Pot1 (protection of telomeres 1) - Rat Genome Database

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Gene: Pot1 (protection of telomeres 1) Rattus norvegicus
Analyze
Symbol: Pot1
Name: protection of telomeres 1
RGD ID: 1562696
Description: Predicted to enable DEAD/H-box RNA helicase binding activity; DNA binding activity; and telomerase inhibitor activity. Predicted to be involved in chromosome organization; establishment of protein localization to telomere; and regulation of DNA metabolic process. Predicted to act upstream of or within chromosome organization. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in colorectal cancer; familial melanoma; hepatocellular carcinoma; lung cancer; and ovarian cancer. Orthologous to human POT1 (protection of telomeres 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; decabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC500054; LOC500054; Pot1a; protection of telomeres 1 homolog; protection of telomeres 1 homolog (S. pombe); protection of telomeres 1A; protection of telomeres protein 1; similar to POT1-like telomere end-binding protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8455,170,821 - 55,228,588 (-)NCBIGRCr8
mRatBN7.2454,205,330 - 54,263,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl454,205,332 - 54,263,042 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx459,206,940 - 59,263,878 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0455,120,524 - 55,177,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0453,525,039 - 53,581,975 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,888,632 - 51,946,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,888,634 - 51,946,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0451,664,672 - 51,722,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4452,233,404 - 52,289,574 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera449,343,691 - 49,398,232 (-)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer. Fujii K, etal., Int J Mol Med. 2008 May;21(5):599-604.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Hosgood HD, etal., Lung Cancer. 2009 Nov;66(2):157-61. doi: 10.1016/j.lungcan.2009.02.005. Epub 2009 Mar 13.
4. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Ishigaki K, etal., Nat Genet. 2020 Jul;52(7):669-679. doi: 10.1038/s41588-020-0640-3. Epub 2020 Jun 8.
5. Telomere 1 (POT1) gene expression and its association with telomerase activity in colorectal tumor samples with different pathological features. Izgi A, etal., Biomed Pharmacother. 2014 Sep;68(7):841-6. doi: 10.1016/j.biopha.2014.08.014. Epub 2014 Aug 20.
6. Prognostic impact of telomere maintenance gene polymorphisms on hepatocellular carcinoma patients with chronic hepatitis B. Jung SW, etal., Hepatology. 2014 May;59(5):1912-20. doi: 10.1002/hep.26655. Epub 2014 Mar 27.
7. Telomere structure and maintenance gene variants and risk of five cancer types. Karami S, etal., Int J Cancer. 2016 Dec 15;139(12):2655-2670. doi: 10.1002/ijc.30288. Epub 2016 Sep 8.
8. Telomere length variation and expression analysis of shelterin complex genes during gallbladder carcinogenesis. Poojary SS, etal., J Cancer Res Ther. 2017 Apr-Jun;13(2):235-239. doi: 10.4103/0973-1482.184512.
9. GOA pipeline RGD automated data pipeline
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Telomere Maintenance Variants and Survival after Colorectal Cancer: Smoking- and Sex-Specific Associations. Yin H, etal., Cancer Epidemiol Biomarkers Prev. 2020 Sep;29(9):1817-1824. doi: 10.1158/1055-9965.EPI-19-1507. Epub 2020 Jun 25.
Additional References at PubMed
PMID:12768206   PMID:12781132   PMID:15181449   PMID:15383534   PMID:15632080   PMID:15657433   PMID:16030011   PMID:16043710   PMID:16880378   PMID:17053789   PMID:17237767   PMID:17237768  
PMID:17632522   PMID:19135898   PMID:19734539   PMID:19854130   PMID:21852327   PMID:22039056   PMID:22763445   PMID:23685356   PMID:24120135   PMID:24270157   PMID:25589350   PMID:26586433  
PMID:29227966  


Genomics

Comparative Map Data
Pot1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8455,170,821 - 55,228,588 (-)NCBIGRCr8
mRatBN7.2454,205,330 - 54,263,137 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl454,205,332 - 54,263,042 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx459,206,940 - 59,263,878 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0455,120,524 - 55,177,464 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0453,525,039 - 53,581,975 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0451,888,632 - 51,946,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,888,634 - 51,946,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0451,664,672 - 51,722,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4452,233,404 - 52,289,574 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera449,343,691 - 49,398,232 (-)NCBICelera
Cytogenetic Map4q22NCBI
POT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387124,822,386 - 124,929,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7124,822,386 - 124,929,983 (-)EnsemblGRCh38hg38GRCh38
GRCh377124,462,440 - 124,569,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367124,249,676 - 124,357,273 (-)NCBINCBI36Build 36hg18NCBI36
Build 347124,057,263 - 124,131,201NCBI
Celera7119,267,687 - 119,375,230 (-)NCBICelera
Cytogenetic Map7q31.33NCBI
HuRef7118,827,419 - 118,935,017 (-)NCBIHuRef
CHM1_17124,395,753 - 124,503,350 (-)NCBICHM1_1
T2T-CHM13v2.07126,139,780 - 126,247,229 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27123,851,834 - 123,959,412 (-)NCBI
Pot1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39625,743,939 - 25,809,280 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl625,743,736 - 25,809,245 (-)EnsemblGRCm39 Ensembl
GRCm38625,743,940 - 25,809,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl625,743,737 - 25,809,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv37625,693,735 - 25,759,226 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36625,693,745 - 25,759,236 (-)NCBIMGSCv36mm8
Celera625,744,313 - 25,810,007 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
cM Map611.65NCBI
Pot1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554796,140,501 - 6,209,031 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554796,140,599 - 6,230,512 (-)NCBIChiLan1.0ChiLan1.0
POT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26161,671,016 - 161,789,306 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1713,677,851 - 13,799,556 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07116,807,913 - 116,926,998 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17129,487,571 - 129,605,558 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7129,487,571 - 129,605,558 (-)Ensemblpanpan1.1panPan2
POT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11410,987,385 - 11,067,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1410,987,494 - 11,066,956 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1410,683,957 - 10,766,907 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01410,769,382 - 10,849,644 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1410,769,491 - 10,849,644 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11410,960,833 - 11,041,479 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01410,693,633 - 10,773,611 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01410,852,699 - 10,933,293 (+)NCBIUU_Cfam_GSD_1.0
Pot1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511851,284,826 - 51,367,106 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936605836,769 - 920,201 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936605836,824 - 919,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1822,885,749 - 22,981,890 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11822,885,704 - 22,981,893 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21824,394,687 - 24,526,564 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12193,572,139 - 93,688,374 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2193,571,272 - 93,655,869 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660429,761,660 - 9,885,572 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pot1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478311,138,303 - 11,223,044 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478311,138,222 - 11,223,329 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pot1
316 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:115
Count of miRNA genes:85
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000060459
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42690728575585128Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)42690728575585128Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)42949419581006281Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)43443048482490359Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)43443048482490359Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)43950527573892441Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)43952426474726312Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
10450818Scl76Serum cholesterol level QTL 763.60.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450821Scl77Serum cholesterol level QTL 774.10.01blood VLDL cholesterol amount (VT:0005144)blood high density lipoprotein cholesterol level (CMO:0000052)44917811657114705Rat
10450825Scl78Serum cholesterol level QTL 783.70.01blood VLDL cholesterol amount (VT:0005144)blood low density lipoprotein cholesterol level (CMO:0000053)44917811657114705Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 29 33 18 19 18 1 1 74 23 35 11 1
Low 1 14 24 23 23 7 10 12 6 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000060459   ⟹   ENSRNOP00000057203
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl454,205,332 - 54,259,856 (-)Ensembl
Rnor_6.0 Ensembl451,888,634 - 51,943,519 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079130   ⟹   ENSRNOP00000070115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl454,205,334 - 54,259,851 (-)Ensembl
Rnor_6.0 Ensembl451,888,949 - 51,946,715 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080575   ⟹   ENSRNOP00000070503
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl454,209,367 - 54,263,042 (-)Ensembl
Rnor_6.0 Ensembl451,892,065 - 51,931,112 (-)Ensembl
RefSeq Acc Id: NM_001395151   ⟹   NP_001382080
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8455,170,821 - 55,228,543 (-)NCBI
mRatBN7.2454,205,330 - 54,263,047 (-)NCBI
RefSeq Acc Id: NM_001395152   ⟹   NP_001382081
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8455,170,821 - 55,228,543 (-)NCBI
mRatBN7.2454,205,330 - 54,263,047 (-)NCBI
RefSeq Acc Id: XM_008762811   ⟹   XP_008761033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8455,170,821 - 55,228,586 (-)NCBI
mRatBN7.2454,205,330 - 54,263,137 (-)NCBI
Rnor_6.0451,888,632 - 51,946,764 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063286481   ⟹   XP_063142551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8455,170,821 - 55,228,588 (-)NCBI
RefSeq Acc Id: XR_010065689
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8455,172,537 - 55,228,588 (-)NCBI
RefSeq Acc Id: XR_010065690
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8455,172,488 - 55,228,588 (-)NCBI
RefSeq Acc Id: XP_008761033   ⟸   XM_008762811
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JY35 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070115   ⟸   ENSRNOT00000079130
RefSeq Acc Id: ENSRNOP00000070503   ⟸   ENSRNOT00000080575
RefSeq Acc Id: ENSRNOP00000057203   ⟸   ENSRNOT00000060459
RefSeq Acc Id: NP_001382081   ⟸   NM_001395152
- UniProtKB: A0A0G2JX31 (UniProtKB/TrEMBL),   A6IE97 (UniProtKB/TrEMBL),   A0A0G2JY35 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001382080   ⟸   NM_001395151
- UniProtKB: A0A0G2JX31 (UniProtKB/TrEMBL),   A6IE97 (UniProtKB/TrEMBL),   A0A0G2JY35 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142551   ⟸   XM_063286481
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JX31 (UniProtKB/TrEMBL),   A6IE97 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX31-F1-model_v2 AlphaFold A0A0G2JX31 1-638 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692917
Promoter ID:EPDNEW_R3433
Type:multiple initiation site
Name:Pot1_1
Description:protection of telomeres 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0451,946,711 - 51,946,771EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562696 AgrOrtholog
BioCyc Gene G2FUF-45462 BioCyc
Ensembl Genes ENSRNOG00000019986 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000060459 ENTREZGENE
  ENSRNOT00000060459.4 UniProtKB/TrEMBL
  ENSRNOT00000079130 ENTREZGENE
  ENSRNOT00000079130.2 UniProtKB/TrEMBL
  ENSRNOT00000080575.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.140 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134840 IMAGE-MGC_LOAD
InterPro NA-bd_OB-fold UniProtKB/TrEMBL
  POT1 UniProtKB/TrEMBL
  POT1_C_insert UniProtKB/TrEMBL
  POT1PC UniProtKB/TrEMBL
  Telomer_end_bd UniProtKB/TrEMBL
KEGG Report rno:500054 UniProtKB/TrEMBL
MGC_CLONE MGC:94460 IMAGE-MGC_LOAD
NCBI Gene 500054 ENTREZGENE
PANTHER PROTECTION OF TELOMERES PROTEIN 1 UniProtKB/TrEMBL
  PTHR14513 UniProtKB/TrEMBL
Pfam POT1_C_insert UniProtKB/TrEMBL
  POT1PC UniProtKB/TrEMBL
  Telo_bind UniProtKB/TrEMBL
PhenoGen Pot1 PhenoGen
RatGTEx ENSRNOG00000019986 RatGTEx
SMART Telo_bind UniProtKB/TrEMBL
Superfamily-SCOP Nucleic_acid_OB UniProtKB/TrEMBL
UniProt A0A0G2JX31 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JY35 ENTREZGENE, UniProtKB/TrEMBL
  A6IE97 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2W8_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-01-31 Pot1  protection of telomeres 1  Pot1  protection of telomeres 1 homolog (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Pot1  protection of telomeres 1 homolog (S. pombe)  Pot1a  protection of telomeres 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-21 Pot1a  protection of telomeres 1A  Pot1  protection of telomeres 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-21 Pot1  protection of telomeres 1A  LOC500054  similar to POT1-like telomere end-binding protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500054  similar to POT1-like telomere end-binding protein      Symbol and Name status set to provisional 70820 PROVISIONAL