AQP1 (aquaporin 1 (Colton blood group)) - Rat Genome Database

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Gene: AQP1 (aquaporin 1 (Colton blood group)) Sus scrofa
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Symbol: AQP1
Name: aquaporin 1 (Colton blood group)
RGD ID: 14123985
Description: ENCODES a protein that exhibits ammonium transmembrane transporter activity (ortholog); carbon dioxide transmembrane transporter activity (ortholog); glycerol transmembrane transporter activity (ortholog); INVOLVED IN ammonium transport (ortholog); camera-type eye morphogenesis (ortholog); carbon dioxide transmembrane transport (ortholog); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Animal Mammary Neoplasms (ortholog); autosomal recessive polycystic kidney disease (ortholog); FOUND IN apical part of cell (ortholog); apical plasma membrane (ortholog); axon terminus (ortholog); INTERACTS WITH cadmium dichloride; diprotium oxide; mercury dichloride
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AQP-1; aquaporin-1; aquaporin-CHIP; water channel protein for red blood cells and kidney proximal tubule
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,063,481 - 42,076,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,063,482 - 42,076,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ammonium transmembrane transport  (IEA)
ammonium transport  (ISS)
camera-type eye morphogenesis  (IEA,ISO)
carbon dioxide transmembrane transport  (IBA,ISS)
carbon dioxide transport  (ISS)
cell volume homeostasis  (ISS)
cellular homeostasis  (ISS)
cellular hyperosmotic response  (ISS)
cellular response to cAMP  (ISS)
cellular response to copper ion  (ISS)
cellular response to dexamethasone stimulus  (ISS)
cellular response to hydrogen peroxide  (ISS)
cellular response to hypoxia  (ISS)
cellular response to inorganic substance  (ISS)
cellular response to mechanical stimulus  (ISS)
cellular response to mercury ion  (ISS)
cellular response to nitric oxide  (ISO)
cellular response to retinoic acid  (ISS)
cellular response to salt stress  (ISS)
cellular response to UV  (ISS)
cellular water homeostasis  (ISS)
cerebrospinal fluid secretion  (ISO)
cGMP-mediated signaling  (ISS)
corticotropin secretion  (IEA,ISO)
defense response to Gram-negative bacterium  (IEA)
establishment or maintenance of actin cytoskeleton polarity  (ISS)
glomerular filtration  (IEA,ISO)
glycerol transport  (IEA,ISS)
hyperosmotic response  (IBA,ISO)
hyperosmotic salinity response  (ISO)
lateral ventricle development  (IEA,ISO,ISS)
lipid digestion  (IEA,ISO)
maintenance of symbiont-containing vacuole by host  (IEA,ISS)
metanephric descending thin limb development  (IEA,ISO)
metanephric glomerulus vasculature development  (IEA,ISO)
metanephric proximal convoluted tubule segment 2 development  (IEA,ISO)
metanephric proximal straight tubule development  (IEA,ISO)
multicellular organismal water homeostasis  (ISO)
negative regulation of apoptotic process  (ISS)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
nitric oxide transport  (ISS)
odontogenesis  (ISO)
pancreatic juice secretion  (ISO)
positive regulation of angiogenesis  (ISS)
positive regulation of cell migration  (IEA,ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of fibroblast proliferation  (ISS)
positive regulation of lamellipodium assembly  (ISO)
positive regulation of saliva secretion  (ISS)
potassium ion transmembrane transport  (IEA)
potassium ion transport  (ISO)
renal water absorption  (IEA,ISO)
renal water transport  (IBA,ISS)
response to estrogen  (ISO)
response to hormone  (ISO)
secretion by cell  (ISO)
secretory granule organization  (IEA,ISO)
sensory perception of pain  (IEA,ISO)
transepithelial water transport  (ISS)
water homeostasis  (ISO)
water transport  (IBA,ISO,ISS)
wound healing  (IEA,ISO)

References
Additional References at PubMed
PMID:14681463   PMID:16534851   PMID:17145712   PMID:18824632   PMID:20828411   PMID:22139335   PMID:25317682   PMID:26988150   PMID:27089501   PMID:27226190   PMID:29267208   PMID:29532265  


Genomics

Comparative Map Data
AQP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,063,481 - 42,076,746 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,063,482 - 42,076,741 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
AQP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl730,911,694 - 30,925,517 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl730,911,853 - 30,925,517 (+)EnsemblGRCh38hg38GRCh38
GRCh38730,911,853 - 30,925,516 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37730,951,468 - 30,965,131 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,917,993 - 30,931,656 (+)NCBINCBI36hg18NCBI36
Build 34730,724,707 - 30,738,371NCBI
Celera730,940,621 - 30,954,337 (+)NCBI
Cytogenetic Map7p14.3NCBI
HuRef730,833,637 - 30,847,351 (+)NCBIHuRef
CHM1_1730,951,350 - 30,965,064 (+)NCBICHM1_1
CRA_TCAGchr7v2731,000,921 - 31,014,637 (+)NCBI
Aqp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,313,284 - 55,325,540 (+)NCBIGRCm39mm39
GRCm39 Ensembl655,313,417 - 55,325,540 (+)Ensembl
GRCm38655,336,299 - 55,348,555 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,336,432 - 55,348,555 (+)EnsemblGRCm38mm10GRCm38
MGSCv37655,286,293 - 55,298,549 (+)NCBIGRCm37mm9NCBIm37
MGSCv36655,266,010 - 55,278,133 (+)NCBImm8
Celera655,870,108 - 55,882,362 (+)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.38NCBI
Aqp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2484,482,512 - 84,494,690 (+)NCBI
Rnor_6.0 Ensembl485,551,502 - 85,569,360 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0485,551,503 - 85,563,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04150,203,461 - 150,215,641 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4484,098,346 - 84,110,524 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1484,384,810 - 84,396,991 (+)NCBI
Celera479,349,727 - 79,361,905 (+)NCBICelera
Cytogenetic Map4q24NCBI
Aqp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541032,066,196 - 32,078,717 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541032,066,196 - 32,078,661 (+)NCBIChiLan1.0ChiLan1.0
AQP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1731,644,331 - 31,658,141 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,644,331 - 31,658,141 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0731,524,933 - 31,538,602 (+)NCBIMhudiblu_PPA_v0panPan3
AQP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,592,266 - 43,603,903 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,578,721 - 43,605,720 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1443,024,519 - 43,036,159 (+)NCBI
ROS_Cfam_1.01443,532,873 - 43,544,517 (+)NCBI
UMICH_Zoey_3.11443,648,522 - 43,660,154 (+)NCBI
UNSW_CanFamBas_1.01443,325,031 - 43,336,701 (+)NCBI
UU_Cfam_GSD_1.01443,686,308 - 43,697,947 (+)NCBI
Aqp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,935,407 - 87,948,638 (+)NCBI
SpeTri2.0NW_0049364787,146,997 - 7,160,369 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AQP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,456,553 - 27,473,196 (-)NCBI
ChlSab1.1 Ensembl2127,456,259 - 27,470,728 (-)Ensembl
Aqp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624783164,615 - 177,317 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 5 3 3 2 2 2
Low 5 1 3 2 5 1 1
Below cutoff 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000055832   ⟹   ENSSSCP00000047109
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1842,063,481 - 42,076,746 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000086405   ⟹   ENSSSCP00000060449
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1842,063,485 - 42,076,600 (-)Ensembl
RefSeq Acc Id: NM_214454   ⟹   NP_999619
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,065,384 - 42,076,551 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021078524   ⟹   XP_020934183
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,063,482 - 42,076,741 (-)NCBI
Sequence:
RefSeq Acc Id: XR_002340208
RefSeq Status:
Type: NON-CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11842,063,482 - 42,076,711 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999619 (Get FASTA)   NCBI Sequence Viewer  
  XP_020934183 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS98212 (Get FASTA)   NCBI Sequence Viewer  
  Q6PQZ1 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020934183   ⟸   XM_021078524
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999619   ⟸   NM_214454
- UniProtKB: Q6PQZ1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSSSCP00000047109   ⟸   ENSSSCT00000055832
RefSeq Acc Id: ENSSSCP00000060449   ⟸   ENSSSCT00000086405


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000033190 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070005506 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000047109 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000060449 UniProtKB/TrEMBL
  ENSSSCP00070008544 UniProtKB/TrEMBL
  ENSSSCP00070008550 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000055832 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000086405 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070010409 UniProtKB/TrEMBL
  ENSSSCT00070010415 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1080.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Aquaporin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aquaporin_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIP_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:407773 UniProtKB/Swiss-Prot
NCBI Gene AQP1 ENTREZGENE
PANTHER PTHR19139 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS AQUAPORIN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MINTRINSICP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81338 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287AT23_PIG UniProtKB/TrEMBL
  A0A4X1T010_PIG UniProtKB/TrEMBL
  A0A4X1T015_PIG UniProtKB/TrEMBL
  A0A5G2QAN2_PIG UniProtKB/TrEMBL
  AQP1_PIG UniProtKB/Swiss-Prot, ENTREZGENE