Iddm1 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Iddm1 (Insulin dependent diabetes mellitus QTL 1) Rattus norvegicus

Symbol: Iddm1
Name: Insulin dependent diabetes mellitus QTL 1
RGD ID: 61365
Previously known as: Iddm2
Trait: blood glucose amount   (VT:0000188)    
Measurement Type: blood glucose level   (CMO:0000046)    
LOD Score: 3.54
P Value: 0.001
Variance: Not Available
Position No map positions available.
Cross Type: F2
Strains Crossed: BBDP/Rhw LEW 



Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
BBDP/Rhw  (IEA)
LEW  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
2. Genetic dissection of autoimmune type I diabetes in the BB rat Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
Related QTLs

Related QTL Description Reference
Iddm2 interacts with RGD:61075


Region

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch

Additional Information

Database Acc Id Source(s)
NCBI Gene Iddm1


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-28 Iddm1  Insulin dependent diabetes mellitus QTL 1  Iddm1  Insulin-dependent diabetes mellitus QTL 1  Name updated 68913 APPROVED
2001-01-19 Iddm1  Insulin-dependent diabetes mellitus QTL 1      QTL symbol assigned 61482 APPROVED
2001-01-19 Iddm2  Insulin-dependent diabetes mellitus QTL 2      QTL symbol reassigned 61482 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
qtl_disease u-haplotype from the BB strain is transferred to Buf and Long-Evans 61075
qtl_general linked to the MHC complex in a semidominant fashion, significant differences is observed in the pancreatic insulin content of the litters 61075
qtl_general in the cross between BB and Lewis the presence of one haplotype was noticed which demonstrated a significant condition for diabetis,several ratsof the backcross BB rats with Long-Evans have diabetes 631164