SNCA (synuclein alpha) - Rat Genome Database
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Gene: SNCA (synuclein alpha) Pan paniscus
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Symbol: SNCA
Name: synuclein alpha
RGD ID: 11670181
Description: ENCODES a protein that exhibits actin binding (ortholog); alpha-tubulin binding (ortholog); arachidonic acid binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); adult locomotory behavior (ortholog); aging (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Alzheimer's disease (ortholog); amphetamine abuse (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); axon terminus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: alpha-synuclein
Orthologs:
Homo sapiens (human) : SNCA (synuclein alpha)  HGNC  Alliance
Mus musculus (house mouse) : Snca (synuclein, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Snca (synuclein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Snca (synuclein alpha)
Canis lupus familiaris (dog) : SNCA (synuclein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Snca (synuclein alpha)
Sus scrofa (pig) : SNCA (synuclein alpha)
Chlorocebus sabaeus (African green monkey) : SNCA (synuclein alpha)
Heterocephalus glaber (naked mole-rat) : Snca (synuclein alpha)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1492,737,608 - 92,851,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl492,737,608 - 92,850,600 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0482,018,585 - 82,132,938 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
adult locomotory behavior  (ISO)
aging  (ISO)
behavioral response to cocaine  (ISO)
calcium ion homeostasis  (ISO)
cellular response to copper ion  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to oxidative stress  (ISO)
chemical synaptic transmission  (ISO)
dopamine biosynthetic process  (ISO)
dopamine metabolic process  (ISO)
excitatory postsynaptic potential  (ISO)
fatty acid metabolic process  (ISO)
long-term synaptic potentiation  (ISO)
membrane organization  (ISO)
microglial cell activation  (ISO)
mitochondrial ATP synthesis coupled electron transport  (ISO)
mitochondrial membrane organization  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of chaperone-mediated autophagy  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
negative regulation of dopamine metabolic process  (ISO)
negative regulation of dopamine uptake involved in synaptic transmission  (ISO)
negative regulation of exocytosis  (ISO)
negative regulation of histone acetylation  (ISO)
negative regulation of microtubule polymerization  (ISO)
negative regulation of monooxygenase activity  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron death  (ISO)
negative regulation of norepinephrine uptake  (ISO)
negative regulation of platelet-derived growth factor receptor signaling pathway  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of serotonin uptake  (ISO)
negative regulation of thrombin-activated receptor signaling pathway  (ISO)
negative regulation of transporter activity  (ISO)
neutral lipid metabolic process  (ISO)
oxidation-reduction process  (ISO)
phospholipid metabolic process  (ISO)
positive regulation of endocytosis  (ISO)
positive regulation of exocytosis  (ISO)
positive regulation of glutathione peroxidase activity  (ISO)
positive regulation of hydrogen peroxide catabolic process  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of inositol phosphate biosynthetic process  (ISO)
positive regulation of neuron death  (ISO)
positive regulation of neurotransmitter secretion  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of receptor recycling  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
positive regulation of SNARE complex assembly  (ISO)
positive regulation of synaptic transmission  (ISO)
protein complex oligomerization  (ISO)
protein destabilization  (ISO)
protein tetramerization  (ISO)
receptor internalization  (ISO)
regulation of acyl-CoA biosynthetic process  (ISO)
regulation of dopamine secretion  (ISO)
regulation of glutamate secretion  (ISO)
regulation of locomotion  (ISO)
regulation of long-term neuronal synaptic plasticity  (ISO)
regulation of macrophage activation  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of neuron death  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neurotransmitter secretion  (ISO)
regulation of norepinephrine uptake  (ISO)
regulation of phospholipase activity  (ISO)
regulation of presynapse assembly  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
regulation of transmembrane transporter activity  (ISO)
response to cocaine  (ISO)
response to desipramine  (ISO)
response to drug  (ISO)
response to interferon-gamma  (ISO)
response to interleukin-1  (ISO)
response to iron(II) ion  (ISO)
response to lipopolysaccharide  (ISO)
response to magnesium ion  (ISO)
SNARE complex assembly  (ISO)
synapse organization  (ISO)
synaptic transmission, dopaminergic  (ISO)
synaptic vesicle endocytosis  (ISO)
synaptic vesicle exocytosis  (ISO)
synaptic vesicle priming  (ISO)
synaptic vesicle transport  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:15028296  


Genomics

Comparative Map Data
SNCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1492,737,608 - 92,851,720 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl492,737,608 - 92,850,600 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0482,018,585 - 82,132,938 (-)NCBIMhudiblu_PPA_v0panPan3
SNCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl489,700,345 - 89,838,315 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl489,724,099 - 89,838,315 (-)EnsemblGRCh38hg38GRCh38
GRCh38489,724,099 - 89,838,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37490,645,250 - 90,759,447 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36490,865,728 - 90,977,156 (-)NCBINCBI36hg18NCBI36
Build 34491,004,212 - 91,114,009NCBI
Celera487,942,196 - 88,056,576 (-)NCBI
Cytogenetic Map4q22.1NCBI
HuRef486,396,384 - 86,510,518 (-)NCBIHuRef
CHM1_1490,621,712 - 90,735,909 (-)NCBICHM1_1
Snca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39660,708,557 - 60,806,839 (-)NCBI
GRCm38660,731,573 - 60,829,855 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl660,731,575 - 60,829,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv37660,681,567 - 60,779,849 (-)NCBIGRCm37mm9NCBIm37
MGSCv36660,661,161 - 60,759,433 (-)NCBImm8
Celera662,883,898 - 62,982,187 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map629.15NCBI
Snca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0490,782,412 - 90,883,236 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl490,782,374 - 90,882,285 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04155,592,411 - 155,690,724 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4489,613,731 - 89,722,807 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1489,858,155 - 89,967,232 (-)NCBI
Celera484,478,545 - 84,578,894 (-)NCBICelera
Cytogenetic Map4q24NCBI
Snca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955405853,946 - 965,403 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955405854,011 - 962,741 (-)NCBIChiLan1.0ChiLan1.0
SNCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3212,916,215 - 13,060,383 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13212,915,871 - 13,079,338 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Snca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366852,077,017 - 2,175,298 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8129,248,819 - 129,388,307 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18129,247,724 - 129,388,307 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28138,635,406 - 138,774,240 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNCA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl738,081,509 - 38,191,479 (-)Ensembl
ChlSab1.1738,083,154 - 38,194,068 (-)NCBI
Snca
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475717,393,046 - 17,528,783 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000027770   ⟹   ENSPPAP00000006465
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl492,737,608 - 92,850,600 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000027781   ⟹   ENSPPAP00000006467
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl492,740,129 - 92,849,079 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000027784   ⟹   ENSPPAP00000006468
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl492,835,167 - 92,849,079 (-)Ensembl
RefSeq Acc Id: XM_003829888   ⟹   XP_003829936
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1492,737,608 - 92,850,632 (-)NCBI
Mhudiblu_PPA_v0482,018,587 - 82,131,740 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829889   ⟹   XP_003829937
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1492,739,554 - 92,850,577 (-)NCBI
Mhudiblu_PPA_v0482,018,587 - 82,131,742 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829890   ⟹   XP_003829938
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1492,739,554 - 92,851,720 (-)NCBI
Mhudiblu_PPA_v0482,018,587 - 82,132,938 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008955294   ⟹   XP_008953542
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1492,737,608 - 92,849,620 (-)NCBI
Mhudiblu_PPA_v0482,018,585 - 82,130,827 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034958917   ⟹   XP_034814808
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0482,018,585 - 82,131,102 (-)NCBI
RefSeq Acc Id: XM_034958918   ⟹   XP_034814809
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0482,018,587 - 82,131,770 (-)NCBI
RefSeq Acc Id: XM_034958919   ⟹   XP_034814810
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0482,018,585 - 82,131,552 (-)NCBI
RefSeq Acc Id: XM_034958920   ⟹   XP_034814811
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0482,018,587 - 82,132,938 (-)NCBI
RefSeq Acc Id: XM_034958921   ⟹   XP_034814812
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0482,018,585 - 82,130,840 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_003829936   ⟸   XM_003829888
- Peptide Label: isoform X1
- UniProtKB: P61144 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008953542   ⟸   XM_008955294
- Peptide Label: isoform X1
- UniProtKB: P61144 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_003829938   ⟸   XM_003829890
- Peptide Label: isoform X1
- UniProtKB: P61144 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_003829937   ⟸   XM_003829889
- Peptide Label: isoform X1
- UniProtKB: P61144 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_034814810   ⟸   XM_034958919
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034814808   ⟸   XM_034958917
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034814812   ⟸   XM_034958921
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034814811   ⟸   XM_034958920
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034814809   ⟸   XM_034958918
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000006467   ⟸   ENSPPAT00000027781
RefSeq Acc Id: ENSPPAP00000006468   ⟸   ENSPPAT00000027784
RefSeq Acc Id: ENSPPAP00000006465   ⟸   ENSPPAT00000027770


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000025110 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000006465 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSPPAP00000006467 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000006468 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000027770 UniProtKB/Swiss-Prot
  ENSPPAT00000027781 UniProtKB/TrEMBL
  ENSPPAT00000027784 UniProtKB/TrEMBL
InterPro Synuclein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Synuclein_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report pps:100984304 UniProtKB/Swiss-Prot
NCBI Gene SNCA ENTREZGENE
PANTHER PTHR13820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR13820:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Synuclein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS ASYNUCLEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SYNUCLEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8ZRD1_PANPA UniProtKB/TrEMBL
  A0A2R8ZUB9_PANPA UniProtKB/TrEMBL
  P61144 ENTREZGENE, UniProtKB/Swiss-Prot