Strain Report - Rat Genome Database

Name: BBDR/Rhw
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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General

Strain: BBDR/Rhw
Symbol:	BBDR/Rhw
Strain:	BBDR
Substrain:	Rhw
Ontology ID:	RS:0000073
Type:	inbred
Source:	R. H. William Laboratory, University of Washington, Seattle, Washington
Origin:	S. Bieg and coworkers (1998) generated a congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 +/- 53 days of age after the first and 67 +/- 10 days of age after the 9th cycle.
Last Known Status:	Unknown

Annotation (Toggle Annotation Detail/Summary View)

Phenotype Annotations

Mammalian Phenotype

Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
decreased susceptibility to autoimmune diabetes		IAGP		2306526	compared to BBDR.BBDP-(D4Rhw11-D4Rhw10)/Rhw	RGD
increased inflammatory response		QTM		61067		RGD

Phenotype Values via Phenominer

Related Phenotype Data for Term "BBDR/Rhw" (RS:0000073)

Rat Strains:

BBDR/Rhw

Clinical Measurements:

blood CD4 cell count to CD8 cell count ratio
blood CD4 cell to R73 cell ratio
blood CD8 cell count to R73 cell count ratio
blood R73 cell to total mononuclear cell ratio
calculated serum anti-rat type 2 collagen autoantibody titer
percentage of study population developing chronic experimental arthritis during a period of time
percentage of study population developing type 1 diabetes mellitus during a period of time
post-insult time to onset of diabetes mellitus

Experimental Conditions:

anti-RT6.1 antibody
Freund's incomplete adjuvant
Poly I:C
specific pathogen-free conditions
type II collagen

Measurement Methods:

blood glucose analysis
enzyme linked immunosorbent assay
fluorescence-activated cell sorting method
in vivo visual assessment

Phenotype Annotations

Mammalian Phenotype

decreased susceptibility to autoimmune diabetes (IAGP)

increased inflammatory response (QTM)

Experimental Data Annotations

Rat Strain

BBDR/Rhw (IEA)

Phenotype Values via Phenominer

Options:

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Clinical Measurement

blood CD4 cell count to CD8 cell count ratio

blood R73 cell to total mononuclear cell ratio

blood CD4 cell to R73 cell ratio

blood CD8 cell count to R73 cell count ratio

percentage of study population developing type 1 diabetes mellitus during a period of time

calculated serum anti-rat type 2 collagen autoantibody titer

percentage of study population developing chronic experimental arthritis during a period of time

post-insult time to onset of diabetes mellitus

References - curated

1.	Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2.	Colle E, etal., J Exp Med 1981 Oct 1;154(4):1237-42
3.	Festing, MFW, Inbred Strains, The Laboratory Rat, 1979, Baker HK, Lindsey JR, Weisbroth SH, 55-72, Academic Press
4.	Festing, MFW, Personal Communication Update, Feb-2000
5.	Fuller JM, etal., Physiol Genomics. 2009 Apr 7.
6.	Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
7.	Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
8.	Gulko PS, etal., Arthritis Rheum 1998 Dec;41(12):2122-31
9.	Jacob HJ, etal., Nat Genet 1992 Sep;2(1):56-60
10.	Kawahito Y, etal., Immunogenetics 1998 Oct;48(5):335-8
11.	Klaff LS, etal., Mamm Genome 1999 Sep;10(9):883-7
12.	Kovacs P, etal., Biochem Biophys Res Commun 1997 Jun 18;235(2):343-8
13.	Martin AM, etal., Diabetes 1999 Nov;48(11):2138-44
14.	Remmers EF, etal., Nat Genet 1996 Sep;14(1):82-5
15.	RGD Automated Pipelines

Region

Strain QTL Data

Symbol	Name	Trait
Cia13	Collagen induced arthritis QTL 13	joint integrity trait (VT:0010548)
Cia15	Collagen induced arthritis QTL 15	joint integrity trait (VT:0010548)
Cia16	Collagen induced arthritis QTL 16	joint integrity trait (VT:0010548)
Cia17	Collagen induced arthritis QTL 17	joint integrity trait (VT:0010548)
Cia18	Collagen induced arthritis QTL 18	joint integrity trait (VT:0010548)
Cia19	Collagen induced arthritis QTL 19	joint integrity trait (VT:0010548)
Cia6	Collagen induced arthritis QTL 6	joint integrity trait (VT:0010548)
Cia7	Collagen induced arthritis QTL 7	joint integrity trait (VT:0010548)
Ciaa4	CIA Autoantibody QTL 4	blood autoantibody amount (VT:0003725)
Ciaa5	CIA Autoantibody QTL 5	blood autoantibody amount (VT:0003725)
Iddm2	Insulin dependent diabetes mellitus QTL 2	blood glucose amount (VT:0000188)
Iddm3	Insulin dependent diabetes mellitus QTL 3	blood glucose amount (VT:0000188)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	This strain is Diabetic Resistant.	61032
strain_reproduction	Average litter size at weaning 7.2 pups for the diabetic-resistant colonies.	61032

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2012-04-06	BBDR/Rhw	BBDR/Rhw	Name updated	68913	APPROVED
2010-09-20	BBDR/Rhw	BBDR/Rhw	Name updated	68913	APPROVED
2010-09-20	BBDR/Rhw	BBDR/Rhw	Name updated	68913	APPROVED

More on this Strain
	Strain Nomenclature
	Strain Registration

RGD Object Information
RGD ID:	10003
Created:	2000-05-25
Species:	Rattus norvegicus
Last Modified:	2000-05-25
Status:	ACTIVE

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.

Strain: BBDR/Rhw

Related Phenotype Data for Term "BBDR/Rhw" (RS:0000073)