Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: BBDR/Rhw

Symbol: BBDR/Rhw
Strain: BBDR
Substrain: Rhw
RGD ID: 10003
Citation ID: RRID:RGD_10003
Ontology ID: RS:0000073
Type: inbred
Available Source: Not Available
Origination: R. H. William Laboratory, University of Washington, Seattle, Washington
Description: S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 +/- 53 days of age after the first and 67 +/- 10 days of age after the 9th cycle.
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene. Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
6. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
7. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
8. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
9. Genetic dissection of autoimmune type I diabetes in the BB rat Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
10. A genetic linkage map of rat chromosome 20 derived from five F2 crosses. Kawahito Y, etal., Immunogenetics 1998 Oct;48(5):335-8
11. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Klaff LS, etal., Mamm Genome 1999 Sep;10(9):883-7
12. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
13. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Martin AM, etal., Diabetes 1999 Nov;48(11):2138-44
14. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
15. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Cia13 Collagen induced arthritis QTL 13 joint integrity trait   (VT:0010548)    
Cia15 Collagen induced arthritis QTL 15 joint integrity trait   (VT:0010548)    
Cia16 Collagen induced arthritis QTL 16 joint integrity trait   (VT:0010548)    
Cia17 Collagen induced arthritis QTL 17 joint integrity trait   (VT:0010548)    
Cia18 Collagen induced arthritis QTL 18 joint integrity trait   (VT:0010548)    
Cia19 Collagen induced arthritis QTL 19 joint integrity trait   (VT:0010548)    
Cia6 Collagen induced arthritis QTL 6 joint integrity trait   (VT:0010548)    
Cia7 Collagen induced arthritis QTL 7 joint integrity trait   (VT:0010548)    
Ciaa4 CIA Autoantibody QTL 4 blood autoantibody amount   (VT:0003725)    
Ciaa5 CIA Autoantibody QTL 5 blood autoantibody amount   (VT:0003725)    
Iddm2 Insulin dependent diabetes mellitus QTL 2 blood glucose amount   (VT:0000188)    
Iddm3 Insulin dependent diabetes mellitus QTL 3 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain is Diabetic Resistant. 61032
strain_reproduction Average litter size at weaning 7.2 pups for the diabetic-resistant colonies. 61032

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-06 BBDR/Rhw    BBDR/Rhw    Name updated 68913 APPROVED
2010-09-20 BBDR/Rhw    BBDR/Rhw    Name updated 68913 APPROVED
2010-09-20 BBDR/Rhw    BBDR/Rhw    Name updated 68913 APPROVED