POT1 (protection of telomeres 1) - Rat Genome Database

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Gene: POT1 (protection of telomeres 1) Canis lupus familiaris
Analyze
Symbol: POT1
Name: protection of telomeres 1
RGD ID: 12203061
Description: ENCODES a protein that exhibits single-stranded telomeric DNA binding (ortholog); telomeric DNA binding (ortholog); telomeric G-quadruplex DNA binding (ortholog); INVOLVED IN chromosome organization (ortholog); positive regulation of helicase activity (ortholog); regulation of DNA helicase activity (ortholog); ASSOCIATED WITH chromosomal disease (ortholog); Chromosome Aberrations (ortholog); Cutaneous Malignant Melanoma, Susceptibility To, 1 (ortholog); FOUND IN chromosome, telomeric region (ortholog); shelterin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: POT1 protection of telomeres 1 homolog; protection of telomeres 1 homolog; protection of telomeres protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11410,987,385 - 11,067,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1410,987,494 - 11,066,956 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1410,683,957 - 10,766,907 (+)NCBI
ROS_Cfam_1.01410,769,382 - 10,849,644 (+)NCBI
UMICH_Zoey_3.11410,960,833 - 11,041,479 (+)NCBI
UNSW_CanFamBas_1.01410,693,633 - 10,773,611 (+)NCBI
UU_Cfam_GSD_1.01410,852,699 - 10,933,293 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
POT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11410,987,385 - 11,067,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1410,987,494 - 11,066,956 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1410,683,957 - 10,766,907 (+)NCBI
ROS_Cfam_1.01410,769,382 - 10,849,644 (+)NCBI
UMICH_Zoey_3.11410,960,833 - 11,041,479 (+)NCBI
UNSW_CanFamBas_1.01410,693,633 - 10,773,611 (+)NCBI
UU_Cfam_GSD_1.01410,852,699 - 10,933,293 (+)NCBI
POT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7124,822,386 - 124,929,983 (-)EnsemblGRCh38hg38GRCh38
GRCh387124,822,386 - 124,929,825 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377124,462,440 - 124,569,879 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367124,249,676 - 124,357,273 (-)NCBINCBI36hg18NCBI36
Build 347124,057,263 - 124,131,201NCBI
Celera7119,267,687 - 119,375,230 (-)NCBI
Cytogenetic Map7q31.33NCBI
HuRef7118,827,419 - 118,935,017 (-)NCBIHuRef
CHM1_17124,395,753 - 124,503,350 (-)NCBICHM1_1
CRA_TCAGchr7v27123,851,834 - 123,959,412 (-)NCBI
Pot1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39625,743,939 - 25,809,280 (-)NCBIGRCm39mm39
GRCm39 Ensembl625,743,736 - 25,809,245 (-)Ensembl
GRCm38625,743,940 - 25,809,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl625,743,737 - 25,809,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv37625,693,735 - 25,759,226 (-)NCBIGRCm37mm9NCBIm37
MGSCv36625,693,745 - 25,759,236 (-)NCBImm8
Celera625,744,313 - 25,810,007 (-)NCBICelera
Cytogenetic Map6A3.1NCBI
Pot1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2454,205,330 - 54,263,137 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl454,205,332 - 54,263,042 (-)Ensembl
Rnor_6.0451,888,632 - 51,946,764 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl451,888,634 - 51,946,715 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0451,664,672 - 51,722,749 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4452,233,404 - 52,289,574 (-)NCBIRGSC3.4rn4RGSC3.4
Celera449,343,691 - 49,398,232 (-)NCBICelera
Cytogenetic Map4q22NCBI
Pot1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554796,140,501 - 6,209,031 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554796,140,599 - 6,230,512 (-)NCBIChiLan1.0ChiLan1.0
POT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17129,487,571 - 129,605,558 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7129,487,571 - 129,605,558 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v07116,807,913 - 116,926,998 (-)NCBIMhudiblu_PPA_v0panPan3
Pot1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511851,284,826 - 51,367,106 (-)NCBI
SpeTri2.0NW_004936605836,824 - 919,099 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1822,827,029 - 22,981,890 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11822,885,704 - 22,981,893 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21824,394,687 - 24,526,564 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12193,572,139 - 93,688,374 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl2193,571,272 - 93,655,869 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660429,761,660 - 9,885,572 (+)NCBIVero_WHO_p1.0
Pot1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478311,138,222 - 11,223,329 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 8 4 8
Low 5 5 14 6 6 6 6 6 8 8 2 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005628437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005628439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005628440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022427281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000002746   ⟹   ENSCAFP00000002549
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1410,987,494 - 11,066,956 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000062245   ⟹   ENSCAFP00000059365
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1410,987,494 - 11,066,956 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000080986   ⟹   ENSCAFP00000057529
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1411,011,625 - 11,066,956 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000082826   ⟹   ENSCAFP00000059682
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1410,988,229 - 11,066,956 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000086242   ⟹   ENSCAFP00000056356
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1411,000,634 - 11,066,956 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000087472   ⟹   ENSCAFP00000043864
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1411,000,634 - 11,066,956 (+)Ensembl
RefSeq Acc Id: XM_005628437   ⟹   XP_005628494
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11410,987,434 - 11,067,473 (+)NCBI
Dog10K_Boxer_Tasha1410,684,075 - 10,766,907 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005628439   ⟹   XP_005628496
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11410,987,386 - 11,067,473 (+)NCBI
Dog10K_Boxer_Tasha1410,683,957 - 10,766,907 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005628440   ⟹   XP_005628497
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11410,987,385 - 11,067,473 (+)NCBI
Dog10K_Boxer_Tasha1410,684,032 - 10,766,907 (+)NCBI
Sequence:
RefSeq Acc Id: XM_022427281   ⟹   XP_022282989
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11410,987,434 - 11,067,473 (+)NCBI
Dog10K_Boxer_Tasha1410,684,075 - 10,766,907 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038494334   ⟹   XP_038350262
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11410,960,951 - 11,041,479 (+)NCBI
RefSeq Acc Id: XM_038494335   ⟹   XP_038350263
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11410,960,951 - 11,041,479 (+)NCBI
RefSeq Acc Id: XM_038494336   ⟹   XP_038350264
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11410,960,833 - 11,041,479 (+)NCBI
RefSeq Acc Id: XM_038494337   ⟹   XP_038350265
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11410,960,908 - 11,041,479 (+)NCBI
RefSeq Acc Id: XM_038556632   ⟹   XP_038412560
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01410,852,817 - 10,933,293 (+)NCBI
RefSeq Acc Id: XM_038556633   ⟹   XP_038412561
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01410,852,817 - 10,933,293 (+)NCBI
RefSeq Acc Id: XM_038556634   ⟹   XP_038412562
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01410,852,699 - 10,933,293 (+)NCBI
RefSeq Acc Id: XM_038556635   ⟹   XP_038412563
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01410,852,774 - 10,933,293 (+)NCBI
RefSeq Acc Id: XM_038620561   ⟹   XP_038476489
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01410,693,751 - 10,773,611 (+)NCBI
RefSeq Acc Id: XM_038620562   ⟹   XP_038476490
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01410,693,751 - 10,773,611 (+)NCBI
RefSeq Acc Id: XM_038620563   ⟹   XP_038476491
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01410,693,633 - 10,773,611 (+)NCBI
RefSeq Acc Id: XM_038620564   ⟹   XP_038476492
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01410,693,708 - 10,773,611 (+)NCBI
RefSeq Acc Id: XM_038686251   ⟹   XP_038542179
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01410,769,501 - 10,849,644 (+)NCBI
RefSeq Acc Id: XM_038686252   ⟹   XP_038542180
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01410,769,501 - 10,849,644 (+)NCBI
RefSeq Acc Id: XM_038686253   ⟹   XP_038542181
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01410,769,382 - 10,849,644 (+)NCBI
RefSeq Acc Id: XM_038686254   ⟹   XP_038542182
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01410,769,457 - 10,849,644 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005628494   ⟸   XM_005628437
- UniProtKB: F1P716 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005628496   ⟸   XM_005628439
- UniProtKB: F1P716 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005628497   ⟸   XM_005628440
- UniProtKB: F1P716 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022282989   ⟸   XM_022427281
- Sequence:
RefSeq Acc Id: ENSCAFP00000043864   ⟸   ENSCAFT00000087472
RefSeq Acc Id: ENSCAFP00000056356   ⟸   ENSCAFT00000086242
RefSeq Acc Id: ENSCAFP00000059365   ⟸   ENSCAFT00000062245
RefSeq Acc Id: ENSCAFP00000059682   ⟸   ENSCAFT00000082826
RefSeq Acc Id: ENSCAFP00000057529   ⟸   ENSCAFT00000080986
RefSeq Acc Id: ENSCAFP00000002549   ⟸   ENSCAFT00000002746
RefSeq Acc Id: XP_038350264   ⟸   XM_038494336
RefSeq Acc Id: XP_038350265   ⟸   XM_038494337
RefSeq Acc Id: XP_038350262   ⟸   XM_038494334
RefSeq Acc Id: XP_038350263   ⟸   XM_038494335
RefSeq Acc Id: XP_038476491   ⟸   XM_038620563
RefSeq Acc Id: XP_038476492   ⟸   XM_038620564
RefSeq Acc Id: XP_038476489   ⟸   XM_038620561
RefSeq Acc Id: XP_038476490   ⟸   XM_038620562
RefSeq Acc Id: XP_038542181   ⟸   XM_038686253
RefSeq Acc Id: XP_038542182   ⟸   XM_038686254
RefSeq Acc Id: XP_038542179   ⟸   XM_038686251
RefSeq Acc Id: XP_038542180   ⟸   XM_038686252
RefSeq Acc Id: XP_038412562   ⟸   XM_038556634
RefSeq Acc Id: XP_038412563   ⟸   XM_038556635
RefSeq Acc Id: XP_038412560   ⟸   XM_038556632
RefSeq Acc Id: XP_038412561   ⟸   XM_038556633

Promoters
RGD ID:13685719
Promoter ID:EPDNEW_C3787
Type:multiple initiation site
Name:POT1_1
Description:protection of telomeres 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11410,987,418 - 10,987,478EPDNEW
Damaging Variants


Assembly: CanFam3.1

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
14 11037774 11037775 T G snv German Shepherd (GS6), Chinese indigenous dogs (LJ2), West Highland White Terrier (WW64), Iranian Wolf (SRS661488), Tibetan Mastiff (TM10)
14 11056588 11056589 C T snv Basenji (BJ003)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001754 Ensembl
NCBI Gene POT1 ENTREZGENE
UniProt F1P716 ENTREZGENE
VGNC ID VGNC:44823 ENTREZGENE