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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncaincreases abundanceISOSNCA (Homo sapiens)6480464CTDSNCA protein results in increased abundance of Reactive Oxygen SpeciesPMID:27424009
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTDferrous sulfate promotes the reaction [SNCA protein results in increased abundance of Reactive Oxygen Species]; SNCA gene inhibits the reaction [DJR-1.1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]; SNCA gene inhibits the reaction [PDR-1 mutant form promotes the reaction [manganese chloride results in increased abundance of Reactive Oxygen Species]]PMID:24452053 PMID:27424009
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