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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncaincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of SNCA mRNAPMID:23353026
Sncamultiple interactionsEXP 6480464CTDHydrogen Peroxide promotes the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]PMID:23353026
Sncaaffects response to substanceISOSNCA (Homo sapiens)6480464CTDSNCA protein affects the susceptibility to Hydrogen PeroxidePMID:22319455
Sncaincreases expressionISOSNCA (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of SNCA mRNA alternative formPMID:19857570
Sncaincreases response to substanceISOSNCA (Homo sapiens)6480464CTDSNCA gene mutant form results in increased susceptibility to Hydrogen PeroxidePMID:24290359
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTD[SNCA gene mutant form results in increased susceptibility to Hydrogen Peroxide] which results in increased metabolism of MEF2C proteinPMID:24290359
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