TRADD (TNFRSF1A associated via death domain) - Rat Genome Database
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Gene: TRADD (TNFRSF1A associated via death domain) Homo sapiens
Analyze
Symbol: TRADD
Name: TNFRSF1A associated via death domain
RGD ID: 1350695
HGNC Page HGNC
Description: Exhibits death domain binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in several processes, including cellular response to tumor necrosis factor; positive regulation of NF-kappaB transcription factor activity; and positive regulation of intracellular signal transduction. Localizes to cytoplasm; plasma membrane; and tumor necrosis factor receptor superfamily complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Hs.89862; MGC11078; TNFR1-associated death domain protein; TNFRSF1A-associated via death domain; tumor necrosis factor receptor type 1 associated death domain protein; tumor necrosis factor receptor type 1-associated DEATH domain protein; tumor necrosis factor receptor-1-associated protein
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1667,154,185 - 67,159,909 (-)EnsemblGRCh38hg38GRCh38
GRCh381667,154,185 - 67,159,909 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,188,088 - 67,193,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,745,589 - 65,751,313 (-)NCBINCBI36hg18NCBI36
Build 341665,745,604 - 65,747,759NCBI
Celera1651,696,331 - 51,702,055 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,061,605 - 53,067,329 (-)NCBIHuRef
CHM1_11668,595,406 - 68,601,130 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1'-acetoxychavicol acetate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
6-propyl-2-thiouracil  (ISO)
all-trans-retinoic acid  (EXP)
Aloe emodin  (EXP)
ammonium chloride  (ISO)
Anacardic acid  (EXP)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bisphenol F  (EXP)
cadmium atom  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP)
clofibrate  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
coumarin  (EXP)
curcumin  (EXP)
cylindrospermopsin  (EXP)
dexamethasone  (EXP)
diazinon  (ISO)
dieldrin  (ISO)
dioscin  (EXP)
disodium selenite  (EXP)
dorsomorphin  (EXP)
entinostat  (EXP)
ethanol  (ISO)
folic acid  (ISO)
hesperidin  (EXP)
hydrogen peroxide  (EXP)
hydroquinone  (EXP)
hydroxyurea  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
kojic acid  (ISO)
leflunomide  (EXP)
mangiferin  (ISO)
melatonin  (ISO)
menadione  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (EXP)
methotrexate  (EXP)
monocrotaline  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nitrates  (ISO)
o-anisidine  (EXP)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
parthenolide  (EXP)
pentachlorophenol  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
progesterone  (ISO)
propylparaben  (EXP)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
Rhein  (EXP)
rifampicin  (ISO)
SB 431542  (EXP)
simvastatin  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
trichostatin A  (EXP)
triclosan  (EXP)
valproic acid  (EXP,ISO)
vorinostat  (EXP)
zerumbone  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:1040062   PMID:7758105   PMID:8565075   PMID:8612133   PMID:8621670   PMID:8681376   PMID:8702708   PMID:8934525   PMID:8943045   PMID:8985253   PMID:9020361   PMID:9082980  
PMID:9356494   PMID:9427646   PMID:9430227   PMID:9560245   PMID:9714541   PMID:9915703   PMID:9916731   PMID:9916988   PMID:10187805   PMID:10356400   PMID:10400625   PMID:10544141  
PMID:10848577   PMID:10892748   PMID:10911999   PMID:10980203   PMID:11032752   PMID:11035039   PMID:11112409   PMID:11112773   PMID:11181075   PMID:11226577   PMID:11374864   PMID:11435712  
PMID:11479302   PMID:11684708   PMID:11821416   PMID:11934887   PMID:12045187   PMID:12107169   PMID:12417987   PMID:12446787   PMID:12477932   PMID:12576460   PMID:12604596   PMID:12665801  
PMID:12753742   PMID:12761501   PMID:12796506   PMID:12887920   PMID:12911633   PMID:14585990   PMID:14644197   PMID:14660619   PMID:14702039   PMID:14743216   PMID:15103018   PMID:15247912  
PMID:15310755   PMID:15485837   PMID:15489334   PMID:15707590   PMID:15761471   PMID:16006552   PMID:16227624   PMID:16344560   PMID:16603398   PMID:16611992   PMID:17051333   PMID:17235653  
PMID:17540176   PMID:17567906   PMID:17702576   PMID:17922260   PMID:18174230   PMID:18198944   PMID:18309324   PMID:18661484   PMID:18776134   PMID:18939944   PMID:18990758   PMID:19151112  
PMID:19176810   PMID:19287455   PMID:19336370   PMID:19379743   PMID:19453261   PMID:19524513   PMID:19573080   PMID:19641494   PMID:19773279   PMID:19781631   PMID:19815541   PMID:19854717  
PMID:20005846   PMID:20568250   PMID:20628368   PMID:21068102   PMID:21421854   PMID:21724995   PMID:21813773   PMID:21873635   PMID:22099304   PMID:22170762   PMID:22179575   PMID:22297296  
PMID:22333735   PMID:22510408   PMID:22561347   PMID:23429285   PMID:23732909   PMID:23908590   PMID:23955153   PMID:23982205   PMID:24025841   PMID:24070137   PMID:24130170   PMID:24361886  
PMID:24374337   PMID:24686082   PMID:24735611   PMID:24758719   PMID:24980434   PMID:25033841   PMID:25230327   PMID:25643035   PMID:25732226   PMID:25791120   PMID:26475675   PMID:26496610  
PMID:26673895   PMID:26760575   PMID:27197753   PMID:27270888   PMID:27307491   PMID:27458237   PMID:27545878   PMID:27552911   PMID:27562714   PMID:27768232   PMID:27960153   PMID:28337828  
PMID:28514442   PMID:28611389   PMID:28698006   PMID:28765645   PMID:29108854   PMID:29656893   PMID:30021884   PMID:30420664   PMID:30561431   PMID:32007500   PMID:32296183   PMID:32303335  
PMID:32968279  


Genomics

Comparative Map Data
TRADD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1667,154,185 - 67,159,909 (-)EnsemblGRCh38hg38GRCh38
GRCh381667,154,185 - 67,159,909 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371667,188,088 - 67,193,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,745,589 - 65,751,313 (-)NCBINCBI36hg18NCBI36
Build 341665,745,604 - 65,747,759NCBI
Celera1651,696,331 - 51,702,055 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,061,605 - 53,067,329 (-)NCBIHuRef
CHM1_11668,595,406 - 68,601,130 (-)NCBICHM1_1
Tradd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398105,985,207 - 105,991,226 (-)NCBIGRCm39mm39
GRCm39 Ensembl8105,984,918 - 105,991,241 (-)Ensembl
GRCm388105,258,575 - 105,264,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8105,258,286 - 105,264,609 (-)EnsemblGRCm38mm10GRCm38
MGSCv378107,782,475 - 107,788,494 (-)NCBIGRCm37mm9NCBIm37
MGSCv368108,147,704 - 108,153,723 (-)NCBImm8
Celera8109,481,639 - 109,487,742 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.04NCBI
Tradd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,136,148 - 33,142,714 (-)NCBI
Rnor_6.0 Ensembl1937,214,471 - 37,216,572 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01937,214,461 - 37,221,099 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01948,081,076 - 48,086,774 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,073,150 - 35,075,251 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,078,569 - 35,079,048 (-)NCBI
Celera1932,565,129 - 32,567,230 (-)NCBICelera
Cytogenetic Map19q11NCBI
Tradd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554849,456,301 - 9,462,425 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554849,456,268 - 9,462,425 (+)NCBIChiLan1.0ChiLan1.0
TRADD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11666,888,543 - 66,892,501 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1666,889,006 - 66,891,016 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01647,499,881 - 47,506,220 (-)NCBIMhudiblu_PPA_v0panPan3
TRADD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl582,206,111 - 82,210,963 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1582,200,430 - 82,211,430 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tradd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647517,628,297 - 17,634,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRADD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl627,797,607 - 27,804,423 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1627,797,594 - 27,804,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TRADD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1560,296,777 - 60,303,076 (+)NCBI
ChlSab1.1 Ensembl560,297,375 - 60,303,579 (+)Ensembl
Tradd
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474619,155,058 - 19,165,702 (+)NCBI

Position Markers
TRADD_1477  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371667,188,061 - 67,188,842UniSTSGRCh37
Build 361665,745,562 - 65,746,343RGDNCBI36
Celera1651,696,304 - 51,697,085RGD
HuRef1653,061,578 - 53,062,359UniSTS
RH78922  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371667,188,201 - 67,188,377UniSTSGRCh37
Build 361665,745,702 - 65,745,878RGDNCBI36
Celera1651,696,444 - 51,696,620RGD
Cytogenetic Map16q22UniSTS
HuRef1653,061,718 - 53,061,894UniSTS
GeneMap99-GB4 RH Map16404.27UniSTS
NCBI RH Map16508.6UniSTS
RH69054  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371667,188,260 - 67,188,381UniSTSGRCh37
Build 361665,745,761 - 65,745,882RGDNCBI36
Celera1651,696,503 - 51,696,624RGD
Cytogenetic Map16q22UniSTS
HuRef1653,061,777 - 53,061,898UniSTS
GeneMap99-GB4 RH Map16401.5UniSTS
NCBI RH Map16508.6UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1650
Count of miRNA genes:726
Interacting mature miRNAs:851
Transcripts:ENST00000345057, ENST00000486556, ENST00000563348, ENST00000566104, ENST00000566247
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 2359 2120 1451 371 1766 213 3335 967 1142 366 1130 1546 169 1188 1968 5 2
Low 80 871 275 253 181 252 939 1230 2583 53 329 67 5 1 16 820 1
Below cutoff 3 81 8 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001323552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005256213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017023815 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC074143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ307882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ311614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ311615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ311616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK090673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK301593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY575851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY995114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004491 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG717460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ707739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA426418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA353575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD119556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000345057   ⟹   ENSP00000341268
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1667,154,185 - 67,159,909 (-)Ensembl
RefSeq Acc Id: ENST00000486556   ⟹   ENSP00000462591
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1667,154,199 - 67,156,249 (-)Ensembl
RefSeq Acc Id: ENST00000563348
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1667,155,539 - 67,156,681 (-)Ensembl
RefSeq Acc Id: ENST00000566104
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1667,155,751 - 67,159,898 (-)Ensembl
RefSeq Acc Id: ENST00000566247
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1667,154,833 - 67,155,418 (-)Ensembl
RefSeq Acc Id: NM_001323552   ⟹   NP_001310481
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,154,185 - 67,159,909 (-)NCBI
CHM1_11668,595,406 - 68,601,130 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003789   ⟹   NP_003780
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,154,185 - 67,159,909 (-)NCBI
GRCh371667,188,088 - 67,193,812 (-)ENTREZGENE
GRCh371667,188,088 - 67,193,812 (-)NCBI
Build 361665,745,589 - 65,751,313 (-)NCBI Archive
HuRef1653,061,605 - 53,067,329 (-)ENTREZGENE
CHM1_11668,595,406 - 68,601,130 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005256213   ⟹   XP_005256270
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,154,185 - 67,159,904 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017023815   ⟹   XP_016879304
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381667,154,185 - 67,159,811 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_003780   ⟸   NM_003789
- UniProtKB: Q15628 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005256270   ⟸   XM_005256213
- Peptide Label: isoform X2
- UniProtKB: Q15628 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001310481   ⟸   NM_001323552
- UniProtKB: Q15628 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016879304   ⟸   XM_017023815
- Peptide Label: isoform X1
- UniProtKB: Q15628 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000341268   ⟸   ENST00000345057
RefSeq Acc Id: ENSP00000462591   ⟸   ENST00000486556
Protein Domains
Death

Promoters
RGD ID:6793524
Promoter ID:HG_KWN:24010
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Lymphoblastoid,   NB4
Transcripts:UC002ERH.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361665,746,826 - 65,747,967 (-)MPROMDB
RGD ID:6793124
Promoter ID:HG_KWN:24011
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000268834,   OTTHUMT00000268841,   UC002ERJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361665,750,556 - 65,751,432 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2
pathogenic
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1
pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q21-22.1(chr16:62179331-67770414)x1 copy number loss See cases [RCV000053333] Chr16:62179331..67770414 [GRCh38]
Chr16:62213235..67804317 [GRCh37]
Chr16:60770736..66361818 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:63318997-70555249)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|See cases [RCV000053334] Chr16:63318997..70555249 [GRCh38]
Chr16:63352901..70589152 [GRCh37]
Chr16:61910402..69146653 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-22.1(chr16:64311275-68062011)x1 copy number loss See cases [RCV000053335] Chr16:64311275..68062011 [GRCh38]
Chr16:64345179..68095914 [GRCh37]
Chr16:62902680..66653415 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q22.1(chr16:66694180-67865445)x1 copy number loss See cases [RCV000053336] Chr16:66694180..67865445 [GRCh38]
Chr16:66728083..67899348 [GRCh37]
Chr16:65285584..66456849 [NCBI36]
Chr16:16q22.1
pathogenic
NM_033309.2(B3GNT9):c.672C>T (p.Phe224=) single nucleotide variant Malignant melanoma [RCV000071180] Chr16:67149814 [GRCh38]
Chr16:67183717 [GRCh37]
Chr16:65741218 [NCBI36]
Chr16:16q22.1
not provided
GRCh38/hg38 16q21-22.1(chr16:66245888-67473023)x1 copy number loss See cases [RCV000134709] Chr16:66245888..67473023 [GRCh38]
Chr16:66279791..67506926 [GRCh37]
Chr16:64837292..66064427 [NCBI36]
Chr16:16q21-22.1
pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1
pathogenic
GRCh38/hg38 16q22.1(chr16:66893204-67357178)x3 copy number gain See cases [RCV000137368] Chr16:66893204..67357178 [GRCh38]
Chr16:66927107..67391081 [GRCh37]
Chr16:65484608..65948582 [NCBI36]
Chr16:16q22.1
likely pathogenic|uncertain significance
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3
pathogenic
GRCh38/hg38 16q22.1(chr16:66921669-67312444)x3 copy number gain See cases [RCV000142764] Chr16:66921669..67312444 [GRCh38]
Chr16:66955572..67346347 [GRCh37]
Chr16:65513073..65903848 [NCBI36]
Chr16:16q22.1
uncertain significance
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3
pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3
pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1
pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3
uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Ductal breast carcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2
likely pathogenic|uncertain significance
Single allele complex Ductal breast carcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q21-22.1(chr16:66537021-67369281)x3 copy number gain See cases [RCV000510388] Chr16:66537021..67369281 [GRCh37]
Chr16:16q21-22.1
uncertain significance
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3
uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss PARP Inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss PARP Inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3
drug response
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3
pathogenic
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3
pathogenic
GRCh37/hg19 16q22.1(chr16:67180171-67234134)x1 copy number loss not provided [RCV000739191] Chr16:67180171..67234134 [GRCh37]
Chr16:16q22.1
benign
GRCh37/hg19 16q22.1(chr16:67181999-67233266)x3 copy number gain not provided [RCV000739192] Chr16:67181999..67233266 [GRCh37]
Chr16:16q22.1
benign
GRCh37/hg19 16q22.1(chr16:67132790-68166320) copy number loss not provided [RCV000767617] Chr16:67132790..68166320 [GRCh37]
Chr16:16q22.1
pathogenic
GRCh37/hg19 16q21-22.1(chr16:65669673-70180183)x1 copy number loss not provided [RCV001006797] Chr16:65669673..70180183 [GRCh37]
Chr16:16q21-22.1
pathogenic
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3
not provided

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12030 AgrOrtholog
COSMIC TRADD COSMIC
Ensembl Genes ENSG00000102871 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000341268 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000462591 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000345057 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000486556 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.680 UniProtKB/Swiss-Prot
GTEx ENSG00000102871 GTEx
HGNC ID HGNC:12030 ENTREZGENE
Human Proteome Map TRADD Human Proteome Map
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  TRADD UniProtKB/Swiss-Prot
  TRADD_N UniProtKB/Swiss-Prot
  TRADD_N_sf UniProtKB/Swiss-Prot
KEGG Report hsa:8717 UniProtKB/Swiss-Prot
NCBI Gene 8717 ENTREZGENE
OMIM 603500 OMIM
PANTHER PTHR14913 UniProtKB/Swiss-Prot
Pfam Death UniProtKB/Swiss-Prot
  TRADD_N UniProtKB/Swiss-Prot
PharmGKB PA36707 PharmGKB
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot
SMART DEATH UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot
  SSF55044 UniProtKB/Swiss-Prot
UniProt Q15628 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary B2RDS3 UniProtKB/Swiss-Prot
  B3KQZ9 UniProtKB/Swiss-Prot
  Q52NZ1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-26 TRADD  TNFRSF1A associated via death domain  TRADD  TNFRSF1A-associated via death domain  Symbol and/or name change 5135510 APPROVED