Aqp1 (aquaporin 1) - Rat Genome Database

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Gene: Aqp1 (aquaporin 1) Mus musculus
Symbol: Aqp1
Name: aquaporin 1
RGD ID: 10181
Description: Exhibits ephrin receptor binding activity; potassium ion transmembrane transporter activity; and water transmembrane transporter activity. Involved in several processes, including corticotropin secretion; glomerular filtration; and metanephros development. Localizes to several cellular components, including basolateral plasma membrane; extracellular exosome; and symbiont-containing vacuole. Predicted to colocalize with symbiont-containing vacuole membrane. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; sensory organ; and skeleton. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AQP-1; aquaporin-1; aquaporin-CHIP; CHIP; CHIP28; delayed early response protein 2; DER2; growth factor-induced delayed early response protein; water channel protein for red blood cells and kidney proximal tubule
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39655,313,284 - 55,325,540 (+)NCBIGRCm39mm39
GRCm39 Ensembl655,313,417 - 55,325,540 (+)Ensembl
GRCm38655,336,299 - 55,348,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,336,432 - 55,348,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv37655,286,293 - 55,298,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36655,266,010 - 55,278,133 (+)NCBImm8
Celera655,870,108 - 55,882,362 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (ISO)
1,1-dichloroethene  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-methoxy-17beta-estradiol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
acetazolamide  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
atrazine  (ISO)
benazepril  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
capsaicin  (EXP)
captan  (EXP)
carbon nanotube  (EXP)
chlorogenic acid  (ISO)
ciglitazone  (ISO)
clofibrate  (EXP)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cytarabine  (ISO)
D-glucose  (ISO)
Deoxycorticosterone acetate  (ISO)
dexamethasone  (EXP)
dextran sulfate  (EXP)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (EXP,ISO)
diprotium oxide  (EXP,ISO)
diuron  (ISO)
doxorubicin  (ISO)
etoposide  (EXP)
finasteride  (ISO)
flavonoids  (ISO)
flutamide  (ISO)
folpet  (EXP)
genistein  (ISO)
gentamycin  (ISO)
glucose  (ISO)
glycidol  (ISO)
GW 4064  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (ISO)
indometacin  (ISO)
iodide salt  (ISO)
kojic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP,ISO)
mercaptoethanol  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (ISO)
naringin  (EXP)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
ochratoxin A  (ISO)
Osajin  (ISO)
oxaliplatin  (ISO)
oxybenzone  (ISO)
ozone  (ISO)
p-chloromercuribenzenesulfonic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
PCB138  (EXP)
peptidoglycan  (ISO)
perchlorate  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
Pomiferin  (ISO)
potassium chloride  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
propiconazole  (EXP)
prostaglandin E2  (EXP)
puerarin  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
roflumilast  (ISO)
Rosavin  (ISO)
SB 203580  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
sodium arsenite  (EXP)
streptozocin  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetraethylammonium  (ISO)
tetrathiomolybdate(2-)  (ISO)
thioacetamide  (ISO)
thiourea  (ISO)
titanium dioxide  (EXP)
topotecan  (ISO)
triadimefon  (ISO)
triclosan  (ISO)
Triptolide  (ISO)
tungsten  (EXP)
urethane  (EXP)
valproic acid  (ISO)
valsartan  (ISO)
verapamil  (ISO)
vinclozolin  (ISO)
vitamin E  (ISO)
water  (EXP,ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ammonium transport  (ISO)
camera-type eye morphogenesis  (IMP)
carbon dioxide transmembrane transport  (IBA,ISO)
carbon dioxide transport  (ISO)
cell volume homeostasis  (ISO)
cellular homeostasis  (ISO)
cellular hyperosmotic response  (ISO)
cellular response to cAMP  (ISO)
cellular response to copper ion  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to inorganic substance  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to mercury ion  (ISO)
cellular response to nitric oxide  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to salt stress  (ISO)
cellular response to UV  (ISO)
cellular water homeostasis  (ISO)
cerebrospinal fluid secretion  (ISO)
cGMP-mediated signaling  (ISO)
corticotropin secretion  (IMP)
defense response to Gram-negative bacterium  (IMP,ISO)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
glomerular filtration  (IMP)
glycerol transport  (ISO)
hyperosmotic response  (IBA,ISO)
hyperosmotic salinity response  (ISO)
lateral ventricle development  (IEP,ISO)
lipid digestion  (IMP)
maintenance of symbiont-containing vacuole by host  (IMP,ISO)
metanephric descending thin limb development  (IEP)
metanephric glomerulus vasculature development  (IEP)
metanephric proximal convoluted tubule segment 2 development  (IEP)
metanephric proximal straight tubule development  (IEP)
multicellular organismal water homeostasis  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
nitric oxide transport  (ISO)
odontogenesis  (ISO)
pancreatic juice secretion  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell migration  (IMP)
positive regulation of epithelial cell migration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of saliva secretion  (ISO)
potassium ion transport  (IDA)
renal water absorption  (IGI,IMP)
renal water transport  (IBA,ISO)
response to estrogen  (ISO)
response to hormone  (ISO)
secretion by cell  (IMP)
secretory granule organization  (IMP)
sensory perception of pain  (IMP)
transepithelial water transport  (ISO)
transmembrane transport  (IEA)
water homeostasis  (IMP)
water transport  (IBA,IDA,IGI,IMP,ISO)
wound healing  (IMP)


References - curated
1. Banales JM, etal., Am J Pathol. 2008 Dec;173(6):1637-46. Epub 2008 Nov 6.
2. Fukuda M, etal., Exp Eye Res. 2010 Jan;90(1):17-25. Epub 2009 Sep 11.
3. Kim JE, etal., Neuroscience. 2009 Oct 20;163(3):781-9. Epub 2009 Jul 18.
4. Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5.
5. Li J and Verkman AS, J Biol Chem 2001 Aug 17;276(33):31233-7. Epub 2001 Jun 13.
6. Ma T, etal., J Biol Chem 1998 Feb 20;273(8):4296-9.
7. MGD and Homologene mouse data transfer
8. MGD data from the GO Consortium
10. Motulsky E, etal., Mol Vis. 2010 Apr 3;16:602-10.
11. Nesic O, etal., J Neurochem. 2008 May;105(3):628-40. Epub 2008 Jan 28.
12. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. Paul L, etal., Neurosurgery. 2011 Feb;68(2):462-73.
14. Pipeline to import KEGG annotations from KEGG into RGD
15. Pipeline to import SMPDB annotations from SMPDB into RGD
16. Popescu BF, etal., Acta Neuropathol Commun. 2013 Jul 25;1(1):40. doi: 10.1186/2051-5960-1-40.
17. Qin Y, etal., Exp Eye Res. 2009 Nov;89(5):741-7. Epub 2009 Jul 9.
18. Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13.
19. RGD automated import pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Tian YM, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Feb;27(1):7-11.
23. Tomassoni D, etal., Brain Res. 2010 Apr 14;1325:155-63. Epub 2010 Feb 12.
24. Wang YF, etal., Brain Res. 2011 Jan 25;1370:220-6. Epub 2010 Nov 16.
Additional References at PubMed
PMID:1508193   PMID:8586439   PMID:8703970   PMID:9374641   PMID:9507200   PMID:9689137   PMID:9757370   PMID:9822113   PMID:9886922   PMID:10021457   PMID:10021464   PMID:10191100  
PMID:10232700   PMID:10349636   PMID:10400615   PMID:10613915   PMID:10642600   PMID:10644730   PMID:10662735   PMID:10698922   PMID:10724035   PMID:10788316   PMID:10795927   PMID:10836992  
PMID:10839360   PMID:10856128   PMID:10870513   PMID:11035042   PMID:11042159   PMID:11066060   PMID:11076861   PMID:11078688   PMID:11121384   PMID:11217851   PMID:11382807   PMID:11415940  
PMID:11698654   PMID:11741725   PMID:11891232   PMID:11954676   PMID:12031518   PMID:12034763   PMID:12083525   PMID:12096051   PMID:12133842   PMID:12181190   PMID:12477932   PMID:12565800  
PMID:12600999   PMID:12676067   PMID:12759225   PMID:12943377   PMID:14637313   PMID:14675051   PMID:14753499   PMID:15003543   PMID:15163632   PMID:15283758   PMID:15489334   PMID:15496149  
PMID:15507545   PMID:15557451   PMID:15632069   PMID:15647343   PMID:15647389   PMID:15713911   PMID:15815633   PMID:15838507   PMID:15844003   PMID:15859952   PMID:15952169   PMID:15998844  
PMID:16039047   PMID:16079275   PMID:16133142   PMID:16141072   PMID:16141073   PMID:16319116   PMID:16427635   PMID:16472605   PMID:16476579   PMID:16508653   PMID:16508658   PMID:16525162  
PMID:16571784   PMID:16574458   PMID:16582023   PMID:16602821   PMID:16624821   PMID:16871401   PMID:16936111   PMID:17195181   PMID:17251353   PMID:17257750   PMID:17377981   PMID:17633275  
PMID:17728008   PMID:17868659   PMID:17898307   PMID:17913837   PMID:17941896   PMID:17943079   PMID:17965968   PMID:18172001   PMID:18231833   PMID:18287559   PMID:18296079   PMID:18353863  
PMID:18434389   PMID:18511498   PMID:18554416   PMID:18600340   PMID:18618131   PMID:18665841   PMID:18806227   PMID:19136711   PMID:19179619   PMID:19215235   PMID:19291583   PMID:19298815  
PMID:19367412   PMID:19570847   PMID:19584911   PMID:19628672   PMID:19668215   PMID:19724054   PMID:19774080   PMID:19855135   PMID:20018876   PMID:20029450   PMID:20121927   PMID:20231275  
PMID:20235219   PMID:20530543   PMID:20639513   PMID:20668095   PMID:20853510   PMID:20938728   PMID:20957496   PMID:20978075   PMID:21040788   PMID:21147077   PMID:21181199   PMID:21267068  
PMID:21269951   PMID:21347258   PMID:21451971   PMID:21511033   PMID:21519870   PMID:21677750   PMID:21705333   PMID:21735643   PMID:21854740   PMID:21859894   PMID:21873635   PMID:21925491  
PMID:21947380   PMID:22043022   PMID:22076439   PMID:22174795   PMID:22226856   PMID:22237799   PMID:22323586   PMID:22357733   PMID:22491945   PMID:22674028   PMID:22820194   PMID:22999937  
PMID:23029502   PMID:23087172   PMID:23177919   PMID:23197380   PMID:23238222   PMID:23243273   PMID:23341629   PMID:23404107   PMID:23808411   PMID:23948641   PMID:24049145   PMID:24058167  
PMID:24164893   PMID:24194600   PMID:24231830   PMID:24334548   PMID:24700466   PMID:24879973   PMID:24939938   PMID:25119150   PMID:25160756   PMID:25168025   PMID:25229686   PMID:25249460  
PMID:25270072   PMID:25339696   PMID:25573755   PMID:25585012   PMID:25659450   PMID:25719758   PMID:25725069   PMID:25793528   PMID:25810521   PMID:25993027   PMID:26014508   PMID:26081645  
PMID:26348407   PMID:26631503   PMID:26649797   PMID:26760974   PMID:26847765   PMID:27091563   PMID:27252655   PMID:27307076   PMID:27383386   PMID:27559317   PMID:27582005   PMID:27638854  
PMID:28011038   PMID:28025141   PMID:28129470   PMID:28334964   PMID:28384265   PMID:28409279   PMID:28527294   PMID:28701737   PMID:28760814   PMID:29033846   PMID:29044946   PMID:29196765  
PMID:29249622   PMID:29393658   PMID:29626438   PMID:29844208   PMID:30044992   PMID:30050452   PMID:30133325   PMID:30293570   PMID:30580569   PMID:30809535   PMID:30813473   PMID:30885981  
PMID:30898767   PMID:30940800   PMID:31023968   PMID:31068677   PMID:31251110   PMID:31351040   PMID:31534052   PMID:31700003   PMID:31814527   PMID:31836710   PMID:31898815   PMID:31970899  
PMID:32046744   PMID:32063362   PMID:32311233   PMID:32540373   PMID:32542408   PMID:32747435   PMID:33046507   PMID:33058832   PMID:33469018   PMID:33526661  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39655,313,284 - 55,325,540 (+)NCBIGRCm39mm39
GRCm39 Ensembl655,313,417 - 55,325,540 (+)Ensembl
GRCm38655,336,299 - 55,348,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,336,432 - 55,348,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv37655,286,293 - 55,298,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36655,266,010 - 55,278,133 (+)NCBImm8
Celera655,870,108 - 55,882,362 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.38NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl730,911,694 - 30,925,517 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl730,911,853 - 30,925,517 (+)EnsemblGRCh38hg38GRCh38
GRCh38730,911,853 - 30,925,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,951,468 - 30,965,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,917,993 - 30,931,656 (+)NCBINCBI36hg18NCBI36
Build 34730,724,707 - 30,738,371NCBI
Celera730,940,621 - 30,954,337 (+)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,833,637 - 30,847,351 (+)NCBIHuRef
CHM1_1730,951,350 - 30,965,064 (+)NCBICHM1_1
CRA_TCAGchr7v2731,000,921 - 31,014,637 (+)NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2484,482,512 - 84,494,690 (+)NCBI
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0485,551,503 - 85,563,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04150,203,461 - 150,215,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,098,346 - 84,110,524 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1484,384,810 - 84,396,991 (+)NCBI
Celera479,349,727 - 79,361,905 (+)NCBICelera
Cytogenetic Map4q24NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495541032,066,196 - 32,078,717 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541032,066,196 - 32,078,661 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1731,644,331 - 31,658,141 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,644,331 - 31,658,141 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0731,524,933 - 31,538,602 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.11443,592,266 - 43,603,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,578,721 - 43,605,720 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1443,024,519 - 43,036,159 (+)NCBI
ROS_Cfam_1.01443,532,873 - 43,544,517 (+)NCBI
UMICH_Zoey_3.11443,648,522 - 43,660,154 (+)NCBI
UNSW_CanFamBas_1.01443,325,031 - 43,336,701 (+)NCBI
UU_Cfam_GSD_1.01443,686,308 - 43,697,947 (+)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440511887,935,407 - 87,948,638 (+)NCBI
SpeTri2.0NW_0049364787,146,997 - 7,160,369 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1842,063,481 - 42,076,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,063,482 - 42,076,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12127,456,553 - 27,473,196 (-)NCBI
ChlSab1.1 Ensembl2127,456,259 - 27,470,728 (-)Ensembl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_004624783164,615 - 177,317 (+)NCBI

Position Markers
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38655,347,195 - 55,347,319UniSTSGRCm38
MGSCv37655,297,189 - 55,297,313UniSTSGRCm37
Celera655,881,002 - 55,881,126UniSTS
Cytogenetic Map6B3UniSTS
cM Map627.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38655,345,870 - 55,346,976UniSTSGRCm38
MGSCv37655,295,864 - 55,296,970UniSTSGRCm37
Celera655,879,677 - 55,880,783UniSTS
Cytogenetic Map6B3UniSTS
cM Map627.0UniSTS
cM Map627.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6B3UniSTS
cM Map627.0UniSTS
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38655,347,735 - 55,348,179UniSTSGRCm38
MGSCv37655,297,729 - 55,298,173UniSTSGRCm37
Celera655,881,542 - 55,881,986UniSTS
Cytogenetic Map6B3UniSTS
cM Map627.0UniSTS

QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25440480Moaq2_mmodifier of alien QTL 2 (mouse)61117500000Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139100000Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487426034Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396656149Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396656149Mouse
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396656149Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396656149Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080600000Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414873387692Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268671322775Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62380000057800000Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62500000080000000Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2831405962314181Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3172656565726677Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63270000066700000Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3285065078238974Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63389528167895420Mouse
11252142Mom12_mModifier of Min 12 (mouse)63389528167895420Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63629634770296450Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63647147170471591Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3676447870764478Mouse
14746995Manh60_mmandible shape 60 (mouse)63722567771225677Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63866962592607450Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64089129671379171Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64160000075600000Mouse
1301266Lmr4_mleishmaniasis resistance 4 (mouse)Not determined64211637376116515Mouse
11040600Lmr4c_mleishmaniasis resistance 4c (mouse)64211637376116515Mouse
11040601Lmr4a_mleishmaniasis resistance 4a (mouse)64211637376116515Mouse
11533915Mts4_mmammary tumor susceptibility 4 (mouse)64211637376116515Mouse
12910785Pwgrq16_mpost-weaning growth rate QTL 16 (mouse)64382681377811523Mouse
12910798Pwgrq5_mpre-weaning growth rate QTL 5 (mouse)64382681377811523Mouse
12910802Pwbwq12_mpost-weaning body weight QTL 12 (mouse)64382681377811523Mouse
12910807Pwbwq11_mpost-weaning body weight QTL 11 (mouse)64382681377811523Mouse
12910809Pwbwq10_mpost-weaning body weight QTL 10 (mouse)64382681377811523Mouse
12910820Ogrq3_moverall growth rate QTL 3 (mouse)64382681377811523Mouse
10043885Cia6c_mcollagen induced arthritis QTL 6c (mouse)Not determined64446587171119467Mouse
1300618Pgia19_mproteoglycan induced arthritis 19 (mouse)Not determined64531405987426034Mouse
10412157Fl1n_mfatty liver 1 in NSY (mouse)Not determined645314059128835032Mouse
4142259Tabw2_mtally ho associated body weight 2 (mouse)Not determined46935985136423692Mouse
25314319Histh6_mhistamine hypersensitivity 6 (mouse)648720000125360000Mouse
25314320Histh5_mhistamine hypersensitivity 5 (mouse)648720000148450000Mouse
4140983Srilp_msleep response to influenza, light phase (mouse)Not determined4872655675447710Mouse
1301962Eila2_methanol induced locomotor activity 2 (mouse)Not determined648726556125356785Mouse
1301254Skts11_mskin tumor susceptibility 11 (mouse)Not determined65117915085179300Mouse
14696807Rbcn2_mrod bipolar cell number 2 (mouse)65121000056210000Mouse
1357683Igf1sl1_mIGF-1 serum levels 1 (mouse)Not determined652161713116155267Mouse
4141028Mclr_mmethylcholanthrene lymphoma resistance (mouse)Not determined5437342788379171Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:817
Count of miRNA genes:496
Interacting mature miRNAs:609
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.



Reference Sequences
RefSeq Acc Id: ENSMUST00000004774   ⟹   ENSMUSP00000004774
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl655,336,432 - 55,348,555 (+)Ensembl
RefSeq Acc Id: NM_007472   ⟹   NP_031498
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm39655,313,284 - 55,325,540 (+)NCBI
GRCm38655,336,299 - 55,348,555 (+)ENTREZGENE
MGSCv37655,286,293 - 55,298,549 (+)RGD
Celera655,870,108 - 55,882,362 (+)RGD
Reference Sequences
RefSeq Acc Id: NP_031498   ⟸   NM_007472
- UniProtKB: Q02013 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000004774   ⟸   ENSMUST00000004774

RGD ID:6838940
Promoter ID:MM_KWN:46107
SO ACC ID:SO:0000170
Tissues & Cell Lines:3T3L1_Day1,   Kidney,   Liver,   Lung,   MEF_B4,   Spleen
Mouse AssemblyChrPosition (strand)Source
MGSCv36655,286,246 - 55,286,746 (+)MPROMDB
RGD ID:6889806
Promoter ID:EPDNEW_M8354
Type:single initiation site
Description:Mus musculus aquaporin 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm38655,336,432 - 55,336,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:103201 AgrOrtholog
Ensembl Genes ENSMUSG00000004655 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000004774 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000004774 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:11826 UniProtKB/Swiss-Prot
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Aqp1 PhenoGen
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q542P1 UniProtKB/Swiss-Prot
  Q91VY8 UniProtKB/Swiss-Prot