary endothelial cells. Tomi M, etal., Biochim Biophys Acta. 2008 Oct;1778(10):2138-42. doi: 10.1016/j.bbamem.2008.04.012. Epub 2008 May 3.
16. Widespread microRNA dysregulation in multiple system atrophy - disease-related alteration in miR-96. Ubhi K, etal., Eur J Neurosci. 2014 Mar;39(6):1026-41. doi: 10.1111/ejn.12444. Epub 2013 Dec 5.
17. Deletion of the γ-aminobutyric acid transporter 2 (GAT2 and SLC6A13) gene in mice leads to changes in liver and brain taurine contents. Zhou Y, etal., J Biol Chem. 2012 Oct 12;287(42):35733-35746. doi: 10.1074/jbc.M112.368175. Epub 2012 Aug 15.
Additional References at PubMed
PMID:1465453   PMID:9375654   PMID:11772953   PMID:12824447   PMID:17153592   PMID:17153615   PMID:17252307   PMID:17962336   PMID:18950702   PMID:19240036   PMID:19682207   PMID:20801504  
PMID:21207658   PMID:22166889   PMID:31903486  


Genomics

Comparative Map Data
Slc6a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24124,195,186 - 124,268,880 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4124,195,218 - 124,268,875 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4129,662,156 - 129,732,221 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04125,436,590 - 125,506,651 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04124,061,127 - 124,131,197 (+)NCBIRnor_WKY
Rnor_6.04123,638,619 - 123,713,469 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4123,642,210 - 123,713,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04188,172,660 - 188,246,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44125,875,817 - 125,945,795 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14126,120,297 - 126,190,631 (+)NCBI
Celera4113,114,633 - 113,184,598 (+)NCBICelera
Cytogenetic Map4q34NCBI
SLC6A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38314,402,576 - 14,489,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl314,402,576 - 14,489,349 (+)EnsemblGRCh38hg38GRCh38
GRCh37314,444,076 - 14,530,857 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36314,419,110 - 14,505,861 (+)NCBINCBI36Build 36hg18NCBI36
Build 34314,419,109 - 14,503,973NCBI
Celera314,382,349 - 14,469,089 (+)NCBICelera
Cytogenetic Map3p25.1ENTREZGENE
HuRef314,380,198 - 14,466,798 (+)NCBIHuRef
CHM1_1314,395,197 - 14,481,943 (+)NCBICHM1_1
T2T-CHM13v2.0314,405,068 - 14,491,755 (+)NCBIT2T-CHM13v2.0
Slc6a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39691,661,031 - 91,736,044 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl691,661,034 - 91,736,047 (+)EnsemblGRCm39 Ensembl
GRCm38691,684,048 - 91,759,063 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl691,684,053 - 91,759,066 (+)EnsemblGRCm38mm10GRCm38
MGSCv37691,634,061 - 91,709,057 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36691,649,599 - 91,724,567 (+)NCBIMGSCv36mm8
Celera693,577,782 - 93,652,873 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map640.73NCBI
Slc6a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542917,098,268 - 17,130,433 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542917,097,753 - 17,130,079 (+)NCBIChiLan1.0ChiLan1.0
SLC6A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1314,384,213 - 14,476,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0314,323,251 - 14,411,949 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1314,663,949 - 14,752,326 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl314,663,955 - 14,752,326 (+)Ensemblpanpan1.1panPan2
SLC6A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1204,544,739 - 4,616,797 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl204,531,771 - 4,620,605 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha204,569,550 - 4,653,981 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0204,553,241 - 4,637,965 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl204,553,024 - 4,638,198 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1204,272,086 - 4,356,526 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0204,594,760 - 4,679,179 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0204,605,361 - 4,690,391 (+)NCBIUU_Cfam_GSD_1.0
Slc6a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494218,633,842 - 18,667,901 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936602233,753 - 274,982 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1370,094,079 - 70,173,582 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11370,094,073 - 70,173,581 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21377,572,736 - 77,608,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12250,344,781 - 50,431,765 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2250,344,805 - 50,431,766 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041116,063,292 - 116,150,295 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc6a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248721,266,007 - 1,310,361 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248721,266,240 - 1,318,710 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc6a6
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000012875
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
12798527Anxrr58Anxiety related response QTL 584.110.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4119463257147278687Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4120260281147278687Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4120926564148090731Rat
634347Hcar8Hepatocarcinoma resistance QTL 85.8liver integrity trait (VT:0010547)liver tumorous lesion area to total liver area ratio (CMO:0001075)4123143783168143783Rat

Markers in Region
D4Arb22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24124,264,787 - 124,265,103 (-)MAPPERmRatBN7.2
Rnor_6.04123,642,406 - 123,642,721NCBIRnor6.0
Rnor_5.04188,176,447 - 188,176,762UniSTSRnor5.0
RGSC_v3.44125,945,267 - 125,945,583RGDRGSC3.4
RGSC_v3.44125,945,268 - 125,945,583UniSTSRGSC3.4
RGSC_v3.14126,190,108 - 126,190,424RGD
Celera4113,184,069 - 113,184,386UniSTS
RH 3.4 Map4736.04UniSTS
RH 3.4 Map4736.04RGD
RH 2.0 Map4805.8RGD
SHRSP x BN Map455.49RGD
FHH x ACI Map471.32RGD
Cytogenetic Map4q34UniSTS
D4Wox56  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24124,194,958 - 124,195,252 (-)MAPPERmRatBN7.2
Rnor_6.04123,713,414 - 123,713,707NCBIRnor6.0
Rnor_5.04188,246,087 - 188,246,380UniSTSRnor5.0
RGSC_v3.44125,875,429 - 125,875,722UniSTSRGSC3.4
Celera4113,114,245 - 113,114,538UniSTS
Cytogenetic Map4q34UniSTS
AW531182  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24124,221,697 - 124,221,870 (-)MAPPERmRatBN7.2
Rnor_6.04123,686,615 - 123,686,787NCBIRnor6.0
Rnor_5.04188,219,288 - 188,219,460UniSTSRnor5.0
RGSC_v3.44125,902,167 - 125,902,339UniSTSRGSC3.4
Celera4113,141,020 - 113,141,192UniSTS
RH 3.4 Map4735.93UniSTS
Cytogenetic Map4q34UniSTS
RH138809  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24124,236,686 - 124,236,873 (-)MAPPERmRatBN7.2
Rnor_6.04123,671,743 - 123,671,929NCBIRnor6.0
Rnor_5.04188,204,416 - 188,204,602UniSTSRnor5.0
RGSC_v3.44125,917,154 - 125,917,340UniSTSRGSC3.4
Celera4113,155,972 - 113,156,158UniSTS
RH 3.4 Map4735.71UniSTS
Cytogenetic Map4q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 38 22 19 22 1 1 74 35 40 11 1
Low 4 19 19 19 7 10 1 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012875   ⟹   ENSRNOP00000012875
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4124,195,347 - 124,265,299 (+)Ensembl
Rnor_6.0 Ensembl4123,642,210 - 123,713,319 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086982   ⟹   ENSRNOP00000072080
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4124,232,539 - 124,265,299 (+)Ensembl
Rnor_6.0 Ensembl4123,642,616 - 123,713,464 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103627   ⟹   ENSRNOP00000087986
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4124,195,225 - 124,236,872 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117501   ⟹   ENSRNOP00000094249
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4124,195,218 - 124,268,875 (+)Ensembl
RefSeq Acc Id: NM_017206   ⟹   NP_058902
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,195,347 - 124,265,315 (+)NCBI
Rnor_6.04123,642,194 - 123,713,319 (-)NCBI
Rnor_5.04188,172,660 - 188,246,142 (-)NCBI
RGSC_v3.44125,875,817 - 125,945,795 (+)RGD
Celera4113,114,633 - 113,184,598 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236903   ⟹   XP_006236965
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,195,188 - 124,268,880 (+)NCBI
Rnor_6.04123,638,619 - 123,713,469 (-)NCBI
Rnor_5.04188,172,660 - 188,246,142 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008763123   ⟹   XP_008761345
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,195,188 - 124,268,880 (+)NCBI
Rnor_6.04123,638,619 - 123,713,469 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107206   ⟹   XP_038963134
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,201,677 - 124,268,880 (+)NCBI
RefSeq Acc Id: XM_039107207   ⟹   XP_038963135
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,201,513 - 124,268,880 (+)NCBI
RefSeq Acc Id: XM_039107208   ⟹   XP_038963136
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,201,677 - 124,268,880 (+)NCBI
RefSeq Acc Id: XM_039107209   ⟹   XP_038963137
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,201,568 - 124,268,880 (+)NCBI
RefSeq Acc Id: XM_039107210   ⟹   XP_038963138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24124,195,186 - 124,258,395 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058902   ⟸   NM_017206
- UniProtKB: P31643 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236965   ⟸   XM_006236903
- Peptide Label: isoform X2
- UniProtKB: P31643 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008761345   ⟸   XM_008763123
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K227 (UniProtKB/TrEMBL),   A0A8I6AL67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012875   ⟸   ENSRNOT00000012875
RefSeq Acc Id: ENSRNOP00000072080   ⟸   ENSRNOT00000086982
RefSeq Acc Id: XP_038963138   ⟸   XM_039107210
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038963135   ⟸   XM_039107207
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963137   ⟸   XM_039107209
- Peptide Label: isoform X2
- UniProtKB: P31643 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038963134   ⟸   XM_039107206
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AL67 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963136   ⟸   XM_039107208
- Peptide Label: isoform X2
- UniProtKB: P31643 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000087986   ⟸   ENSRNOT00000103627
RefSeq Acc Id: ENSRNOP00000094249   ⟸   ENSRNOT00000117501

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P31643-F1-model_v2 AlphaFold P31643 1-621 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693264
Promoter ID:EPDNEW_R3780
Type:multiple initiation site
Name:Slc6a6_1
Description:solute carrier family 6 member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04123,713,449 - 123,713,509EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61912 AgrOrtholog
BioCyc Gene G2FUF-43710 BioCyc
Ensembl Genes ENSRNOG00000009019 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012875 ENTREZGENE
  ENSRNOP00000012875.4 UniProtKB/Swiss-Prot
  ENSRNOP00000072080.2 UniProtKB/TrEMBL
  ENSRNOP00000087986.1 UniProtKB/TrEMBL
  ENSRNOP00000094249 ENTREZGENE
  ENSRNOP00000094249.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012875 ENTREZGENE
  ENSRNOT00000012875.7 UniProtKB/Swiss-Prot
  ENSRNOT00000086982.2 UniProtKB/TrEMBL
  ENSRNOT00000103627.1 UniProtKB/TrEMBL
  ENSRNOT00000117501 ENTREZGENE
  ENSRNOT00000117501.1 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Na/ntran_symport_taurine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SNS_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29464 UniProtKB/Swiss-Prot
NCBI Gene 29464 ENTREZGENE
PANTHER PTHR11616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SODIUM- AND CHLORIDE-DEPENDENT TAURINE TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc6a6 PhenoGen
PRINTS NANEUSMPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TAUTRANSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF161070 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC226966
UniProt A0A0G2K227 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6X3_RAT UniProtKB/TrEMBL
  A0A8I6AL67 ENTREZGENE, UniProtKB/TrEMBL
  P31643 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc6a6  solute carrier family 6 member 6  Slc6a6  solute carrier family 6 (neurotransmitter transporter), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc6a6  solute carrier family 6 (neurotransmitter transporter), member 6  Slc6a6  solute carrier family 6 (neurotransmitter transporter, taurine), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc6a6  solute carrier family 6 (neurotransmitter transporter, taurine), member 6    solute carrier family 6, member 6  Name updated 1299863 APPROVED
2002-06-10 Slc6a6  solute carrier family 6, member 6      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process required for the uptake of taurine (2-aminoethanesulfonic acid) which is involved in bile acid conjugation in hepatocytes, modulation of calcium flux and neural excitability, osmoregulation, detoxification, and membrane stabilization 61757
gene_regulation transportor activity is inhibited by beta-alanine and gamma-aminobutyric acid 61757