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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2141
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aqp1
Name: aquaporin 1
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aqp1affects localizationEXP 6480464CTDProgesterone affects the localization of AQP1 proteinPMID:16452730
Aqp1increases expressionEXP 6480464CTDProgesterone results in increased expression of AQP1 mRNAPMID:20726854
Aqp1multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of AQP1 mRNA; [Estradiol co-treated with Progesterone] results in increased expression of AQP1 protein; [Progesterone co-treated with Estrogens] affects the localization of AQP1 protein; Quercetin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of AQP1 mRNA]; Quercetin promotes the reaction [[Estradiol co-treated with Progesterone] results in increased expression of AQP1 protein]PMID:16452730 PMID:28341573
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