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Gene: Ogg1 (8-oxoguanine DNA glycosylase) Rattus norvegicus
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Symbol: Ogg1
Name: 8-oxoguanine DNA glycosylase
Description: Exhibits damaged DNA binding activity and oxidized purine nucleobase lesion DNA N-glycosylase activity. Involved in several processes, including aging; cellular response to cadmium ion; and response to estradiol. Localizes to the mitochondrion and nucleus. Biomarker of hepatitis; middle cerebral artery infarction; renal cell carcinoma; status epilepticus; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; angiomyolipoma; carcinoma (multiple); endocrine gland cancer (multiple); and eye disease (multiple). Orthologous to human OGG1 (8-oxoguanine DNA glycosylase); PARTICIPATES IN base excision repair pathway; INTERACTS WITH (+)-pilocarpine; (R)-rosmarinic acid; (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 8-oxoguanine DNA-glycosylase 1; 8-oxoguanine-DNA-glycosylase; N-glycosylase/DNA lyase
Orthologs:
Homo sapiens (human) : OGG1 (8-oxoguanine DNA glycosylase)  HGNC  Alliance
Mus musculus (house mouse) : Ogg1 (8-oxoguanine DNA-glycosylase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ogg1 (8-oxoguanine DNA glycosylase)
Pan paniscus (bonobo/pygmy chimpanzee) : OGG1 (8-oxoguanine DNA glycosylase)
Canis lupus familiaris (dog) : OGG1 (8-oxoguanine DNA glycosylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ogg1 (8-oxoguanine DNA glycosylase)
Sus scrofa (pig) : OGG1 (8-oxoguanine DNA glycosylase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04145,282,828 - 145,289,367 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04208,580,193 - 208,586,457 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44149,209,745 - 149,219,081 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14149,454,585 - 149,463,922 (+)NCBI
Celera4135,032,266 - 135,038,520 (+)NCBICelera
Cytogenetic Map4q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ogg1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621168
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.