RGD Reference Report - Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells. - Rat Genome Database

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Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells.

Authors: Mori, F  Inenaga, C  Yoshimoto, M  Umezu, H  Tanaka, R  Takahashi, H  Wakabayashi, K 
Citation: Mori F, etal., Acta Neuropathol. 2002 Feb;103(2):145-51. Epub 2001 Oct 18.
RGD ID: 6218996
Pubmed: PMID:11810180   (View Abstract at PubMed)
DOI: DOI:10.1007/s004010100443   (Journal Full-text)

Alpha-synuclein is known to play an important role in several neurodegenerative diseases. Moreover, it is expressed in central nervous system neuronal tumors, and another member of the synuclein family, gamma-synuclein, is overexpressed in breast and ovarian carcinomas. However, the expression of alpha-synuclein has not been reported hitherto in the peripheral nervous system (PNS). In the present study, we investigated normal PNS tissue and schwannomas in human postmortem and biopsy samples using both immunocytochemistry and immunoelectron microscopy with antibodies against alpha-, beta- and gamma-synuclein. In normal PNS tissue, Schwann cells, but not axons or myelin, were immunopositive for alpha-synuclein. In schwannomas, almost all of the tumor cells showed diffuse cytoplasmic staining for alpha-synuclein (30 cases). Ultrastructurally, alpha-synuclein immunoreactivity was found in the cytoplasm of normal and neoplastic Schwann cells, in association with the plasma membrane, ribosomes, rough endoplasmic reticulum, small vesicles, Golgi apparatus and the nuclear outer membrane. No beta- or gamma-synuclein immunoreactivity was found in those cells. These results indicate that in the PNS, alpha-synuclein is a useful marker of Schwann cells and that it is not involved in tumorigenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SNCAHumanneurilemmoma  ISOSnca (Rattus norvegicus)protein:increased expression:cytoplasmRGD 
SncaRatneurilemmoma  IEP protein:increased expression:cytoplasmRGD 
SncaMouseneurilemmoma  ISOSnca (Rattus norvegicus)protein:increased expression:cytoplasmRGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SncaRatnuclear outer membrane  IDA  RGD 
SncaRatribosome  IDA  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Snca  (synuclein alpha)

Genes (Mus musculus)
Snca  (synuclein, alpha)

Genes (Homo sapiens)
SNCA  (synuclein alpha)


Additional Information