Aak1 (AP2 associated kinase 1) - Rat Genome Database

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Gene: Aak1 (AP2 associated kinase 1) Rattus norvegicus
Analyze
Symbol: Aak1
Name: AP2 associated kinase 1
RGD ID: 1305520
Description: Enables AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in presynaptic endocytosis and regulation of clathrin-dependent endocytosis. Located in cell leading edge and terminal bouton. Part of clathrin complex. Is active in calyx of Held. Orthologous to human AAK1 (AP2 associated kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
Previously known as: Aak1_predicted; adaptor-associated kinase 1; AP2 associated kinase 1 (predicted); AP2-associated protein kinase 1; LOC312519; LOC500244; RGD1563580; similar to AP2 associated kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,845,012 - 121,009,170 (+)NCBIGRCr8
mRatBN7.24119,300,128 - 119,451,834 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4124,774,675 - 124,914,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,549,404 - 120,688,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,173,657 - 119,313,191 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBICelera
Cytogenetic Map4q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
6-propyl-2-thiouracil  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
baricitinib  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cantharidin  (ISO)
carbamazepine  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dicrotophos  (ISO)
dimethylselenide  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
fluoxetine  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
maneb  (ISO)
methyl methanesulfonate  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
reactive oxygen species  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thiram  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis. Conner SD and Schmid SL, J Cell Biol. 2002 Mar 4;156(5):921-9. Epub 2002 Mar 4.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Hidden proteome of synaptic vesicles in the mammalian brain. Taoufiq Z, etal., Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33586-33596. doi: 10.1073/pnas.2011870117. Epub 2020 Dec 21.

Genomics

Comparative Map Data
Aak1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84120,845,012 - 121,009,170 (+)NCBIGRCr8
mRatBN7.24119,300,128 - 119,451,834 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4124,774,675 - 124,914,216 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04120,549,404 - 120,688,946 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04119,173,657 - 119,313,191 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04118,653,851 - 118,806,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04183,225,133 - 183,365,259 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44121,008,188 - 121,153,112 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14121,252,862 - 121,334,845 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBICelera
Cytogenetic Map4q34NCBI
AAK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38269,457,997 - 69,643,739 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl269,457,997 - 69,674,349 (-)EnsemblGRCh38hg38GRCh38
GRCh37269,685,129 - 69,870,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36269,538,631 - 69,724,481 (-)NCBINCBI36Build 36hg18NCBI36
Celera269,535,200 - 69,722,074 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef269,421,353 - 69,607,695 (-)NCBIHuRef
CHM1_1269,614,737 - 69,800,612 (-)NCBICHM1_1
T2T-CHM13v2.0269,470,304 - 69,656,050 (-)NCBIT2T-CHM13v2.0
Aak1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39686,826,252 - 86,980,209 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl686,826,499 - 86,980,205 (+)EnsemblGRCm39 Ensembl
GRCm38686,849,274 - 87,003,227 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl686,849,517 - 87,003,223 (+)EnsemblGRCm38mm10GRCm38
MGSCv37686,799,511 - 86,953,221 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36686,815,474 - 86,957,498 (+)NCBIMGSCv36mm8
Celera688,789,320 - 88,942,625 (+)NCBICelera
Cytogenetic Map6D1NCBI
cM Map637.75NCBI
Aak1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542415,483,465 - 15,627,664 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542415,480,783 - 15,640,471 (+)NCBIChiLan1.0ChiLan1.0
AAK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21256,769,969 - 56,957,632 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A56,773,915 - 56,961,578 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A69,506,651 - 69,686,765 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A70,626,408 - 70,804,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A70,638,470 - 70,804,579 (-)Ensemblpanpan1.1panPan2
AAK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11068,181,584 - 68,336,266 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1068,134,902 - 68,335,988 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1068,071,405 - 68,227,419 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01069,203,126 - 69,359,380 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1069,199,727 - 69,359,723 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,888,872 - 69,077,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01069,184,012 - 69,340,378 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01069,481,396 - 69,637,824 (-)NCBIUU_Cfam_GSD_1.0
Aak1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629214,673,456 - 14,855,467 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649113,729,727 - 13,897,923 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649113,720,687 - 13,897,899 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AAK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl372,794,158 - 72,968,194 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1372,793,977 - 72,960,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AAK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11437,492,885 - 37,669,953 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1437,576,872 - 37,658,050 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604574,325,972 - 74,505,290 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aak1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247623,723,113 - 3,866,417 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247623,722,429 - 3,873,105 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aak1
505 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:738
Count of miRNA genes:306
Interacting mature miRNAs:426
Transcripts:ENSRNOT00000043082
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)485253748148090731Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)495174120140174120Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4105789505150789505Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)490850165135850165Rat
1300116Hrtrt5Heart rate QTL 53.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)4116179486151161268Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4110870972155870972Rat
1331802Srn5Serum renin concentration QTL 53.045renin activity (VT:0005581)plasma renin activity level (CMO:0000116)4119428175157578333Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4109827074154827074Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)493308457167139447Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4106649412151649412Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4109866907167139601Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)484728680129854654Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)4106805662151805662Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4109827074154827074Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)486730991131730991Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)485379421167139601Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4114627026159627026Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)487327165132327165Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)485253748150276390Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4103194656148194656Rat
1331759Hrtrt13Heart rate QTL 133.54628heart pumping trait (VT:2000009)heart rate (CMO:0000002)4110275411168266883Rat
724535Cm18Cardiac mass QTL 182.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)4118856416163856416Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)487327165132327165Rat

Markers in Region
RH132363  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,433,433 - 119,433,647 (+)MAPPERmRatBN7.2
Rnor_6.04118,788,331 - 118,788,544NCBIRnor6.0
Rnor_5.04183,357,816 - 183,358,029UniSTSRnor5.0
RGSC_v3.44121,140,486 - 121,140,699UniSTSRGSC3.4
Celera4108,402,931 - 108,403,144UniSTS
RH 3.4 Map4698.6UniSTS
Cytogenetic Map4q34UniSTS
RH132368  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,440,487 - 119,440,671 (+)MAPPERmRatBN7.2
Rnor_6.04118,795,385 - 118,795,568NCBIRnor6.0
Rnor_5.04183,364,870 - 183,365,053UniSTSRnor5.0
RGSC_v3.44121,147,540 - 121,147,723UniSTSRGSC3.4
Celera4108,409,985 - 108,410,168UniSTS
RH 3.4 Map4698.4UniSTS
Cytogenetic Map4q34UniSTS
RH143910  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24119,300,181 - 119,300,375 (+)MAPPERmRatBN7.2
Rnor_6.04118,654,682 - 118,654,875NCBIRnor6.0
Rnor_5.04183,224,106 - 183,224,299UniSTSRnor5.0
RGSC_v3.44121,007,018 - 121,007,211UniSTSRGSC3.4
Celera4108,269,697 - 108,269,890UniSTS
RH 3.4 Map4696.0UniSTS
Cytogenetic Map4q34UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001173450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236833 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592819 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592821 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039108162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000043082   ⟹   ENSRNOP00000044665
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,301,228 - 119,440,877 (+)Ensembl
Rnor_6.0 Ensembl4118,655,728 - 118,795,774 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096717   ⟹   ENSRNOP00000094963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,301,228 - 119,448,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100088   ⟹   ENSRNOP00000086691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,295,257 - 119,450,969 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000100839   ⟹   ENSRNOP00000087662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,301,228 - 119,440,877 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102896   ⟹   ENSRNOP00000088529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,301,228 - 119,448,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104791   ⟹   ENSRNOP00000078415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,301,228 - 119,445,850 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000116423   ⟹   ENSRNOP00000087063
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,429,746 - 119,448,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118607   ⟹   ENSRNOP00000084865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4119,301,228 - 119,450,969 (+)Ensembl
RefSeq Acc Id: NM_001173450   ⟹   NP_001166921
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,567 - 120,998,214 (+)NCBI
mRatBN7.24119,301,228 - 119,440,877 (+)NCBI
Rnor_6.04118,655,728 - 118,795,774 (+)NCBI
Rnor_5.04183,225,133 - 183,365,259 (+)NCBI
Celera4108,270,743 - 108,410,374 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236833   ⟹   XP_006236895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,529 - 120,998,208 (+)NCBI
mRatBN7.24119,301,210 - 119,440,871 (+)NCBI
Rnor_6.04118,655,703 - 118,795,768 (+)NCBI
Rnor_5.04183,225,133 - 183,365,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236834   ⟹   XP_006236896
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 120,998,208 (+)NCBI
mRatBN7.24119,301,210 - 119,440,871 (+)NCBI
Rnor_6.04118,655,703 - 118,795,768 (+)NCBI
Rnor_5.04183,225,133 - 183,365,259 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592817   ⟹   XP_017448306
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,702 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592818   ⟹   XP_017448307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,845,012 - 121,009,170 (+)NCBI
mRatBN7.24119,300,128 - 119,451,834 (+)NCBI
Rnor_6.04118,653,851 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592819   ⟹   XP_017448308
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,702 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592820   ⟹   XP_017448309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,703 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592821   ⟹   XP_017448310
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,703 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592822   ⟹   XP_017448311
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,502 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
Rnor_6.04118,655,703 - 118,806,796 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108159   ⟹   XP_038964087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_039108160   ⟹   XP_038964088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_039108161   ⟹   XP_038964089
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_039108162   ⟹   XP_038964090
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 121,009,170 (+)NCBI
mRatBN7.24119,301,209 - 119,451,834 (+)NCBI
RefSeq Acc Id: XM_063286530   ⟹   XP_063142600
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,555 - 121,009,170 (+)NCBI
RefSeq Acc Id: XM_063286531   ⟹   XP_063142601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 121,009,170 (+)NCBI
RefSeq Acc Id: XM_063286532   ⟹   XP_063142602
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84120,858,556 - 120,998,208 (+)NCBI
Protein Sequences
Ensembl Protein ENSRNOP00000044665.4
  ENSRNOP00000078415.1
  ENSRNOP00000084865.1
  ENSRNOP00000086691.1
  ENSRNOP00000087063.1
  ENSRNOP00000087662.1
  ENSRNOP00000088529.1
  ENSRNOP00000094963.1
GenBank Protein P0C1X8 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001166921   ⟸   NM_001173450
- Sequence:
RefSeq Acc Id: XP_006236895   ⟸   XM_006236833
- Peptide Label: isoform X12
- Sequence:
RefSeq Acc Id: XP_006236896   ⟸   XM_006236834
- Peptide Label: isoform X13
- Sequence:
RefSeq Acc Id: XP_017448307   ⟸   XM_017592818
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448306   ⟸   XM_017592817
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017448308   ⟸   XM_017592819
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017448309   ⟸   XM_017592820
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017448310   ⟸   XM_017592821
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_017448311   ⟸   XM_017592822
- Peptide Label: isoform X10
- Sequence:
Ensembl Acc Id: ENSRNOP00000044665   ⟸   ENSRNOT00000043082
RefSeq Acc Id: XP_038964088   ⟸   XM_039108160
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038964087   ⟸   XM_039108159
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038964089   ⟸   XM_039108161
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038964090   ⟸   XM_039108162
- Peptide Label: isoform X11
Ensembl Acc Id: ENSRNOP00000087063   ⟸   ENSRNOT00000116423
Ensembl Acc Id: ENSRNOP00000088529   ⟸   ENSRNOT00000102896
Ensembl Acc Id: ENSRNOP00000094963   ⟸   ENSRNOT00000096717
Ensembl Acc Id: ENSRNOP00000086691   ⟸   ENSRNOT00000100088
Ensembl Acc Id: ENSRNOP00000078415   ⟸   ENSRNOT00000104791
Ensembl Acc Id: ENSRNOP00000087662   ⟸   ENSRNOT00000100839
Ensembl Acc Id: ENSRNOP00000084865   ⟸   ENSRNOT00000118607
RefSeq Acc Id: XP_063142600   ⟸   XM_063286530
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063142601   ⟸   XM_063286531
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063142602   ⟸   XM_063286532
- Peptide Label: isoform X14
Protein Domains
BMP-2-inducible protein kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C1X8-F1-model_v2 AlphaFold P0C1X8 1-962 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693215
Promoter ID:EPDNEW_R3740
Type:multiple initiation site
Name:Aak1_1
Description:AP2 associated kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04118,655,718 - 118,655,778EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305520 AgrOrtholog
BioCyc Gene G2FUF-43880 BioCyc
Ensembl Genes ENSRNOG00000018317 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043082.5 UniProtKB/TrEMBL
  ENSRNOT00000096717.1 UniProtKB/TrEMBL
  ENSRNOT00000100088.1 UniProtKB/TrEMBL
  ENSRNOT00000100839.1 UniProtKB/TrEMBL
  ENSRNOT00000102896.1 UniProtKB/TrEMBL
  ENSRNOT00000104791.1 UniProtKB/TrEMBL
  ENSRNOT00000116423.1 UniProtKB/TrEMBL
  ENSRNOT00000118607.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AP2_assoc_SerThr_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BMP2K_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:500244 UniProtKB/TrEMBL
NCBI Gene Aak1_predicted ENTREZGENE
PANTHER AP2-ASSOCIATED PROTEIN KINASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BMP2K_C UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aak1 PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018317 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZKV0_RAT UniProtKB/TrEMBL
  A0A8I6A256_RAT UniProtKB/TrEMBL
  A0A8I6A3P1_RAT UniProtKB/TrEMBL
  A0A8I6A463_RAT UniProtKB/TrEMBL
  A0A8I6A6D5_RAT UniProtKB/TrEMBL
  A0A8I6ALS6_RAT UniProtKB/TrEMBL
  A0A8I6GFC9_RAT UniProtKB/TrEMBL
  AAK1_RAT UniProtKB/Swiss-Prot
  F1LRI7_RAT UniProtKB/TrEMBL
  P0C1X8 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-08 Aak1  AP2 associated kinase 1  Aak1_predicted  AP2 associated kinase 1 (predicted)  Symbol and Name updated 1299863 APPROVED
2008-05-08 Aak1_predicted  AP2 associated kinase 1 (predicted)  Aak1  AP2 associated kinase 1  Data merged from RGD:1563580 737654 APPROVED
2008-03-07 Aak1  AP2 associated kinase 1  RGD1563580_predicted  similar to AP2 associated kinase 1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Aak1  AP2 associated kinase 1  Aak1  AP2 associated kinase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1563580_predicted  similar to AP2 associated kinase 1 (predicted)  LOC500244  similar to AP2 associated kinase 1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC500244  similar to AP2 associated kinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Aak1_predicted  AP2 associated kinase 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED