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Gene: Aak1 (AP2 associated kinase 1) Rattus norvegicus
Symbol: Aak1
Name: AP2 associated kinase 1
Description: Exhibits AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in protein autophosphorylation and regulation of clathrin-dependent endocytosis. Localizes to the cell leading edge; clathrin complex; and terminal bouton. Orthologous to human AAK1 (AP2 associated kinase 1); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; Brodifacoum.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: adaptor-associated kinase 1; AP2-associated protein kinase 1; LOC312519; LOC500244; RGD1563580; similar to AP2 associated kinase 1
Homo sapiens (human) : AAK1 (AP2 associated kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Aak1 (AP2 associated kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aak1 (AP2 associated kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AAK1 (AP2 associated kinase 1)
Canis lupus familiaris (dog) : AAK1 (AP2 associated kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aak1 (AP2 associated kinase 1)
Sus scrofa (pig) : AAK1 (AP2 associated kinase 1)
Chlorocebus sabaeus (African green monkey) : AAK1 (AP2 associated kinase 1)
Heterocephalus glaber (naked mole-rat) : Aak1 (AP2 associated kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Aak1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1305520
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.