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Strain Registration

Strain: Iusm:NP

Symbol: Iusm:NP
Strain: NP
Substrain: Iusm
Full Name: alcohol-nonpreferring
RGD ID: 1641873
Citation ID: RRID:RGD_1641873
Ontology ID: RS:0001375
Alleles: Snca
Also Known As: iNP; NP/Iusm
Type: outbred
Available Source: Not Available
Origination: Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana
Description: These were developed at Indiana University for alcohol-preferring behavior through bidirectional selective breeding of Wistar rats from the Walter Reed Army Institute of Research, Washington, DC. A single pair of rats with high preference and another pair with low preference were mated to develop a preference line (Iusm:P, RGD:1641867) and this non-preference line (Iusm:NP).
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Identification of Candidate Genes for Alcohol Preference by Expression Profiling of Congenic Rat Strains. Carr LG, etal., Alcohol Clin Exp Res. 2007 Apr 19;.
2. Development of Congenic Rat Strains for Alcohol Consumption Derived from the Alcohol-Preferring and Nonpreferring Rats. Carr LG, etal., Behav Genet. 2006 Feb 10;:1-6.
3. Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats. Li TK and Lumeng L, Alcohol Clin Exp Res. 1984 Sep-Oct;8(5):485-6. doi: 10.1111/j.1530-0277.1984.tb05708.x.
4. Selective breeding for alcohol preference and associated responses. Li TK, etal., Behav Genet 1993 Mar;23(2):163-70.
5. alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats. Liang T, etal., Proc Natl Acad Sci U S A 2003 Apr 15;100(8):4690-5.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2. Spence JP, etal., Alcohol. 2013 Feb;47(1):63-7. doi: 10.1016/j.alcohol.2012.10.005.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics These have low voluntary oral consumption of alcohol which results in low blood alcohol. 631849

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-03-08 Iusm:NP  alcohol-nonpreferring  NP/Iusm  alcohol-nonpreferring  Symbol and/or name change 68913 APPROVED