Strain Report - Rat Genome Database

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Strain: BBDR/Rhw

Symbol: BBDR/Rhw
Strain: BBDR
Substrain: Rhw
RGD ID: 10003
Citation ID: RRID:RGD_10003
Ontology ID: RS:0000073
Type: inbred
Source: R. H. William Laboratory, University of Washington, Seattle, Washington
Origin: S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 +/- 53 days of age after the first and 67 +/- 10 days of age after the 9th cycle.
Last Known Status: Unknown





References

References - curated
# Reference Title Reference Citation
1. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2. Spontaneous diabetes mellitus syndrome in the rat. I. Association with the major histocompatibility complex. Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3. Inbred Strains Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4. Update to previous Strain Data Festing, MFW, Personal Communication Update, Feb-2000
5. Genetic Dissection Reveals Diabetes Loci Proximal to the Gimap5 Lymphopenia Gene. Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
6. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
7. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
8. Identification of a new non-major histocompatibility complex genetic locus on chromosome 2 that controls disease severity in collagen-induced arthritis in rats. Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
9. Genetic dissection of autoimmune type I diabetes in the BB rat Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
10. A genetic linkage map of rat chromosome 20 derived from five F2 crosses. Kawahito Y, etal., Immunogenetics 1998 Oct;48(5):335-8
11. BB rat diabetes susceptibility and body weight regulation genes colocalize on chromosome 2. Klaff LS, etal., Mamm Genome 1999 Sep;10(9):883-7
12. Novel quantitative trait loci for blood pressure and related traits on rat chromosomes 1, 10, and 18. Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
13. Diabetes-prone and diabetes-resistant BB rats share a common major diabetes susceptibility locus, iddm4: additional evidence for a "universal autoimmunity locus" on rat chromosome 4. Martin AM, etal., Diabetes 1999 Nov;48(11):2138-44
14. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
15. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Cia13 Collagen induced arthritis QTL 13 joint integrity trait   (VT:0010548)    
Cia15 Collagen induced arthritis QTL 15 joint integrity trait   (VT:0010548)    
Cia16 Collagen induced arthritis QTL 16 joint integrity trait   (VT:0010548)    
Cia17 Collagen induced arthritis QTL 17 joint integrity trait   (VT:0010548)    
Cia18 Collagen induced arthritis QTL 18 joint integrity trait   (VT:0010548)    
Cia19 Collagen induced arthritis QTL 19 joint integrity trait   (VT:0010548)    
Cia6 Collagen induced arthritis QTL 6 joint integrity trait   (VT:0010548)    
Cia7 Collagen induced arthritis QTL 7 joint integrity trait   (VT:0010548)    
Ciaa4 CIA Autoantibody QTL 4 blood autoantibody amount   (VT:0003725)    
Ciaa5 CIA Autoantibody QTL 5 blood autoantibody amount   (VT:0003725)    
Iddm2 Insulin dependent diabetes mellitus QTL 2 blood glucose amount   (VT:0000188)    
Iddm3 Insulin dependent diabetes mellitus QTL 3 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics This strain is Diabetic Resistant. 61032
strain_reproduction Average litter size at weaning 7.2 pups for the diabetic-resistant colonies. 61032

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-06 BBDR/Rhw    BBDR/Rhw    Name updated 68913 APPROVED
2010-09-20 BBDR/Rhw    BBDR/Rhw    Name updated 68913 APPROVED
2010-09-20 BBDR/Rhw    BBDR/Rhw    Name updated 68913 APPROVED