SNCA (synuclein alpha) - Rat Genome Database

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Pathways
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Advanced Search (OLGA)
Gene: SNCA (synuclein alpha) Chlorocebus sabaeus
Analyze
Symbol: SNCA
Name: synuclein alpha
RGD ID: 18728644
Description: ENCODES a protein that exhibits beta-tubulin binding (ortholog); enzyme binding (ortholog); fatty acid binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); amyloid fibril formation (ortholog); behavioral response to cocaine (ortholog); PARTICIPATES IN apoptotic cell death pathway; Parkinson's disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN axon terminus (ortholog); cytoplasmic vesicle membrane (ortholog); growth cone (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: alpha-synuclein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1738,083,154 - 38,194,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl738,081,509 - 38,191,479 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
adult locomotory behavior  (IEA,ISO)
amyloid fibril formation  (ISO)
behavioral response to cocaine  (ISO)
calcium ion homeostasis  (ISO)
cellular response to copper ion  (IEA)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to oxidative stress  (IEA,ISO)
chemical synaptic transmission  (IEA,ISO)
dopamine biosynthetic process  (IEA,ISO)
dopamine metabolic process  (IEA,ISO)
excitatory postsynaptic potential  (IEA,ISO)
fatty acid metabolic process  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
membrane organization  (IEA,ISO)
microglial cell activation  (IEA,ISO)
mitochondrial ATP synthesis coupled electron transport  (IEA,ISO)
mitochondrial membrane organization  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of chaperone-mediated autophagy  (IEA)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
negative regulation of dopamine metabolic process  (ISO)
negative regulation of dopamine uptake involved in synaptic transmission  (IEA)
negative regulation of exocytosis  (IEA)
negative regulation of microtubule polymerization  (IEA)
negative regulation of monooxygenase activity  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of norepinephrine uptake  (IEA)
negative regulation of platelet-derived growth factor receptor signaling pathway  (IEA)
negative regulation of protein phosphorylation  (ISO)
negative regulation of serotonin uptake  (IEA)
negative regulation of thrombin-activated receptor signaling pathway  (IEA)
negative regulation of transporter activity  (IEA)
neuron apoptotic process  (IEA,ISO)
neurotransmitter secretion  (IEA,ISO)
neutral lipid metabolic process  (IEA,ISO)
phospholipid metabolic process  (IEA,ISO)
positive regulation of endocytosis  (IEA)
positive regulation of exocytosis  (IEA)
positive regulation of glutathione peroxidase activity  (IEA)
positive regulation of hydrogen peroxide catabolic process  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of inositol phosphate biosynthetic process  (IEA)
positive regulation of neurotransmitter secretion  (IEA,ISO)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of protein localization to cell periphery  (IEA)
positive regulation of protein serine/threonine kinase activity  (IEA)
positive regulation of receptor recycling  (IEA)
positive regulation of release of sequestered calcium ion into cytosol  (IEA)
positive regulation of SNARE complex assembly  (IEA)
positive regulation of synaptic transmission  (IEA,ISO)
protein complex oligomerization  (IEA)
protein destabilization  (IEA)
protein tetramerization  (IEA)
receptor internalization  (IEA)
regulation of acyl-CoA biosynthetic process  (IEA,ISO)
regulation of dopamine secretion  (IEA,ISO)
regulation of glutamate secretion  (IEA,ISO)
regulation of locomotion  (IEA,ISO)
regulation of long-term neuronal synaptic plasticity  (IEA,ISO)
regulation of macrophage activation  (IEA,ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neuronal synaptic plasticity  (IEA,ISO)
regulation of neurotransmitter secretion  (IEA,ISO)
regulation of norepinephrine uptake  (IEA)
regulation of phospholipase activity  (IEA)
regulation of presynapse assembly  (IEA)
regulation of reactive oxygen species metabolic process  (IEA)
regulation of transmembrane transporter activity  (IEA)
response to cocaine  (ISO)
response to desipramine  (ISO)
response to interleukin-1  (IEA)
response to iron(II) ion  (IEA)
response to lipopolysaccharide  (IEA)
response to magnesium ion  (IEA)
response to type II interferon  (IEA)
response to xenobiotic stimulus  (IEA,ISO)
SNARE complex assembly  (IEA)
synapse organization  (IEA,ISO)
synaptic transmission, dopaminergic  (IEA,ISO)
synaptic vesicle endocytosis  (IEA)
synaptic vesicle exocytosis  (IEA)
synaptic vesicle priming  (IEA)
synaptic vesicle transport  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SNCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1738,083,154 - 38,194,068 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl738,081,509 - 38,191,479 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,841 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SNCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38489,724,099 - 89,838,304 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl489,700,345 - 89,838,315 (-)EnsemblGRCh38hg38GRCh38
GRCh37490,645,250 - 90,759,455 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36490,865,728 - 90,977,156 (-)NCBINCBI36Build 36hg18NCBI36
Build 34491,004,212 - 91,114,009NCBI
Celera487,942,196 - 88,056,576 (-)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef486,396,384 - 86,510,518 (-)NCBIHuRef
CHM1_1490,621,712 - 90,735,909 (-)NCBICHM1_1
T2T-CHM13v2.0493,055,378 - 93,169,553 (-)NCBIT2T-CHM13v2.0
Snca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39660,708,557 - 60,806,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl660,708,559 - 60,806,839 (-)EnsemblGRCm39 Ensembl
GRCm38660,731,573 - 60,829,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl660,731,575 - 60,829,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv37660,681,567 - 60,779,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36660,661,161 - 60,759,433 (-)NCBIMGSCv36mm8
Celera662,883,898 - 62,982,187 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map629.15NCBI
Snca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8491,026,474 - 91,127,444 (-)NCBIGRCr8
mRatBN7.2489,696,420 - 89,797,240 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl489,696,420 - 89,796,262 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx494,908,873 - 95,008,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0490,684,174 - 90,784,124 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0489,081,018 - 89,195,868 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0490,782,412 - 90,883,236 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl490,782,374 - 90,882,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04155,592,411 - 155,690,724 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4489,613,731 - 89,722,807 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1489,858,155 - 89,967,232 (-)NCBI
Celera484,478,545 - 84,578,894 (-)NCBICelera
Cytogenetic Map4q24NCBI
Snca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955405853,946 - 965,403 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955405854,011 - 962,741 (-)NCBIChiLan1.0ChiLan1.0
SNCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2387,735,233 - 87,847,648 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1487,997,402 - 88,109,710 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0482,018,585 - 82,132,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1492,737,608 - 92,851,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl492,737,608 - 92,850,600 (-)Ensemblpanpan1.1panPan2
SNCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13212,915,871 - 13,079,338 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3212,916,215 - 13,060,383 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3228,876,711 - 29,040,565 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03212,968,680 - 13,133,813 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3212,966,388 - 13,113,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13213,053,952 - 13,218,226 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03212,876,233 - 13,041,037 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03226,872,693 - 27,039,258 (+)NCBIUU_Cfam_GSD_1.0
Snca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530128,380,373 - 28,478,711 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366852,076,651 - 2,175,338 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366852,077,017 - 2,175,298 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8129,248,819 - 129,271,128 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18129,247,724 - 129,388,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28138,635,406 - 138,774,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Snca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475717,392,998 - 17,528,320 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475717,393,046 - 17,528,783 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007999261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999265 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_007999271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037989925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037989930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037989938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037989943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_037989947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCSAT00000002253   ⟹   ENSCSAP00000000583
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl738,081,509 - 38,191,479 (-)Ensembl
RefSeq Acc Id: XM_007999262   ⟹   XP_007997453
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1738,083,154 - 38,192,938 (-)NCBI
Vero_WHO_p1.0NW_02366603716,869,729 - 16,979,963 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007999263   ⟹   XP_007997454
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1738,083,154 - 38,192,983 (-)NCBI
Vero_WHO_p1.0NW_02366603716,869,729 - 16,979,968 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007999264   ⟹   XP_007997455
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1738,083,154 - 38,194,068 (-)NCBI
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,815 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007999265   ⟹   XP_007997456
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1738,083,154 - 38,193,987 (-)NCBI
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,668 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007999268   ⟹   XP_007997459
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1738,083,154 - 38,192,932 (-)NCBI
Vero_WHO_p1.0NW_02366603716,869,729 - 16,979,753 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007999269   ⟹   XP_007997460
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1738,083,154 - 38,192,983 (-)NCBI
Vero_WHO_p1.0NW_02366603716,869,729 - 16,979,944 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037989925   ⟹   XP_037845853
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,837 (-)NCBI
RefSeq Acc Id: XM_037989930   ⟹   XP_037845858
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603716,869,729 - 16,979,027 (-)NCBI
RefSeq Acc Id: XM_037989938   ⟹   XP_037845866
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,841 (-)NCBI
RefSeq Acc Id: XM_037989943   ⟹   XP_037845871
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603716,869,729 - 16,980,666 (-)NCBI
RefSeq Acc Id: XM_037989947   ⟹   XP_037845875
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366603716,869,729 - 16,916,564 (-)NCBI
RefSeq Acc Id: XP_007997455   ⟸   XM_007999264
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007997456   ⟸   XM_007999265
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007997460   ⟸   XM_007999269
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QW44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007997454   ⟸   XM_007999263
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007997453   ⟸   XM_007999262
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007997459   ⟸   XM_007999268
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QW44 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000000583   ⟸   ENSCSAT00000002253
RefSeq Acc Id: XP_037845866   ⟸   XM_037989938
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QW44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037845853   ⟸   XM_037989925
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037845871   ⟸   XM_037989943
- Peptide Label: isoform X2
- UniProtKB: A0A0D9QW44 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037845858   ⟸   XM_037989930
- Peptide Label: isoform X1
RefSeq Acc Id: XP_037845875   ⟸   XM_037989947
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000004228 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000002253.1 UniProtKB/TrEMBL
Gene3D-CATH Helix hairpin bin UniProtKB/TrEMBL
InterPro Synuclein UniProtKB/TrEMBL
  Synuclein_alpha UniProtKB/TrEMBL
NCBI Gene SNCA ENTREZGENE
PANTHER PTHR13820 UniProtKB/TrEMBL
  PTHR13820:SF5 UniProtKB/TrEMBL
Pfam Synuclein UniProtKB/TrEMBL
PRINTS ASYNUCLEIN UniProtKB/TrEMBL
  SYNUCLEIN UniProtKB/TrEMBL
Superfamily-SCOP Synuclein UniProtKB/TrEMBL
UniProt A0A0D9QW44 ENTREZGENE, UniProtKB/TrEMBL