Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | RGD:1618841 | 6480464 | 1, 2-Dimethylhydrazine results in decreased expression of AAK1 mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | RGD:1313595 | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1618841 | 6480464 | Tetrachlorodibenzodioxin affects the expression of AAK1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of AAK1 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of AAK1 mRNA | CTD | PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2,4,6-tribromophenol | decreases expression | ISO | RGD:1313595 | 6480464 | 2 more ... | CTD | PMID:31675489 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | RGD:1313595 | 6480464 | tetrabromobisphenol A results in decreased expression of AAK1 protein | CTD | PMID:31675489 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of AAK1 mRNA | CTD | PMID:24780913 | aconitine | increases expression | EXP | | 6480464 | Aconitine results in increased expression of AAK1 protein | CTD | PMID:33236894 | aflatoxin B1 | increases expression | ISO | RGD:1618841 | 6480464 | Aflatoxin B1 results in increased expression of AAK1 mRNA | CTD | PMID:19770486 | aflatoxin B1 | increases methylation | ISO | RGD:1313595 | 6480464 | Aflatoxin B1 results in increased methylation of AAK1 intron | CTD | PMID:30157460 | aflatoxin B1 | decreases methylation | ISO | RGD:1313595 | 6480464 | Aflatoxin B1 results in decreased methylation of AAK1 gene | CTD | PMID:27153756 | Aflatoxin B2 alpha | increases methylation | ISO | RGD:1313595 | 6480464 | aflatoxin B2 results in increased methylation of AAK1 intron | CTD | PMID:30157460 | antirheumatic drug | decreases expression | ISO | RGD:1313595 | 6480464 | Antirheumatic Agents results in decreased expression of AAK1 mRNA | CTD | PMID:24449571 | arsane | multiple interactions | ISO | RGD:1313595 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of AAK1 mRNA | CTD | PMID:32525701 | arsenic atom | multiple interactions | ISO | RGD:1313595 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of AAK1 mRNA | CTD | PMID:32525701 | baricitinib | decreases activity | ISO | RGD:1313595 | 6480464 | baricitinib results in decreased activity of AAK1 protein | CTD | PMID:32113509 | benzo[a]pyrene | decreases methylation | ISO | RGD:1618841 | 6480464 | Benzo(a)pyrene results in decreased methylation of AAK1 intron | CTD | PMID:27901495 | bis(2-chloroethyl) sulfide | increases phosphorylation | ISO | RGD:1313595 | 6480464 | Mustard Gas results in increased phosphorylation of AAK1 protein | CTD | PMID:19845377 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of AAK1 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | ISO | RGD:1313595 | 6480464 | bisphenol A results in decreased expression of AAK1 protein | CTD | PMID:31675489 | bisphenol A | multiple interactions | ISO | RGD:1313595 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of AAK1 gene | CTD | PMID:31601247 | bisphenol A | decreases methylation | ISO | RGD:1313595 | 6480464 | bisphenol A results in decreased methylation of AAK1 gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of AAK1 mRNA | CTD | PMID:30816183 more ... | bisphenol A | affects expression | ISO | RGD:1313595 | 6480464 | bisphenol A affects the expression of AAK1 mRNA | CTD | PMID:30903817 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of AAK1 gene | CTD | PMID:28505145 | Brodifacoum | decreases expression | EXP | | 6480464 | bromfenacoum results in decreased expression of AAK1 protein | CTD | PMID:28903499 | cadmium atom | multiple interactions | ISO | RGD:1313595 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AAK1 mRNA | CTD | PMID:35301059 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of AAK1 mRNA | CTD | PMID:33453195 | cadmium dichloride | multiple interactions | ISO | RGD:1313595 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of AAK1 mRNA | CTD | PMID:35301059 | caffeine | affects phosphorylation | ISO | RGD:1313595 | 6480464 | Caffeine affects the phosphorylation of AAK1 protein | CTD | PMID:35688186 | cantharidin | decreases expression | ISO | RGD:1618841 | 6480464 | Cantharidin results in decreased expression of AAK1 mRNA | CTD | PMID:36907384 | carbamazepine | affects expression | ISO | RGD:1313595 | 6480464 | Carbamazepine affects the expression of AAK1 mRNA | CTD | PMID:25979313 | CGP 52608 | multiple interactions | ISO | RGD:1313595 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to AAK1 gene] | CTD | PMID:28238834 | chloroprene | increases expression | EXP | | 6480464 | Chloroprene results in increased expression of AAK1 mRNA | CTD | PMID:23125180 | cisplatin | increases expression | ISO | RGD:1618841 | 6480464 | Cisplatin results in increased expression of AAK1 mRNA | CTD | PMID:21151649 | clofibrate | multiple interactions | ISO | RGD:1618841 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of AAK1 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AAK1 mRNA] | CTD | PMID:17585979 | copper(II) sulfate | increases expression | ISO | RGD:1313595 | 6480464 | Copper Sulfate results in increased expression of AAK1 mRNA | CTD | PMID:19549813 | coumarin | decreases phosphorylation | ISO | RGD:1313595 | 6480464 | coumarin results in decreased phosphorylation of AAK1 protein | CTD | PMID:35688186 | cyclosporin A | increases expression | ISO | RGD:1313595 | 6480464 | Cyclosporine results in increased expression of AAK1 mRNA | CTD | PMID:25562108 | decabromodiphenyl ether | decreases expression | ISO | RGD:1313595 | 6480464 | decabromobiphenyl ether results in decreased expression of AAK1 protein | CTD | PMID:31675489 | dicrotophos | increases expression | ISO | RGD:1313595 | 6480464 | dicrotophos results in increased expression of AAK1 mRNA | CTD | PMID:28302478 | dimethylselenide | multiple interactions | ISO | RGD:1313595 | 6480464 | [[Reactive Oxygen Species results in increased oxidation of dimethylselenide] which results in decreased expression of THY1-AS1 mRNA] which results in increased expression of AAK1 mRNA | CTD | PMID:33656867 | dorsomorphin | multiple interactions | ISO | RGD:1313595 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | RGD:1313595 | 6480464 | entinostat results in increased expression of AAK1 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | RGD:1313595 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AAK1 mRNA | CTD | PMID:27188386 | enzyme inhibitor | multiple interactions | ISO | RGD:1313595 | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of AAK1 protein | CTD | PMID:23301498 | epoxiconazole | decreases expression | ISO | RGD:1618841 | 6480464 | epoxiconazole results in decreased expression of AAK1 mRNA | CTD | PMID:35436446 | ethanol | affects splicing | ISO | RGD:1618841 | 6480464 | Ethanol affects the splicing of AAK1 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | RGD:1313595 | 6480464 | Ethyl Methanesulfonate results in increased expression of AAK1 mRNA | CTD | PMID:23649840 | fenvalerate | increases expression | EXP | | 6480464 | fenvalerate results in increased expression of AAK1 mRNA | CTD | PMID:30307764 | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of AAK1 mRNA | CTD | PMID:34044035 | fluoxetine | decreases expression | EXP | | 6480464 | Fluoxetine results in decreased expression of AAK1 mRNA | CTD | PMID:17033635 | folic acid | decreases expression | ISO | RGD:1313595 | 6480464 | Folic Acid results in decreased expression of AAK1 mRNA | CTD | PMID:21867686 | formaldehyde | increases expression | ISO | RGD:1313595 | 6480464 | Formaldehyde results in increased expression of AAK1 mRNA | CTD | PMID:23649840 | fulvestrant | multiple interactions | ISO | RGD:1313595 | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of AAK1 gene | CTD | PMID:31601247 | glyphosate | decreases expression | ISO | RGD:1313595 | 6480464 | glyphosate results in decreased expression of AAK1 mRNA | CTD | PMID:28711546 | hydrogen peroxide | multiple interactions | ISO | RGD:1618841 | 6480464 | [Hydrogen Peroxide co-treated with N-(oxo-5 more ... | CTD | PMID:31494107 | ivermectin | decreases expression | ISO | RGD:1313595 | 6480464 | Ivermectin results in decreased expression of AAK1 protein | CTD | PMID:32959892 | maneb | multiple interactions | ISO | RGD:1618841 | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of AAK1 mRNA | CTD | PMID:36117858 | methyl methanesulfonate | increases expression | ISO | RGD:1313595 | 6480464 | Methyl Methanesulfonate results in increased expression of AAK1 mRNA | CTD | PMID:23649840 | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of AAK1 mRNA | CTD | PMID:25729387 | paracetamol | multiple interactions | ISO | RGD:1618841 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of AAK1 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of AAK1 mRNA] | CTD | PMID:17585979 | paracetamol | increases expression | ISO | RGD:1313595 | 6480464 | Acetaminophen results in increased expression of AAK1 mRNA | CTD | PMID:29067470 | paracetamol | decreases expression | ISO | RGD:1313595 | 6480464 | Acetaminophen results in decreased expression of AAK1 mRNA | CTD | PMID:21420995 | paracetamol | affects expression | ISO | RGD:1618841 | 6480464 | Acetaminophen affects the expression of AAK1 mRNA | CTD | PMID:17562736 | paraquat | multiple interactions | ISO | RGD:1618841 | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of AAK1 mRNA | CTD | PMID:36117858 | perfluorooctanoic acid | increases expression | ISO | RGD:1313595 | 6480464 | perfluorooctanoic acid results in increased expression of AAK1 mRNA, perfluorooctanoic acid results in increased expression of AAK1 protein | CTD | PMID:26879310, PMID:36326898 | phenylmercury acetate | increases expression | ISO | RGD:1313595 | 6480464 | Phenylmercuric Acetate results in increased expression of AAK1 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1313595 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AAK1 mRNA | CTD | PMID:27188386 | reactive oxygen species | multiple interactions | ISO | RGD:1313595 | 6480464 | [[Reactive Oxygen Species results in increased oxidation of dimethylselenide] which results in decreased expression of THY1-AS1 mRNA] which results in increased expression of AAK1 mRNA | CTD | PMID:33656867 | SB 431542 | multiple interactions | ISO | RGD:1313595 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenate | multiple interactions | ISO | RGD:1313595 | 6480464 | [sodium arsenate results in increased abundance of Arsenic] which results in decreased expression of AAK1 mRNA | CTD | PMID:32525701 | sunitinib | increases expression | ISO | RGD:1313595 | 6480464 | Sunitinib results in increased expression of AAK1 mRNA | CTD | PMID:31533062 | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of AAK1 mRNA | CTD | PMID:25729387 | Tributyltin oxide | decreases phosphorylation | ISO | RGD:1618841 | 6480464 | bis(tri-n-butyltin)oxide results in decreased phosphorylation of AAK1 protein | CTD | PMID:22174045 | trichostatin A | increases expression | ISO | RGD:1313595 | 6480464 | trichostatin A results in increased expression of AAK1 mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:1313595 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AAK1 mRNA | CTD | PMID:27188386 | tungsten | decreases expression | ISO | RGD:1618841 | 6480464 | Tungsten results in decreased expression of AAK1 mRNA | CTD | PMID:30912803 | urethane | increases expression | ISO | RGD:1313595 | 6480464 | Urethane results in increased expression of AAK1 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | RGD:1313595 | 6480464 | Valproic Acid affects the expression of AAK1 mRNA | CTD | PMID:25979313 | valproic acid | multiple interactions | ISO | RGD:1313595 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of AAK1 mRNA | CTD | PMID:27188386 | valproic acid | increases expression | ISO | RGD:1313595 | 6480464 | Valproic Acid results in increased expression of AAK1 mRNA | CTD | PMID:23179753 more ... | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of AAK1 mRNA | CTD | PMID:19015723 | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of AAK1 mRNA | CTD | PMID:23034163 | vorinostat | decreases expression | ISO | RGD:1313595 | 6480464 | vorinostat results in decreased expression of AAK1 mRNA | CTD | PMID:27188386 | | 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