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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3729
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Snca
Name: synuclein alpha
Acc ID: CHEBI:82664
Term: iron(0)
Definition: An elemental iron in which the atom has an oxidation state of zero.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sncaaffects localizationISOSNCA (Homo sapiens)6480464CTDIron affects the localization of SNCA proteinPMID:12401952
Sncaincreases response to substanceISOSNCA (Homo sapiens)6480464CTDSNCA protein mutant form results in increased susceptibility to IronPMID:14535945
Sncamultiple interactionsISOSNCA (Homo sapiens)6480464CTDCytarabine promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]; Hydroxyurea promotes the reaction [SNCA protein mutant form results in increased susceptibility to Iron]; SNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Iron]PMID:14535945 PMID:27324791
Sncamultiple interactionsISOSnca (Mus musculus)6480464CTDEUK-189 results in decreased susceptibility to [Iron co-treated with Paraquat co-treated with SNCA gene mutant form]PMID:21039522
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